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Conceptual design of a novel power-augmented hydrokinetic run-of- river turbine
Get PDFOther than the water stream from ocean, river stream is also being considered as a viable source of renewable energy. Many researchers has approached and started the studies of river stream in order to harness the maximum power from the rivers. River stream offers promising energy especially to the rural areas which are surrounded by rivers. From previous studies, it shows that majority of the hydrokinetic run-of-river turbine systems are designed in vertical and horizontal axis. Besides, some of the vertical and horizontal axis turbines are also enclosed by the duct or diffuser in order to guide the river stream and increase the flow velocity. However, the design of the shape of diffuser faced the challenges during fabrication phase and additional supporting structures are needed during installation, causing the increases in the overall cost. In this paper, the authors would like to propose a conceptual design of a novel power-augmented hydrokinetic run-of-river turbine which utilizes the concept of cross-axis wind turbine and simple augmented guide vane. This conceptual design of hydrokinetic turbine able to capture the advantages of both the horizontal and vertical axis turbines. Helical blade design was chosen for this conceptual design due to its ability to capture the skewed flow created by the difference in velocity of upper and lower faces of turbine. When the vertical-axis turbine rotates, the angle of attack of each blade varies cyclically. The cyclical variation of the angle of attack creates cyclical blade loading, which increases the fatigue experienced by blades. Most of the cyclical loading can be alleviated by using helical instead of straight blades. The conceptual design of this cross-axis turbine with helical blade is similar to the Gorlov helical turbine but there are some differences in the radial blades which are designed as 8 degrees upper and lower respectively to the horizontal axis of the connector hub. The two layers radial blade-rotors are offset by 60 degrees. The turbine
system is designed by intercepting the two guide vanes in between three individual turbines and also two diffuservanes
as the outer part of the system. The NACA 0015 airfoil profile is used as turbine blade in this design. The
construction costs of cross-axis concept turbine and the helical blades are relatively low (about 30%) compared
with the huge ducted and diffuser turbine. A 3D model was constructed and simulated by using the computational
fluid dynamics software, ANSYS-Fluent. In the simulation, the velocity of water flow and the rotational speed of
turbine were increased with the integration of the guide-vane and diffuser features. It is estimated that this
conceptual design turbine will achieve 60% increase in energy gain
Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways
No full textThe innate immune system serves as the first line of defense to protect the host from pathogen infection. As a first step, the pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs), such as non-self DNA derived from pathogens, and damage-associated molecular patterns (DAMPs), such as self DNA released from damaged or injured cells. Sensing of such DNAs elicits innate immune responses through the production of type I interferons (IFNs) and proinflammatory cytokines resulting from the activation of interferon regulatory factor 3 (IRF3) and nuclear factor kappa B (NF-κB), respectively. These cytokines are key players in interlinking innate and adaptive immune responses. However, defects in DNA sensors and their signaling cascades lead to dysregulation of immune responses, autoimmune diseases, and cancer progression. Here we provide an update on DNA signaling pathways in response to pathogen infection and cell injury, and on the roles of regulators in governing the immune system and maintaining host homeostasis. We also discuss the evasion of immunosurveillance by pathogens
Short-term effects of biochar amendment on soil microbial community in humid tropics
No full textBiochar is known to ameliorate soil fertility and improve crop production but information regarding soil microbiota responses on biochar amendment remains limited. The experiment was conducted to study the effect of biochars from palm kernel (pyrolysed at 400°C) and rice husk (gasified at 800°C) in a sandy loam Acrisol from Peninsular Malaysia. The soil was amended with palm kernel shell biochar (PK), rice husk biochar (RH), palm kernel biochar with fertilizer (FPK), rice husk biochar with fertilizer (FRH), fertilizer and control soil. Soil samples were taken during maize harvesting and were analysed for physico-chemical properties, microbial biomass, microbial abundance and microbial diversity. Increase in pH, moisture content, CEC, organic C, and labile C were recorded in all biochar amended soils. Microbial biomass C was 65% and 36% higher in RH and FRH, respectively, than control. Microbial biomass N was greatest in FPK and FRH with respective increment of 359% and 341% than control. β-glucosidase and xylanase activities were significantly increased in all biochar treated soils than control. A shift in microbial diversity was not detected. The biochar affects the microbial community by altering the soil environment and increasing labile active carbon sources in the short-term amendment
One-step green hydrothermal synthesis of biocompatible graphene/TiO2 nanocomposites for non-enzymatic H2O2 detection and their cytotoxicity effects on human keratinocyte and lung fibroblast cells
No full textHighly sensitive and selective immunosensors that can detect disease biomarkers at ultra-low levels in early stages are urgently needed to reduce mortality risks. A facile and efficient approach using sonochemical-assisted solvent graphene exfoliation and a hydrothermal synthesis method has been used to prepare graphene/titanium dioxide (G/TiO2) nanocomposites. Nanocomposites containing different ratios of graphene and TiO2 precursors were prepared to determine the optimum composition of G/TiO2 that has the highest conductivity and electrocatalytic properties. Characterisation methods such as X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), and high resolution TEM (HRTEM) were used to study the crystallinity, surface characteristics, elemental composition, and morphology of the synthesised nanocomposites. The synthesised materials were also confirmed via Raman spectroscopy. Using ferricyanide as the redox active probe, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) analyses indicated that 1:8 ratio of G/TiO2 exhibited the best current response and the lowest charge transfer resistance (Rct) of 1525 Ω. The potential of G/TiO2 for electrochemical sensing application was investigated using hydrogen peroxide (H2O2), a by-product of most enzymatic processes, as the analyte of interest. The sensitivity of the sensor towards H2O2 was 0.557 μA mM-1, with a limit of detection (LOD) at 56.89 μM. An in vitro cell proliferation assay was carried out to investigate the biocompatibility of the nanocomposites. The half-maximal inhibitory concentration (IC50) values obtained were >500 μg ml-1 for human lung fibroblasts (MRC5) and 5-25 μg ml-1 for human skin cells (HaCat)
A three-dimensional virtual morphometry study of the sigmoid notch of the distal radius
No full textPurpose: Our primary objectives were to create a reliable, noninvasive method for three-dimensional morphometry of deep bony parameters within the sigmoid notch of the distal radius, to identify its morphological patterns, and to identify any significant variation between the left and the right wrists. Our secondary objectives were to obtain morphometric values that could represent our population and to identify any possible ethnic variations. Methods: Computed tomography scans of 102 wrists from 51 healthy individuals were analyzed using a virtualization software. Four anatomical parameters at the distal radius sigmoid notch, namely, the radius of curvature, depth, version angle, and sagittal slope were measured. Morphological patterns of the sigmoid notch surface were identified. The results were statistically analyzed to assess the reliability of the technique and were compared with previously published literature. Results: Comparing our findings with previously published values, our study revealed a slightly larger radius of curvature and sagittal slope, while revealing a smaller depth and version. We identified the S-type, C-type, and ski-slope morphological variants. The flat-face morphological variant, however, was not identified. The sigmoid notch at the left and right wrists were similar, except for the radius of curvature. Conclusion: This study demonstrates a noninvasive, fast, reliable, and reproducible technique for analyzing the sigmoid notch of the distal radius. In wrist injuries with intact distal radius sigmoid notch but involving comminuted fractures of the ulnar head, ulnar head replacement may be indicated. In such cases, analysis of the ipsilateral intact sigmoid notch would allow us to prepare an ulnar head prosthesis of appropriate size
Colloidal stability measurements of graphene nanoplatelets covalently functionalized with tetrahydrofurfuryl polyethylene glycol in different organic solvents
No full textIn this study, a facile, efficient, and cost-effective method was proposed for mass-production of tetrahydrofurfuryl polyethylene glycol-functionalized graphene nanoplatelets (TFPEG-treated GNPs) with improved colloidal stability in water and different organic solvents. In this method, zirconium(IV) oxychloride octahydrate was used as catalyst to covalently functionalize GNPs with TFPEG via direct esterification of carboxylic acid on the GNPs with the hydroxyl chains of TFPEG. Covalent functionalization was verified by Fourier transform infrared spectroscopy, Raman spectroscopy, and thermogravimetric analysis. Further, the morphology of the TFPEG-treated GNPs was determined via a high-resolution transmission electron microscopy. The stability of the treated GNPs in colloidal form was examined by dispersing 0.01 wt% of the solid sample into different organic solvents namely distilled water, methanol, ethanol, ethylene glycol, and 1-hexanol. It was found that the sedimentation rate of TFPEG-treated GNPs in distilled water, methanol, ethanol, ethylene glycol, and 1-hexanol was at 11, 25, 36, 18, and 47%, respectively, recorded after 15 days. Viscosity and thermal conductivity of water-based TFPEG-treated GNP nanofluids were also measured at different concentrations (0.100, 0.075, 0.050, and 0.025 wt%). The results suggest that these nanofluids have great potential for use as working fluids in industrial heat transfer systems
Single and co-breeding of different mosquito species in fogging-free and dengue risk areas in west Malaysia
No full textOvitrap surveillance was carried out in fifteen localities encompassing fogging-free and dengue risk areas in West Malaysia to determine on the dispersal and prevalence of single and co-breeding of mosquito larvae particularly Aedes. Ovitraps were sited randomly indoors and outdoors within human settlements in all study areas. All the localities exhibited positive ovitraps with single breeding of Ae. albopictus that ranged between 64.29% and 100.00%. These findings indicated Ae. albopictus as the predominant container-breeding species in all study areas. The co-breeding of Ae. aegypti with Ae. albopictus larvae (34 ovitraps), Ae. albopictus with Culex quinquefasciatus larvae (32 ovitraps) as well as Cx. quinquefasciatus with Armigeres subalbatus larvae (1 ovitrap) were also detected in certain study localities. Interestingly, co-breeding of Ae. albopictus with Ar. subalbatus larvae as well as Ae. albopictus with Uranotaenia sp. larvae in Malaysia is reported for the first time in the present study. Better understanding of the co-breeding scenario involving different species of mosquito larvae is needed to ensure the efficacy of vector control actions to be conducted
Architectural examination on Feng Shui Bedroom
No full textBedroom Feng Shui practices have been criticized as myth over the years but in fact having its scientific origin that is not purely superstitious. This paper aims to examine whether the architects' design practice for bedroom interior arrangement is concurring with the recommended bedroom Feng Shui practices. The study has successfully interviewed 16 architects from diverse backgrounds to avoid bias, seeking their design perspectives in bedroom interior configuration. Subsequently, the interviewees submitted sketches of ideal bedroom layout based on their expertise, with pre-set requirements. Data from semi-structured interviews were analyzed using mixed method approach. In agreement with our expectations, majority of the interviewees have matching thoughts that "bed arrangement" is the primary consideration in bedroom interior configuration. Most of the design outputs were highly attached to favorable Feng Shui conditions. The overall findings implied that bedroom Feng Shui is not merely superstitious but most components are practical design references for architects from diverse backgrounds
Microfluidic production of bioactive fibrin micro-beads embedded in crosslinked collagen used as an injectable bulking agent for urinary incontinence treatment
No full textEndoscopic injection of bulking agents has been widely used to treat urinary incontinence, often due to urethral sphincter complex insufficiency. The aim of the study was to develop a novel injectable bioactive collagen-fibrin bulking agent restoring long-term continence by functional muscle tissue regeneration. Fibrin micro-beads were engineered using a droplet microfluidic system. They had an average diameter of 140 μm and recombinant fibrin-binding insulin-like growth factor-1 (α2PI1-8-MMP-IGF-1) was covalently conjugated to the beads. A plasmin fibrin degradation assay showed that 72.5% of the initial amount of α2PI1-8-MMP-IGF-1 loaded into the micro-beads was retained within the fibrin micro-beads. In vitro, the growth factor modified fibrin micro-beads enhanced cell attachment and the migration of human urinary tract smooth muscle cells, however, no change of the cellular metabolic activity was seen. These bioactive micro-beads were mixed with genipin-crosslinked homogenized collagen, acting as a carrier. The collagen concentration, the degree of crosslinking, and the mechanical behavior of this bioactive collagen-fibrin injectable were comparable to reference samples. This novel injectable showed no burst release of the growth factor, had a positive effect on cell behavior and may therefore induce smooth muscle regeneration in vivo, necessary for the functional treatment of stress and other urinary incontinences. Statement of Significance: Urinary incontinence is involuntary urine leakage, resulting from a deficient function of the sphincter muscle complex. Yet there is no functional cure for this devastating condition using current treatment options. Applied physical and surgical therapies have limited success. In this study, a novel bioactive injectable bulking agent, triggering new muscle regeneration at the injection site, has been evaluated. This injectable consists of cross-linked collagen and fibrin micro-beads, functionalized with bound insulin-like growth factor-1 (α2PI1-8-MMP-IGF-1). These bioactive fibrin micro-beads induced human smooth muscle cell migration in vitro. Thus, this injectable bulking agent is apt to be a good candidate for regeneration of urethral sphincter muscle, ensuring a long-lasting treatment for urinary incontinence
Visualization of the Scholarly Output on Evidence Based Librarianship: A Social Network Analysis
No full textObjective - This paper aimed to analyze worldwide research on evidence based librarianship (EBL) using Social Network Analysis (SNA). Methods - This descriptive study has been conducted using scientometrics and a SNA approach. The researchers identified 523 publications on EBL, as indexed by Scopus and Web of Science with no date limitation. A range of software tools (Ravar PreMap, Netdraw, UCINet and VOSviewer) were utilized for data visualization and analysis. Results - Results of the study revealed that the United Kingdom (UK) and the United States (US) occupied the topmost positions regarding centrality measures, clearly indicating their important structural roles in EBL research. The network of EBL research in terms of the degree of connectedness showed low density in the co-authorship networks of both authors (0.013) and countries (0.214). Seven subject clusters were identified in the EBL research network, four of which related to health and medicine. The occurrence of the keywords related to these four subject clusters suggested that EBL research had a greater association with the setting of health and medicine than with traditional librarianship elements such as human resources or library collection management. Conclusion - This study provided a systematic understanding of topics, research, and researchers in EBL by visualizing the networks and may thus inform the development of future aspects of EBL research and education