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An Investigation of the Anti-Stemness Actions of two miRNAs After Their Induction by Aminoflavone in Luminal A Breast Cancer
Full text linkApproximately 40% of estrogen receptor positive breast cancer (BC) patients develop resistance to endocrine therapy (ET) agents like tamoxifen (Tam). Resistance promotes metastasis, recurrence, and death since metastatic BC is often incurable. Breast cancer stem cells (CSCs) greatly contribute to disease progression and drug resistance. We previously showed that aryl hydrocarbon receptor (AhR) agonist aminoflavone (AF) inhibits the expression of CSC biomarker α6-integrin (ITGA6) to disrupt the formation of endocrine-sensitive and -resistant luminal A mammospheres. In this study, we performed miRNAsequencing analysis of luminal A MCF-7 and MCF-7TamR mammospheres before and after AF treatment to further develop the mechanism of AF-mediated antistemness activity. AF significantly upregulated over 70 miRNAs in Tam-sensitive mammospheres, including miR125b-2-3p. In TamR mammospheres, AF significantly upregulated 63 miRNAs including miR135a-5p. Both miRNAs are predicted stemness gene regulators. miR125b-2-3p mimic inhibited the expression of ITGA6 in MCF-7 cells and mammospheres while antagomiR125b-2-3p reversed AF-mediated suppression of ITGA6. Both miRNA mimics regulated stemness properties in endocrine-sensitive and -resistant MCF-7 cells. miR125b- 2-3p mimic decreased proliferation, migration, and mammosphere formation, while the antagomiR125b-2-3p increased proliferation and mammosphere formation in ET-sensitive cells. miR135a-5p mimic reduced proliferation and mammosphere formation in ET-resistant cells while the antagomiR increased these properties in ET-sensitive cells. AF induced AhR- and miR125b2-3pdependent anti-proliferation, anti-migration, and mammosphere disruption in ET-sensitive cells. AF induced miR135a-5p-dependent anti-proliferation, and mammosphere disruption in ET-resistant cells. Our findings suggest both miRNAs are anti-stemness tumor suppressors in ET-sensitive and -resistant MCF-7 cells and that AF upregulates these miRNAs to reduce CSCs via mechanisms that rely at least partially on AhR in luminal A breast cancer cells
Accuracy of Implant Placement Comparing a Tissue Level Static Guide vs. Dynamic Navigation Using the X-Mark Protocol on Edentulous Mandibles: A Laboratory Study
Full text linkIntroduction: With the use of computer-aided design/computer-aided manufacturing (CAD/CAM), along with cone beam computed tomography (CBCT), clinicians can have a static surgical guide fabricated to aid in the placement of implants. Dynamic navigation forgoes the step of fabricating a static surgical guide. A new software and protocol have been created for dynamic navigation surgery. Data for the accuracy of this protocol on fully edentulous arches is limited and therefore leads us to this study.
Purpose: The aim of this study is to compare the accuracy of implant placement in an edentulous ridge using static tissue level surgical guides vs. dynamic navigation using the edentulous surgical protocol.
Materials and Methods: Virtually planned implants were placed in edentulous mandibular models with either a 3D printed static tissue level surgical guide (n = 24) or by using dynamic navigation (n = 24) (X-Guide, X-Nav Technologies, LLC, Lansdale, PA). Post-operative CBCT scans were taken of models and the position of the implants were compared for accuracy against the original virtual plan to determine deviations.
Results: The results showed mean deviations of 4.25° ± 2.01° angular, 2.47 ± 0.82 mm global platform and 2.88 ± 0.69 mm global apical with the use of tissue level surgical guides. The dynamic navigation group had deviations of 0.80° ± 0.38° angular, 1.84 ± 0.60 mm global platform and 1.84 ± 0.57 mm global apical. Statistically significant differences in deviations were found for the parameters of angular (p = \u3c.001), global platform (p = 0.004) and global apical (p = \u3c.001). Conclusion: The accuracy of implant placement was shown to be more accurate when using dynamic navigation when compared to a tissue level surgical guide. The clinical relevance of this study is that treatment planning time could be decreased. Also, changes can be made to the surgical plan at the time of surgery, this could be done chairside and then the clinician would still be able to continue with a completely guided surger
Maynard Vernon Campbell (1902-1987)
No full textMaynard Vernon Campbell was born in 1902 and died in 1987. At the time of the 1946 General Conference Session he was the president of the Northern Union Conference.https://scholarsrepository.llu.edu/general-conference-1946-gallery/1002/thumbnail.jp
Emperor Haile Selassie
No full textEmperor Haile Selassie sits with local kings and chiefs. On June 14, during the 1946 General Conference of Seventh-day Adventists, Della Hanson discussed her time working for the emperor as chef and housekeeper.https://scholarsrepository.llu.edu/general-conference-1946-gallery/1020/thumbnail.jp
James Lamar McElhany (1889-1959)
No full textJames Lamar McElhany was elected to his second term as president of the General Conference of Seventh-day Adventists at the 1946 session.https://scholarsrepository.llu.edu/general-conference-1946-gallery/1013/thumbnail.jp
Combined Treatment Model Program for Survivors of Intimate Partner Violence
Full text linkThis project seeks to fill a void in the mental health field by providing a combined treatment model program to address the needs of survivors of intimate partner violence. As such, the primary purpose of this project is the development of a treatment program with services that are easily accessible by survivors that is intended for future implementation in shelters or agencies that have contact with this population of women. This program offers a means to engage an underserved population in access to services and self-development to improve overall mental and physical health outcomes and attempt to prevent recurrent intimate partner violence traumatic experiences.
This program will utilize a psycho-educational approach to addressing specific lack of knowledge about intimate partner violence, family systems, and healthy relationships. Additionally, participants are integrated in both individual therapy and family therapy while being connected with community-based resources and support groups. Two key conceptual foundations of this program are Bronfenbrenner’s Ecological Systems Theory and Family Systems Theory. Ecological theory is proposed as the meta-theory in the conceptual foundation of the program with Family Systems Theory integrated within the scope of ecological theory. The implementation of the two theories aims to improve educational awareness, mental health, and social support of individuals who have experienced intimate partner violence. The four components of the program include providing resources, access to educational material, receiving and connecting to support, and engaging in therapy. This fluid process of services aims to allow clients to access priority services while acquiring knowledge and improving their mental health that will prevent recurrent intimate partner violent situations.
The initial contact with the program is with a service navigator who completes enrollment paperwork, background information, facilitates assessments, and creates a priority service plan for each individual client. This is an important process in the program implementation in order to ensure clients are accessing their most crucial needs first. Participants will be linked to the various services offered by the service navigator. Participants will ultimately access all program components. By building relationships with others in support groups and psycho-educational classes, an increase in social support will happen organically and sustainably.
The service navigator will check in with participants as needed and will be available during the opening time of psycho-educational classes to discuss changes that need to be made among service plans and order of services offered. The support groups are highly malleable to specific group needs as the facilitator will continually assess client feedback and the topics that were presented that week within the psychoeducational classes. The group sessions can take multiple directions based on group needs and specific cohort necessities. This aims to help group members feel like the topics can be personalized and the needs that are present are being specifically addressed through education, support, resources, and therapy.
The culmination of the program includes completing assessments to determine overall effectiveness of the program per participant. Participants have continued access to needed services such as resources, continued support groups/connections, and therapy. The last unit of the psycho-educational classes is a ‘Healthy Relationship Unit’ where focus is maintained on what a healthy relationship looks like, creating boundaries, understanding the equity wheel, identifying healthy vs. unhealthy relationships, and planning for the future. Continuing to focus on healthy relationships while engaging in work in therapy and accessing connections to community support is the culminating goal. This program aims to build a foundational base for each participant that is focused on improved mental health, access to education, connections to resources, and engagement in support groups to stay on a path of eliminating incidents of intimate partner violence within their lives
Alumni Journal - Volume 93, Number 2
Full text linkEditorials2 | From the Editor4| From the President6 | From the Dean
News8 | School of Medicine News10 | Alumni News11 | This and That12 | Students14 | AIMS Report16 | Department Report: Gynecology and Obstetrics
Graduation 202219 | Graduation Feature
Features34 | By the Graduates38 | Graduate Medical Education at LLUH42 | Curriculum Transformation46 | Historical Snapshot47 | Alumni Spotlight
In Memoriam49 | Alumni Remembered: Featured obituaries - George T. Harding IV \u2753-B; John W. Mace \u2764https://scholarsrepository.llu.edu/sm-alumni-journal/1036/thumbnail.jp
Power: A Qualitative Exploration of POWs in Captivity and Their Responses to Loss of Control
Full text linkThis qualitative study explored how American Prisoners of War (POWs) from the Vietnam War coped with the dramatic imbalance of power between them and their North Vietnamese captors. Semi-structured interviews with POWs (n = 16) were analyzed using phenomenological and grounded theory approaches to identify major themes and coping strategies embedded in their experiences of powerlessness. POWs shared emergent themes of Communication, Connection, Heroic Leadership, Establishing Our Routine, and Honor and Loyalty, which were then linked with components of Emerson’s theory of power-dependence relations. Many of these strategies functioned interdependently, which allowed these men to more effectively combat imbalances of power and produce a limited sense of agency for themselves and their fellow captured service members. These findings may aid clinicians in identifying critical areas for intervention with individuals who suffered traumas in group settings and may inform how future service members are trained
Community Resiliency Model Treatment Manual for Loma Linda University Healthcare
Full text linkBurnout is a national phenomenon on the United States, effecting between 60% and 78% of healthcare professionals (21) across a variety of settings. Burnout results in increased cost to the healthcare industry, significantly decreased quality of patient care, and increased malpractice claims. At the same time, healthcare providers are increasingly under demands to their time that limit their ability to access wellness resources to mitigate the effects of burnout, such as outpatient psychotherapy. In order to address this growing crisis and respond to the specific needs of healthcare providers, we have utilized the biological basis and six skills comprising the Community Resiliency Model (CRM) to create a brief, three-session, in service training to provide wellness skills to these providers. We shortened the CRM training from its current five-day training, into a three hour training would allow for the skills to be transmitted to healthcare providers in order to decrease their levels of burnout and improve their wellness and coping skills
Medical Student Experiences Implementing Bias Reduction Strategies: A Qualitative Study
Full text linkResearch has shown that health care provider bias negatively impacts the provider-patient relationship and health outcomes. Studies have identified strategies effective at reducing bias, but there is minimal research implementing these strategies in health care settings, and little is known about effective curricular interventions to teach strategies to medical students. The purpose of the present study was to explore medical students’ experiences implementing evidence-based bias reduction strategies with their patients after participating in a bias reduction didactic. The study aimed to 1) determine which bias-reduction strategies medical students most frequently used, and 2) explore student perceptions of the effects of strategy implementation on the medical encounter. Investigators qualitatively analyzed responses to open-ended questions about medical students’ experiences implementing evidence-based bias reduction strategies with their patients. Two coders independently reviewed all responses, identified themes, developed codebooks, and double coded student responses. Coders identified three overarching categories of student-perceived implications of strategy implementation: implications for the provider, implications for the patient, and implications for the provider-patient interaction. Each category comprised multiple themes. Themes most frequently described by the students included the patient feeling more supported/psychologically safe, the student experiencing greater empathy for the patient, and an improvement in connection/rapport with the patient. Study limitations and the implications of findings to inform future research, instrument development, and bias-reduction curricular interventions with medical students are discussed