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The effect of mobile application-based rehabilitation in patients with Parkinson?s disease: A systematic review and meta-analysis
No full textObjective: Mobile app-based telerehabilitation is practical and cost-effective in neurological rehabilitation. The present systematic review aimed to investigate the effectiveness of mobile application-based rehabilitation in patients with Parkinson's Disease.Methods: Literature was searched via databases of "Web of Science (WoS), PubMed, Cochrane, Scopus and ScienceDirect". Physiotherapy Evidence Database (PEDro) and Revised Cochrane risk-of-bias tool for randomized trials (RoB2) were used to evaluate the quality analysis and risk of bias evaluation. Both narrative and quantitative synthesis were carried out.Results: A total of 2175 articles were screened (WoS=41, PubMed=42, Cochrane=84, Scopus=114, ScienceDirect=1894). A total of 5 studies were included in the systematic review following the screening and eligibility procedures. Two studies were enrolled in meta-analysis regarding the data homogeneity. PEDro scores of the trials ranged from 4 to 7 (median:6), indicating good quality. All studies were in the "some concerns" category. The mobile application-based intervention yielded better results on quality of life and patient adherence in two studies. Application-based rehabilitation was not superior to standard treatment on MiniBESTest (ES:0.15, 95 % CI:-0.33 to 0.26) and UPDRS III (ES:0.86, 95 % CI:-0.94 to 2.46) scores.Conclusion: Mobile application-based rehabilitation is not superior to standard treatments in balance and disease severity. However, mobile technologies could be preferred to increase patient adherence and quality of life. The limited study and the low number of cases in the review may reduce the level of evidence for the results
Diversity, phylogeny and intraspecific variability of Paradiplozoon species (Monogenea: Diplozoidae) parasitizing endemic cyprinoids in the Middle East
No full textDiplozoidae are common monogenean ectoparasites of cyprinoid fish, with the genus Paradiplozoon being the most diversified. Despite recent studies on Diplozoidae from Europe, Africa and Asia, the diversity, distribution and phylogeny of this parasite group appears to be still underestimated in the Middle East. The objective of this study was to inves-tigate the diversity, endemism and host specificity of diplozoids parasitizing cyprinoid fish from the Middle East, considering this region as an important historical interchange of fish fauna, and to elucidate the phylogenetic position of Middle Eastern Paradiplozoon species within Diplozoidae. Four Paradiplozoon species were collected from 48 out of 94 investigated cyprinoid species. Three known species, Paradiplozoon homoion, Paradiplozoon bliccae and Paradiplozoon bingolensis, were recorded on new cyprinoid host species, and a new species, Paradiplozoon koubkovae n. sp., was recorded on Luciobarbus capito and Capoeta capoeta from the Caspian Sea basin in Iran and Turkey. Paradiplozoon bliccae, exhibiting a wide host range in the Middle East, expressed both morphological and genetic intraspecific vari-abilities. The four Paradiplozoon species collected in the Middle East were placed in divergent clades, showing the rich evolutionary history of diplozoid parasites in the Middle East. Our study also revealed that two lineages of African diplozoids have a Middle Eastern origin. We stress the importance of applying an integrative approach combining morphological, eco-logical and molecular methods to reveal the real diversity of diplozoids
Determination of the Effects of Bee Venom on Triple Negative Breast Cancer Cells in Vitro
No full textHoneybees provide multiple products such as bee venom (BV) which are used for various nutritional and medicinal purposes. BV has received great attention due to its wide range of bioactive components with potential anti-cancer effects on different cancers. Triple negative breast cancer (TNBC) is defined as an aggressive type of breast cancer and new therapeutic targets are required for its treatment. In the current literature information is varied about the composition and quantity of BV bioactive compounds as well as the origin of BV and its significance. In this context, the cytotoxic and apoptotic effects of BV with a higher rate of mellitin from Apis mellifera anatoliaca (Muğla ecotype) on MDA-MB-231 cells was evaluated, in vitro. The cytotoxic, apoptotic and morphological effects of BV were determined by WST-1, Annexin V, cell cycle analysis and Acridine Orange staining. The results showed that BV caused apoptotic cell death in TNBC cells at a lower dose (0.47 μg/mL, p<0.01). This study suggests that BV could be developed as a potential therapeutic agent for cancer treatment. However, the mechanism of BV-induced apoptosis death should be clarified at the molecular level
Single-session repair of multiple pressure ulcers in non-ambulatory patients
No full textOBJECTIVE: Pressure ulcers (PUs) are highly prevalent and challenging wounds. In this study, patients with either tetraplegia or paraplegia, all of whom had multiple grade 4 PUs and who underwent single-session surgical treatment were included. In order to increase the mobility of the musculocutaneous flap, the gluteus maximus muscle, which cannot be used by immobile patients, was detached and inserted into the flap. METHOD: This was a retrospective case series and all PUs were reconstructed within the same surgical session. RESULTS: A total of nine patients participated in the study, all of whom were male. Mean age was 33 years (range: 20-42 years). Mean follow-up period was 14.3 months (range: 9-24 months). All patients had a successful single-session repair of all PUs. Total or partial flap losses were not observed. Mean and total number of reconstructed PUs were 2.55 and 23, respectively. The mean area of reconstructed open wounds per patient was 174.6cm2 and the mean operation duration was 253 minutes. The level of blood loss was acceptable as the decrease in haemoglobin levels was not more than 2g/dl for each patient. CONCLUSION: Multiple PUs can be repaired in one session using gluteus maximus musculocutaneous flaps in immobile patients. Based on the fact that the gluteus maximus is an essential muscle for ambulation, our approach can only be used in the treatment of patients with irreversible paraplegia or tetraplegia. When all prerequsities are met, the amount of blood loss and operation duration are acceptable, and returning the patient to a wound-free state can be achieved more quickly compared to multi-session repairs. Air-fluidised beds are vital tools for accomplishing single session repairs of multiple PUs. The data shows that the approach is safe and can be used in patients with multiple PUs
Investigation of Structural, Morphological and Photoluminescence Properties of Electrospun Cu@PMMA Nanofibers
No full textIn this work, a tetrameric Cu(II) Schiff base complex [Tetrakis((µ3-N-(3,5-dichlorosalicyclideneamino)ethanolato)-Cu(II))], (1), has been synthesized and structurally characterized by single crystal X-ray diffraction technique. In different concentrations (5–20 wt%), complex (1) has been doped into poly(methylmethacrylate) (PMMA) as the polymer matrix using by electrospinning technique to form Cu@PMMA nanofibers. Both complex (1) and electrospun Cu@PMMA nanofibers were characterized using various techniques including field emission scanning electron microscopy (FESEM), photoluminescence (PL) and Fourier transform infrared (FT-IR) spectroscopy. The photoluminescence (PL) characteristics of Cu@PMMA composite fibers in the solid-state were studied at room temperature. Furthermore, the temperature-dependent PL properties of Cu@PMMA nanofibers, with a weight% of 15%, were investigated within a temperature range of 10–300 K. Cu@PMMA nanofibers exhibited blue emission with excitation wavelength of 349 nm. Brilliant values of the chromaticity coordinates of the prepared photoluminescent nanofibers predict their possible use in blue solid-state lighting applications
Proactive personality and job performance during cross-cultural service encounters: a moderated mediation model
No full textPurposeDrawing on the person-environment fit theory, in this paper the authors aim to propose and test a moderated mediation model that examines the relationships among proactive personality and job performance, cultural intelligence and emotional intelligence.Design/methodology/approachThe authors collected the multisource data from a total of 120 hotel service employees and the employees' immediate supervisors. The authors used the PROCESS, an SPSS macro, to conduct multiple regression analyses to test this moderated mediation model.FindingsThe results suggest that cultural intelligence mediates the relationship between proactive personality and job performance during cross-cultural service encounters. Furthermore, the indirect effect of proactive personality on job performance during cross-cultural service encounters via cultural intelligence is stronger for service employees who are high in emotional intelligence.Practical implicationsThis study has several implications for hospitality management in terms of developing effective strategies to foster cultural and emotional intelligence of service employees and improve the employees' performance.Originality/valueConsidering the limited number of studies showing why, how and in which situations personality can enhance performance, this study contributes to the literature by revealing the effect of proactive personality on the performance of service employees through important constructs such as cultural intelligence and emotional intelligence
A framework for dispatching of an electric vehicle fleet using vehicle-to-grid technology
No full textFuture planning of the energy supply and transportation should be taken into consideration simultaneously. The cooperation of related stakeholders, especially institutions, distribution companies and new technology developers is of great importance in terms of foreseeing and preventing the problems to be encountered and of benefiting together. As it becomes more challenging to maintain the balance between energy supply and demand in electric power systems due to the stochasticity of both load demands and renewable power generation, Electric Vehicle (EV) batteries can play a critical role in supporting this balance for a given period. In this study, an optimization algorithm based on mixed integer linear programming is used to evaluate the economic and technical benefits of EVs when they are used as mobile energy storage systems by system operators, which is called the concept of “Vehicle for Grid” (VfG). It is particularly aimed to alleviate the load demand on grid during the peak energy periods. The results obtained for two types of EVs with different characteristics show that the economic and operational benefits can be maximized when the optimum number and specification of EVs to be integrated into the system are determined. In the best-case scenario in which 15 EVs each with a capacity of 200 kWh are used, the peak-to-average power ratio of the load curve decreases by 6.56
Hastanede Yatan Akut İnmeli Hastalarda Gastrostomi: “NöroTek” Türkiye Nokta Prevalans Çalışması Alt Grup Analizi
No full textObjective: Nutritional status assessment, dysphagia evaluation and enteral feeding decision are important determinants of prognosis in acute neurovascular diseases. Materials and Methods: NoroTek is a point prevalence study conducted with the participation of 87 hospitals spread across all health sub regions of Turkey conducted on 10-May-2018 (World Stroke Awareness Day). A total of 972 hospitalized neurovascular patients [female: 53%, age: 69 +/- 14; acute ischemic stroke in 845; intracerebral hematoma (ICH) in 119 and post-resuscitation encephalopathy (PRE) in 8] with complete data were included in this sub-study. Results: Gastrostomy was inserted in 10.7% of the patients with ischemic stroke, 10.1% of the patients with ICH and in 50% of the patients with PRE. Independent predictors of percutaneous endoscopic gastrostomy (PEG) administration were The National Institutes of Health Stroke Scale score at admission [exp (ss): 1.09 95% confidence interval (CI): 1.05-1.14, per point] in ischemic stroke; and mechanical ventilation in ischemic [exp (ss): 6.18 (95% CI: 3.16-12.09)] and hemorrhagic strokes [exp (ss): 26.48 (95% CI: 1.36-515.8)]. PEG was found to be a significant negative indicator of favorable (modified Rankin's scale score 0-2) functional outcome [exp (ss): 0.032 (95% CI: 0.004-0.251)] but not of in-hospital mortality [exp (ss): 1.731 (95% CI: 0.785-3.829)]. Nutritional and swallowing assessments were performed in approximately two-thirds of patients. Of the nutritional assessments 69% and 76% of dysphagia assessments were completed within the first 2 days. Tube feeding was performed in 39% of the patients. In 83.5% of them, tube was inserted in the first 2 days; 28% of the patients with feeding tube had PEG later. Conclusion: The NoroTek study provided the first reliable and large-scale data on key quality metrics of nutrition practice in acute stroke in Turkey. In terms of being economical and accurate it makes sense to use the point prevalence method.Amaç: Akut nörovasküler hastalıklarda nütrisyonel durum ve disfaji değerlendirmesi ve enteral beslenme kararı önemli prognoz belirleyicilerindendir.
Gereç ve Yöntem: NöroTek, 10 Mayıs 2018’de (Dünya İnme Farkındalık Günü) Türkiye’nin tüm sağlık alt bölgelerine yayılmış 87 hastanenin katılımıyla
gerçekleştirilen bir nokta prevalans çalışmasıdır. Hastanede yatan ve bu alt çalışma için toplanan verisi tam olan toplam 972 nörovasküler hasta (kadın: %53, yaş:
69±14 yıl; 845’i akut iskemik inme; 119’u intraserebral hematom ve 8’i post-resüsitasyon ensefalopatisi) analiz edildi Bulgular: Gastrostomi iskemik inmeli hastaların %10,7, intraserebral kanamalıların %10,1 ve post-resusitasyon ensefalopatisi olanların %50’sine uygulanmıştır.
Perkütan endoskopik gastrostomi (PEG) gereksiniminin bağımsız belirleyicileri, iskemik inme grubunda kabul NIHSS [exp (β): 1,09, %95 güven aralığı (GA):
1,05-1,14, puan başına] ile hem iskemik hem de hemorajik inmelerde mekanik ventilasyon uygulanmış olmasıdır [iskemik için: exp (β): 6,18, %95 GA: 3,16-
12,09] ve hemorajik inme için: [exp (β): 26,48, 95% GA: 1,36-515,8]. İnme olgularında PEG uygulaması hastane içi mortalite için bağımsız belirleyici değildi
[exp (β): 1,731, 95% GA: 0,785-3,829]. Ancak, PEG uygulanmış olması taburculuk esnasında iyi prognoza (modifiye Rankin skoru 0-2) sahip olabilme için
anlamlı bir negatif etmen olarak bulundu [exp (β): 0,032, %95 GA: 0,004-0,251]. Hastanede yatan nörovasküler hastaların yaklaşık üçte ikisinde malnütrisyon
ve yutma bozukluğu açısından değerlendirme yapılmıştı. Nutrisyonel status değerlendirmesinin %69’u ve disfaji değerlendirmesinin %76’sı ilk 48 saat içinde
gerçekleştirilmişti. Tüple enteral nütrisyon uygulama oranı %39’du. Beslenme tüplerinin %83,5’i ilk 2 gün içinde yerleştirilirken beslenme tüpü olan hastaların
%28’ine daha sonra PEG açılmıştı.
Sonuç: NöroTek çalışması ile Türkiye’de hastanede yatan akut inme hastalarında nutrisyonel uygulamaların temel kalite ölçütlerine ilişkin ilk güvenilir ve büyük
ölçekli veri sağlanmıştır. Ekonomik olması ve doğruluğu açısından nokta yaygınlık yönteminin bu tip verilerin temini için daha fazla kullanılması mantıklıdır
Novel Graph Neighborhoods Emerging from Ideals
No full textRough set theory is a mathematical approach that deals with the problems of uncertainty and ambiguity in knowledge. Neighborhood systems are the most effective instruments for researching rough set theory in general. Investigations on boundary regions and accuracy measures primarily rely on two approximations, namely lower and upper approximations, by using these systems. The concept of the ideal, which is one of the most successful and effective mathematical tools, is used to obtain a better accuracy measure and to decrease the boundary region. Recently, a generalization of Pawlak’s rough set concept has been represented by neighborhood systems of graphs based on rough sets. In this research article, we propose a new method by using the concepts of the ideal and different neighborhoods from graph vertices. We examine important aspects of these techniques and produce accuracy measures that exceed those previously = reported in the literature. Finally, we show that our method yields better results than previous techniques utilized in chemistry