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Fasudil: Biomarker Analysis for a Phase-2 Clinical Trial of a Rho-Kinase Inhibitor in the Treatment of Amyotrophic Lateral Sclerosis
No full textThe treatment of Amyotrophic Lateral Sclerosis (ALS) is an infamous problem: the disease progresses rapidly with a devastating pathogenesis. Unfortunately, there is no known cure for the condition. Despite this, several therapeutic drugs have been ingeniously designed to minimize patient suffering and extend survival. The therapeutic drug which was studied and evaluated here is a Rho-associated protein kinase (ROCK) inhibitor called Fasudil. This study design is a replicate of a recent study (P.A. van Eijk et al. 2025), but with a higher treatment dose of 240 mg/day. The sample population was treated with this dose for 24 weeks, and samples of blood serum were obtained from the population before treatment (B0), and after 12 and 24 weeks of treatment (WK12 and WK24). Four biomarkers (neurofilament light chain (NfL), glial-fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase L1 (UCHL1), and Tau) were measured using Single Molecular Array (Simoa™) technology for each patient, at each point of sample collection. The biomarker concentrations (pg/mL) were processed into patient and cohort means and run through a one-way ANOVA and (conditionally) paired t-tests. The results demonstrated that there was no statistically significant change in the mean serum levels of NfL or GFAP, but that there was a significant increase in mean serum UCHL1 levels and a significant decrease in mean serum Tau levels. These data suggest that high dose Fasudil was largely ineffective at altering biomarkers associated with ALS disease progression; however, the interpretation of the data is hindered by the use of an open-label study design with no placebo control group
Bridging the Gap Between Muslim Students and School Leadership in the United States
No full textEntering the third decade of the 21st century, the political landscape in the United States presents a challenging environment for Muslims, mirroring the global trend of oppression and discrimination faced by this community (Neptune, 2021). Despite being the fastest-growing demographic in the nation (Lipka, 2017), Muslim Americans increasingly encounter discrimination. By actively addressing and dismantling these stereotypes, educators can cultivate an inclusive environment where the needs of Muslim students are understood and respected. Understanding the stories and experiences of these students is vital for school leaders, as it enables the creation of an environment where every student feels a genuine sense of belonging and acceptance. This qualitative case study aims to illuminate the experiences of Muslim students attending schools in a Rocky Mountain region state of the U.S. Employing an instrumental case study design, this research seeks to unravel the K-12 educational journey of Muslim students, uncover potential cultural and religious barriers they faced, and offer practical recommendations to educational practitioners, including educators, principals, teachers, and school personnel, for fostering a more inclusive and accommodating environment. This study addresses a significant gap in the existing literature by bridging the culture/knowledge gap between American educators and Muslim students.
Utilizing the frameworks of Ahmed (2022) and MusCrit (Ali, 2022) as my conceptual framework, the central research question guiding this inquiry is: What are the experiences of Muslim students in the Rocky Mountain region schools with respect to their religious identity? The findings were organized according to three research questions. The first section addressed the challenges Muslim students faced, including internal struggles in maintaining their Muslim identity, external challenges from other students and educators in the form of ignorance, stereotyping, and Islamophobia, as well as institutional and systemic barriers. Supports for Muslim students included accommodations for prayer, Ramadan, and dress code, the presence of Muslim Student Associations, an inclusive school culture, and supportive educators and families. Suggestions for improvement included the inclusion of a prayer room, addressing the knowledge gap regarding Islam, the intentional creation of inclusive spaces for Muslims, and enhanced community and family engagement
Development, Optimization, and Validation of a High-Sensitivity Capillary Zone Electrophoresis System for Bioanalytical Applications
No full textCapillary zone electrophoresis (CZE) is a powerful analytical technique widely used for biomolecular separation due to its high resolution, efficiency, and sensitivity. This report presents the development and validation of a novel CZE system designed to improve modularity, reproducibility, and operational efficiency. The system integrates a laser-induced fluorescence (LIF) detection method with a 488 nm laser, enhanced fluid control through a negative pressure system, and a user-friendly GUI for automated operation and data acquisition. Performance verification included pressure stability tests, fluorescence accuracy assessments, and electrophoretic reproducibility studies. Comparative analysis with a previous CZE iteration confirmed improved baseline stability, peak resolution, and modular integration, while maintaining comparable sensitivity. A vacuum pump vibration dampener was also developed to minimize interference. The new CZE system addresses key limitations of earlier models, enhancing usability and adaptability for biomedical research applications, particularly in neurodegenerative disease diagnostics and biomarker discovery
The Struggle to Spread Evidenced-Based Care and Collaborative Therapeutic Assessment
No full textA Doctoral Paper presented to the Faculty of the Graduate School of Professional Psychology
Why Rural Matters 2025: A Preview and a Forward Look
No full textThis presentation will provide a preview of the Why Rural Matters 2025 report that is currently in progress, including an overview of statistical gauges and indicators, topical essays, and key findings. Additionally, and looking forward beyond the report, presentation and discussion will engage the topic of cuts to federal programs that provide extant data essential for projects like Why Rural Matters and consider the implications for scholars, practitioners, and the general public
Concentration Effects on Nitroxides
Full text linkWe need to distinguish line broadening due to restricted motion from line broadening due to concentration of the same or other paramagnetic species. For example, if you increase the concentration of nitroxyl to get better S/N, the lines will broaden due to collisions with other nitroxyl molecules
Participant 11 – English, French, and Swahili
Full text linkAn interview with Samantha Tshibanda, a multilingual undergraduate student at the University of Denver, about the benefits and challenges of multilingualism in education as part of Professor Kamila Kinyon\u27s Multilingual DU study
Distinction on Carbon Dioxide Emissions
No full textThe purpose of this paper is to find variables to predict carbon dioxide emissions on a state level using simple and multiple linear regression models. After thorough analysis of models, a simple linear regression model was the best model to predict carbon dioxide emissions. This model used total energy consumed as an independent variable. Simple linear models using population and total number of cars were also used. The first multiple linear regression was statistically insignificant and while the second was significant, it did not make logical sense
Is She Being “Fast?”: Exploration of African American Women’s Experience with Sexual Objectification
Full text linkIssues of sexual objectification have been intertwined in America’s history since enslavement. This phenomenology study aimed to explore African American women’s lived experiences with sexual objectification and to understand the essential themes and conceptualizations that African American women attribute to sexual objectification. Through semi-structured interviews with a criterion sampling of African American women, the research sought to identify core themes surrounding sexual objectification experiences. In the results of this study, it was found that this population conceptualizes their sexual objectification experiences through seven themes: Earliest Sexual Objectification Experiences (SOE), SOE, Responses to SOE, Parental Protection, Reasons for SOE, SOE places, and Navigating SOE. These findings shed light on African American women\u27s unique perspectives. The results of this study demonstrate a need for mental health providers working with this population to become aware of the ways that these experiences can affect and inform treatment
The Pragmatic Engagement Arc
No full textWe don’t just buy tangible items anymore; we buy services that foster deeper and deeper relationships between ourselves and the companies that provide them. Even classic manufacturing companies have begun to consider the interaction with their customers as ongoing relationships beyond a goods exchange. Researchers in the field of consumer engagement view this relationship through consideration of intangible operant resources that generate value. The goal of this methodological study was to apply the methodology of educational criticism and connoisseurship to the field of consumer engagement. This approach allowed for consideration of the consumer-brand relationship without relying on discordant value-laden categories currently permeating the field of consumer engagement. The results found four major themes in a consumer’s brand engagement including the importance of strong previous experience with a brand, the importance of small details on brand separation, the replacement of in-person shopping with video sites such as YouTube, and the impact on concept-of-self through brand relationships