Sarah Lawrence College
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Melodies of Strength: Exploring Black Resilience in American Musicals
Get PDFThis thesis examines the evolution of strategies for portraying Black resilience in musicals with a focus on narratives, musical components, and thematic progression in productions such as The Wiz, Dreamgirls, and The Color Purple. It also explores the historical context of Black resilience as it relates to the post-Civil Rights Movement era, and determines how these musicals display and challenge societal stereotypes and systemic oppression faced by the Black community. By investigating characters’ journeys and struggles for self-discovery and empowerment, this paper intends to highlight the enduring theme of resilience and its importance within the Black American musical genre
Further understanding atypical Panorama non-invasive prenatal testing results via pregnancy outcomes: a retrospective study
No full textNon-invasive prenatal testing (NIPT) is used to assess the risk for a pregnancy to be affected by an aneuploidy by analyzing placental cell-free DNA. Aneuploidies commonly screened for by NIPT are Trisomy 21, Trisomy 18, Trisomy 13, and sex chromosome aneuploidies. This study analyzes Natera’s unique Panorama NIPT, which utilizes SNP-based next-generation aneuploid testing. This test historically reported high-risk, low-risk, or no-call results. In 2020, Natera began reporting an additional type of result: atypical. Currently, there is limited existing literature surrounding atypical results. In order to further understand the potential cause of an atypical result, we sought to characterize pregnancy outcomes for cases that received an atypical result on the Panorama NIPT from 2020 through 2022 performed through LifeLabs Genetics.
Of the 496 cases with atypical results, we were able to obtain outcome information for 235 cases. The cases were categorized into: “live birth, normal” (35.74%), normal diagnostic testing but lost to further follow-up (30.64%), diagnosed fetal abnormality (14.47%), miscarriage or intrauterine fetal demise (11.06%), unavailable outcome information (4.68%), termination (2.55%), twin-to-twin transfusion syndrome (1 case), or vanishing twin (1 case). Fetal conditions reported included: aneuploidy, mosaic aneuploidy, microdeletion or microduplication, region of homozygosity, derivative X chromosome, or other genetic syndromes. For all of the cases in which a pregnancy outcome was not determined, there was a maternal condition identified that was the likely cause of the atypical result. There were a total of 29 cases involving a maternal condition. Maternal conditions reported included: sex chromosome mosaicism, partial X chromosome deletion, derivative X chromosome, single-gene genetic syndromes, history of stem cell transplantation, use of non-self egg donor, maternal cancer and a genetic change involving chromosome 2.
Given the use of NIPT to further guide prenatal care and inform a patient’s decision to undergo invasive fetal diagnostic testing or maternal genetic investigation, we hope these results can help genetic counselors and patients facing atypical results in the clinic
Characterizing the genetic counselor\u27s role in hematology
No full textHematology is a newly emerging subspecialty in genetic counseling. In order to improve and standardize practice, it is crucial to characterize the role of genetic counselors (GCs) working in this space. To date, no such characterization has been established. The purpose of this study was twofold: (1) to gain insights into the roles and perspectives of practicing hematology GCs and (2) to assess whether non-hematology GCs perceived a value in having designated hematology GCs at their institutions. A 54-question survey was distributed through the National Society of Genetic Counselors (NSGC) listserv. 92 responses were received, of which 84 participants met the inclusion criteria. When compared to their non-hematology GCs counterparts, this study found that GCs in hematology felt significantly less prepared by their graduate training. Both clinical and non-clinical hematology GCs typically spent more than 30% of their time working with indications such as hemolytic anemia and cytopenias; whereas non-hematology GCs felt least equipped to work with those indications. The majority of non-hematology GCs perceived value in having a designated hematology GC at their institution(s), citing limited capacity to see all hematological indications. The results from this study helped characterize the roles of hematology GCs and emphasized the need for dedicated resources and expertise to address patient needs in this subspecialty. Furthermore, the findings suggested that GCs emerge from graduate programs prepared for the tasks common to other GCs roles while hematology specialty knowledge is typically acquired on the job
