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Annual Juried Student Exhibition
No full texthttps://scholarship.depauw.edu/peeler_exhibit/1207/thumbnail.jp
October 2025 Table of Contents Newsletter - Open Access Week
No full textJoin Victoria Peters (Scholarly Communication and Resource Services Librarian) in discussing Open Access at DePauw Tuesday, Oct. 21 - 11:30am in the Wood Study (Roy O. West Library). Open Access Week’s theme seeks to encourage a candid conversation about which approaches to open scholarship prioritize the best interests of the public and the academic community—and which do not. By situating our campus OA history within the broader movement, this session will help faculty understand the ethical and practical implications of open access, see how institutional policies support their work, and identify opportunities to contribute to a more equitable scholarly ecosystem
November 2025 Table of Contents Newsletter - Archives
No full textFrom illuminated manuscripts to miniature books, you can find it in the Archives! Take a look at our new Special Collections and Rare Books LibGuide, which will be updated on a continual basis. We’re happy to provide a tour or an instructional session for your group or class. For more information, visit the Teaching with Archives and Special Collections LibGuide
The Interwoven Systems of Oppression: How Inadequate Education and Medical Negligence Perpetuate a Pipeline of Disparities for Black Women
No full textLove in Fragments: Reimagining Romance in the Shadow of War in Elizabeth Bowen’s The Last September and Summer Night
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Blue Chairs and Broken Minds: The Troubled Teen Industry’s Legacy of Abuse
Full text linkThe Troubled Teen Industry (TTI) operates under the veil of rehabilitating adolescents with behavioral challenges. However, evidence reveals a system rife with abuse, manipulation, and inadequate oversight. From the infamous blue chairs of Straight, Inc., to the isolation tactics of WWASP program, this industry has maintained a facade of treatment while subjecting youth to severe abuse. This paper explores the history, recruitment tactics, institutional failures, survivor recovery journeys, and legal battles that define the TTI. Advocacy movements, including Breaking Code Silence and WWASP Survivors, have emerged to combat industry malpractice and push for policy changes to protect vulnerable youth. Additionally, this paper evaluates alternative intervention methods that prioritize healing, connection, and individualized support, such as Wraparound Services and trauma-informed care models. By exposing the ethical and systemic flaws of the TTI and presenting effective alternatives, this research aims to contribute to a growing movement toward accountability, regulation, and justice for survivors
CRISPR Generated Gene-Knockout Mutants for Studying Nicotine-Seeking and Avoidance Behavior in Zebrafish
No full textThe use of tobacco products remains one of the leading causes of preventable diseases worldwide and in the United States. Although the use of tobacco products in the United States declined about 28 million adults in the United States still smoke. Both environmental and genetic factors contribute to nicotine use behavior. To identify targets for potential pharmacotherapeutics that could lower nicotine use behavior, we used a nicotine seeking and avoidance behavioral assay to test larval zebrafish with nonfunctional acetylcholine receptor subunit genes (knockout genes) that we generated in our lab using CRISPR. Genotyping of individual zebrafish was used to identify mutants with one (heterozygous) or two (homozygous) mutant alleles. Off-spring from homozygous mutants was used for behavioral tests. The knockout of different acetylcholine receptor genes resulted in differential shifts of nicotine seeking behavior of larval zebrafish related to cumulative time spent in the nicotine compartment and to tested nicotine concentrations. The gene knockouts also impacted the percentages of nicotine seeking and avoiding larval zebrafish slightly. Overall, the results indicate that acetylcholine receptor subunits play a role in nicotine-seeking and avoidance behavior in larval zebrafish.https://scholarship.depauw.edu/srfposters/1221/thumbnail.jp
MiRNA-Mediated Regulation of S100B: A Review
No full textS100β is a significant signaling molecule and biomarker that is primarily expressed in the brain. At low physiological concentrations, S100β induces astrocyte maturation, microglial migration, and neural proliferation. However, high concentrations activate inflammatory and pro-apoptotic pathways. Due to this dual role, increased research is being invested into the role of S100β in neuronal homeostasis and inflammation. In fact, increased S100β expression is seen in many neuropathologies including Alzheimer’s disease, Parkinson’s disease, cerebral ischemia, and traumatic brain injury. High S100β is generally associated with worsened disease outcome. Here, we provide an overview of the structure and role of S100β in various pathways, particularly in the context of neurological disorders. Modulation of S100β levels also holds promise as a therapeutic strategy. Micro-RNAs (miRNA) post-transcriptionally regulate gene expression and provide a novel approach reduce excess S100β protein. However, much of this research is still in its infancy. We outline current studies identifying miRNA in human and animal models of various neurological disorders. S100β itself has several predicted miRNA interactions although most have not yet been directly validated. Together, we compile the literature identifying S100β and miRNAs to guide future research in this field. We also comment on the feasibility and future uses of miRNA for pharmaceutical regulation of S100β, particularly for neurological treatment