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The Effects of Using Ultrasound Guidance Versus Traditional Method for Peripheral Intravenous Placement
Get PDFRoughly 230 million peripheral intravenous (PIV) catheters are placed in the United States each year (Helm et al., 2015). The establishment of a PIV access may be lifesaving in times when emergent medications or procedures are critical for survival. The literature suggests the use of ultrasound guidance (USG) may decrease the attempts, decrease the length of time to obtain PIV access and improve patient satisfaction. The primary purpose of this study was to compare the longevity of ultrasound guidance PIVs versus the traditional method within the population of patients 18 years and older. A secondary outcome was to determine the most frequently used gauge needle, commonly used location of PIV and infiltration rate. The research was guided by the American Association of College of Nursing’s (AACN) Synergy Model as it best provided insight into improving patient outcomes by aligning patient needs and nurse competencies. A retrospective chart review was conducted with a total of 200 charts reviewed. Results concluded as follows: the traditional method was found to be superior in regards to longevity and was also found to have a lower rate of infiltrations. There were a number of limitations to this study such as the lack of information on the training of the health care provider placing the PIV, including the use of the Vascular Access Team or USG training. The number of attempts to obtain PIV access was not available for data analysis. Further research is needed with a specific focus on the extended dwell product along with the additional data collection of factors which may have affected the USG group
In the Devil\u27s Shadow: Sacred Agency, Cosmic Struggle, and the Cultural-Religious Clashes that Shaped Colonial New England, 1620-1693
Get PDFThe diabolic portrayal of resident native populations featured prominently in the seventeenth-century colonial Separatist and Puritan worldview, with the Algonquian peoples cast as a corrupted race in the service of the Devil; a means by which God challenged religious complacency or chastised collective sin; and, in times of spiritual crisis and despair, a mortal threat to the rule of saints in the region. This study focuses on the real-world impact of the nonconforming Reformed Anglo-Protestant belief system and the resulting cultural-religious clashes that shaped New England\u27s early colonial period
The Responsibility to Protect and Syria- Looking at the Future of Humanitarian Intervention
Get PDFThis thesis assesses the legality of humanitarian intervention in the context of the Syrian Civil War. It specifically investigates the international legal principle the Responsibility to Protect (R2P) and critiques it
How has Portuguese diplomacy evolved since the 15th century?
No full texthttps://digitalcommons.ric.edu/iplws_lectures_interviews/1001/thumbnail.jp
Students Lead the Charge! Using Project-Based Learning with Pre-service Teachers to redesign a Curriculum Resource Center
Get PDFProject-based learning (PBL) allows students to identify and find solutions to real-world
problems using inquiry-based learning. While increasingly used in the K-12 classroom, PBL has not had widespread adoption in higher education. With the exception of Correll and Bornstein (2018), very little has been written about using PBL to redesign college and university Curriculum Resource Centers. However, because PBL is primarily a K-12 teaching pedagogy, it is the perfect fit to give pre-service teachers the active learning skills they will need for their future K-12 classrooms. The skills developed through project-based learning teach pre-service teachers to become independent and resourceful through learning how to develop their professional voices through inquiry. The authors of this article used PBL in conjunction with the Association of College and Research Libraries (ACRL) Guidelines for Curriculum Materials Centers (CMCs) and the three themes for PBL success in higher education identified by Lee et al. (2014) to work with a small class of upper-level elementary education pre-service teachers to redesign an academic library Curriculum Resource Center
Between the Axe and the Anvil: Internal Reconstructions of Modern Subjectivity in Alfred Döblin\u27s Berlin, Alexanderplatz
Get PDFBerlin, Alexanderplatz holds a unique place in literary history; for despite being considered one of the major Großstadt—or big city—novels of the modernist period, it has largely been forgotten. Between the Axe and the Anvil: Internal (Re)constructions of Modern Subjectivity in Berlin, Alexanderplatz is an essay that grapples with the problem of subjectivity within the city—a problem that is peculiarly similar to the novel’s, as both seem to have been lost amidst the buildings and crowds of Weimar Berlin. By reading the text as a dialectic between the social pressures of modernization and the spatiality of the city, Berlin, Alexanderplatz serves as an excellent case study for examining the ways in which subjectivity is both deconstructed and reconstructed within the textual and industrial city alike
Expression and Purification of N-terminally Acetylated microtubule binding protein Tau
Get PDFThe microtubule-associated protein Tau (MAPT) plays a critical role in many neurodegenerative diseases. Tau functions to stabilize microtubule structures that are essential for transport within the neuron, and transport disruption leads to loss of neuronal function. Tau binding is regulated by phosphorylation with the help of kinases that add phosphate groups which block microtubule binding sites, and phosphatases that remove phosphate groups and expose the microtubule-binding regions. Tau can be found in hyper-phosphorylated states, which causes Tau to self-assemble into aggregates and prevent microtubule binding. It\u27s clear that post-translational modifications (PTMs) of Tau play a key role in the dysregulation of neuronal function due to abnormal conformational changes, however not all PTMs are as thoroughly studied as phosphorylation. N-terminal acetylation is the most common PTM of all proteins and Tau is predicted to be a target. N-terminal acetylation is a co-translational process that is catalyzed by N-terminal acetyltransferases, which adds an acetyl group to the N-terminus of Tau, thus neutralizing the positive charge on the N-terminus. Commonly, studies endogenously express Tau in a prokaryotic system that lack PTMs. Utilizing a co-expression system in E. coli allows for the purification of Tau with a modified N-terminus. Purifying modified Tau with Fast Protein Liquid Chromatography (FPLC) will allow us to probe the structural and functional effects of N-terminal acetylation by assessing changes in Tau’s aggregation and microtubule binding affinity and polymerization
Misexpression of alx4a and alx4b in the zebrafish, Danio rerio
No full textNeural crest cells are a population of undifferentiated, multipotent cells that differentiate into a vast array of adult cell types. As part of their development, they undergo an epithelial-to-mesenchymal transition (EMT) at the dorsal neural tube to migrate throughout the embryo. An unregulated EMT occurs in cancers such as malignant melanoma, where neural crest-derived melanocytes invade other tissues of the adult body. In the zebrafish, Danio rerio, the neural crest generates three pigment cell types: black melanocytes, iridescent iridophores, and yellow xanthophores. The changes in gene expression that regulate migration, specification, and differentiation of neural crest cells into fully mature pigment cells are still not fully elucidated. Previous studies suggest that some iridophores and melanocytes share a precursor and that an unknown transcription factor is required to promote iridophore fate. Recent work showed that alx4a and alx4b are highly expressed in iridophores and not in melanocytes. I hypothesized that alx4a and/or alx4b act to inhibit melanocyte fate and promote iridophore fate. To test the roles of alx4a and alx4b in pigment cell fate, we designed and constructed a series of expression clones. These expression clones were injected into wild-type (WT) zebrafish embryos at the 1-cell stage, and embryos were examined for fluorescent reporters and alterations in pigment cell development. Identifying and understanding the genes required for iridophore fate specification and melanocyte repression may provide valuable insight into neural crest-derived cancers such as malignant melanoma
Incorporating the Critical Music Framework: An Autoethnographic Reflection
Get PDFI articulate an autoethnographic narrative of using different songs to counter dominant interpretations of gender, class, immigration, slavery, and education in the secondary social studies classroom. Framing it as the Critical Music Framework, the practice of using music addressing social issues and historical representations of women and people of color provided students with reflective learning opportunities. The resulting conversations illustrate the importance of music not just on the personal but also the academic aspects of individuals