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Variações vasculares da cabeça do nervo óptico no glaucoma pseudoesfoliativo e primário de ângulo aberto
No full textPurpose: The purpose of this study was to assess the optic nerve head microvascular changes in pseudoexfoliative and primary open-angle glaucoma and define the relationship between vessel density and retinal nerve fiber layer thickness.
Methods: This observational cross-sectional study assessed 72 eyes with primary open-angle glaucoma, 41 eyes with pseudoexfoliative glaucoma, and 60 healthy eyes. On the basis of optic nerve head-centered, 4.5 mm × 4.5 mm scan size images, we evaluated the vessel density, as well as the peripapillary sector, inside disk, and all sectoral quadrants.
Results: Both glaucoma Groups had lower vessel density in all regions compared with the healthy Group (p<0.05 for all variables). Vessel densities of the nasal inferior, inferior nasal, and inferior temporal sectors in both glaucoma Groups showed similar results (p=0.157, p=0.128, p=0.143, respectively). Eyes with pseudoexfoliative glaucoma had significantly lower vessel densities than eyes with primary open-angle glaucoma in all other regions (p<0.05 for all variables). For both glaucoma Groups, the average retinal nerve fiber layer thickness positively correlated with vessel density in all peripapillary sectors (p<0.05 for all variables).
Conclusions: Reduction in vessel density correlated with the thinning of retinal nerve fiber layer in both glaucoma Groups. Decreased vessel density in the optic nerve head can be used to demonstrate the microvascular pathologies and possible ischemic changes that lead to faster progression and worse prognosis in pseudoexfoliative glaucoma
Volatile Compound Profiling of Seven Tuber Species Using HS-SPME-GC-MS and Classification by a Chemometric Approach
No full textEdible mushrooms are important providers of nutrients and are well recognized for their particular organoleptic properties. The volatiles that Tuber releases serve purposes beyond simply appealing to our sense of smell. Truffles have different smells and tastes due to the fact that they contain different volatile components; therefore, aroma is essential in defining the organoleptic properties and quality of truffles. In this research, seven Tuber species, namely, Tuber ferrugineum, Tuber nitidum, Tuber excavatum, Tuber rufum, Tuber puberulum, Tuber aestivum, and Tuber borchii were selected. The primary objective of this study was to carry out the first in-depth investigation of the volatile compounds and chemometric analysis of seven truffle species from the Tuber genus that are grown in Turkey. The SPME headspace combined with GC-MS analysis identified 60 volatiles from different classes, with the abundance of terpenes being followed in a decreasing order by alcohols, aldehydes, sulfides, ketones, and other aromatic compounds. According to the chemometric analysis, methional, 3-methyl-4,5-dihydrothiophene, p-(methylthio) benzaldehyde, 3-octene, linalyl acetate, methyl caproate, and β-trans-ocimene could be highlighted as markers for T. borchii grown in Turkey. This investigation was conducted for the first time using T. ferrugineum, T. puberulum, and T. nitidum. The comparison of the volatile profile of these tubers' species displayed branded differences. Thus, the knowledge gained from this research may pave the way to identify the key aroma contributors in the chosen Tuber species
Development of a Sensitive Method for Cadmium Determination in Fish Tissue and Drinking Water Samples by FAAS Using SQT In Situ Atom Trapping
No full textA sensitive and robust trap method was developed for the determination of cadmium (Cd) by using a slotted quartz tube. Using this method at a sample suction rate of 7.4 mL/min for 4.0 min collection, a 1467-fold increase in sensitivity was obtained compared to the flame atomic absorption spectrometry method. Under the optimized conditions, a limit of detection of 0.075 ng mL-1 was obtained for the trap method. The interference effects of hydride-forming elements, transition metals, and some anions on the Cd signal were investigated. The developed method was evaluated by analyzing "Sewage Sludge-industrial origin (BCR no: 146R)", "NIST SRM 1640a Trace elements in natural water", and "DOLT: 5 Dogfish Liver". There was a good agreement between the certified and found values at the 95% confidence level. This method was applied successfully for the determination of Cd in drinking water and some fish tissue samples (liver, muscle, and gill) obtained from Muğla province
Agreement between video-based clinician-rated tools and patient-reported outcomes on gait assessment in individuals with multiple sclerosis
No full textPurpose: To our knowledge, no studies compared the video-clinician-based tools and patient-reported questionnaires in assessing gait and balance in people with MS (pwMS). The present study investigated the correlation and agreement between video-clinician-based objective measurement tools and patient-reported outcome measures (PROMs) in gait and balance evaluation. Methods: A prospective cross-sectional study was conducted with 55 pwMS. Video analysis-based gait was evaluated by the Tinetti Gait Assessment (TGA), Gait Assessment and Intervention Tool (GAIT), and Functional Ambulation Classification Scale (FACS) by the clinician. Participants’ self-reported gait and balance were assessed with the Multiple Sclerosis Walking Scale-12 (MSWS-12) and Activity-Specific Balance Confidence Scale (ABC). Results: There was a moderate positive correlation between ABC with TGA and FACS (r 1: 0.552, r 2: 0.510, p < 0.001). ABC was strongly correlated with GAIT (r: − 0.652, p < 0.001). A moderate positive correlation was observed between MSWS-12 with TGA and FACS (r 1: − 0.575, r 2: − 0.524, p < 0.001). In addition, there was a strong positive correlation between MSWS-12 and GAIT (r: − 0.652, p < 0.001). Clinician-rated tools and PROMs were within the agreement limits regarding the unstandardized beta values p < 0.001). Conclusions: Clinician-based gait and balance tools demonstrate consistent results with PROMs in pwMS. Considering the low cost and practical use of PROMs, in cases where video-based clinician-based measurements cannot be provided (time, space, and technical inadequacies), questionnaires can provide concordant results at moderate and severe levels compared with objective tools
Management of Nasal Lobular Capillary Hemangioma with Sunitinib
No full textLobular capillary hemangioma (LCH) or pyogenic granuloma is a rare benign lesion originating from the nasal cavity. We pre-sent a case of nasal LCH successfully palliated with sunitinib. A 65-year-old male patient was hospitalized because of swelling and hyper-emia in the periorbital region for 3 months. A month before admission, episodic epistaxis occurred. Magnetic resonance imaging showed a 35×62×63-mm solid mass filling the right half of the nasal cavity. The biopsy showed LCH, and the patient was diagnosed with metastatic renal cell carcinoma (RCC). The tumor board discussed a strategy that can primarily treat metastatic RCC and symptomatic palliation of LCH. Moreover, sunitinib treatment provided palliation of symptoms related to nasal LCH. He reported that swelling, pain, and epistaxis disappeared during the treatment
Research on the Designing Apiroute within the Scope of Developing Apitourism: The Case of Marmaris
No full textÇalışmanın amacı, dinlence, deniz ve çeşitli alternatif turizm faaliyetlerinin gerçekleştiği Marmaris’in, kırsal alanında arıcılık faaliyetleri ile ziyaretçi çekmeyi sağlayacak ve bölgede değer yaratacak apirota önerisi oluşturmaktır. Araştırma, Eylül 2022 tarihinde gerçekleşmiştir. Araştırma alanı Marmaris’in Hisarönü Körfezi ile İçmeler Koyu arasında çizilecek hattın güneyinde kalan ve arıcılık faaliyetleri yapılan kırsaldır. Çalışmada, nitel araştırma yöntemi kullanılmıştır. Araştırma alanında, apiturizmi geliştirme ve apirota oluşturmaya yönelik görüşlerin toplanması için görüşme tekniğinden yararlanılmıştır. Görüşmelerde yarı yapılandırılmış toplam 7 açık uçlu soru sorulmuştur. Araştırma alanı ile ilgili derinlemesine bilgi sahibi olan yerel arıcı ve turizm profesyonellerinden oluşan 10 katılımcının görüşlerine başvurulmuştur. Araştırma sonucunda araştırma alanının, apiturizm arzına sahip olduğu; kırsaldaki kültürel, tarihi ve doğal zenginliklerin bu arzı zenginleştireceği; apiturizm kapsamında yapılabilecek uygulamaların ve ürünlerin çeşitlendirilmesi gerektiği ortaya koyulmuştur. Elde edilen veriler ışığında apiturizmin gelişimine katkı sağlayacağı düşünülen bir apirota geliştirilmiştir.The study aims to design an apiroute that will attract visitors with beekeeping activities in the rural area of Marmaris, and create value in the region. The research was carried out in September 2022. The research area is the countryside between Hisarönü Gulf and İçmeler Bay of Marmaris, which is located to the south of the line to be drawn and where beekeeping activities are carried out. The opinions of 10 participants, consisting of local beekeepers and tourism professionals who have in-depth knowledge about the research area, were taken. The qualitative research method was used in the research. In the field of research, the interview technique was used to collect opinions on developing apitourism and creating apiroute. A total of 7 open-ended questions were asked during the interviews. In the research findings; the research area has an apitourism supply; cultural, historical, and natural riches in the countryside will enrich this supply; It has been found that the practices and products that can be made within the scope of apitourism should be diversified. In light of the data obtained, an apiroute, which is thought to contribute to the development of apitourism, has been developed
The reliability and validity of the Turkish version of the fatigue assessment scale in patients with multiple sclerosis a; b Send mail to Özden F.;
No full textObjective: To demonstrate the psychometric properties of the Turkish Fatigue Assessment Scale (FAS). Materials and Methods: A total of 104 patients were recruited. The patients were assessed twice, 1 week apart. Patients completed the FAS, Fatigue Severity Scale (FSS), EuroQol-5 dimensions-3 L (EQ-5D-3 L), and Beck Depression Scale (BDS) in the initial assessment. Thirty-four patients completed the FAS again in the second assessment. Results: The mean age of the patients with multiple sclerosis (MS) was 37.6 ± 10.1 years. The intraclass correlation coefficient (ICC) of the FAS was excellent (ICC = 0.812). The Cronbach alpha coefficient of the FAS was 0.914. The alpha of the FAS was excellent (>0.80). Standard error of measurement and minimal detectable change of the FAS were 3.51 and 9.73 respectively. The relationship between the FAS (test, retest) and the FSS was excellent (r1 = 0.767, r2 = 0.782, P < 0.01). The EQ-5D-3 L index score was both strongly related with FAS (test, retest) (r1 = -0.500, r2 = -0.745, P < 0.01). The EQ-5D-3 L Visual Analog Scale score was also highly correlated with FAS (test, retest) (r1 = -0.536, r2 = -0.764, P < 0.01). Besides, FAS (test, retest) scores were strongly correlated with BDS total scores (r1 = 0.540, r2 = 0.571, P < 0.01). Conclusions: The Turkish FAS is a reliable and valid scale for individuals with MS
Melhora da Pressão Arterial após Jejum Intermitente na Hipertensão: O Sistema Renina-Angiotensina e o Sistema Nervoso Autônomo Podem Funcionar?
No full textBackground: Although it has been reported that the intermittent fasting (IF) diet has positive effects on heart health and improvement in blood pressure, it has not been sufficiently clarified how it could have these positive effects yet.
Objective: We aimed to evaluate the effects of IF on the autonomic nervous system (ANS) and renin-angiotensin system (RAS), which are closely related to blood pressure.
Methods: Seventy-two hypertensive patients were included in the study, and the data of 58 patients were used. All the participants fasted for about 15-16 hours for 30 days. Participants were evaluated with 24-hour ambulatory blood pressure monitoring and Holter electrocardiography before and after IF; also, 5 ml venous blood samples were taken for assessment of Serum angiotensin I (Ang-I) and angiotensin II (Ang-II) levels and angiotensin-converting enzyme (ACE) activity. For data analysis, the p-value <0.05 was accepted as significant.
Results: Compared to pre-IF, a significant decrease was observed in the patients' blood pressures in post-IF. An increase in high-frequency (HF) power and the mean root square of the sum of squares of differences between adjacent NN intervals (RMSSD) were observed after the IF protocol (p=0.039, p=0.043). Ang-II and ACE activity were lower in patients after IF (p=0.034, p=0.004), and decreasing Ang-II levels were determined as predictive factors for improvement of the blood pressure, like the increase in HF power and RMSSD.
Conclusion: The present findings of our study demonstrated an improvement in blood pressure and the relationship of blood pressure with positive outcomes, including HRV, ACE activity, and Ang-II levels after the IF protocol
Comparison of the effect of different glide path files on amount of apically extruded debris in curved root canals
No full textIt is essential to create a glide path before root canal preparation with nickel–titanium rotary files to avoid file breakage and preserve the original canal structure. The aim of this study was to compare the amount of apically extruded debris after using different glide path files. A total of 96 first mandibular molars with curved mesial roots were randomly divided into six groups (n = 16) which are K-files, Proglider, R-Pilot, TruNatomy Glider, WaveOne Gold Glider and group without a glide path. Apically extruded debris was measured after glide path and canal preparation. The highest amount of debris was found in the control group without a glide path and using a glide path file caused less debris and significant differences were observed between R-Pilot, TruNatomy Glider, ProGlider, WaveOne Gold Glider and K-file groups. It may be recommended to create a glide path before root canal shaping to reduce the amount of extrusion debris from the apical. Especially in curved and narrow root canals, it is recommended to use an R-Pilot file before root canal shaping in order to reduce the amount of apically extruded debris
Sertraline-Induced Leukocytoclastic Vasculitis with Definite Causal Association: A Case Report
No full textAntidepressants like sertraline are frequently used to treat psychiatric diseases like depression, panic disorder, and obsessive-compulsive disorder. Small-vessel vasculitis called leukocytoclastic vasculitis is defined histopathologically by immune complex-mediated vasculitis of the dermal capillaries and venules. Typically, it shows up as purpura on the lower extremities, either with or without systemic involvement. Leukocytoclastic vasculitis can be idiopathic but it can also happen in conjunction with several medications. Here, we present data on sertraline-induced leukocytoclastic vasculitis in a patient with major depressive disorder. To our knowledge, sertraline and other selective serotonin reuptake inhibitors have not previously been definitively linked to leukocytoclastic vasculitis, which is rare with antidepressants