37903 research outputs found
Sort by
A Rheumatoid Nodule at the Sternoclavicular Joint: An uncommon presentation of a common problem
Get PDFMost rheumatoid nodules are found at joints or pressure points. They rarely require medical intervention and even fewer require surgery. A 78-year-old female developed a 7.2 x 3.2 x 2.8 cm rheumatoid nodule originating at the right sternoclavicular joint, a novel site for a common pathology. Management involved a complex differential diagnosis and surgical treatment was resection from adjacent vascular and neural structures. Following surgical excision, the patient maintained good mobility and sensation of the neck and surrounding areas
Spatially Controlled Monolayers for Electrically Switchable Biomolecule Detection
Get PDFThe development of biosensors that are low-waste, highly stable, and possess an ability to be interchanged between capturing and non-capturing configurations is promising for the biodetector field. Stable packing and attachment of the sensor, the ability to create an interchangeable detecting probe of interest relatively easily, and dynamic control of the probe via a reversible bias can provide for that. With the set goals to control all those properties, DNA-dendron conjugate molecules were designed, synthesized in solution, purified, and utilized to make self-assembled monolayers of single-stranded DNA on gold. To be able to manipulate the conjugates’ sensing qualities in the described manners, generation 4 (G4) polyamidoamine dendrimers were conjugated to ssDNA oligomers (18 bases) in a one-to-one ratio and functionalized to provide multiple thiol groups for possible surface assembly. DNA-dendron successful conjugation and their purification were confirmed by using gel electrophoresis. The height profiles and dynamic switchability were tested by utilizing atomic force microscopy. The conjugates’ attachment, packing density, and sensing ability were all measured from surface plasmon resonance experiments. The results outlined in this study demonstrate the potential of these novel DNA-dendron conjugates to advance the biosensors field and introduce a new way of thinking about the manufacturing of DNA monolayers on gold substrates
Christine Yolanda Rush
Get PDFJamilla Jones and Dr. Kelli Johnson conducting an oral history interview with Christina Yolanda Rush.
This oral history is part of the National Park Service African Americans Civil Rights History and Appalachia Grant Program.https://mds.marshall.edu/african_american_oral_nps/1008/thumbnail.jp
