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Human Behavior and the Social Environment II
No full textThese materials will help students and instructors alike explore human behavior and how it is shaped and impacted by both traditional and non-traditional paradigms. This text will also support the reader in having a deeper understanding of how the environment/ in all of its complexity/ can affect individuals/ families/ groups/ and communities. It is my hope that the information contained in this book will help you/ as a future social worker/ approach client systems with empathy/ understanding/ and a compassionate curiosity that allows for comprehensive assessment/ individualized approaches to treatment/ and continuity of care.https://mds.marshall.edu/oa-textbooks/1752/thumbnail.jp
Strategic Management
No full textThis open source textbook is derived from many sources/ initially from the Principles of Management by Carpenter/ Bauer/ and Erdogan/ but there is abundant new content as well. It is published under a Creative Commons license and as such there is no charge ever for this textbook. The most important change from 1e is that static content was removed to make room for student-generated dynamic content. Throughout the book look for the names of contributing students in the red colored example boxes. As the term progresses/ you will see new examples appear as fellow students research and summarize topics for current events/ all are curated by the instructor.https://mds.marshall.edu/oa-textbooks/1754/thumbnail.jp
New Media Futures
No full textThis book is intended for use in a large introductory class in new media in a program that covers the “full-stack” including critical/cultural studies/ media management/ diffusion of innovation/ and synthetic media production. The first half of this basic sequence covered new media and democracy/ finance/ intellectual property law/ basic games/ and transmedia. The second half of the sequence covers many topics related to aesthetics/ design/ technology/ and methodology. To that end/ this book needed to be written so that it would be helpful for many different professors and trajectories of study. This book is in neither engineering/ social science/ nor the humanities/ but also all of those. At the same time/ this is a program in the Communication Studies and Media Studies traditions of the United States and that texture will come across.https://mds.marshall.edu/oa-textbooks/1764/thumbnail.jp
A Primer for Computational Biology
No full textA Primer for Computational Biology aims to provide life scientists and students the skills necessary for research in a data-rich world. The text covers accessing and using remote servers via the command-line/ writing programs and pipelines for data analysis/ and provides useful vocabulary for interdisciplinary work. The book is broken into three parts: Introduction to Unix/Linux: The command-line is the “natural environment” of scientific computing/ and this part covers a wide range of topics/ including logging in/ working with files and directories/ installing programs and writing scripts/ and the powerful “pipe” operator for file and data manipulation. Programming in Python: Python is both a premier language for learning and a common choice in scientific software development. This part covers the basic concepts in programming (data types/ if-statements and loops/ functions) via examples of DNA-sequence analysis. This part also covers more complex subjects in software development such as objects and classes/ modules/ and APIs. Programming in R: The R language specializes in statistical data analysis/ and is also quite useful for visualizing large datasets. This third part covers the basics of R as a programming language (data types/ if-statements/ functions/ loops and when to use them) as well as techniques for large-scale/ multi-test analyses. Other topics include S3 classes and data visualization with ggplot2.https://mds.marshall.edu/oa-textbooks/1778/thumbnail.jp
Spanish I: Beginning Spanish Language and Culture
No full textThis peer-reviewed textbook is designed for the true beginner with U.S. college students in mind. It contains themed chapters/ which are divided into 8 sections. Each section has its own set of learning objectives/ and is further separated into three types of assignments/ Para estudiar en casa (with detailed explanations)/ Para practicar en casa (homework exercises)/ and Para practicar en clase (paired and group classwork activities). The explanations and primary input are written to be easily comprehensible. The individual exercises are geared towards acquisition of form and function/ and the communicative classwork exercises promote interpersonal exchanges between students. The digital copy includes some embedded audio files/ and we are developing a website to house many more resources.https://mds.marshall.edu/oa-textbooks/1800/thumbnail.jp
Grasty User Guide
No full textThe User Guide for the Library of Appalachian Preaching is a Google Sheet that can be searched, sorted, and downloaded for offline use.
This part of the Guide provides information about Grasty\u27s sermons. It includes the title, sermon text, date and place the sermon was preached (if known), and so on. This information is available in the master list of sermons as well.https://mds.marshall.edu/grasty_johnsharshall/1002/thumbnail.jp
Young African-American man holding a trumpet
No full textYoung African-American man holding a trumpethttps://mds.marshall.edu/proctor_collection/1008/thumbnail.jp
American Mythology: How Storytelling Shapes Modern Cultural Perceptions
Get PDFThis thesis will examine the American storytelling tradition, paying particular attention to American folktales and legends that arose as the nation expanded westward, such as the stories of Paul Bunyan, John Henry, Billy the Kid, etc. This text will utilize a lens of European narrative tradition (especially those which lent themselves to the written records of oral fairy tales and folktales) and trace the cultural significance and social purpose of these formative American stories. I will discuss the reasons why we so readily recognize the echoes of outside narrative traditions in American storytelling and the ethical implications of these narratives that, according to Hanna Meretoja’s critical examination of the ethics of storytelling “can promote exclusion that amounts to annihilation” (Meretoja 2017). Because stories are not just stories – they are the method by which social norms are communicated and internalized by the members of a given culture.
The sections of this manuscript will focus on various topics that perform this purpose of communicating norms and values – why and how do these get communicated through narratives? What does the shift from oral traditions to written literature have to say about the persistence of these stories? How do these stories shape the modern perception of history? What can be gleaned from the division of narrative tropes between the tragic female narrative and the heroic male narrative? And, most of all, how were these stories used not only to polish the edges away from a less than ideal past but also to look towards the future with rose-tinted lenses
Through Their Eyes: An Analysis of Misrepresentation in Popular Lesbian Television Narratives
Get PDFThe purpose of this thesis is to explore lesbian television narratives that shape popular discourse. My goal is to find and expose the implications of monolithic expressions of queerness through both queer and heteronormative presenting television narratives. This exploration of the queer narrative voice addresses three distinct movements of cultural production: the proclaimed self-represented queer television narrative, the connotatively queer heterocentric television narrative, and the queer narrative produced in fan-based literature. For concision, I focus on the popular television dramas The L Word and Rizzoli & Isles, as well as the fan works produced for the latter. Through the lens of these narratives, I explore the policing of lesbian cultural expression through narrative voice and the cultural implications of overarchingly monolithic narratives.
Using a combination of queer, feminist, and glitch theories I discuss the multi-faceted systems of oppression that dictate queer narratives in mass media. Acknowledging Michel Foucault’s concept of heterotopia, the following analysis establishes narrative space as a constantly contested landscape, socially constructed by the privileged producer. With the digital humanities concept of cultural glitch, I explore the solicitous Hollywood tactic of queerbaiting television narratives and the benefits of self-representation through fan production. Such exploration of the policed narrative leads to my analysis of the social implication of distorting representations of queer life and actionable resolutions for the queer consumer
Targeting Epigenetic Mechanisms in Endometriosis
Get PDFEndometriosis is a complex and elusive gynecological disease in which the inner lining of the uterus grows in locations outside of the uterus and forms lesions. It is known to affect 1 in 9 women of reproductive age worldwide. Symptoms of endometriosis include severe pain, heavy periods, and infertility. While multiple theories of origin exist, none fully encompass all aspects of the disease, although all theories agree that this is an inflammation-driven disease. Due to this, many researchers are turning towards epigenetics to explain the initiation and progression of endometriosis. However, what is causing these epigenetic changes is still a mystery. We hypothesize that peritoneal fluid (PF) from women with endometriosis, full of chemokines, cytokines, and inflammatory molecules, is the initiator behind the changes seen, specifically the Polycomb repressive complex 2 (PRC2) and its catalytic subunit Enhancer of zeste homolog 2 (EZH2). We noted that there was an upregulation of the PRC2 complex and EZH2 in tissue from women with endometriosis. This upregulation was also seen when endometrial cells were treated with PF from women with endometriosis. miR-155 was also shown to be upregulated in the endometrial lesions and endo PF treated cells examined. Interactions between EZH2 and other genes that may be mechanistically working in the pathogenesis of endometriosis were seen through the use of ChIP-qPCR. The results of this study showed us that the PF from women with endometriosis is playing a role in initiating epigenetic mechanisms as well as providing us a potential novel cross-talk between miR-155 and the PRC2 complex. We used the results of upregulation of EZH2 due to PF from women with endometriosis and examined whether these changes could be inhibited or reversed through targeting an inflammatory pathway, the CXCR4- CXCL12-CXCR7 axis, in endometriosis through the use of a CXCR4 agonist AMD3100. We also examined if the EZH2 inhibitor GSK126 would target this inflammatory pathway. Both cells and tissues from women without endometriosis were treated with a combination of control or endo PF and/or AMD3100 or GSK126 in order to examine gene expression as well as changes in cell proliferation and migration. Endometrial PF was shown to increase the expression of EZH2, as well as the proliferation of the cells. When AMD3100 or GSK126 was added to the cells and the tissues in the presence of endometriosis PF, dual results were noted, suggesting that a one-sided approach, targeting just the inflammation or just the epigenetic mechanisms is not the correct approach for treatment. The best alteration of gene expression, suppression of cell proliferation, and suppression of migration was noted when combining the two compounds for a dual-sided treatment. Overall, the studies presented in this thesis show that both epigenetic mechanisms and inflammatory pathways drive the progression of endometriosis. Further studies will examine the effects that the compounds used in these studies have in animal models of endometriosis where lesion growth and pain levels will be observed