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Inhibition of the mTOR signaling pathway in clear cell renal cell carcinoma cells
No full textThe mammalian target of Rapamycin (mTOR) is a Serine/threonine kinase that is found in two large protein complexes that are known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Torin 1 is an ATP-competitive inhibitor of mTOR that inhibits mTOR activity in both mTORC1 and mTORC2. In this study, we hypothesized that dual inhibition of mTORC1 and mTORC2 with Torin 1 promotes the apoptosis of clear cell renal cell carcinoma cells. The human clear cell renal cell cancer line, 786-0, was treated with Torin 1, and markers of apoptosis, including PARP, Caspase 3, and Caspase 9, and their cleaved subunit proteins were studied using the Western Blot technique. To further investigate the role of mTORC2, short interfering RNA (siRNA) experiments in 786-0 cells were performed to selectively reduce the expression of Rictor, the defining subunit of mTORC2. Our findings demonstrate increased expression of Caspase 3 and Cleaved PARP in 786-0 cells treated with Torin1 which confirms activation of apoptosis. No human or animal was involved in this study
Implications of Twitter during its use in public health practice involving the distribution of the COVID-19 vaccine
Get PDFIntroduction – There were 4.89 projected billion social media users in 2023. Social media platforms such as Twitter have allowed public health organizations to spread information regarding COVID-19 vaccines to the public. Twitter permits government organizations and public health agencies to release accurate information as a primary level of rapid communication.
Purpose – The purpose of this research was to explore the impact of the social media platform, Twitter, on public health information throughout the COVID-19 pandemic regarding the spread of information involving COVID-19 vaccine distribution to the public.
Methodology – This study utilized a literature review with a semi-structured survey with an industry expert. There were five databases used to collect resources. The references were reviewed and thirty-two were in the research with eleven sources used in the results section.
Results – The results overviewed Twitter as a public health tool, barriers to vaccine safety and vaccine hesitancy, and publicly offering thoughts on the COVID-19 vaccination and distribution numbers. Positive and negative dissemination of views on Twitter regarding the vaccine was evident.
Discussion/Conclusion – In conclusion, there was not enough evidence to show the number of vaccinated persons with the COVID-19 vaccine increasing due to the use of Twitter; however, Twitter would have continued to be utilized as a healthcare tool for reliable, credible sources for the public in regards to vaccine resources
May 25th Letter from Chuck Yeager to Glennis
Get PDFLetter, year not listed, in which they discuss Mike and Don Yeager.https://mds.marshall.edu/yeager/1191/thumbnail.jp
Good Swimming Holes
Get PDFGood Swimming Holes
For Elwood Childers
The way you tell it there were two or three
good swimming holes along Twelve Pole Cree
September 13th Letter from Don Yeager to Yeager Family
Get PDFLetter from Don Yeager to the Yeager Family in which he describes an uneventful period of his duty in Vietnam.https://mds.marshall.edu/yeager/1204/thumbnail.jp
September 7th Letter from Don Yeager to Yeager Family
Get PDFLetter from Don Yeager to the Yeager Family in which he describes some of his day-to-day as a soldier in Vietnam, and the oncoming monsoon season.https://mds.marshall.edu/yeager/1206/thumbnail.jp