10368 research outputs found
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Above the Rim
No full textJackie Carson \u2700 went beyond the basketball court to advocate for and lift up the Furman community
Xylylethynyl Titanocene with a Microsecond Emission Lifetime Photosensitizes Singlet-Oxygen Formation and Photon Upconversion
No full textCoordination complexes containing d0 metals with long-lived ligand-to-metal charge transfer (LMCT) excited states are promising candidates for use as photosensitizers. Previously, Cp*2Ti(C2Ph)2CuBr (where Cp* = pentamethylcyclopentadienyl and C2Ph = phenylethynyl) was reported to be emissive in THF solution at room temperature (RT) from an excited state with significant Cp*-to-Ti LMCT character (λem = 693 nm, τ = 0.18 μs). However, the corresponding cyclopentadienyl complex was not emissive. Structural constraint was hypothesized as a reason for the enhanced photophysics of the Cp* complex. To further test this hypothesis, the corresponding complex with o-xylylethynyl ligands, Cp*2Ti(C2PhMe2)2CuBr, has been prepared and characterized. X-ray crystallography demonstrates significant steric congestion caused by the additional methyl substituents. This xylylethynyl complex is emissive in THF solution at RT and the lifetime is approximately 10-fold greater (λem = 734 nm, τ = 1.6 μs) than the corresponding phenylethynyl complex. Spectroscopic and computational data are consistent with this emission being phosphorescence with significant Cp*-to-Ti and xylylethynyl-to-Ti LMCT character. The evidence is also consistent with an excited state that is less distorted for the xylylethynyl complex than the phenylethynyl complex. The sterically induced, long lifetime of the xylylethynyl complex enabled its use in photon upconversion and 1O2 formation
The Comeback: Cuisine Around the Corner
No full textA sweet treat, a caffeinated pick-me-up, a frothy brew to wind down after a long day, a working lunch. Whether reuniting with old friends or for a break in the middle of the workweek, Greenville, Travelers Rest, Simpsonville and points all around Furman have some of the most unique spots to stop. Not only that, but those spots are owned and operated by Furman alumni
Shelf Life
No full textAuthors write about forbidden love in the \u2770s South, examine gender rules in Shakespeare, illustrate to children the art of listening, and tell a story about an unlikely friendship
Melinda Menzer and Bob Richey
No full texthttps://scholarexchange.furman.edu/cothran/1010/thumbnail.jp
Evaluating the Effeciency of Sunscreen Brands
No full textIndividuals are at risk for skin cancer now more than ever due to insufficient sunscreen brands and not knowing when to reapply. It is known that during this research project, there is a statistical difference between the amount of UVA rays allowed through three different sunscreen brands being tested (Blue Lizard, Equate, & Hawaiian Tropic). Throughout this experiment, gelatin (mimicking skin) was placed in a petri dish with sunscreen applied on top. A UVA light sensor was placed under the petri dish, and a UVA light was placed above the petri dish. A spark device was used to generate the amount of UVA rays coming through the sunscreen and onto the light sensor. After calculating the results, it was found that Blue Lizard sunscreen blocks the most UVA rays, allowing only 7.00 W/M^2 through. An ANOVA test was run where the F-ratio was higher than the critical value, showing that there is a statistical difference between the different sunscreen brands. In conclusion, Blue Lizard sunscreen is the most effective way to block the most UVA rays. This experiment showed that there are statistical differences in the effectiveness of sunscreen brands. To further this experiment, more sunscreen brands and longer trials will be tested
NaviCane
No full textThere are over 43 million blind people globally who face challenges in navigating the outside world safely due to not being able to afford guide dogs or smart canes. For this project, it is expected that a smart cane that is equipped with ultrasonic sensors, LEDs, vibration motors, and buzzers could detect obstacles to allow for safe independent travel. The smart cane also utilizes an Arduino Elegoo Uno R3 microcontroller board and a 9V alkaline battery that is programmed to detect objects up to over a meter away, triggering warnings based on the proximity of the object. Preliminary testing indicates that the cane effectively detects objects up to 1.092 m, activating the LED, buzzer, and vibration motor at varying frequencies based on the distance. Data analysis suggests that the smart cane provides timely alerts that allow the consumer to react in time. These findings support the hypothesis that a sensor-based smart cane can increase mobility and independence for visually impaired individuals. Future work will consist of optimizing power consumption and improving detection accuracy
Cancer Cachexia Effect on Cardiac Muscle Structure/Function
No full textMost cancer patients suffer from a complex metabolic wasting disease known as cancer cachexia, especially at advanced stages of certain cancers, including colon cancer. Muscle wasting, cardiac remodeling, and cardiac dysfunction are the main symptoms that patients with cancer-induced cardiac cachexia suffer from, ultimately leading to heart failure and death in most patients. There has not been much research done on the correlation between colon cancer-induced cachexia and cardiac muscle. The objective of this project is to determine the effect of colon cancer-induced cachexia on cardiac muscle structure. In this work it was hypothesized that colon-cancer cachexia induced cells differ in structure to normal cardiac muscle cells. To test this hypothesis, H9c2 cells cultured and differentiated in the absence of serum were treated with the conditioned media of CT26 (cachectic) and MC38 (non-cachectic) cell lines. The data indicated that CT26 resulted in increased H9c2 cells detachment compared to MC38 cells. In addition, cellular morphology of H9c2 cells was strikingly different when they were cultured in CT26 and MC38 conditioned media. Collectively, the results validate the hypothesis and suggest that cardiac muscle cells, as modeled by H9c2 cells, are negatively impacted by colon cancer-induced cachexia. My ongoing research in ApcMin/+ mice will investigate the colon cancer-induced cardiac cachexia in vivo in the mouse heart
The Effect of Structural Variation on Gene Expression
No full textShort-read RNA sequencing captures only fragments of gene transcripts, requiring computational reconstruction and limiting transcript diversity knowledge. In contrast, long-read sequencing provides full-length RNA transcripts without reconstruction. Dr. Mahmoud et al. identified 389 medically relevant genes, selecting glucose-6-phosphate isomerase (GPI) on chromosome 19 and its neighboring genes (GARRE1, PDCD2L, UBA2) due to their links to genetic disorders. Analyzing 130 haplotypes from 65 diverse individuals in the Human Genome Structural Variation Consortium (HGSVC), repeat masking was performed using RepeatMasker with the Dfam library. Gene and exon locations were determined using Ensembl (release 113). A custom exon library was created, retaining only exon hits with less than 5% divergence. For each haplotype, the intronic region between exons 9 and 10 of GPI was identified and analyzed using k-mers (15-79 bases). The 64 unique k-mers were aligned with MUSCLE, producing a 50-base consensus sequence dubbed the dark region repeat consensus sequence. This sequence was analyzed with nhmmer, retaining hits with e-values below 0.01. Multiple sequence alignment using Clustal Omega revealed eight network-based component consensus sequences (NCCs), used to reannotate the region, yielding 13 unique GPI dark region haplotypes. A key structural variation found was a deletion in one individual\u27s haplotype, leading to the loss of a novel isoform. This study highlights long-read sequencing\u27s ability to uncover previously unknown transcript variations