16812 research outputs found
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A Text Mining and Sentiment Analysis of Valuable CIE Texts Using R
No full textThe purpose of this project was to perform a sentiment analysis of three texts used in Ursinus College\u27s Common Intellectual Experience (CIE) course: Between the World and Me by Ta-Nehisi Coates, The New Jim Crow by Michelle Alexander and Discourse on Method by Rene Descartes. Word count and word cloud analysis were also performed on the texts as well as term frequency and bigram analysis
Robin Mays, Campus Security
No full textDigital photograph of Robin Mays standing in Bomberger Memorial Hall at Ursinus College. A printed version of this photograph was temporarily installed on the exterior of the Wismer Dining Hall building on campus as part of the Spring 2025 COSA celebration.https://digitalcommons.ursinus.edu/art_envportraits/1036/thumbnail.jp
Deb Giandonato, Upper Wismer Supervisor 2
No full textDigital photograph of Deb Giandonato cheering in the bleachers of the football field at Ursinus College. A printed version of this photograph was temporarily installed on the interior vestibule of the Wismer Dining Hall building on campus as part of the Spring 2025 COSA celebration.https://digitalcommons.ursinus.edu/art_envportraits/1034/thumbnail.jp
Leannie Jusino Installation Site
No full textGrace DiMattia creates her photography installation in the interior of the Myrin Library building on the Ursinus College campus. Student photographs of staff, such as Leannie Jusino, were created for a documentary photography class and temporarily installed around campus as part of the Spring 2025 COSA celebration.https://digitalcommons.ursinus.edu/art_envportraits/1045/thumbnail.jp
Evaluation of the Energy and Timing Resolution of Cerium Bromide Detectors for Nuclear Applications
No full textWe tested the timing and energy resolution of cerium bromide (CeBr3) detectors for use in the CeBrA array of gamma-ray detectors in the John D. Fox lab at Florida State University. Using different sources, we calibrated energy spectra and analyzed FWHM values to determine the energy resolution. Timing resolution from a 60Co source was measured using coincident gamma rays from the sources. Our results showed the expected energy dependence and confirmed that the detectors meet performance standards
Utilizing the Combinatory Power of Chemotherapeutic Compounds in Triple Negative Breast Cancer Cells
No full textBreast cancer is the leading cause of cancer-related deaths among women worldwide and the second most common cause of cancer deaths in women in the United States. Genetic variants that increase the risk of breast cancer include mutations in the breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2). Apoptosis, or programmed cell death, is a natural process that helps the body remove aged cells. However, in cancer, deregulated apoptotic signaling—especially the activation of anti-apoptotic mechanisms—enables cancer cells to evade this process, leading to uncontrolled proliferation, tumor survival, therapeutic resistance, and cancer recurrence. Most anti-cancer drugs function as chemotherapeutic agents by inhibiting the proliferation of cancer cells and inducing apoptosis. This study investigates the apoptotic induction activity of carboplatin, a cytotoxic agent, and tucidinostat (chidamide), an HDAC-inhibiting chemotherapy drug, in breast cancer cells (BT-549). We determined the IC50 values for both compounds were evaluated, and their synergistic and antagonistic effects on BT-549 cells were assessed. The cytotoxic effects of these compounds, both individually and in combination, were assessed using the MTT assay. The impact of these drugs on metabolic functions was analyzed using the clonogenic assay and cell death assays
Dual Action Dynamics: Assessing Hypopharyngeal Cancer Cell Survival Using Combination Chemotherapy
No full textTargeting glucose metabolism is an attractive strategy for cancer treatment, as cancer cells rely more heavily on glycolysis than oxidative phosphorylation, a phenomenon known as the Warburg Effect (Wang et al 2015). Reversing this metabolic reprogramming can impair cancer cell proliferation. NG52, a small-molecule inhibitor of PGK1, has been shown to effectively reverse the Warburg Effect and reduce cancer cell viability (Wycliffe et al. 2007). Paclitaxel, commonly Taxol, is a chemotherapeutic agent that disrupts mitotic spindle function, causing mitotic arrest and apoptosis (Markman et al 2005). In this study, we aimed to evaluate the individual and combined effects of NG52 and Paclitaxel on FaDu cells, a hypopharyngeal squamous carcinoma. We hypothesized that combining NG52 and Paclitaxel would produce a synergistic effect, enhancing cytotoxicity. FaDu cells were treated with varying concentrations of NG52 and Paclitaxel, alone and in combination, and cell activity inhibition was assessed using an MTT assay and an apoptosis and necrosis assay. IC₅₀ values were determined using CompuSyn software, and synergy was evaluated through the Chou-Talalay method. Results demonstrated that both agents decreased FaDu cell viability in a dose-dependent manner, yet their combination exhibited a combination index (CI) values equal to and greater than 1, indicating an additive and antagonistic interaction. These findings suggest that dual targeting of metabolic and mitotic pathways is not as effective for the treatment of hypopharyngeal cancers in comparison to single treatment by either of the two compounds
Digital Spark Presentation: Tri-County Urgent Care
No full textIn this presentation, Alena Rowan, Ursinus College Class of 2027, discusses her summer experience working with Tri-County Urgent Care, a health care provider in Phoenixville, Pennsylvania
The Perfect Woman 7
No full textGraphite drawing of a woman\u27s portrait. Presented as part of the 2025 Annual Student Exhibit in the Berman Museum of Art at Ursinus College.
One of a series of eight.https://digitalcommons.ursinus.edu/asae_2025_images/1021/thumbnail.jp
Swimming in Our Memory
No full textOil painting on canvas depicting a goldfish swimming in a bowl. Presented as part of the 2025 Annual Student Exhibit in the Berman Museum of Art at Ursinus College.https://digitalcommons.ursinus.edu/asae_2025_images/1026/thumbnail.jp