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Exploring the effects of β-N-methylamino-L-alanine on the GluN1/GluN2A NMDA receptor in Schmidtea mediteranea.
No full textβ-N-methylamino-L-alanine, known as BMAA, is a neurotoxin produced by several species of cyanobacteria and eukaryotic microorganisms such as diatoms and dinoflagellates. BMAA has been implicated in neurodegenerative diseases such as ALS, Parkinson’s disease, and Alzheimer’s disease. Because it is biomagnified through the food chain, accumulation occurs in its symbionts like cycad seeds and seafood, which can be ingested by humans and potentially result in neurological disease. There is evidence that BMAA is an N-methyl-D-aspartate (NMDA) receptor agonist. NMDA receptors are a family of L-glutamate receptors that play a critical role in learning and memory, and in inducing excitotoxicity in neurons. The role of BMAA in inducing motor neuronal death is not well understood. Schmidtea mediterranea (planarians) produce endogenous glutamate and express genes for glutamate receptors making them a desirable model for investigating the interaction between BMAA and NMDA receptors. Previous work suggested that BMAA exposure induced neuronal damage and, ultimately, death in planarians. The present study examined (1) the localization of NMDA receptors in Schmidtea mediterranea via in situ hybridization (2) the interaction between BMAA and NMDA receptors via RNAi and BMAA exposure trials.https://digitalcommons.snc.edu/collaborative_presentations/1114/thumbnail.jp
Determining the role of temperature on vgrG promoter expression in Burkholderia cepacia
No full textBurkholderia cepacia is a bacterial species that causes infection in plants and animals. Recent work in our lab has focused on a specific strain of B. cepacia that has a mutated vgrG gene. This gene is part of a cluster of genes that are predicted to make up a complex structure called the Type 6 secretion system (T6SS). This system functions to inject toxins into other cells for competition or infection. It is hypothesized that the vgrG gene encodes a protein that is required for the function of this T6SS during infection. Previous bioinformatics work determined that there are 19 vgrG genes in the B. cepacia genome, and we hypothesize that some of these will be required for infection in our system. We plan to start by examining the expression of these vgrG genes to determine which genes may be involved in infection. We will do this by characterizing activity of the promoter sequences associated with the vgrG genes. We hypothesize that there is variability in when the vgrG genes are expressed and that the vgrG promoters are temperature-dependent. We are currently establishing a method to test the gene expression of each vgrG gene of interest at varying temperatures using colorimetric assays. The results will allow us to distinguish between the activity of the different promoters as well as the effects of temperature on vgrG promoter activity. Understanding the expression of the vrgG genes will demonstrate the effect of temperature on B. cepacia virulence.https://digitalcommons.snc.edu/collaborative_presentations/1113/thumbnail.jp
Secondary Derivations and the Universal Property
No full textWe introduce a generalization of derivations. We then establish a universal property which paves the way to relating secondary Kahler differentials with secondary derivations.https://digitalcommons.snc.edu/collaborative_presentations/1109/thumbnail.jp
Fall/Winter 2022: Sociology Alum Fights Crime From Behind the Scenes
Get PDFJonah Riggle ’16 leverages his sociology and criminal justice education from St. Norbert College to serve as a crime analyst for the Green Bay Police Department, using data and GIS mapping to support law enforcement and combat crime.https://digitalcommons.snc.edu/snc_magazine_archives_2019-2023/1297/thumbnail.jp
Summer 2023: A Big Picture to Awaken Campus Memories
Get PDFOur “Big Picture” spread, a regular feature in St. Norbert College Magazine, delivers stunning images of our beautiful riverfront campus and the vibrant college community that it sustains.https://digitalcommons.snc.edu/snc_magazine_archives_2019-2023/1004/thumbnail.jp
Spring 2023: Archival Research of Rare Text Published, With a Prize
Get PDFMedieval literature scholar Bernardo Hinojosa (English) first encountered works from the Middle Ages as an undergraduate at Columbia University. “It completely changed my life,” says Hinojosa. He latched on to the experimentation and innovation of the period: “The beginnings of a literary tradition were being built for the first time,” he says.https://digitalcommons.snc.edu/snc_magazine_archives_2019-2023/1006/thumbnail.jp
Spring 2023: Musician Finds Community Through Performance
Get PDFAlready an orchestra director with the Appleton (Wis.) School District, director of the New Horizons Orchestra and a bassoonist with the Green Bay Civic Symphony, Rachel (Meagher) Richards ’04 decided she didn’t quite have enough music in her life. Recommended by several people in the Fox Valley, Wis., community, she is now at the helm of youth orchestras for the Fox Valley Symphony.https://digitalcommons.snc.edu/snc_magazine_archives_2019-2023/1012/thumbnail.jp
“Learning the Rules of the Game”
No full textA junior from Medford who’s double majoring in economics and philosophy, Seth Mayrer shares his experience with cerebral palsy and how his trials have shaped who he is today. He has come to realize how important his challenges were in guiding him through life
