10368 research outputs found
Sort by
Then: Reflection on the Importance of Furman as it was
Get PDFI came to Furman with the support of a proverbial village
Q&A: Just Human Enough
Get PDFDarren Hick, an assistant professor of philosophy, explains how one form of artificial intelligence is already changing our lives
The Comeback
Get PDFAll around Greenville, memorials and landmarks honor the history of the city and its people, as well as its connections to Furman University
Shelf Life
Get PDFA policymaking how-to, a peek into small-town South Carolina, tainted legacies, and one alumna;s wit and wisdo
2023 Sub-Librarians Meeting: Education Never Ends - Teaching and Learning with Sherlock Holmes
Get PDFStudents of all ages are attracted to the character of Sherlock Holmes. How can this curiosity be harnessed into active learning experiences in a course structure? Drake University Professor Michael Couvillon and Professor/Library Dean Emeritus Rod Henshaw draw on their experience teaching courses for both first-year college students and for older adults to demonstrate how Holmes\u27 and Watson\u27s methods can be translated into four life-long learning skills: Interaction, Introspection, lntercultural Awareness, and Information Literacy. Participate in active learning exercises that demonstrate Sherlock\u27s methods and serve as springboards for acquiring learning skills; learn proven techniques for use of media, library materials, and other resources; and gain insight into generating joy in the learning experience
2023 Furman University Faculty Scholarship Reception Program
Get PDFOn February 10, 2023, the Libraries and the Office of the Provost hosted Furman’s sixth Faculty Scholarship Reception. The reception showcased accomplishments from the 2022 calendar year, highlighting Furman faculty members who have completed a degree, received a grant from an external funding source totaling more than $1,000, and/or published books, book chapters, journal articles, exhibits, recordings, performances, films, or other works. The following faculty provided four-minute presentations on their scholarly or creative works: Mahan Ellison, Associate Professor of Modern Languages and Literatures Bronwen Forbay, Visiting Associate Professor of Voice James Guth, Professor of Politics and International Affairs Nick Radel, Professor of English Alison Roark, Associate Professor of Biolog
Design Strategies for Luminescent Titanocenes: Improving the Photoluminescence and Photostability of Arylethynyltitanocenes
No full textComplexes that undergo ligand-to-metal charge transfer (LMCT) to d0 metals are of interest as possible photocatalysts. Cp2Ti(C2Ph)2 (where C2Ph = phenylethynyl) was reported to be weakly emissive in room-temperature (RT) fluid solution from its phenylethynyl-to-Ti 3LMCT state but readily photodecomposes. Coordination of CuX between the alkyne ligands to give Cp2Ti(C2Ph)2CuX (X = Cl, Br) has been shown to significantly increase the photostability, but such complexes are not emissive in RT solution. Herein, we investigate whether inhibition of alkyne-Ti-alkyne bond compression might be responsible for the increased photostability of the CuX complexes by investigating the decomposition of a structurally constrained analogue, Cp2Ti(OBET) (OBET = o-bis(ethynyl)tolane). To investigate the mechanism of nonradiative decay from the 3LMCT states in Cp2Ti(C2Ph)2CuX, the photophysical properties were investigated both upon deuteration and upon rigidifying in a poly(methyl methacrylate) film. These investigations suggested that inhibition of structural rearrangement may play a dominant role in increasing emission lifetimes and quantum yields. The bulkier Cp*2Ti(C2Ph)2CuBr was prepared and is emissive at 693 nm in RT THF solution with a photoluminescent quantum yield of 1.3 × 10–3 (τ = 0.18 μs). Time-dependent density functional theory (TDDFT) calculations suggest that emission occurs from a 3LMCT state dominated by Cp*-to-Ti charge transfer
Garcinolic Acid Distinguishes Between GACKIX Domains and Modulates Interaction Networks
Get PDFNatural products are often uniquely suited to modulate protein-protein interactions (PPIs) due to their architectural and functional group complexity relative to synthetic molecules. Here we demonstrate that the natural product garcinolic acid allosterically blocks the CBP/p300 KIX PPI network and displays excellent selectivity over related GACKIX motifs. It does so via a strong interaction (KD 1 μM) with a non-canonical binding site containing a structurally dynamic loop in CBP/p300 KIX. Garcinolic acid engages full-length CBP in the context of the proteome and in doing so effectively inhibits KIX-dependent transcription in a leukemia model. As the most potent small-molecule KIX inhibitor yet reported, garcinolic acid represents an important step forward in the therapeutic targeting of CBP/p300