19672 research outputs found
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Pembelajaran dan pemudahcaraan (PdPc) Pendidikan Seni Visual dalam menghadapi revolusi industri 4.0
No full textSatu cabaran yang perlu dihadapi dalam dunia pendidikan kini ialah menyesuaikan pembelajaran dan pemudahcaraan (pdPc) bagi mendepani revolusi industri 4.0. Ledakan Revolusi lndustri 4.0 memberi kesan yang besar kepada guru dalam
menyediakan pelajar yang berkemahiran tinggi, berpemikiran kritikal dan penyelesaian masalah, boleh berkomunikasi, berkolaborasi, kreativiti dan mempunyai kesejahteraan
emosi. Guru Pendidikan Seni Visual perlu mengambil inisiatif celik Revolusi lndustri 4.0, kreatif dan inovatif menggunakan kepelbagaian sumber dan media yang sesuai bagi
menghasilkan PdPc yang lebih menarik. Penulisan ini membincangkan PdPc Pendidikan Seni Visual yang relevan dengan konteks Revolusi lndustri 4.0 melalui penerapan kemahiran Pembelajaran Abad 21, pembelajaran autentik, kemahiran insaniah dan Kemahiran Berfikir Aras Tinggi (KBAT). Turut dibincangkan ialah cabaran yang dihadapi guru dalam merealisasikan pembelajaran Seni ke arah revolusi lndustri 4.0
Synchronization of chaotic-type delayed neural networks and its application
No full textOur proposed image encryption is based on synchronization of chaotic fuzzy cellular neural networks (FCNNs) with different time delays and uses sampled-data controller. (i) It is known that the chaotic system plays a vital role in secure communication. (ii) FCNNs are more suitable for image processing due to its local connectedness. (iii) There are some results derived on theory part for the problem of synchronization of chaotic delayed FCNNs. (iv) We raise the following question: Is it possible to utilize these obtained chaotic values via FCNNs to image encryption? (v) Finally, we tried the above and succeed. Moreover, numerical instance and comparison results show that the proposed scheme works well and is resistant to differential attack
Disk solid-phase extraction of multi-class pharmaceutical residues in tap water and hospital wastewater, prior to ultra-performance liquid chromatographic-tandem mass spectrometry (UPLC-MS/MS) analyses
No full textIn this work, a new clean-up and pre-concentration method based on disk solid-phase extraction (SPE) was developed to determine multi-class pharmaceutical residues covering a wide range of polarities (log K ow values from −0.5 to 5.1) in water systems, prior to ultra-performance liquid chromatographic-tandem mass spectrometry (UPLC-MS/MS) analyses. Electrospray ionisation in positive and negative modes was used for the simultaneous determination of both acidic and basic pharmaceuticals. The performances of disk SPE and cartridge SPE were compared. The targeted pharmaceutical compounds list included bronchodilators, antidiabetic drugs, antihypertensive drugs, a lipid-lowering agent, analgesics, and anti-inflammatory drugs. Based on our results, the disk SPE demonstrated a higher sensitivity and recovery value and less analysis time as compared to the cartridge SPE method. The limits of detection (LOD) for the new method ranged from 0.02-3.2 ng L −1 , 0.02-3.1 ng L −1 and 0.02-4.7 ng L −1 for tap, effluent and influent wastewater, respectively. The method's absolute recovery values ranged from 70% to 122% for tap water, 62% to 121% for effluent wastewater and 62% to 121% for influent wastewater, except for metformin in which the absolute recovery value was approximately 48% for all samples. Intra-day precision for tap water, effluent and influent wastewater ranged from 3-12%, 4-9% and 2-8%, respectively. The method developed was applied for the determination of targeted pharmaceuticals in tap, effluent, and influent wastewater from one hospital treatment plant in Malaysia. The results revealed that the highest concentrations of certain pharmaceuticals were up to 49 424 ng L −1 (acetaminophen) and 1763 ng L −1 (caffeine) in the influent and effluent wastewater, respectively. The results also showed a variation in the treatment efficiencies for the hospital treatment plant from one compound to another. Nevertheless, the removal efficiencies ranged from 0-99%
Antiproliferative effects of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF expression
No full textImatinib mesylate is an anti-neoplastic targeted chemotherapeutic agent, which can inhibit tyrosine kinase receptors, including BCR-ABL, platelet-derived growth factor receptors (PDGFRs) and c-Kit. Cellular processes, including differentiation, proliferation and survival are regulated by these receptors. The present study aimed to evaluate the antiproliferative effects of imatinib mesylate, and its effects on apoptotic induction and cell cycle arrest in breast cancer cell lines. In addition, the study aimed to determine whether the effects of this drug were associated with the mRNA and protein expression levels of PDGFR-β, c-Kit, and their corresponding ligands PDGF-BB and stem cell factor (SCF), which may potentially modulate cell survival and proliferation. To assess the antiproliferative effects of imatinib mesylate, an MTS assay was conducted following treatment of cells with 2-10 μM imatinib mesylate for 96, 120 and 144 h; accordingly the half maximal inhibitory concentration of imatinib mesylate was calculated for each cell line. In addition, the proapoptotic effects and cytostatic activity of imatinib mesylate were investigated. To evaluate the expression of imatinib-targeted genes, PDGFR-β, c-Kit, PDGF-BB and SCF, under imatinib mesylate treatment, mRNA expression was detected using semi-quantitative polymerase chain reaction and protein expression was detected by western blot analysis in ZR-75-1 and MDA-MB-231 breast carcinoma cell lines. Treatment with imatinib mesylate suppressed cell proliferation, which was accompanied by apoptotic induction and cell cycle arrest in the investigated cell lines. In addition, PDGFR-β, PDGF-BB, c-Kit and SCF were expressed in both breast carcinoma cell lines; PDGFR-β and c-Kit, as imatinib targets, were downregulated in response to imatinib mesylate treatment. The present results revealed that at least two potential targets of imatinib mesylate were expressed in the two breast carcinoma cell lines studied. In conclusion, the antiproliferative, cytostatic and proapoptotic effects of imatinib mesylate may be the result of a reduction in the expression of c-Kit and PDGFR tyrosine kinase receptors, thus resulting in suppression of the corresponding ligand PDGF-BB. Therefore, imatinib mesylate may be considered a promising target therapy for the future treatment of breast cancer
Persekitaran Kanak-kanak dalam Novel Beruk (Children Environmental in Beruk)
No full textThis study aims to examine the environment in the Beruk novel (2010) by Azizi Haji Abdullah that encompasses children's lives in influencing the behavior of children. Problems involving children are increasingly prevalent and often populated in the newspaper. Children's novels are one of the mediums in looking at the environment that helps the psychological development of children. Hence, a healthy environment can shape a balanced child in both the spiritual and physical development. Therefore, environmental aspects should be emphasized in children's novels to provide guidance not only to novel writers but also to the society. In the context of literary works, the environments surrounding childhood are manifested through individuals who surround children's lives. This analysis will show an environment surrounding the main character in the novel. This study applied one of the principles in Bronfenbrenner ecological theory (1979); a microsystem of analyzing texts. The method used in this study is library method and text analysis. The findings show that the environment surrounding children's lives affects the behavior of children. A healthy environment can produce balanced children in spiritual and physical aspects. This situation also manifests the importance of a healthy environment in the lives of children. Parents, friends, teachers and neighbors are important environment in influencing a child’s character. In conclusion, the environment in the children’s novel using the microsystems in ecological theory Bronfenbrenner (1979) can explain the influence of the environment on children in the novel Beruk
iTRAQ analysis of urinary proteins: Potential use of gelsolin and osteopontin to distinguish benign thyroid goiter from papillary thyroid carcinoma
No full textBackground: Benign thyroid goiter (BTG) and papillary thyroid carcinoma (PTC) are often interchangeably misdiagnosed. Methods: Pooled urine samples of patients with BTG (n = 10), patients with PTC (n = 9) and healthy controls (n = 10) were subjected to iTRAQ analysis and immunoblotting. Results: The ITRAQ analysis of the urine samples detected 646 proteins, 18 of which showed significant altered levels (p 1.5) between patients and controls. Whilst four urinary proteins were commonly altered in both BTG and PTC patients, 14 were unique to either BTG or PTC. Amongst these, four proteins were further chosen for validation using immunoblotting, and the enhanced levels of osteopontin in BTG patients and increased levels of a truncated gelsolin fragment in PTC patients, relative to controls, appeared to corroborate the findings of the iTRAQ analysis. Conclusion: The data of the present study is suggestive of the potential application of urinary osteopontin and gelsolin to discriminate patients with BTG from those with PTC non-invasively. However, this needs to be further validated in studies of individual urine samples
Seismic isolation retrofitting solution for an existing steel cable-stayed bridge
No full textThis paper investigated the seismic retrofitting of an existing cable-stayed bridge through the use of a seismic isolation system. The bridge is situated in a high seismic zone. During the Saguenay earthquake 1988, one of the anchorage plates of the bridge supports failed. Herein, several configurations of seismic isolation system were considered to identify an appropriate solution for the seismic retrofitting of the bridge in both the longitudinal and transverse directions. A three-dimensional model of the bridge was created, and its seismic behavior studied through nonlinear dynamic time-history analysis. The comparative performance study among the five retrofitting configurations showed that the partial seismic isolation of the bridge led to an enhancement of the seismic response of the bridge in one direction only. However, the overall seismic response of the cable-stayed bridge substantially improved in the longitudinal and transverse directions in cases where the isolation systems were utilized between the supports and the deck-tower connection of the bridge
Efficacy of Rebamipide in Organic and Functional Dyspepsia: A Systematic Review and Meta-Analysis
No full textObjective: The role of gastritis in dyspepsia remains controversial. We aimed to examine the efficacy of rebamipide, a gastric mucosal protective agent, in both organic and functional dyspepsia. Design: A systematic review and meta-analysis was performed. The following databases were searched using the keywords (“rebamipide” OR “gastroprotective agent*” OR “mucosta”) AND (“dyspepsia” OR “indigestion” OR “gastrointestinal symptoms”): PubMed, Wed of Science, Embase, CINAHL, Cochrane Clinical Trials Register. The primary outcome was dyspepsia or upper GI symptom score improvement. Pooled analysis of the main outcome data were presented as risk ratio (RR) for dichotomous data and standardized mean difference (SMD) for continuous data. Results: From an initial 248 records, 17 randomised controlled trial (RCT) publications involving 2170 subjects (1224 rebamipide, 946 placebo/control) were included in the final analysis. Twelve RCTs were conducted in subjects with organic dyspepsia (peptic ulcer disease, reflux esophagitis or NSAID-induced gastropathy) and five RCTs were conducted in patients with functional dyspepsia (FD). Overall, dyspepsia symptom improvement was significantly better with rebamipide compared to placebo/control drug (RR 0.77, 95% CI = 0.64–0.93; SMD −0.46, 95% CI = −0.83 to −0.09). Significant symptom improvement was observed both in pooled RR and SMD in subjects with organic dyspepsia (RR 0.72, 95% CI = 0.61–0.86; SMD −0.23, 95% CI = −0.4 to −0.07), while symptom improvement in FD was observed in pooled SMD but not RR (SMD −0.62, 95% CI = −1.16 to −0.08; RR 1.01, 95% CI = 0.71–1.45). Conclusion: Rebamipide is effective in organic dyspepsia and may improve symptoms in functional dyspepsia
Piper sarmentosum as an Antioxidant: A Systematic Review
No full textPiper sarmentosum (PS) is an herb with various medicinal properties. The antioxidant activity of PS contributes to many of its pharmacological effects such as anti-hypertension, anti-cancer and anti-diabetes. This systematic review provides information regarding the antioxidant activity of PS. The review was conducted systematically to identify relevant published articles on the antioxidant activity of PS. The collected data was based on the searched articles through PubMed, Science Direct and Scopus databases between the years 1946 until March 2018. Only articles written in English and related to antioxidant activity of PS were included in this review. Based on the literature searched, 130 potential articles were identified and 19 articles met the inclusion criteria. Ten studies related to chemical assays, five studies combined in vivo animal and chemical assays, three studies combined chemical assays and in vitro studies and a single study combined chemical assay, in vitro and in vivo studies were included in this review. All studies showed positive effects of PS against oxidation, indicating the potential of PS as a source of natural antioxidant
A Comparative Study of Phase Offset Disposition Sinusoidal Pulse Width Modulation (POD-SPWM) and Symmetrical Pulse Width Modulation Switching Techiques for Generalized Current Source Multilevel Inverter(MCSI)
No full textThis paper presents a comparison between two switching techniques namely Phase Offset Disposition Sinusoidal PWM (POD-SPWM) and Symmetrical PWM switching for a generalized current source multilevel inverter (MCSI) topology. One of the advantages of MCSI is it can reduce the total harmonic distortion (THD) at the output load current with a sinusoidal current waveform. In this paper, the generalized MCSI with the different levels has been developed with Matlab@simulation software in order to study the performance of the two switching schemes for the operation of the MCSI. From the simulation results, POD-SPWM switching technique can give better THD results compare to symmetrical switching technique