1025 research outputs found
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Synthesis and Evaluation of Apoptotic Induction of Human Cancer Cells by Ester Derivatives of Thujone
No full textThujone (1), thujol (2), and aromatic thujol esters (3–9) were evaluated for their ability to induce cell death in human cervical (HeLa), melanoma (A375), and colon (HCT-116) cancer cell lines, using etoposide as a positive control. The compounds showed dose-dependent activity at concentrations ranging from 50–400 μg/mL. Etoposide exhibited an IC50 value of 116 μg/ mLin HeLa cells, and α-thujone, α/β-thujone (7:1), and thujol showed comparable activity with IC50 values of 191, 198, and 1234567890();,: 1234567890();,: 136 μg/mL, respectively. All seven ester derivatives were cytotoxic to HeLa and HCT-116 cells, while a subset was cytotoxic to A375 cells. In HeLa cells, t-cinnamate (4), t-isonicotinate (5), t-nicotinate (6), and t-furoate (8) were more potent than either α-thujone or α/β-thujone. Similarly, t-furoate (8) was more potent than thujone in A375 cells, and t-isonicotinate (5) and t-nicotinate (6) were more potent against HCT-116 cells. Based on cell morphology, PARP cleavage and an increase in the caspase-3/7 levels, the esters exert their cytotoxic effects by induction of apoptosis
Exploring nonvoting and electoral integrity in the 2016 presidential election
No full textWhile voter turnout has been a subject of research for decades, comparatively little attention has been paid to nonvoters. Just as voters can be mobilized by demographic and contextual factors, we theorize that these factors can serve to demobilize people as well. Our study identifies four potential types of nonvoters and theorizes how they differ in their demographics and their motivations for not voting. Using data from the Cooperative Congressional Election Study (CCES) and the Electoral Integrity Project (EIP), we examine nonvoters in the 2016 general election in the United States. We find that apathetic, obstructed, incapable, and conditional nonvoters are each unique. Low electoral integrity can demobilize obstructed nonvoters, while apathetic, incapable, and conditional nonvoters are driven more by political and demographic factors
At Large in the Empire of Things: The Museum of Sundry Objects
No full textThe Museum of Sundry Objects, located in Sólgarður, about 25 kilometers north of Akureyri, offers a site to think carefully about a number of key elements of museum practice, including the logic of collection, the practice of object ‘array,’ and the role of the museum ‘heroic’ object. Where the heroic object directs one to move from the individual to the imagined array, the array opens a different set of possibilities for recognizing the singularity of objects. In addition, a close examination of the Sundry suggests that ‘the museum’ may simply be one stage of many in the ongoing life of the object, an extended liminal phase that offers a number of opportunities for the re-enlivening of the objects, a different set of steps on the path of the in between
Accounting Information Quality and the Clustering of Stock Prices
Get PDFThe foundation of economic theory is based on the premise that prices will converge to their equilibrium value. However, prior research has documented that stock prices cluster on round pricing increments. In this study, we develop and test the hypothesis that audit quality and the management of earnings—both of which affects the information environment of the firm—influence the degree of price clustering. Results show that firms with Big 4 auditors have less clustering in their stock prices while firms with higher abnormal audit fees, more discretionary accruals, and firms that tend to manipulate earnings have a higher degree of price clustering. These findings support our hypothesis and suggest that accounting information quality helps explain the price clustering anomaly and subsequently influences the efficiency of financial markets
Case Study of the Egyptian Revolution
Get PDFMany political scientists argue that anocracies, or semi-democracies, are more prone to political violence than countries that are either strictly democratic or strictly authoritarian (Vreeland 2003, 401). An anocracy is defined as, “a type of regime that mixes democratic with autocratic features.” To test this theory, I will study the governmental system of Egypt, a country that has long been deemed a semi-democratic nation. Egypt has a score of -4 on the Polity Data Series, which ranges from -10 to 10, and is titled a “closed anocracy” (Polity IV). I will examine the governmental history of Egypt. I will particularly look at civil war and revolution within the government, and the history of violence as it has risen and fallen with levels of popular sovereignty. Lessons that can be learned from a study of this sort is the need for a strong, centralized government in a state
Arts Integration Self Study Research
Get PDFThe goal of Ms. Reed and Mr. Torres was to determine how the use of arts integration could impact the classroom setting and their teaching practices. Through the use of performance and visual arts, the data represents their findings, as they monitored their research question during the course of their eight-week practicum. They both discovered that, through arts integration, their students\u27 engagement and overall classroom management had improved. Continuing, Ms. Reed also found a positive correlation with her students’ academic scores, as well
Nutrient Composition and Sediment Size in Stream Sediments
Get PDFPrecision conservation is the use of geospatial analysis of high-resolution datasets to determine the location where restoration will be the most effective based on elements like stream location, watershed size, and neighboring land use. For four years, Susquehanna University has worked with the Chesapeake Conservancy to study the effects of stream restoration throughout nine different watersheds in Centre, Montour, Union, and Northumberland counties. Sites are monitored before and after stream restoration has been implemented to determine the effects of restoration and best management practices on factors such as species diversity, fish populations, water quality, mean grain size of sediments, and nutrient concentrations in stream sediment. At 31 different sites, a one hundred-meter reach is electroshocked for fish, and five sediment samples are taken from a pool, riffle, eddy, a run from pool to a riffle, and a run from a riffle to a pool. The sediment samples were analyzed for grain size and nutrient concentrations, including ammonia, nitrate, and phosphate. Stream restoration should help improve stream quality by reducing erosion and the amount of fine sediments entering the stream. It was found that as mean grain size of sediments decreased, nitrate and ammonia concentrations increased, while phosphate concentrations showed no significant correlations to grain size. Increasing amounts of clay, silt, and ammonia in sediment samples also correlated to heavily agriculturally impacted streams. Also, fish populations decreased as nutrient concentrations increased, with a significant correlation to nitrate. By studying nutrient concentrations and their correlation to mean grain size, we hope to demonstrate that best management practices can improve both fish and macroinvertebrate habitat and reduce the potential nutrient storage in the stream channel sediments
Herbicide Effects on the Feeding Behavior of the Wolf Spider Pardosa milvina
Get PDFHerbicides can potentially impact feeding behavior of beneficial predators in agricultural systems and subsequently compromise integrated pest management efficacy. We measured variation in feeding behaviors of an agriculturally abundant wolf spider, Pardosa milvina, when exposed to soil with field-relevant concentrations of five commonly used herbicides. Tested herbicides included atrazine, S-metolachlor, rimsulfuron, mesotrione, glyphosate, a mixture of all five herbicides, and a distilled water control. Spiders were housed individually in containers with topsoil previously sprayed with a recommended herbicide dosage or water control. Tested spiders were collected from two adjacent fields: one kept under continuous crop rotation for over twenty years and sprayed with various combinations of all these herbicides while the other was an alfalfa field with no pesticides applied for the last 12 years. Adult males and females from each plot were exposed to the seven treated soil substrates (N=1,214, n=43). Spiders were maintained on these treated substrates for 14 days and fed crickets (Gryllodes sigillatus). Their predatory behaviors toward an individual cricket were observed on untreated substrates. Individual spiders from each herbicide treatment were standardized for hunger then presented a cricket one week and two weeks after initial treatment exposure. We found no significant differences in prey capture latency for spiders across herbicide treatments during the first week of exposure, but large differences emerged by the second week. We also found large sex and collecting site differences in prey capture efficiency and weight change across treatments. Mesotrione and rimsulfuron-treated spiders showed the greatest weight loss between the first and second week of exposure while atrazine, glyphosate and s-metalachlor treated spiders gained more weight than the control group. Our results show that some herbicides can significantly reduce or increase feeding responses in this important agriculturally abundant predator and should be considered in integrated pest management decisions
Do Hands-on Activities Affect the Teaching of a Classroom?
Get PDFThe purpose of this study was to see if the use of hands on activities, in math, have an impact on teaching. This study observed teaching behaviors and how students were felt about hands on activities. Findings showed that teaching increased and students’ understandings of mathematical concepts increased
Incorporating Collaboration into the School Setting
Get PDFThe purpose of this study was to understand the correlation between collaboration and teaching practices and outcomes. This was conducted in a rural third grade classroom in a self-study format through the student teaching process. Self-reflections, surveys, and feedback forms were used to collect data. Findings showed that collaboration increased learning and improved lessons of both students and teachers. Furthermore, findings revealed that collaboration is not a natural process, but one that needs to be supported, reflected upon, and organized. In addition to this study was the ability of third grade students to participate in a collaborative setting. Scaffolding discussions and reflective practices lead to significant progress with these students as well as among the teachers. Finally, collaboration was influential in allowing for significant learning to be made for the student teacher in best preparing for future learning