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March 2025 Library & Learning Newsletter
Full text linkPDF version of the March 2025 (Volume 3, Issue 5) Library & Learning Newsletter
October 2025 Library & Learning Newsletter
No full textPDF version of the October 2025 (Volume 4, Issue 3) Library & Learning Newsletter
Impact of HIV-2 ROD9 Vpx Mutations on SAMHD1 Degradation and Vpx Nuclear Trafficking
No full textHuman Immunodeficiency Virus (HIV) is a leading cause of death in many parts of the world. HIV-2, endemic to West Africa, has infected over 2 million people globally. A key difference between HIV-2 and the more widespread HIV-1 is the HIV-2 protein Vpx, which facilitates infection in non-dividing cells by targeting SAMHD1, a host innate immune protein, for proteasomal degradation. This research aims to identify specific amino acid residues in HIV-2 ROD9 Vpx that are essential for mediating SAMHD1 degradation by the proteosome. I hypothesize that amino acid residues located in the C-terminal region of Vpx play a critical role in its ability to mediate SAMHD1 degradation. To test this hypothesis, site-directed mutagenesis was used to alter HIV-2 ROD9 Vpx; these mutated constructs were then transfected along with SAMHD1 into 293T cells. Protein degradation was evaluated by Western blot and densitometric analysis. While wildtype HIV-2 ROD9 Vpx mediated moderate (approximately 32%) degradation of SAMHD1, I identified a mutant, R77K, which led to approximately 60% SAMHD1 degradation. I then hypothesized that this enhanced degradation compared to all other HIV-2 ROD9 Vpx mutants observed might result from increased nuclear localization of the Vpx protein, thereby improving access to nuclear SAMHD1. However, contrary to my hypothesis, confocal microscopy analysis revealed that the HIV-2 ROD9 Vpx R77K mutant did not show increased nuclear localization compared to the wild-type, with no statistically significant difference observed between the two. This suggests that the enhanced SAMHD1 degradation mediated by the R77K variant occurred via a localization-independent mechanism. Together with previous work in the field, these findings increase fundamental understanding of this key viral protein
Genomics Nursing: Scope and Standards of Practice
No full textThe Genomics Nursing: Scope and Standards of Practice, 3rd Edition, formerly Genetics/Genomics Nursing, is an essential document for every genomics nurse practicing in the United States. The scope of practice statement answers the who, what, when, where, how, and why questions of genomics nursing. The standards provide authoritative statements of the actions and behaviors that all genomics nurses are expected to competently perform, regardless of role, population, specialty, and setting. Each standard is accompanied by detailed competencies for two practice levels. The product of extensive thought work by many genomics nurses, this new edition provides 18 national standards of practice and professional performance. Each standard is accompanied by detailed competencies for genomics nurses. This premier professional resource informs and guides genomics nurses in their vital work providing safe, quality, and competent care.https://cornerstone.lib.mnsu.edu/university-archives-msu-authors/1507/thumbnail.jp
Second Star to the Right: Essays on Leadership in Star Trek
No full text\u27Star Trek\u27 provides an opportunity to explore the final frontier of leadership through its nearly six decades of series and films. With its basis in Enlightenment thinking (reason coupled to compassion) and its encouragement of diversity in its myriad forms, \u27Star Trek\u27 offers guidance on how to improve the human condition that has application in leadership across academic and professional fields. Leaders are constantly called upon to solve problems, direct institutional growth, and, on occasion, even solve humanitarian crises. Leadership development need not be complicated or overly staid. It should be engaging. \u27Star Trek\u27 provides us a venue through which to make it so. This book explores the application of \u27Star Trek\u27 to the practice of leadership across a diverse array of professional and academic fields. \u27Second Star to the Right: Essays on Leadership in Star Trek\u27 provides a set of exceptional chapters from a diverse range of scientists, professionals, writers, and thinkers. It will help you to utilize the wealth of \u27Star Trek\u27 canon applied across a robust array of fields to broadly inform the practice of leadership for a better world.https://cornerstone.lib.mnsu.edu/university-archives-msu-authors/1488/thumbnail.jp
Enhancing Counselor Development Through Designing and Supervising Online Training Groups
No full textProviding group counseling in an online format has increased in popularity in recent years, highlighting the need to offer opportunities for counselors in training to participate in online groups to enhance their professional development. This article will offer considerations for designing, facilitating, and assessing effective counseling groups for graduate students in an online environment to create an engaging and meaningful learning experience. Strategies and activities to enhance the group process and dynamics in an online format will also be explored, along with diversity and ethical considerations
Interview with Dr. Mimi Khúc on dear elia
No full textJJ Pionke interviews Dr. Mimi Khúc about her books dear elia: Letters from the Asian American Abyss and Open in Emergency, how she deliberately incorporated care into her teaching during the chaotic early days of the COVID-19 pandemic, and the process and purpose of creating a tarot deck rooted in Asian American culture
Sumatran Tigers at Risk: Saving these Fierce Big Cats
No full textSumatran tigers have characteristics that protect them from predators, from their teeth and claws to their camouflage fur. But these big cats are endangered. Hunting and a shrinking habitat are two reasons their population is shrinking. Readers will learn why Sumatran tigers are at risk, what it means to be endangered, and how people can help. Each title includes activities and trivia questions to help readers connect with the content.https://cornerstone.lib.mnsu.edu/university-archives-msu-authors/1506/thumbnail.jp
African Elephants at Risk: Saving These Majestic Mammals
No full textAfrican elephants have behaviors and features that keep them safe from predators, from the herds they live in to their large size. But these elephants are endangered. Because of humans, their habitat is shrinking, and climate change is hurting their food supply and their health. Human hunters are also putting these creatures at risk. Readers will learn why African elephants are at risk, what it means to be endangered, and how people can help. Each title includes activities and trivia questions to help readers connect with the content.https://cornerstone.lib.mnsu.edu/university-archives-msu-authors/1501/thumbnail.jp