NUI Maynooth Eprint Archive
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What thou liv’st, live well
No full textIn paring away what was considered inessential to the economic decision,
economists have pared away human flesh leaving only the bone. To revivify
and incarnate this skeleton I draw on insights from the social psychology
of Deci and Ryan, Dweck, and Bandura to broaden the foundation of
utility theory and expand the types of resources individuals have at their
disposal, both individually and as part of a group, to effect their wellbeing.
These theories recognize that the effects of society on the individual are not
always to the good. Their nuanced understanding of the individual in society
helps put meat and muscle on economic agents’ bones by placing these
agents in society, suggesting how society affects agents and revealing how
agents work together to adapt and change society. A model is developed to
incorporate some of these features and examples are analyzed. The behavior
of the individual that arises is not easily characterized, but its essential, even
economic, humanness is
Working Remotely with Special Collections & Archives during the Pandemic: Experiences from Maynooth University Library
No full textAs a result of the outbreak of Covid-19 in 2020, special collections and archives across the UK and Ireland were forced to close their doors. Even through difficult times, staff worked tirelessly behind the scenes to ensure a quality service was maintained and that our very special collections continue to be cared for to the highest standards. Lockdown provided us with the opportunity to rethink how we access some of our world-renowned collections. For the Autumn newsletter of the CILIP Rare Books and Special Collections Group, we explore some of the experiences from Special Collections & Archives of Maynooth University Library including a discussion on the challenges we've faced this year, new teaching models, archival work during lockdown and new initiatives introduced during this period
New Old Irish Inscriptions from County Cavan
No full textThis article presents two stones with short inscriptions in Early Irish that were discovered by Brian Callaghan of the Moybologue Historical Society at Moybologue Old Graveyard and at Enniskeen Graveyard, in 2017 and 2019 respectively. Both sites are on the Cavan-Meath border and are approxi-mately 10.5km distant from each other
The Church of St. Paul/Church of All Saints, Moyglare – historical connections near and far
No full textAbstract is included in the text
Learning to live with it: reflections on surviving critical times from Irish adult education
No full textAn announcement was made by the Irish Taoiseach (Prime Minister) Leo Varadkar TD on
the morning of 12th March 2020 that educational institutions would close from 6pm that
evening, to support efforts to contain the spread of Covid-19 (DES, 2020). As in other parts
of the world, this was followed over the coming weeks by closure of most sectors of Irish
society in "unprecedented actions to respond to an unprecedented emergency” (Doyle,
2020). These are indeed ‘critical times’ as the title states in more than one sense. Critical for
population health in the short and medium term certainly, but also critical for us as adult
educators in how we manage our being and doing as we transition from proximity to
remoteness and distance. We hope this paper, based on student evaluations and tutor
feedback, captures some of our shared experiences and reflections about living with
uncertainty, learning in uncertainty and finding hope in emerging possibilities
Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro
No full textBackground: Glycosylation is one of the most fundamental post-translational modifications. Importantly, glycosylation is altered in many cancers. These alterations have been proven to impact on tumor progression and to promote tumor cell survival. From the literature, it is known that there is a clear link between chemoresistance and hypoxia, hypoxia and epigenetics and more recently glycosylation and epigenetics.
Methods and Results: Our objective was to investigate these differential parameters, in an in vitro model of ovarian and breast cancer. Ovarian (A2780, A2780cis, PEO1, PEO4) and triple negative breast cancer (TNBC) (MDA-MB-231 and MDA-MB-436) cells were exposed to differential hypoxic conditions (0.5–2% O2) and compared to normoxia (21% O2). Results demonstrated that in hypoxic conditions some significant changes in glycosylation on the secreted N-glycans from the ovarian and breast cancer cell lines were observed. These included, alterations in oligomannosylated, bisected glycans, glycans with polylactosamine extensions, in branching, galactosylation and sialylation in all cell lines except for PEO1. In general, hypoxia exposed ovarian and TNBC cells also displayed increased epithelial to mesenchymal transition (EMT) and migration, with a greater effect seen in the 0.5% hypoxia exposed samples compared to 1 and 2% hypoxia (p ≤ 0.05). SiRNA transient knock down of GATA2/3 transcription factors resulted in a decrease in the expression of glycosyltransferases ST3GAL4 and MGAT5, which are responsible for sialylation and branching, respectively.
Conclusions: These glycan changes are known to be integral to cancer cell survival and metastases, suggesting a possible mechanism of action, linking GATA2 and 3, and invasiveness of both ovarian and TNBC cells in vitro
The Impact of Reminiscence on Autobiographical Memory, Cognition and Psychological Well-Being in Healthy Older Adults
No full textAbstract
Reminiscence therapy has improved autobiographical memory in older adults with memory impairment. However, there has been a relative
lack of research examining the impact of reminiscence interventions on healthy older adults, despite the fact that healthy ageing has been
associated with a reduction in episodic autobiographical memory. The current study examined the effects of a semi-structured reminiscence
program, compared to a no-intervention control and an active control group focused on current life, in healthy older adults. Before and after
reminiscence or control, we assessed episodic and semantic autobiographical memory, as well as reliving of the memory and re-experiencing the emotion associated with the memory. We also examined new learning and executive function, as well as quality of life,
satisfaction with life, anxiety, depression, and mood. The reminiscence intervention did not lead to a differing impact on autobiographical
memory, cognition or psychological well-being, compared to the control groups. The current results indicate that simple reminiscence does
not lead to enhanced autobiographical memory performance in healthy older adults
Factors impacting the implementation of a psychoeducation intervention within the mental health system: a multisite study using the consolidation framework for implementation research
No full textBackground: Despite a strong evidence base and policy recommendation supporting the implementation of
psychoeducation interventions within the mental health system, equitable access for many service users and family
members has not been achieved. To enhance translation, developing an evidence-base around the factors that
influence implementation of interventions is critical.
Methods: The aim of the study was to explore the factors influencing implementation of a group cofacilitated
recovery focused psychoeducation intervention. The study design was explorative qualitative descriptive, involving
the collection of data through individual and focus group interviews with key stakeholders (n = 75) involved with
the implementation within 14 mental health sites in the Republic of Ireland. The Consolidation Framework for
Implementation Research (CFIR) was used as a conceptual framework to guide data collection and analysis.
Results: Key enablers and barriers were identified across all CFIR domains of the framework with some factors
(depending on context) being both an enabler and a barrier. Important factors in the outer setting domain
included structural stability within national systems and the peer payment system, while the extent of a recovery�oriented culture, leadership, implementation readiness, and buy-in were influential factors in the inner setting. The
characteristics of the intervention in terms of design, evidence-base and adaptability also shaped the intervention’s
implementation as did the knowledge, beliefs and self-efficacy of facilitators. In terms of processes, implementation
was influenced by the degree of engagement of key individuals who championed and supported the programme.
The results highlight that while some of the barriers were specific to the programme, many reflected systemic and
structural challenges within health services more generally. Conclusion: Findings from this study provide an enhanced understanding of the different layers of determinants to
implementation of an intervention. Overcoming challenges will involve positive and ongoing engagement and
collaboration across the full range of stakeholders that are active within each domain, including policy and
operational levels. The quality of leadership at each domain level is of crucial importance to successful
implementation.
Keywords: Implementation science, Barriers, Enablers, Psychoeducation, Mental health services, Framework analysis,
Consolidation framework for implementation researc
Anxiety and depression in the Republic of Ireland during the COVID-19 pandemic.
No full textBackground:The COVID-19 pandemic in Ireland resulted in anationwide quarantine on March 27, 2020. This study represents thefirst assessment of rates of anxiety and depression in the generalpopulation of Ireland during the pandemic.Aims:Our first aim was to estimate the probable prevalence rates ofgeneralized anxiety disorder (GAD) and depression and to identifysociodemographic risk factors associated with screening positive forGAD or depression. Our second aim was to determine if COVID-19related anxiety was highest amongst those in society at greatest risk ofmorality from COVID-19.Method:Self-report data were collected from a nationallyrepresentative Irish sample (N=1041) online between March 31 andApril 5; the first week of the nationwide quarantine measures.Recognized cut-off scores on the GAD-7 and PHQ-9 were used toestimate rates of GAD and depression. Correlates of screening positivefor GAD or depression were assessed using logistic regression analysis.Results:GAD (20.0%), depression (22.8%) and GAD or depression(27.7%) was common. Screening positive for GAD or depression wasassociated with younger age, female sex, loss of income due to COVID-19, COVID-19 infection and higher perceived risk of COVID-19infection. Citizens aged 65 and older had significantly higher levels ofCOVID-19 related anxiety than adults aged 18–34.Conclusions:Initial results from this multi-wave study monitoringchanges in population anxiety and depression throughout the pandemicindicate that GAD and depression were common experiences in thepopulation during the initial phase of the COVID-19 pandemic