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A normal distribution on time scales with application
No full textWe introduce a new normal distribution on time scales. Based on this generalized normal distribution, a Brownian motion is introduced and its quadratic variation is derived
0881: Mary and J. Churchill Hodges Collection
No full textThere is no information available for this collection at this time
Diverging Effects of Adolescent Ethanol Exposure on Tripartite Synaptic Development across Prefrontal Cortex Subregions
No full textAdolescence is a developmental period that encompasses, but is not limited to, puberty and continues into early adulthood. During this period, maturation and refinement are observed across brain regions such as the prefrontal cortex (PFC), which is critical for cognitive function. Adolescence is also a time when excessive alcohol consumption in the form of binge drinking peaks, increasing the risk of long-term cognitive deficits and the risk of developing an alcohol use disorder later in life. Animal models have revealed that adolescent ethanol (EtOH) exposure results in protracted disruption of neuronal function and performance on PFC-dependent tasks that require higher-order decision-making. However, the role of astrocytes in EtOH-induced disruption of prefrontal cortex-dependent function has yet to be elucidated. Astrocytes have complex morphologies with an extensive network of peripheral astrocyte processes (PAPs) that ensheathe pre- and postsynaptic terminals to form the ‘tripartite synapse.’ At the tripartite synapse, astrocytes play several critical roles, including synaptic maintenance, dendritic spine maturation, and neurotransmitter clearance through proximity-dependent interactions. Here, we investigate the effects of adolescent binge EtOH exposure on astrocyte morphology, PAP-synaptic proximity, synaptic stabilization proteins, and dendritic spine morphology in subregions of the PFC that are important in the emergence of higher cognitive function. We found that adolescent binge EtOH exposure resulted in subregion specific changes in astrocyte morphology and astrocyte-neuronal interactions. While this did not correspond to a loss of astrocytes, synapses, or dendritic spines, there was a corresponding region-specific and EtOH-dependent shift in dendritic spine phenotype. Lastly, we found that changes in astrocyte-neuronal interactions were not a consequence of changes in the expression of key synaptic structural proteins neurexin, neuroligin 1, or neuroligin 3. These data demonstrate that adolescent EtOH exposure results in enduring effects on neuron-glia interactions that persist into adulthood in a subregion-specific PFC manner, suggesting selective vulnerability. Further work is necessary to understand the functional and behavioral implications
Alvora S. Crump
Get PDFOral History taken by Ray Paschall and Dr. Kelli Johnson of Alvora S. Crump in Huntington, West Virginia
20220127: Honors College Convocations, 1974-2019
Get PDFThese items include materials from the Honors College at Marshall University from 1974-2019. Items were received in 2022 and include notable materials from the Honors Convocations as well as a few Drinko Symposium programs.
The digitized versions of the Honors Convocation documents can be located at the following link: here: https://mds.marshall.edu/honors_convocation/
Jones P.O.W. Photograph
No full textCarter Lee Jones on a fighter. Became a prisoner of war in 1944.https://mds.marshall.edu/yeager/1066/thumbnail.jp
League of Women Voters of the Huntington Area E-mail Bulletin, February 2022
Get PDFBulletin has January 2022 at the top but it is the February 2022 newsletter.
The Bulletin is published by the League, which is a nonpartisan political organization that encourages the informed and active participation of citizens in government and influences public policy through education and advocacy.https://mds.marshall.edu/lowv_newsletter_2020-2029/1010/thumbnail.jp
Dr. Thelma V. Owen and Tinker the cat
No full textA photo of Dr. Thelma V. Owen holding the Owen Clinic cat, Tinker, out on the lawn.https://mds.marshall.edu/owen_clinic_institute/1008/thumbnail.jp
First record of the genus \u3cem\u3eCompsobuthus\u3c/em\u3e (Scorpiones: Buthidae) from Maharashtra, India, with description of a new species
Get PDFA new species of the genus Compsobuthus Vachon, 1949 (Buthidae) belonging to the werneri group is described from two localities in Jalgaon District, Maharashtra, India. The new species can be easily distinguished from all four members of the werneri group known from India and Pakistan by combination of nonoverlapping morphological characters. Compsobuthus satpuraensis sp. n. is the first species of this genus to be reported from the state of Maharashtra and fourth to be reported from India