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20221011: Student Conduct and Welfare Committee Minutes, 1980-1987
Get PDFThese items include materials from the office of Faculty Senate at Marshall University from 1980-1987. Items were received in before 2000, but were not accessioned until 2022. Notable materials include minutes and correspondence from the Student Conduct and Welfare Committee as well as correspondence from the years described in this collection. Please download the finding aid for a full list of contents
Anna Belle King
Get PDFKelli Johnson conducting an oral history interview with Anna Belle King.
This oral history is part of the National Park Service African American Civil Rights History and Appalachia Grant Program.https://mds.marshall.edu/african_american_oral_nps/1002/thumbnail.jp
Tele-ICU in the Unites States: Is a cost-effective model?
Get PDFIntroduction: The United States Society of Critical Care Medicine has announced a shortage of all critical care intensivists due to the increased need for critical care for the aging population with comorbidities and improved life expectancy. This shortage has led to tele-ICU programs that have allowed intensivists to care for patients simultaneously remotely.
Methods: This study aimed to assess the potential for the hospital implementation of tele-ICU to determine its overall healthcare cost-effectiveness. The methodology was a review that followed a systematic search approach utilizing 42 sources.
Results: The study findings showed that tele-ICU contributed to reduced hospital LOS by 36% and positive financial outcomes of return of investment and cost-effectiveness. These reduced LOS stay times have allowed for savings up to $11.5 million.
Discussion: The Tele-ICU program\u27s implementation has positively impacted financial and clinical areas, reducing mortality and reduced hospital LOS. Furthermore, it has reduced improved patient safety, care quality, and decreased ventilator days, contributing to a cost-efficient technology
Mortality Risk Associated With Urban Land Use for Adult Eastern Diamondback Rattlesnakes (Crotalus adamanteus)
Get PDFSnakes have been a traditionally under-represented organism in urban ecology, but they face similar, if not greater challenges in the face of growing urban sprawl. Eastern diamondback rattlesnakes (Crotalus adamanteus, EDBs) are under consideration for listing under the Endangered Species Act due to population declines resulting from historical human persecution and habitat loss. This study used radio-telemetry data from a long-term monitoring project of adult EDBs on a developed sea island in South Carolina, USA. I reclassified a National Land Cover Dataset to reflect relative mortality risk for snakes attempting to move through the landscape. High-risk cover types included all developed areas such as roads, parking lots, buildings, and golf courses. Low-risk cover types included forested/naturally vegetated areas where human activity was typically low. To assess when and why snakes may choose to cross high-risk areas, I examined the frequency and probability of high-risk crossings as a function of demographic, spatial, and temporal predictors in mixed effect models that included individuals as a random effect. Reduced activity and movement associated with cool winter temperatures reduced the number of overall crossings, but there was no detectable difference between sexes, even within seasons. Larger home ranges and those with a proportionately greater amount of high-risk cover within the home range were positively correlated with number of high-risk crossings. Considerations for conservation in urban landscapes include assessing the potential impact of urban development on neighboring EDB populations, as well as for managing wildlife-human conflicts
Interview with Indra Das
Get PDFIndra Das is most well-recognized as the author of The Devourers (2015), a novel that won the Lambda Literary Award for straddling the genres of sci-fi, speculative, and fantasy fiction alongside LGBT themes. Das’s short fiction is widely published is horror and sci-fi anthologies, as well as magazines like Tor.com, Strange Horizons, and Asimov’s Science Fiction. He spoke candidly with Alok Amatya over email about the current literary landscape, the work of writing transgressive genre fiction, and his own experiences as an upcoming global author
Longitudinal Associations of Perceived Mastery and Constraints With Coping and Their Implications for Functional Health for Aging Adults
Get PDFThe present study examined longitudinal associations of distinct dimensions of perceived control (i.e., perceived mastery and constraints) with approach and avoidance coping relating to functional health for aging adults, which had not been well studied previously. Using data from two waves of Midlife in the United States (N = 4,963, whose mean age was 55.4 [SD = 12.5]), a longitudinal path model was analyzed for direct and indirect effects among perceived mastery and constraints, approach and avoidance coping, and functional limitations. Bidirectional associations were observed between perceived mastery and approach coping and between perceived constraints and avoidance coping. Moreover, perceived constraints not only were directly associated with functional limitations but also mediated the longitudinal associations of the other factors of interest with functional limitations. These findings can inform future research on perceived control and coping in the context of promoting functional health
Standard-Free Absolute Quantitation of Antibody Deamidation Degradation and Host Cell Proteins by Coulometric Mass Spectrometry
No full textProteomic absolute quantitation strategies mainly rely on the use of synthetic stable isotope-labeled peptides or proteins as internal standards, which are highly costly and time-consuming to synthesize. To circumvent this limitation, we recently developed a coulometric mass spectrometry (CMS) approach for absolute quantitation of proteins without the use of standards, based on the electrochemical oxidation of oxidizable surrogate peptides, followed by mass spectrometry measurement of the peptide oxidation yield. Previously, CMS was only applied for single-protein quantitation. In this study, first, we demonstrated absolute quantitation of multiple proteins in a mixture (e.g., β-lactoglobulin B, α-lactalbumin, and carbonic anhydrase) by CMS in one run, without using any standards. The CMS quantitation result was validated with a traditional isotope dilution method. Second, CMS can be used for absolute quantitation of a low-level target protein in a mixture; for instance, 500 ppm of PLBL2, a problematic host cell protein (HCP), in the presence of a highly abundant monoclonal antibody (mAb) was successfully quantified by CMS with no use of standards. Third, taking one step further, this study demonstrated the unprecedented quantitative analysis of deamidated peptide products arising from the mAb heavy chain deamidation reaction. In particular, absolute quantitation of the deamidation succinimide intermediate which had not been performed before due to the lack of standard was conducted by CMS, for the first time. Overall, our data suggest that CMS has potential utilities for quantitative proteomics and biotherapeutic drug discovery
Effect of umbilical cord essential and toxic elements, thyroid levels, and Vitamin D on childhood development
Get PDFIntroduction: The in-utero environment has dramatic effects on childhood development. We hypothesized prenatal levels of inorganic agents, thyroid levels, and Vitamin D effect childhood development.
Methods: Umbilical cord blood was collected from April 3, 2013 to January 30, 2014 and analyzed for 20 different elements, thyroid and Vitamin D. A retrospective review (n = 60) was performed of well-child examinations from birth to 5 years old (y.o.).
Results: There were associations with calcium and 4 month BMI (p = \u3c0.01), 12 month language (p = 0.03); Magnesium and 6 month language (p = 0.04) and gross motor skills at 5 years old (y.o.) (p = 0.03); Copper and 12 month fine motor (p = 0.02); Zinc with fine motor (p = \u3c0.01) and language (p = 0.03) at 2 y.o.; Manganese was associated with language development at 2 y.o. (p = 0.02); Molybdenum and fine motor at 12 months of age (p = 0.02); Selenium with gross motor (p = 0.04) and BMI (p = 0.02) at 5 y.o.; Lead with cognitive function at 4 months (p = 0.04) and 2 y.o. (p = 0.01); Mercury with gross motor at 4 months (p = 0.04) and language at 2 y.o. (p = 0.02). Platinum at 12 months of age (p = \u3c.01) as well as multiple associations at 5 y.o. (p = \u3c.01). Thyroid function tests for free T3 were associated with multiple cognitive and physical milestones. T3 Uptake was associated with 5 y.o. gross motor skills (p = 0.02). Total and Free T4 was associated with cognitive development (p = \u3c.01) and fine motor development, respectively. Vitamin D was associated with a delay of fine motor development (p\u3c0.01).
Conclusion: There were multiple associations between umbilical cord essential and toxic elements, thyroid levels, and Vitamin D on childhood development
Photo of Major Craven and Major Dregne - World War Two
No full textUndated photo of Major Craven and Major Dregne during World War Two. Irwin Dregne was a member of the 357th Fighter Group that Chuck Yeager was also a member of in World War Two.https://mds.marshall.edu/yeager/1061/thumbnail.jp
Over-the-Counter Analgesic Use Patterns in Appalachian Older Adults, Focusing on Non-Steroidal Anti-Inflammatory Drugs
Get PDFIntroduction
Over-the-counter (OTC) medications are commonly used by elderly patients to self-manage pain symptoms. Medications such as non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen and topical analgesics are readily available and therefore may seem harmless to patients. In the growing population of those 65 years and older, providers need to inquire about OTC medication use due to the increased risk for adverse reactions in this population. Complications related to these medications can be worsened by chronic disease, variable metabolism, polypharmacy, etc. which become more common in the older adults.
Methods
A survey was created to determine the prevalence and habits of OTC use in the central Appalachian population, as well as the potential harms involved related to provider awareness, chronic disease, and polypharmacy.
Results
Of surveyed Appalachian seniors (n = 307), 86.3% take OTC medications. Of these, 57.4% report that they do not tell their provider and 51.3% do not take the medication as directed. Within this population, 19.2% of those on blood thinners, 22.4% of those with hypertension, 34.8% of those with chronic kidney disease, and 30.6% of those with gastrointestinal issues are not only using NSAIDs but also do not inform their physician nor follow the packaging instructions.
Conclusion
Potential complications of NSAID use related to these medical comorbidities are well known. Providers need to regularly ask their older adult patients about the use of OTC medication to prevent adverse events in this vulnerable population