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ASA Libraries, Museums, and Archives for Researching Appalachia
No full textThe Appalachian Studies Association maintains a selected list of academic research centers, archives and manuscript collections, and libraries and museums. The Library of Appalachian Preaching was added to the list in June 2024.https://mds.marshall.edu/aa_about_the_library/1008/thumbnail.jp
Industrial Explosion Survival After Presenting to a Rural Hospital: A Case Report
Get PDFExplosions can lead to numerous injuries.1 Studies show that trauma mortality increases by 14% when patients are treated at rural hospitals compared to non-rural facilities.2 A 43-year-old male arrived at a rural hospital with injuries from an explosion, where only a single board-certified emergency physician was on duty. The patient\u27s polytrauma was severe, resulting in bilateral orbital compartment syndrome and Cushing\u27s triad. Remarkably, he survived these extensive injuries. Despite the limitations of rural healthcare, such as restricted equipment, medications, and longer transfer times, rural emergency physicians should remain optimistic and help guide future management. This high-acuity, low-frequency trauma case underscores the necessity for board-certified emergency physicians to be present in all emergency departments, including those in rural critical access hospitals. Rural emergency physicians should stay optimistic despite limitations in rural care, such as limited equipment, medications, and prolonged transfer times, and help guide future management. This unique case of high-acuity, low-frequency trauma presenting to a rural single-provider emergency department supports the need for emergency physicians to staff all emergency departments, including those in rural critical access hospitals
20241105: Student Affairs, 1981-1990
Get PDFThese items include materials from the office of Student Affairs at Marshall University from 1981-1990. Items were received in the early 1990s, but the actually date was not recorded. Materials in this collection include items from several departments housed under student affairs, including International Students, Women\u27s and Gender Center, Student Health Educational Programs, Upward Bound, and Orientation. Please download the finding aid for a full list of contents
Muslim Association Facebook Videos
No full textThe Muslim Association\u27s Facebook page has videos of khutbas dating back to July 2024. In most cases, the videos have 3 parts: Sheikh Mohamed’s khutba, delivered in Arabic; an English translation/summary by Dr. Ahmad Nusair, a member of the MAH board; and the shortened Friday prayer.Timestamps are provided for each part.https://mds.marshall.edu/muslim_assoc_huntington/1001/thumbnail.jp
Payment Disrupters and Opportunities: Key Trends That Impacted Pharmacy in 2024
Get PDFIn 2023, the United States experienced the most significant increase in prescription drug spending (13.6%), totaling $89 billion.1 This was driven by higher utilization and the introduction of new, expensive specialty and biotech drugs. In 2024, other factors continue to drive costs and disrupt the pharmacy landscape, including the implementation of new business models, pharmacy benefit manager (PBM) practices, the rebate system, regulatory changes, advancements in provider status, and potential Federal Trade Commission (FTC) interventions
Bearing Witness to Native Stories: An Interview with Ahousaht First Nation’s Mark Atleo and Cowichan First Nation’s Adrian Sylvester
Get PDFWalter Fisher (1984) claims that humans are homo narrans, suggesting that not only is narrative the common act in which disparate groups of people engage, but that storytelling itself is a fundamental human undertaking. In this brief interview, we (Henry Wang and Hannah Huo) engage with the stories of two First Nations members, Mark Atleo and Adrian Sylvester, who are of the Ahousaht and Cowichan Tribes, respectively. An important component of storytelling is not just telling or conveying that story to another, but bearing witness to it (Wyles, O’Leary, and Tsantefski 2023). That is what we hope to do here, and what we hope that the reader will do upon encountering these stories—to bear witness to the injustices committed against the First Nations peoples
Role of insulin-like growth factor-1 signaling in diet-enhanced bone elongation
Get PDFChildhood obesity has increased precipitously to the point that almost 20% of children between the ages of 2 and 19 have been diagnosed with obesity. While obesity is a complex metabolic disorder, one contributing factor is diet, particularly a diet high in fat. Among many problems associated with diet-induced obesity, the impact on skeletal health is often overlooked. In addition to increased stress on the skeleton due to excess weight, obesity also disrupts the endocrine and immune systems that, in turn, can secondarily alter skeletal growth. Obesity during the early years of childhood is particularly detrimental because the skeleton is highly sensitive to damaging changes during a critical early period of development.
The process by which bones grow in length is called endochondral ossification and occurs in the cartilaginous regions of long bones called the growth plate. During endochondral ossification, growth plate chondrocytes proliferate, enlarge, differentiate, and mineralize to elongate bones. One of the main modulators of these processes is insulin-like growth factor-1 (IGF-1), which has both endocrine and paracrine/autocrine functions. Paradoxically, children with obesity have normal to low levels of endocrine IGF-1 despite exhibiting accelerated bone growth.
The objective of this dissertation is to determine how excess dietary fat alters IGF-1 bioactivity in the growth plate. The overall hypothesis is that a high-fat diet has both direct and indirect effects on IGF-1 stimulated growth plate activity. The first aim of this dissertation is to determine how a high-fat diet directly alters IGF-1 activity and cell proliferation in the growth plate where we hypothesize that a high-fat diet will increase direct IGF-1 activity in growth plate chondrocytes to accelerate postnatal bone elongation. The second aim of this dissertation is to determine the indirect mechanisms by which a high-fat diet alters IGF1-stimulated growth plate activity. We hypothesize that a high-fat diet has secondary effects on IGF-1 signaling through its effects on IGF binding proteins and inflammatory cytokines.
These experiments are important for understanding how early environmental exposures, such as diet, can impact bone growth in a way that has lasting effects into adulthood. Elucidating the ways in which excess dietary fat can alter IGF-1 activity in the growth plate in both a direct and indirect function can lead to a more targeted approach in identifying children at high risk of developing obesity before problems escalate to adulthood