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Creating a Drosophila SOD1 Mutant Through Homologous Recombination
Get PDFThis works describes the creation and partial phenotypic analysis of a point mutation within the endogenous Drosophila sod gene. The sodS111C allele was generated through a process of mutagenesis and homologous recombination in vivo. SodS111C stocks were created to analyze the mutation’s influence on protein aggregation, if any. We were able to test the effects of this mutant by assessing the function of the protein using genetic assays. To examine the effect of sodS111C on the second chromosome in the presence of sodG85R on the third chromosome appropriate genetic crosses were performed and it was determined that there was no significant difference among the eclosion rates of progenies. All four genotypes of progenies eclosed in Mendelian ratios. This could be explained by the fact that though one class of progeny genotype contained a double mutant sod, there was still the presence of the endogenous sodwt that could have masked for the double mutant
Naloxone Administration by Law Enforcement: Policy and Public Health Nursing Implications
Get PDFOpioid overdose has become a public health epidemic, and the use of naloxone by law enforcement personnel has recently become a controversial policy issue. This pilot research project addresses the question of attitudes regarding addiction, overdose, naloxone administration training, and the expanding role of law enforcement in naloxone administration by law enforcement personnel who have been trained in the administration of naloxone to those experiencing an opioid overdose. A comprehensive literature review was conducted relating to the topic of opioid use and overdose and the use of naloxone by law enforcement. The Theory of Planned Behavior was the theoretical framework chosen to guide this project. The methodology used was an exploratory qualitative approach with individual face-to-face interviews as the data collection method. The results are presented and analyzed including findings of a need for “hands-on” naloxone training, perception of empowerment by some officers since being trained to administer naloxone, and perception of empathy for those who overdose, especially toward the younger victims. Recommendations and implications for nursing practice, policy, research, and leadership are presented including a plan for dissemination to nursing, interprofessional stakeholders, and policy makers
Fall 2015
Get PDFThe 14th issue of the library newsletter (fall, 2015)
Inside this Issue:
-- Adams Library Celebrates 50 Years as a Federal Depository by Rachel Carpenter
-- Special Collections: The Cape Verdean Collection by Lenira Monteiro
-- Friends of the James P. Adams Library by Mark Caprio and Deb Thomson
-- Student-Sourcing Library Orientation: What Student Employees Know About Adams Library by Dragan Gill
-- Lisa Perry, Graduate Intern by Kieran Ayton
-- Dragan Gill, Reference Librarian: Sure, I can do that! by Deb Thomson
-- Library Newsflash: Access to the New York Times and New Computers
-- In Recognition: Tovah Reis, FMLA
-- In Memoriam: Thomas D. Lopes
-- Upcoming Exhibits and Events: Fall 201
Exploring Barriers to Code Status Discussions
Get PDFIt is imperative that Advanced Practice Registered Nurses (APRNs) have the skill set necessary to initiate code status discussions with people. The literature supports that healthcare providers tend to avoid the topic, for reasons that include feeling uncomfortable, not having enough time, and not wanting to take away hope. How do we break down these barriers to ensure that healthcare providers feel comfortable and prepared to have code status discussions? The purpose of this project was to explore perceived barriers encountered by the Advanced Practice Registered Nurse (APRN) student population. A survey was developed that included sections on comfort level with code status discussion, beliefs about DNR, barriers encountered in code status discussions, and two open ended questions. Findings revealed that participants overall were comfortable with having code status discussions, but were unfamiliar with the MOLST tool, a relatively new measure being used to facilitate code status discussions. Most participants believed that patients should always be informed about code status and should be asked if they would like to be a DNR. Numerous barriers were cited, the most common being unrealistic expectations and feeling uncomfortable addressing the issue of code status. More education, time and support, were cited as what would enable participants to have better conversations. Starting these discussions in the primary care office and then ensuring that this information is passed on could potentially improve outcomes. Advocating for policy changes at the institutional, state, and national levels is needed. Quality, patient-centered code status discussions are imperative in ensuring the patients are allowed to have good deaths
CIMRF Suppression of Endogenous Tissue Developments in Ciona Intestinalis Embryos
Get PDFTrans-differentiation of non-muscle tissue to muscle tissue is a well-established property of vertebrate myogenic regulatory factors (MRFs). For instance the vertebrate MRF, MyoD, has been shown to convert nonmuscle cells to muscle cells. During this trans-differentiation, however, endogenous gene activity of the nonmuscle cells is down regulated. To test if this property is also found in invertebrate MRFs our lab has developed a system to analyze the ability of the MRF of Ciona intestinalis, CiMRF, to suppress endogenous gene activity during trans-differentiation. We did this by misexpressing CiMRF in the notochord and endoderm of Ciona embryos, two nonmuscle lineages, and by examining the expression of Brachyury and Alkaline Phosphatase, which are markers of notochord and gut differentiation respectively. Expression of CiMRF in the notochord of Ciona embryos reduced the level of Brachyury expression and resulted in embryos with abnormal tails. This latter result is consistent with studies demonstrating that tail development in Ciona requires Brachyury expression. In addition, expression of CiMRF in the endoderm led to a decrease in the level of alkaline phosphatase activity. These studies indicate that CiMRF functions similarly to vertebrate MRFs in its ability to suppress endogenous gene activity while directing muscle-specific gene activity in nonmuscle cell types
My Soul has Sung Deep Like the Rivers: How the Abolishment of Slavery Birthed Generations of Music
Get PDFThe world of music is vast; there are songs that tell thrilling stories of love or loss, and stories of the ways in which love affects people. The history of such songs is just as immense. Many people may want to know the hidden meaning in Elvis’ “Hound Dog,” but not many think of asking where the rock genre came from. People would love to know how Frank Sinatra came to dominate the jazz industry, yet they rarely think of asking where jazz originated. There are many genres that originated from one background, some include folk and country, and the three genres I will be focusing on are blues, jazz, and rock. One can say blues and rock are somewhat similar in the sense that rock came from the blues genre – yet, jazz is a totally different genre of music! The rhythms, the instruments, they differ across genres; one can wonder how can blue’s, rock, and jazz come from the same origin? When thought about a little more, these differences emerging from the same origins make sense. These three genres come from the oppression brought on by slavery in the eighteenth and nineteenth century. I believe today’s genre of blues, jazz, and rock and roll are the results of the abolishment of slavery
Teaching Progress: A critique of the grand narrative of human rights as pedagogy for marginalized students
Get PDFWith the adoption of the Universal Declaration of Human Rights in 1948, education about human rights became an important focus of the new human rights regime and a core method of spreading its values throughout the world. This story of human rights is consistently presented as a progressive teleology that contextualizes the expansion of rights within a larger grand narrative of liberalization, emancipation, and social justice. This paper examines the disjuncture between the grand narrative on international movements for human rights and social justice and the lived experiences of marginalized students in urban environments in the United States. Drawing on our experience as professors who teach human rights, social justice, and social movements courses at an urban, four-year college in Providence, R.I., with a student body which includes large populations of students who are of color, first-generation, economically disadvantaged, and nontraditional in other ways, we explore the relevance and impact of these grand narratives for the lives of our students and their sense of agency. In particular, we advocate for a critical and transformational approach to human rights pedagogy to counter and overcome the pervasive individualization that underwrites the grand narrative of human rights. We argue that a critical (and radical) human rights pedagogy must evaluate the position of the individual in modern life if liberation through human rights law and activism is to be possible
The Relationship Between Osteoarthritis, Hip Arthroplasty, and Post-Operative Ambulation Distances
Get PDFOsteoarthritis, total hip replacements, and post-operative ambulation distances are three interrelated concepts that lead patients from diagnosis, to intervention, and to the first indications of recovery post-operatively. The purpose of the project was to quantify the ambulation distances of patients with one of three surgical approaches for total hip replacements (THR). The timeframe for measurement was from the day of surgery (day 0) through the second post-operative day (POD 2) comparing different surgical approaches with length of ambulation distances. Pre-operative elective joint replacement educational classes, may play a role in post-operative recovery, which provided the rationale for including them in this project. Electronic health records of 20 patients from each of the three surgical approaches (anterior, posterior, and lateral), were retrieved; data regarding the ambulation distances were averaged for each surgical approach. The results revealed no advantage, in terms of average ambulation distance, of one surgical approach over another. All members of the healthcare team strive to provide patient centered, quality care in the most fiscally responsible manner. Increasing post-operative ambulation distances after a THR may contribute to earlier discharge and economic benefit to the healthcare system. A replication study with a larger sample may yield additional findings and guide the advanced nurse practitioner in developing an evidence based approach to post-operative care of THR patients
An Evaluation of the Palliative Care Provided on a Medical Intensive Care Unit
Get PDFMore patients die in intensive care units (ICUs) than in any other hospital setting. For survivors, ICU treatment is often accompanied by a significant burden of symptoms for both the patient and for the family and may result in long-term cognitive and physical impairments and an unacceptable quality of life. Over the last decade, the idea that palliative care should be provided along with intensive care regardless of prognosis has evolved from a novel formulation to a clinical practice guideline. The purpose of this research was to determine whether the patients on a Medical Intensive Care Unit (MICU) were being offered appropriate palliative care. A retrospective chart review of 250 charts was performed at a 653-bed acute care, teaching facility located in southern New England with a sample of 50 patients. The Care and Communication Bundle was used to measure if primary palliative care needs were met; the Palliative Care Service Consult Tool developed by the palliative care team at the study institution was used to measure if tertiary palliative care need s were met. Results indicated approximately 85% compliance with primary palliative care overall, compliance with the individual items ranged from 40% - 100%. Tertiary palliative care compliance was 7% overall, with only two out of 29 patients actually receiving a consult. Recommendations for practice change include integrating the tool into the electronic medical record as part of the admission assessment. Interdisciplinary staff education on the process and use of the measures is indicated. State and national policies related to palliative care would facilitate the implementation of palliative care programs aimed at providing care for all people in need of these services and ensure equitable access to end-of-life care. Advanced practice nurses have a key role in advocating for policy changes within their institutions, as well as, at the state and national levels that could help patients meet their goals of care, especially at the end of their lives
Transformation 360 : Building an Innovation Lab (Documentary Film)
No full textA documentary tells the story about Rhode Island/Central Fall Innovation lab.Rhode Island College and the Central Falls School District are partners in Achieving Together: The Central Falls/Rhode Island College Innovation Lab (the Innovation Lab). This unique, first-in-the-nation collaboration has the potential to provide a PK-12 and post-secondary urban education model that offers a new paradigm for state and national replication.https://digitalcommons.ric.edu/innovation_lab/1006/thumbnail.jp