5430 research outputs found
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Bass Dining Commons
No full textBass Dining Commons and River Campus in fall, 2022
Photo by Juan Rodriguezhttps://digitalcommons.rockefeller.edu/river_campus/1074/thumbnail.jp
Roentgen Ray Laboratory Admission Log Journal
No full textAdmission log journal, Roentgen Ray laboratory of the Hospital of the Rockefeller Institute for Medical Research, 1921
Courtesy of The Rockefeller University Hospital
Roentgen ray is a term coined around 1890 that preceded X-ray and named for Wilhelm Roentgen, a German professor of physics. Roentgen wanted to prove his hypothesis that cathode rays could penetrate substances besides air. When he saw that he could film his thumb and forefinger and their bones on a screen, the story goes, he replaced the screen with a photographic plate and X-rayed his wife\u27s hand. Roentgen\u27s report of his findings, On a New Kind of Rays, was published by the Physical-Medical Society of Wurzburg in December 1895.https://digitalcommons.rockefeller.edu/objects-tell-stories/1006/thumbnail.jp
The Rockefeller University Concert Program, 1959
No full textThe Rockefeller University Concert program, 1959
In 1958, Rockefeller chemist Theodore Shedlovsky, an ardent music lover, invited a group of his musician friends to perform in the new auditorium, and the Rockefeller Concert Series was born. After a beloved concert-goer, Peggy Rockefeller, wife of honorary chairman and life trustee David Rockefeller, passed away in 1996, President Torsten Wiesel proposed that the concerts be renamed in her honor. For many years, Dr. Shedlovsky put together spectacular concerts, presenting high-caliber musicians and ensembles. Later, he entrusted the concert management to his colleague Gerald Edelman, a Nobel Prize-winning neuroscientist. Currently organized by Professor George N. Reeke, Jr., The Peggy Rockefeller Concerts remain a faculty initiative, exemplifying the important partnership of science and music.https://digitalcommons.rockefeller.edu/objects-tell-stories/1024/thumbnail.jp
Building an Allocentric Traveling-Direction Signal Via Vector Computation
Full text linkMany behavioral tasks require the manipulation of mathematical vectors, but, outside of computational models, it is not known how brains perform vector operations. Here we show how the Drosophila central complex, a region implicated in goal-directed navigation, performs vector arithmetic. First, we describe a neural signal in the fan-shaped body that explicitly tracks a fly\u27s allocentric traveling angle, that is, the traveling angle in reference to external cues. Past work has identified neurons in Drosophila and mammals that track an animal\u27s heading angle referenced to external cues (e.g., head-direction cells), but this new signal illuminates how the sense of space is properly updated when traveling and heading angles differ (e.g., when walking sideways). We then characterize a neuronal circuit that rotates, scales, and adds four vectors related to the fly\u27s egocentric traveling direction––the traveling angle referenced to the body––to compute the allocentric traveling direction. This circuit operates by mapping spatial vectors onto sinusoidal patterns of activity across distinct neuronal populations, with the sinusoid\u27s amplitude representing the vector\u27s length and its phase representing the vector\u27s angle. The principles of this circuit, which performs an egocentric-to-allocentric coordinate transformation and vector addition, may generalize to other brains and to domains beyond navigation where vector operations or reference-frame transformations are required
Stoll, Norman
No full textNorman Stoll, circa late 1950s
Courtesy of JSTOR.org
Norman Stoll (1892-1976) was a medical researcher and, from 1952 to 1973, a consultant on parasitic diseases to the World Health Organization. For almost 50 years he was a professor of medical research at The Rockefeller University. He was also a lecturer on tropical diseases and, in the late 1920s, was a member of a governmental research commission investigating hookworm disease in Panama, Puerto Rico, and China.
His 1946 presidential address to the American Society of Parasitologists posed the question: Just how much human helminthiasis is there in the world? The resultant paper, This Wormy World (Stoll, 1947), was the first systematic attempt to measure the worldwide impact of human parasitism by helminths and remains probably one of the most widely quoted publications in helminthology.
Dr. Stoll attended Syracuse University for two years and graduated from Mount Union College in 1915. He earned a master\u27s degree at the University of Michigan in 1918 and received a doctorate in science from the Johns Hopkins University School of Hygiene and Public Health in 1923.
During World War 1, Dr. Stoll served in the field artillery as a second lieutenant. He was a lieutenant commander with the Navy medical research unit on Guam in World War II.
Years at The Rockefeller University: 1927-1963; emeritus 1963-1976https://digitalcommons.rockefeller.edu/faculty-members/1112/thumbnail.jp
Modulation of Prefrontal Cortex activity and sociability by local interneurons expressing corticotropi-releasing hormone
Full text linkThe cerebral cortex is composed primarily of two neuronal cell types: excitatory pyramidal cells and inhibitory interneurons. Their neurochemical diversity and complex organization into interconnected laminar and columnar circuits imbues the cortex with countless computational and functional possibilities. At the behavioral level, changes in the molecular profile and electrophysiological activity of cortical neurons produce noticeable changes in perception, learning and memory, motor skills, and executive cognitive functions. In the initial chapter of this thesis, I briefly cover the history and progress of cell type studies in cerebral cortex and provide frameworks for understanding and interrogating interneuron diversity. We next apply modern molecular tools to test the validity of a proposed circuit model for cortical serotonin receptor 3 (5-HT3AR) interneurons enriched with corticotropin-releasing hormone (CRH), generated using these established frameworks. Molecular profiling using Translating Ribosome Affinity Purification (TRAP-seq) predicted an elegant, bimodal postsynaptic mechanism for CRH neuron modulation of both pyramidal cells and interneurons. In mouse prefrontal cortex (mPFC), we initiate a host of molecular, anatomical, and electrophysiological studies in this less understood subpopulation and validate that cortical CRH cells are interneurons (CrhINs). Further characterization revealed CrhINs express vasoactive intestinal peptide (VIP), a marker for the disinhibitory class of interneurons. These preliminary findings predict an elegant and multi-layered mechanism for CrhIN activation of prefrontal cortex, achieved through complementary GABAergic signaling and CRH release. In chapter two, we use transgenic mouse lines, RNA sequencing, gene excision, cell type-specific viral approaches, and electrophysiological whole cell patch clamp recordings, in combination with optogenetics and pharmacology, to probe the validity of this proposed circuit. Oxytocin receptor interneurons (OxtR-INs), a subset of somatostatin interneurons first discovered and characterized by Drs. Miho Nakajima, Kun Li, Ines Ibañez-Tallon, and Nathaniel Heintz, were found to mediate prosocial and anxiolytic effects through the release of corticotropin-releasing hormone binding protein (CRHBP). CRHBP, the endogenous antagonist to CRH, sequesters unbound CRH and blocks CRH – CRHR1 signaling, ultimately reducing the excitability of CRHR1 L2/3 pyramidal cells. A critical insight revealed in these initial studies is the identification of CRH peptide expression in VIP interneurons and, in contrast, CRHBP expression in SST interneurons. To test the prediction that CRH/VIP interneurons both inhibit OxtR/SST/CRHBP interneurons and release CRH onto CRHR1 expressing neurons, we applied optogenetic stimulation at both low and high frequency, in parallel with pharmacology, to isolate dual cell type-specific GABA and CRH-mediated currents in mPFC
Kravis Research Building
No full textLobby of the Marie Josee and Henry R. Kravis Research Building, 2022
Photo by Juan Rodriguezhttps://digitalcommons.rockefeller.edu/river_campus/1077/thumbnail.jp
Exhibit Detail
No full textExhibit detail
Idea, design- Olga Nilova
Photograph by Lubosh Stepanekhttps://digitalcommons.rockefeller.edu/five-rockefeller-trailblazers/1010/thumbnail.jp
One of the Original Removable Pegs
No full textOne of the original removable pegs used to fasten the tabletop to one of the Library\u27s lift top table benches , circa 1900shttps://digitalcommons.rockefeller.edu/objects-tell-stories/1005/thumbnail.jp
Inhaler
No full textInhaler, circa 1930s
Courtesy of the Rockefeller University Hospitalhttps://digitalcommons.rockefeller.edu/objects-tell-stories/1015/thumbnail.jp