Hochschulbibliothekszentrum des Landes Nordrhein-Westfalen (hbz)
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The influence of food matrices on the bioavailability of curcuminoids from a dried colloidal turmeric suspension: a randomized, crossover, clinical trial
No full text<jats:p>The absorption and bioavailability of curcuminoids are increased when administered in food matrices, particularly if they contain lipids in a suspended form or polar lipids.</jats:p>
Suture button systems for coronoid fracture fixation: a biomechanical time-zero pilot study
No full text<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Purpose</jats:title>
<jats:p>This study aims to describe a fixation technique for coronoid fractures using suture buttons, and to biomechanically evaluate this technique in comparison to screw fixation as a time-zero pilot study.</jats:p>
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<jats:title>Methods</jats:title>
<jats:p>An O’Driscoll type 2 anteromedial coronoid facet (AMCF) fracture was simulated in 20 fresh-frozen human elbows. The specimens were randomized into two groups and fracture fixation was performed with either a suture button system or a 3.5 mm cannulated screw. Ultimate load-to-failure (N) was then tested for each specimen.</jats:p>
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<jats:title>Results</jats:title>
<jats:p>The mean load-to-failure was 322.6 ± 75.9 N for suture button fixation and 314.2 ± 85.9 N for screw fixation. The differences were not statistically significant (<jats:italic>p</jats:italic> = 0.432). Additional fracturing of the coronoid fragment was observed in two specimens with screw fixation.</jats:p>
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<jats:title>Conclusion</jats:title>
<jats:p>Promising biomechanical evaluations show that this fixation technique using suture buttons in the treatment of coronoid fractures provides equal construct stability as screw fixation. Further studies are required to fully validate this procedure.</jats:p>
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Correction: Determination of a normal orogenic palaeo-geothermal gradient with clay mineral and organic matter indices: a review
No full textExpression of concern: Synthesis and characterization of a novel copper carboxylate complex and a copper complex-coated polyether sulfone membrane for efficient degradation of methylene blue dye under UV irradiation: the single crystal X-ray structure of the copper carboxylate complex
No full text<jats:p>Expression of concern for ‘Synthesis and characterization of a novel copper carboxylate complex and a copper complex-coated polyether sulfone membrane for efficient degradation of methylene blue dye under UV irradiation: the single crystal X-ray structure of the copper carboxylate complex’ by Rupy Dhir <jats:italic>et al.</jats:italic>, <jats:italic>Dalton Trans.</jats:italic>, 2024, <jats:bold>53</jats:bold>, 9441–9451, https://doi.org/10.1039/D4DT00871E.</jats:p>
Integrating wide-swath altimetry data into Level-4 multi-mission maps
No full text<jats:p>Abstract. Real-time observation of ocean surface topography is essential for various oceanographic applications. Historically, these observations have mainly relied on satellite nadir altimetry data, which were limited to observation scales greater than approximately 60 km. However, the recent launch of the wide-swath Surface Water Ocean Topography (SWOT) mission in December 2022 marks a significant advancement, enabling the two-dimensional global observation of finer-scale oceanic scales (∼ 15 km). While the direct analysis of the two-dimensional content of these swaths can provide valuable insights into ocean surface dynamics, integrating such data into mapping systems presents several challenges. This study focuses on integrating the SWOT mission into multi-mission mapping systems. Specifically, it examines the contribution of the SWOT mission to both the current nadir altimetry constellation (six/seven nadirs) and a reduced nadir altimetry constellation (three nadirs). Our study indicates that within the current nadir altimetry constellation, SWOT's impact is moderate, as existing nadir altimeters effectively constrain surface dynamics. However, in a hypothetical scenario where a reduced nadir altimetry constellation is envisioned to be operational by 2030, the significance of wide-swath data in mapping becomes more pronounced. Alternatively, we found that data-driven and dynamical mapping systems can significantly participate in refining the resolution of the multi-mission gridded products. Consequently, integrating high-resolution ocean surface topography observations with advanced mapping techniques can enhance the resolution of satellite-derived products, providing promising solutions for studying and monitoring sea-level variability at finer scales. However, to fully exploit SWOT's capabilities, future research will need to focus on innovations in data gridding and assimilation to extend mapping beyond geostrophically balanced flows.
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Understanding uncertainties in the satellite altimeter measurement of coastal sea level: insights from a round-robin analysis
No full text<jats:p>Abstract. The satellite radar altimetry record of sea level has now surpassed 30 years in length. These observations have greatly improved our knowledge of the open ocean and are now an essential component of many operational marine systems and climate studies. But the use of altimetry close to the coast remains a challenge from both a technical and scientific point of view. Here, we take advantage of the recent availability of many new algorithms developed for altimetry sea level computation to quantify and analyze the uncertainties associated with the choice of algorithms when approaching the coast. To achieve this objective, we did a round-robin analysis of radar altimetry data, testing a total of 21 solutions for waveform retracking, correcting sea surface heights and finally deriving sea level variations. Uncertainties associated with each of the components used to calculate the altimeter sea surface heights are estimated by measuring the spread of sea level values obtained using the various algorithms considered in the round-robin for this component. We intercompare these uncertainty estimates and analyze how they evolve when we go from the open ocean to the coast. At regional scale, complementary analyses are performed through comparisons with independent tide gauge observations. The results show that tidal corrections and uncertainties in the mean sea surface can be significant contributors to uncertainties in sea level estimates in many coastal regions. However, improving the quality and robustness of the retracking algorithm used to derive both the range and the sea state bias correction is today the main factor to bring accurate altimetry sea level data closer to the shore than ever before.
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Gynecologic health of women with multiple sclerosis: An overview on the current status and findings of Pap tests in a low-income setting
No full textBACKGROUND: Women with MS (wwMS), particularly ones in low-income settings, and exposed to disease-modifying therapy (DMT), could have specific gynecological health-related issues. AIM: To assist policy making and lead further research by describing the current status of gynecological health and Pap test results in wwMS. METHODS: Cross-sectional study on wwMS living in Isfahan, Iran. Participants were surveyed and referred for a Pap test, results of which were compared with 1:2 age- and socioeconomic status-matched healthy controls (HC). Primary outcome was the degree of non-benign squamous/glandular cell abnormalities. Secondary outcomes were presence of evidence of infection, and the degree of benign inflammatory/reactive changes. Logistic regression models were utilized for analyses. RESULTS: 197 wwMS were included (mean age [SD], 41.2 [8.3]; median EDSS (IQR) 1.5 [0.5]). 74.1% reported having sexual activity more than once per week in the past year. For contraception, 21.6% and 16.8% used calendar-based methods and male condoms, respectively. 7% had contracted a gynecological infection in the past. Only 1% had received HPV vaccination. Compared to HC, benign reactive/inflammatory changes in Pap tests were less frequently seen in the wwMS (OR: 0.3; 95% CI: 0.2, 0.4; p < 0.001), while evidence of infection was seen more frequently (OR: 11.5, 95% CI: 3.3, 40; p < 0.001). Results were consistent across DMT groups except anti-CD20 therapies. Additionally, the frequency of non-benign changes in wwMS was two times of that in the HC, but the study lacked adequate power to confirm statistical significance (1.5% vs. 0.8%, OR: 2; 95% CI: 0.4, 10.1; p = 0.39). CONCLUSION: There is room for improvement of the gynecological health status of wwMS who live in low-income settings. Also, findings support an immune dysfunction in the cervices of DMT-exposed wwMS. Additionally, further research is merited to determine the risk of changes of malignant potential in cervices of wwMS
Naturido alleviates amyloid β1–42-induced adverse effects in a transgenic Caenorhabditis elegans model of Alzheimer’s disease
No full textAlzheimer’s disease (AD) is a progressive neurodegenerative disorder primarily associated with aging. While the amyloid hypothesis is not the only explanation for AD pathogenesis, it is widely recognized that the accumulation of amyloid β (Aβ) protein triggers pathological changes in the brains of patients. In a previous study, we showed that Naturido, a cyclic peptide derived from the medicinal fungus (Isaria japonica) grown on domestic silkworms (Bombyx mori), could reverse several age-related deficits in senescence-accelerated mice. In this study, we explored the potential of Naturido to reduce Aβ-related toxicity in transgenic Caenorhabditis elegans models of AD, where human Aβ1-42 protein is overexpressed in neurons. Our results demonstrated that Naturido administration alleviated various phenotypes, including Aβ-induced impairment in associative learning, serotonin hypersensitivity, and locomotion in the transgenic C. elegans. These findings suggest the potential of Naturido as a candidate molecule for the prevention and/or treatment of AD
How patients experience nurse-doctor collaborative care at specialist clinics: A qualitative study
No full textINTRODUCTION: Patient experience of interprofessional collaboration in primary care has been well-studied but not in specialist clinics. Our qualitative study aimed to understand patients’ experience of a nurse-doctor collaboration at three specialist clinics (Epilepsy Clinic, Neuroimmunology Clinic, and Persistent Concussion Clinic) in a tertiary neurology care centre in Singapore. METHODOLOGY: Between December 2023 and April 2024, participants of different demographic and disease profiles from the three specialist clinics were recruited using maximum variation selection. We generated observation and interview data to understand patient experience in a multifaceted and in-depth manner. We analyzed the data using Braun and Clarke’s reflexive thematic analysis. RESULTS: We observed 27 patients, of whom 12 agreed to be interviewed. We constructed two themes. The first discussed the patients’ varied receptivity to interprofessional collaboration depending on their perceived healthcare needs. Most patients valued collaborative care as it saved time and enhanced their access to psychosocial and financial support. However, patients whose disease status was still active preferred to consult the doctors for symptomatic management through drug treatment. They were observed to be reticent about sharing their preference with the care team. The second theme examined the absence of formal introduction of the concept of interprofessional collaboration to the patients. Some patients appeared to be unaware that specialist nurses were qualified to collaborate with doctors, and this lowered their perceptions of the nurses’ competence and seemingly weakened their receptivity to IPC. CONCLUSION: Patients’ experience of IPC at specialist clinics varied depending on patients’ perceived healthcare needs. To optimize patients’ receptivity to IPC, the provision of collaborative care should be calibrated to fulfill different patients’ perceived and actual healthcare needs. Doing so may optimize the value of collaborative care to patients. Further enhancements to patients’ receptivity would involve the intentional effort to prepare patients for collaborative practice
Evolving Appetites: Current Evidence and Future Perspectives in Terms of Meat Substitutes in Europe
No full textConsumers are increasingly aware of the environmental and health impacts of their food choices, leading to changes in consumption behavior. This study examines the consumption patterns and behaviors of European consumers regarding meat substitutes and identifies factors influencing their acceptance as alternative protein sources. The study involved 5000 participants from four European countries—France, Germany, Italy, and Spain with data extracted from the Mintel consumer database in 2024. Results indicate that over 50% of consumers in these countries have reduced their intake of red meat, with a notable portion of German consumers adhering to a vegan diet. Across the sample, females significantly differ from males, as they consume less meat, tend to limit their meat intake, and show a greater interest in reducing meat consumption. Baby Boomers predominantly consume more meat and show less interest in reducing their meat intake compared to younger generations. Economic and sustainability aspects are key perceptions driving the perceived benefits of reducing meat consumption. Additionally, preferences for locally sourced products, meat-like taste and texture, and natural ingredients are primary considerations when purchasing meat substitutes. Fish substitutes were rated as popular meat substitutes in France, Italy, and Spain, while breaded or battered meat/poultry substitutes were the most popular choice in Germany. Insights from this study are valuable for market researchers and the food industry, offering guidance on supplying appealing and sustainable protein alternatives that encourage a shift toward healthier and more sustainable consumption behavior