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    The European Health Data Space as a Case Study

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    In May 2022, the European Commission proposed the launch of a health-specific data sharing framework called the European Health Data Space (EHDS), underpinned by legislation, for the use of electronic health data by patients and for research, innovation, policy-making, patient safety, statistics, or regulatory purposes. In this essay, I review some of its more contentious features based on the latest version of the legislative proposal. I suggest that the EHDS is a useful case study to illustrate the need for a translational bioethics approach that shines a critical analytical light on contentious aspects of large-scale research infrastructures

    Inside Out: The Short Stories of Micheál Ó Conghaile

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    In “Trasnú” (Crossing), Gaeltacht poet Cathal Ó Searcaigh revels in the creative tension inherent in the comingling of traditional Irishlanguage culture with late modernity. He describes contemporary identity as a messy hybrid of ancient and tenacious tradition on the one hand and a freeing but fickle globalized culture on the other: “tá muid leath-réamhstairiúil / agus leath-postmodern intertextual” (we are half prehistoric, half postmodern intertextual).1 Few authors exemplify this dual identity better than the Gaeltacht novelist, short-story writer, and playwright Micheál Ó Conghaile. Born in 1962, Ó Conghaile is by no means an old man, yet the upbringing that he describes is now totally unthinkable. While Ireland entered the “Lemass era” of economic change—often considered to have catalyzed radical social transformation over the following decades—Ó Conghaile spent his youth in one of the most dramatically isolated, and consequently culturally stable, parts of the country. Now an acclaimed author with a secure place in the Irish-language canon, Ó Conghaile—who went on to found one of the language’s most important publishers, Cló Iar-Chonnacht—grew up reading by candlelight. His hybrid identity as a rural gay man, a native Irish-speaker, and an educated and welltraveled entrepreneur provides him with a unique and complicated perspective that seems to accommodate both the authority of one on the inside and the marginalization of one inherently different. Difference is accepted as a fact of life in his work, which ranges from realistic testimony to the wildly experimental and obscene

    Irish experiences in the British Army during the Napoleonic Wars a quantitative analysis of Irish military service in the regular army 1808 to 1815

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    The French Revolutionary and Napoleonic wars (1792-1815) resulted in the first truly mass mobilisation of European manpower. The campaigns fought by the British Army during the period 1808-15 were among the most strategically important of the wars for Great Britain and resulted in the expansion of the regular army to a peak of 230,469 men by 1813.1 This placed a significant strain on the British state’s manpower resources and resulted in the large-scale recruitment of Irish men into the regular army, directly impacting many communities across Ireland. While research has been conducted into the mobilisation of British society to meet the demands of ‘total’ war, research within an Irish context has been limited.2 Irish military service during this period has been viewed primarily through the perspective of the Irish militia and yeomanry, with service in the regular army generally considered within the context of the ‘Irish’ regiments of the British Army. This narrow focus has resulted in an under-appreciation of the extent of Irish manpower mobilised by the British state for the defeat of Napoleonic France. Furthermore, it has marginalised or omitted important participants in the historical narrative of the Irish military experience, namely Irish women and children. And finally, it has unintentionally restricted research into the wider impacts on the political, economic, and social relationship between Ireland and Great Britain. This research will address these gaps in the historiography of Irish military service by examining Irish experiences across all regiments of the regular army between 1808 and 1815. The research methodology employed differs significantly from those of other studies of Irish military service during this period as it is based on the quantifiable analysis of data from the military records. Two databases were constructed using biographical details from military service records of enlisted men and officers. A database of 1,913 Irish enlisted men from 45 cavalry and infantry regiments provides unique insights into these men’s social backgrounds and their experiences in the regular army. A second database of 9,378 regular army officers facilitates comparative analysis of the experiences of Irish officers against their English and Scottish colleagues. A third database of 217 regiments and battalions allows for the analysis, by regiment and rank, of the country of birth of 141,527 English, Scottish and Irish enlisted men who served in the regular army. Quantifiable analysis is also conducted on the military records relating to the experiences of thousands of Irish women and children in all regiments of the British Army during the period. This is a new departure for the historiography of early nineteenth century Irish society by placing Irish military experiences during the Napoleonic wars within the broader Anglo/Irish political, social and economic narrative of the period. Analysis of the databases demonstrates that Irish manpower was critical to enabling the British state to prosecute the war in a sustained manner in terms of the numbers of officers and enlisted men serving across all regiments of the regular army. Arising from the scale of Irish recruitment, military service in the regular army impacted Irish society in more ways than previously understood. Men from every parish, town and city in Ireland enlisted in the regular army. Irish women and children accompanied their menfolk and were a significant presence across all regiments of the regular army. This research also addresses important aspects of Irish military service such as religion, welfare, education, discipline and the relationship with military authority, promotion, and transnational experiences. Addressing the topic of Irish military service in a more comprehensive manner utilising empirical based analysis is the focus of this research. It is intended that this will facilitate new perspectives of the relationship between the British Army and the British state with Irish society during this period and in the following decades

    Ireland’s gypsum and brick field: a study of the social and industrial development of a mining community, 1800-2010

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    The mining community, together with the gypsum and brick clay deposits, occupies a small district in the north-east of the Republic of Ireland. The field extends for 12km southwards from Carrickmacross, Co. Monaghan, to east of Kingscourt, Co. Cavan, reaching the Kilmainhamwood area of north Meath. The manufacturing headquarters of each industry is in the latter region, but Kingscourt is regarded as the ‘capital’. The study investigates and relates the nexus of the community and its industries over time; it explains the continuum of developments resulting from this relationship; and acknowledges the local, national, and international events as they contribute to the context and history of the industries. Herein lies the challenge of the thesis. The significance of the study revolves on its primary achievement of providing the first social account of the workings of these important minerals, while recognising their unique and valuable contribution to the Irish construction industry and to export markets. The cast of significant, entrepreneurial characters reveals the attraction of industrial enterprise - many of whom emerge from the obscurity of the archives. The methodology is governed by the nature of the primary sources and the trajectory which they afford the work. Accordingly, the origins, chronology and progression of this narrative, qualitative account, rests on the sequential grants of mineral leases and associated literature. From 1800-1903, these leases were moulded by the Shirley family, the landlords who owned and controlled the minerals. Their archival material was invaluable in providing a social insight on industrial development and nineteenth century tenant society. Following the milestone legislation of Wyndham’s land act in 1903, the leases were mainly negotiated by mining companies with the Irish department of industry and commerce. Launch days were major events for the thesis. They furnished the social, political, and economic milieu, thus placing the industries in their contemporary surroundings. Many sub-themes are also featured such as, rail transport; the role of turf; fertilizer; and environmental concerns. They augment and embellish the central dynamic of the work. The introduction of plasterboard manufacture in 1947 proved a revolutionary development in terms of output, earnings and employment. On the conclusion of the study (2010), both industries have become members of conglomerate enterprises. The many benefits bestowed upon the community from the fountain of employment are described. But social stability, which allows the local heritage to prosper, is the paramount value

    On Loss-Aware Optimal Control of Wave Energy Converters With Electrical Power Take-Offs

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    Incorporating the non-ideal power take-off (PTO) efficiency of wave energy converters (WECs) into energy-maximizing control is crucial for achieving optimal electrical power generation. The majority of previous loss-aware controllers are based on a simplified power-coefficient (PC) model or only consider the copper loss, which remain insufficient to describe a real electrical PTO. In this article, a high-fidelity loss model, encompassing different loss components of the PTO (a generator and a power converter), is developed, and a number of loss-aware model predictive control (MPC) options are derived and compared in a realistic case study. The results highlight the importance of using an appropriate loss model, rather than a PC model, both for power evaluation and for control, and it is shown that a quadratic loss model employed in MPC is effective in approximating the true loss function, so that near-optimal power production can be achieved with fast computation

    Selection of patient-reported outcome measures in pulmonary arterial hypertension clinical trials: a systematic review, meta-analysis and health-related quality of life framework

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    Health-related quality of life (HRQoL) in pulmonary arterial hypertension (PAH) is valued as an outcome measure by patients, clinicians and regulators. The selection of patient-reported outcome measures (PROMs) for measurement of HRQoL in PAH clinical trials lacks systematic evaluation of their suitability, accuracy and reliability. Methods We report a systematic review (PROSPERO ID: CRD42024484021) following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines of PROMs selected in PAH clinical trials. PROM measurement properties were then evaluated according to the 10-step COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist and graded by recommendation for use. Finally, HRQoL was modelled into a conceptual framework using patient interviews and surveys. Results Screening of 896 records identified 90 randomised controlled trials. 43 trials selected PROMs, of which 20 were sufficiently validated to detect meaningful change. Of these, eight trials were adequately powered, using either EuroQol-five dimensions-five levels (EQ-5D-5L), Short-Form-36 (SF-36) or the Living with Pulmonary Hypertension Questionnaire (LPHQ). The COSMIN evaluation recommended EmPHasis-10 and the LPHQ for use (grade A); whereas, SF-36 and EQ-5D-5L require further study (grade B). A conceptual framework of HRQoL was developed from literature comprising 8045 patients. This framework can be used to visualise the different HRQoL concepts measured by different PROMs. Conclusion To improve patient-centred research, greater consistency in PROM selection is required. Three of 90 randomised controlled trials have selected COSMIN-recommended PROMs. Whilst the PROMs evaluated require development across the 10 areas of psychometric property measurement, EmPHasis-10 and the LPHQ can be recommended for use. The ratified conceptual framework can further support PROM selection by identifying the HRQoL concepts they are likely to capture

    Power system stability in the Era of energy Transition: Importance, Opportunities, Challenges, and future directions

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    Utilities are struggling to fulfil increased energy demand from domestic and industrial expansion. Conventional energy sources are insufficient to satisfy this burgeoning global energy demand, and the substantial emissions of pollutants associated with these sources are concerns. The energy transition is becoming more inevitable than ever for mitigating this situation. However, this transition threatens the power system stability by introducing intermittent and low inertia energy resources to the grid. In terms of the energy transition, there is abundant research about design purposes, but those considering the power system stability are still inadequate. The significance, opportunities, challenges, and future directions of the energy transition related to power system stability are covered thoroughly in this article. The IEEE 14-bus system is selected as a case study for renewable energy sources (RES) integration as it includes various voltage levels (132, 33, and 0.4) kV. Various scenarios of RES integration, fault, sudden change of generation and load are simulated using DIgSILENT /MATLAB software. The case study clarifies how power system stability is affected by the energy transition and how the energy storage system improves stability. It also discusses the future direction as a baseline for scholars and industries to accelerate the smooth energy transitio

    PSO‐based optimal placement of electric vehicle charging stations in a distribution network in smart grid environment incorporating backward forward sweep method

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    The transition from conventional fossil‐fuel vehicles to electric vehicles (EVs) is critical for mitigating environmental pollution. The placement of electric vehicle charging stations (EVCS) significantly impacts the utility operator and electrical network. Inappropriately placed EVCS lead to challenges such as increased load, unbalanced generation, power losses, and reduced voltage stability. Incorporating distributed generation (DG) helps mitigate these issues by maximizing EV usage. This study focuses on optimizing EVCS and DG placement in radial distribution networks. The methodology employs a backward and forward sweep method for load flow analysis and utilizes the particle swarm optimization (PSO) algorithm to determine optimal EVCS and DG locations and sizes. This approach, validated on the IEEE‐33 bus system, outperforms existing methods. Results indicate a 2.5 times greater power loss reduction compared to simulated annealing (SA), 1.6 times better than artificial bee colony, and parity with genetic algorithm (GA). Overall, the PSO algorithm demonstrates superior optimization effectiveness and computational efficiency, showcasing 1–2.5 times better performance than other methodologies. Employing this approach yields significantly improved results, making it a promising technique for optimizing EVCS and DG placement in distribution networks

    Topics in Model Evaluation and Comparison

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    Statistical modelling of data in real-world scenarios often require models that can accommodate variability and dependence in a plethora of different ways. Within the generalized linear modelling framework, various extended models are available to address these commonly found problems. In this context, goodness-of-fit assessment is pivotal for ensuring reliable inferential results. This includes, but is not limited to, graphical tools, which can be helpful when deciding whether a data sample can be a plausible realisation of a fitted model. In this thesis, we focussed on the development of diagnostic measures and the comparison of different modelling approaches, when applied to diverse types of data. Initially, we present an overview of diagnostic analyses stemming from generalized linear models, whilst illustrating different tools using two case studies from experiments in ecology and agriculture. Then, we extend the graphical model selection method known as half-normal plots with a simulated envelope. The simulated envelope is such that, under a well-fitted model, the majority of points should fall within its bounds. Nonetheless, closely related models tend to produce very similar graphs. We propose a new distance-based framework that acts as an added quantitative summary to the half-normal plot with a simulated envelope. This new measure can effectively determine the most appropriate model when closely related models are included. An extensive simulation study was carried out taking into account many different scenarios. The results showed that the distance framework exhibits robust performance in finding the true model and is comparable to BIC; in some instances, it even displays superior efficacy. Finally, we present a comparative analysis of different modelling frameworks applied to interval-censored longitudinal data, which is bounded in the interval (0, 1). We considered three approaches, where the first and second involved mixed and marginal models using a transformation of the interval-censored response, and the third incorporated the interval-censored nature in the likelihood. We found that the accounting for the interval-censored nature of the data improved model goodness-of-fit. However, the conclusions drawn from all three approaches were qualitatively similar

    Becoming Édouard Louis and the Transmedial Social Novel

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    This article considers Édouard Louis’s extensive literary œuvre from En finir avec Eddy Bellegueule (2014) to his latest novel, Monique s’évade (2024), in conjunction with his interactions in the public sphere. It first explores how the space of the novel becomes as much a space of exploration of the various processes of domination that shaped his and his family’s lives as it is a space of self-reinvention. In particular, it is Louis’s transformation practice that guides this article. Indeed, this article looks at the ways in which Louis engages in processes of branding, be it the act of making a product or the act of marking something or someone, in turn building one coherent cultural figure commited to social justice and making audible and visible vulnerable lived experiences. Not only an écrivain engagé, Louis has also become a theatre performer and a political activist who deploys and controls his narrative in literature and beyond

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