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A chemometric study on phenolic profiles and biological properties of cotton honeys from Turkey
No full textHoney, a nutritious and healthy product, has recently been the focus of research due to its characteristic chemical composition and a wide variety of biological properties. The current study aims to investigate the phenolic profiles and tyrosinase, acetylcholinesterase (AChE), urease and butyrylcholinesterase (BChE) enzymes inhibitory, anti-inflammatory, antioxidant, antimicrobial and quorum sensing inhibition activities of twelve cotton honeys in 2 different regions from Turkey with the chemometric approach. The phenolic profile was determined by HPLC–DAD and gallic acid (8.95–84.47 μg/g) and p-hydroxybenzoic acid (0.21–1.45 μg/g) were detected in all cotton honeys studied. The SB-coded cotton honey from Şanlıurfa showed the highest activity in β-carotene linoleic acid (IC50: 5.94 ± 0.25 mg/mL), ABTS (IC50: 12.95 ± 0.49 mg/mL), CUPRAC (A0.50: 8.65 ± 0.41 mg/mL), metal chelating (IC50: 5.46 ± 0.28 mg/mL), AChE (13.65 ± 0.21%) and BChE (9.78 ± 0.11%) assays. The SE-coded cotton honey from Şanlıurfa was found to be the strongest in DPPH (IC50: 37.62 ± 1.40 mg/mL), anti-QS (44 mm zone) and swarming motility inhibition (30.47%) activities. Among all the other cotton honeys studied, AK1-coded cotton honey from Adana showed the highest antimicrobial activity against S. aureus (22 mm zone), L. monocytogenes (13 mm zone) bacteria and C. albicans (13 mm zone), C. tropicalis (15 mm zone) strains, and anti-inflammatory activity against COX-2 (16.59 ± 0.24%) and COX-1 (42.71 ± 0.56%). According to the PCA and HCA analysis results of cotton honeys based on phenolic compounds and biological activities, it is seen that cotton honeys from Adana and Şanlıurfa were clustered separately
Multi-item unidimensional measurement scale construct: Perceived hygiene development (pHd)
No full textThe recent COVID-19 pandemic experience intensified the significance of hygiene in the service industry. It is crucial to measure how service practice adaptations and technology adoptions in servicescapes have been perceived by customers regarding hygiene in the post-COVID-19 era. However, the extant hygiene scales do not serve the purpose to measure hygiene contributions of technology-specific and service practice-specific changes. Thus, the purpose of this research was to develop a multi-item unidimensional perceived hygiene construct. Sequential mixed-methods research (Qual-Quan) was employed. Participants were sampled among restaurant patrons. A four-item perceived hygiene development (pHd) construct was successfully developed. Hospitality and service researchers and practitioners can utilize this scale to measure perceived hygiene improvements of particular technology adoptions and service practice adaptations in service settings
Effectiveness of dignity therapy in the context of culturally competent care in people with palliative care needs: a systematic review of systematic reviews
No full textPurpose of reviewThis review aims to synthesise the evidence from systematic reviews and meta-analyses on the efficacy of dignity therapy (DT) in relation to psychosocial and spiritual outcomes in the context of person-centred and culturally competent care for people with supportive and palliative care needs.Recent findingsThirteen reviews were found, including seven conducted by nurses. Most reviews were of high quality, including various study populations such as cancer, motor neurone disease and non-malignant conditions. Six psychosocial and spiritual outcomes were identified: quality of life, anxiety, depression, hopefulness, meaning and purpose in life, and suffering based on the cultural variations in the implementation of DT.SummaryDT has a positive impact on anxiety, depression, suffering, and meaning and purpose in life for people with palliative care needs, but the evidence is somewhat conflicted as to whether DT is effective in improving hope, quality of life and spiritual outcomes in the context of culturally competent care. Nurse-led DT seems desirable given its pivotal role when caring for people with palliative care needs. More randomised controlled trials should be conducted for people with different cultural backgrounds to provide person-centred, culturally competent supportive and palliative care
Comparison of innate lymphoid cells from tissue and blood in chronic tonsillitis and tonsillar hypertrophy
No full textObject: Recurrent tonsillitis and tonsillar hypertrophy are two common diseases in children for which tonsillectomy is the definitive solution. The underlying causes of both diseases are not fully known. The aim of this study was to identify the predominant innate lymphoid cells in both diseases of the palatine tonsils, which are known to play an important role in the immune system. Methods: Children who underwent tonsillectomy were divided into two groups as recurrent tonsillitis and tonsillar hypertrophy according to the indication for surgery. The proportions of innate lymphoid cell (ILC) groups and IFN-gamma, IL-10 and IL-17 secreting T lymphocyte cells were determined in tonsil and blood samples obtained during surgery. Local and peripheral immune responses were evaluated. Innate immune responses and acquired immune responses were compared. Results: The results of our study showed that the proportions of the innate lymphoid cell 1 group (ILC1) were similar in tonsil tissue in patients with recurrent tonsillitis and tonsil hypertrophy, with no statistically significant difference. It was observed that the innate lymphoid cell 2 group (ILC2) was the predominant group in tonsil hypertrophy, the innate lymphoid cell 3 group (ILC3) was the predominant innate lymphoid cell group in recurrent tonsillitis, and the proportion of IL-17 secreting T lymphocytes in blood and tonsillar mononuclear cells was higher in recurrent tonsillitis patients than in tonsil hypertrophy patients. Conclusion: With the results obtained, the predominant innate lymphoid cells in the pathogenesis of both diseases were identified and local and peripheral responses were compared. These findings may be a guide for possible medical treatments for both diseases in the future
Path-Based Visibility Graph Kernel and Application for the Borsa Istanbul Stock Network
No full textUsing networks to analyze time series has become increasingly popular in recent years. Univariate and multivariate time series can be mapped to networks in order to examine both local and global behaviors. Visibility graph-based time series analysis is proposed herein; in this approach, individual time series are mapped to visibility graphs that characterize relevant states. Companies listed on the emerging market index Borsa Istanbul 100 (BIST 100) had their market visibility graphs collected. To further account for the local extreme values of the underlying time series, we constructed a novel kernel function of the visibility graphs. Via the provided novel measure, sector-level and sector-to-sector analyses are conducted using the kernel function associated with this metric. To examine sectoral trends, the COVID-19 crisis period was included in the study’s data set. The findings indicate that an effective strategy for analyzing financial time series has been devised
Emergence of net magnetization by magnetic field biased diffusion in antiferromagnetic L10 NiMn
No full textNiMn is a collinear antiferromagnet with high magnetocrystalline anisotropy (K = -9.7 x 105 J m-3). Through magnetic annealing of NiMn with excess Ni, strongly pinned magnetic moments emerge due to an imbalance in the distribution of Ni in the antiferromagnetic Mn sublattices. The results are explained with a model of magnetic field biased diffusion, supported by ab initio calculations. Another observation is the oxidation of Mn at the surface, causing an enrichment of Ni in the subsurface region. This leads to an additional ferromagnetic response appearing in the magnetization measurements, which can be removed by surface polishing
Butyrylcholinesterase in lipid metabolism: A new outlook
No full textCholinesterase enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are traditionally associated with the termination of acetylcholine mediated neural signaling. The fact that these ubiquitous enzymes are also found in tissues not involved in neurotransmission has led to search for alternative functions for these enzymes. Cholinesterases are reported to be involved in many lipid related disease states. Taking into view that lipases and cholinesterases belong to the same enzyme class and by comparing the catalytic sites, we propose a new outlook on the link between BChE and lipid metabolism. The lipogenic substrates of BChE that have recently emerged in contrast to traditional cholinesterase substrates are explained through the hydrolytic capacity of BChE for ghrelin, 4-methyumbelliferyl (4-mu) palmitate, and arachidonoylcholine and through endogenous lipid mediators such as cannabinoids like anandamide and essential fatty acids. The abundance of BChE in brain, intestine, liver, and plasma, tissues with active lipid metabolism, supports the idea that BChE may be involved in lipid hydrolysis. BChE is also regulated by various lipids such as linoleic acid, alpha-linolenic acid or dioctanoylglycerol, whereas AChE is inhibited. The finding that BChE is able to hydrolyze 4-mu palmitate at a pH where lipases are less efficient points to its role as a backup in lipolysis. In diseases such as Alzheimer, in which elevated BChE and impaired lipid levels are observed, the lipolytic activity of BChE might be involved. It is possible to suggest that fatty acids such as 4-mu palmitate, ghrelin, arachidonoylcholine, essential fatty acids, and other related lipid mediators regulate cholinesterases, which could lead to some sort of compensatory mechanism at high lipid concentrations
Comparison of Delivery Results of Adolescent-Age Pregnant Women and Older Pregnant Women With Those In Normal Age Range
No full textThe negative results of adolescent (10-19 years) and advanced-age pregnancies (AMA) (>40 years) were compared with the results of the pregnancies considered to be within normal reproductive period (20-40 years) in our study. The complications and poor outcomes that might occur during and after pregnancies in these special periods were also uncovered in this respect. The data of the patients were scanned retrospectively through the automation system, and the patients were divided into 3 groups according to their ages at birth; adolescent (10-19 years), normal (20-40 years old), and AMA (>40 years). A total of 100 patients were evaluated in the adolescent age group, 99 patients in the normal age group, and 76 patients in the AMA group. Statistically significant differences were detected between the groups in terms of age, weight, and BMI (p<0.05). Statistically significant differences were found between the groups in terms of active phase duration (p<0.05), which was the highest in women in the AMA group (268.5min). There were statistically significant relations in terms of pregnancy follow-up status (p<0.05); and the rate of non-follow-up was the highest in the adolescent group (32.0%). C/S ratio was the highest in the AMA group (73.7%), the normal delivery rate was the highest in the adolescent group (83.0%). Also, there were statistically significant relations between cesarean section indications (p<0.05).Although fetal distress was the indication for cesarean section in the majority of women in the normal and adolescent group (39.1%-56.3%), the reason for cesarean section was found to be maternal anxiety (patient demand) in the majority (25.0%) of women in the AMA group. Early and late pregnancies should be considered as a special group and follow-up should be planned accordingly. Decreased pregnancy follow-up status in adolescence and increased cesarean section rates in advance-age pregnancies may increase complications
Cryopreservation of Deciduous Teeth Originated Mesenchymal Stem Cells with Different Techniques
No full textObjective: Mesenchymal stem cells (MSCs) are not used immediately after isolation in experimental and clinical studies. Traditional freezing and thawing processes may affect the cell viability or immunological properties of MSCs. In this study, the effect of different freezing methods on the viability, differentiation potential, and immunological properties of MSCs from human exfoliated deciduous teeth (SHED) was investigated.Methods: SHED was isolated from SHED from healthy subjects aged between 8-12 years. The third passage cells were frozen with three different freezing solutions containing distinct concentrations of dimethyl sulfoxide, trehalose, ethylene glycol, or PVP40. After thawing, cells were analyzed for cell viability, co-cultured with mononuclear cells, and analyzed for lymphocyte proliferation rate, and cell viability for evaluating immunological properties.Results: Compared to conventional cell freezing methods, the lymphocyte proliferation rate was suppressed, and cell viability ratios were increased with cryoprotectant solutions containing trehalose and ethylene glycol (p<0.05).Conclusion: Cryoprotectant solutions containing trehalose, ethylene glycol, or PVP40 are more suitable for cell freezing.
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Digital competences of older women in Turkey: gender and ageing as double danger
No full textThe Internet is a massive technological breakthrough in terms of interpersonal communication and social connectivity, facilitating citizenship practices of societies of modern life; yet its potential in the inclusion and empowerment of older adults is hampered by low levels of technology usage and often limited digital competences. Many older adults remain relatively distant from modern digital life, further isolated from society and daily public services. Older adults are considered disadvantaged, tend to live dependent upon others, and occasionally deprived of human and social capital. This divide has been more prevalent during the COVID-19 pandemic, particularly for older women. Promoting specific actions to improve digital competences can contribute to digital inclusion, particularly for disadvantaged segments of society. This study presents findings from a field research conducted to determine the digital competence levels of older women living in southwest Turkey as part of a nationally funded project. Field notes and survey data collected from 377 older women revealed that digital competence may improve through education, that challenges included dependency, safety/fear, and stoicism, and that any support, social interaction, or training offered to older adults could help them to improve their digital competences and self-confidence for daily survival in the digital age, enabling more independent and self-sufficient living in their later years. Future directions include social connectedness and intergenerational interaction for digital competence, lifelong learning activities and training programmes on digital skills and ICT usage for older adults, and improved designs of digital products to prevent their exclusion from today’s technology-dominated society