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Analysis of Employee Use of the PDC-HS to Address a Targeted Problem in the Workplace
No full textThe Performance Diagnostic Checklist – Human Services (PDC-HS) is an informant-based tool used to identify environmental variables that may be contributing to low employee performance and is administered to a supervisor (Carr et al., 2013). The purpose of this study was to evaluate the effects of an intervention identified by the PDC-HS administered to direct-care staff. A concurrent multiple baseline design across participants was used to evaluate the effects of an intervention consisting of weekly feedback and consequences. Results indicated improved performance following intervention, potentially adding support for using the PDC-HS to obtain individual feedback to be used as a form of self-monitoring
The In Vitro Investigation of Natural Products and Derivative Compounds as Potential Treatment of Colorectal Cancer
Get PDFObjectives: To design analogs of natural products with known anticancer and anti-inflammatory activities. Then assess the effects of the compounds on the cell viability of the HCT116 colorectal cancer cell line. Rationale: Analogs of natural products isolated from plants consumed in our diet and with reported anticancer activity, will potentially have activity against colorectal cancer. Methods: Analogs of stilbenes and anethole were synthesized in one step through Wittig reactions. Analogs of caffeic acid were synthesized in one-step reactions using caffeic acid as starting material, N, N′-Dicyclohexylcarbodiimide (DCC) and amines of varying sizes and polarities. The compounds were isolated using automated flash chromatography and the chemical structure was confirmed by nuclear magnetic resonance (NMR). The analogs and parent compounds were tested for their ability to inhibit the cell viability of HCT 116 cells using the MTS assay. Results: A total of six stilbenes and four caffeic acid analogs were successfully synthesized. The synthesis of menthol analogs could not be accomplished and anethole analogs could not be purified. All parent and derivative compounds showed varying concentration dependent levels of anticancer activity, except for caffeic acid. Conclusions: A total of ten derivative compounds were successfully synthesized with moderate yields. Proton and carbon NMR spectra confirmed the structures of the compounds. Most stilbenes exhibited a clear concentration dependent decrease in cell viability, with some appearing to be better than the parent compound. The caffeic acid analogs showed better activity than the parent compound, especially at the highest dose tested
Synthesis of Novel 5-HT7 Receptor Agonists and the Potential Pharmacological Effect on Autism Spectrum Disorder
Get PDFPrevious studies have found that Autism Spectrum Disorder (ASD) has been linked to Serotonin Receptor 7 (5-HT7) agonism. Activation of this receptor has been linked to reduction in repetitive and restrictive behaviors often associated with Autism Spectrum Disorder. Known 5-HT7 agonists have only partial agonism or are nonspecific to the 5-HT7 receptor, therefore, optimization of these structures is needed for potentially greater pharmacological effects. This article focuses on the design and synthesis of 10 novel compounds, and their pharmacological evaluation of novel compounds as potential 5-HT7 agonists. In total, ten novel compounds were synthesized. We are pleased to report that all compounds have the ability to inhibit 70% to 100% of the specific ligand to the 5-HT7 receptor. Further investigation of the specific Ki values is underway
Exploring Burnout Program Effectiveness With Adult Day Health Providers
Get PDFStress and burnout are frequently experienced by those in healthcare professions. While extensive research has been done on the impact of stress and burnout on nurses and physicians, other healthcare fields are less researched. One of these populations of health providers excluded from current studies is adult day health providers. Health providers at adult day health centers provide specialized services to persons with acquired, developmental, and intellectual disabilities. They orient these individuals to the community, administer their medications, provide opportunities for socialization and learning, accommodate leisure activities, and many other services that promote community and personal independence for their clients. As such, they fall under the healthcare umbrella and are subject to similar stressors and burnout experienced by nurses and physicians. This study aims to explore the extent and type of stress experienced by healthcare workers in the adult day health service field and determine if some successful interventions used with other health providers effectively prevent stress and burnout in this population
A Land-Use Planning Framework for Commercial Small Hub Airports for the Adoption and Storage of Liquid Hydrogen Fuel
Get PDFThe objective of this research is to develop a land-use framework for the adoption of Liquid Hydrogen fuel storage in commercial small hub airports
Effects of Restricted and Free-Access to Stimuli on Manding
No full textIncreasing essential language and communication skills in individuals with autism spectrum disorder (ASD) can lead to increased independence. A common way to achieve this goal is with mand training. Given the importance of this intervention, finding a tool to identify mands to be trained would help educators and clinicians. Two individuals with ASD participated in a mand assessment to evaluate the effects of free-access and restricted access to stimuli on manding. Mand training procedures were then conducted, and a final mand assessment was conducted after mand training. Results suggested that the mand assessment identified the presence or absence of manding
CONNECTION IN AN AGE OF CONNECTIVITY: AN EVALUATION OF SYNCHRONOUS AND ASYNCHRONOUS LAW CLASSROOMS
Get PDFAs the world was thrust into a global pandemic, legal education was forced to confront the evolution of technological teaching modalities. While these technological advances allowed legal education to prosper in the short-term emergency education situation, their continued use creates barriers between the student and teacher which diminishes a student’s ability to develop critical lawyering skills. Based on our own roles as professor and student, we agree that deviating from in-person education will have detrimental effects for teachers and students and will undermine the collaborative relationship of the classroom. Legal institutions have refined in-person teaching methods, such as the Socratic Method, as mechanisms to engage and enhance teacher-student relationships. This Article evaluates the merits of distance learning and includes a discussion of a variety of emerging synchronous and asynchronous models but cautions how the evolution of distance education will jeopardize the relationship between teachers and students. The authors conclude that student-teacher collaborative relationships are built on trust and are best achieved through an in-person, synchronous environment
Functional Analysis And Delineating Subtypes Of Restricted Repetitive Behavior In Individuals With Autism Spectrum Disorder
Get PDFTo date, only one behavior analytic study has systematically examined the use of functional analysis to assess arranging and ordering, which is a form of higher-level repetitive behavior (Rodriguez et al., 2012). The authors found this response was automatically maintained and developed effective interventions that involved some form of prompting and response disruption. Hagopian et al. (2015) evaluated a model for subtyping and predicting effective treatments for automatically reinforced self-injurious behavior (SIB). The current study applied Hagopian’s subtyping analysis and treatment model (i.e., competing stimulus assessments) to higher level repetitive behavior (Hagopian et al. 2015, 2017). A variety of assessments, including preference assessments and augmented-competing stimulus assessments (A-CSA) were conducted to inform treatment. Following treatment, generalization probes were conducted. For all participants, effective treatments were identified that consisted of providing competing stimuli identified via the A-CSA
FEDERAL SENTENCING REFORM: DETERMINING THE SCOPE OF THE RETROACTIVE APPLICATION OF THE FIRST STEP ACT OF 2018
Get PDFThe First Step Act of 2018 was signed into law by President Trump in December of 2018. This Act sought to adopt a less-retributive approach on sentencing while advancing criminal justice reform toward reducing excessively long federal sentences. This Note will specifically focus on section 403 of the Act. Section 403 was created to eradicate stacking sentences from second or subsequent convictions within the same indictment. Following the enactment of the First Step Act, only defendants with a prior conviction from a separate, prior indictment would be subject to the imposition of the higher mandatory minimum sentence.
The issue that has arisen from the enactment of section 403(b) of the First Step Act is the question of which cases may apply to get a reduced mandatory minimum sentence under the new Act. Circuit courts have split over determining the scope of the Act’s retroactive application to convictions that occurred prior to the First Step Act’s enactment, where the original sentences have been vacated. Specifically, the question is whether the language in section 403(b) of the Act is meant to include sentences that were vacated before and or after the enactment. This circuit split is causing an unfair disparity in federal sentencing with some defendants having access to the First Step Act’s section 403(b) benefits, while others are not. Currently, section 403(b) states that the First Step Act applies to offenses committed before the Act where a sentence has not been imposed since the date of the Act’s enactment. To address the disparity, the wording of section 403(b) must be more specific as to which sentences fall within the Act’s scope. This Note argues that for offenses committed before the date of enactment, the Act should be applied to sentences that were vacated before or after the enactment, as long as the original vacated sentence was inconsistent with the First Step Act’s prohibition of stacking second or subsequent convictions under the same indictment