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Designing an Attachment Assay for Keratinocytes Stimulated by Fibroblast Conditioned Media
Get PDFCell attachment involves the interaction between an individual cell with its neighbors and the extracellular matrix. These interactions are often regulated by the signaling molecules, including a variety of proteins, cytokines and growth factors. It is found in several studies that keratinocytes in the epidermis communicate with dermal fibroblasts in a bilateral paracrine model, in which they were simultaneously stimulated by the byproduct of the others. We developed this protocol with a simple, low-cost, and effective model to examine keratinocyte attachment that could be applied to examine the effects of fibroblasts on cell adhesion. For this method, we collected the conditioned media from fibroblasts and use it as a treatment for keratinocytes. Treated keratinocytes are then plated in a matrix and quantified with immunofluorescence techniques to determine the amount of attachment based on different treatment concentrations.https://scholarship.depauw.edu/srfposters/1155/thumbnail.jp
Foreign Direct Investment and Global Supply Chain Reshaping in ASEAN
Get PDFThe intensifying geopolitical tensions between the United States and China have led to profound changes in global supply chains, particularly in recent years. Additionally, China\u27s strict Zero Covid policy has further complicated the operations of multinational corporations during the pandemic. These developments have forced companies to rethink their sourcing strategies, diversify their suppliers, and relocate manufacturing to reduce tariff impacts and minimize supply chain risks. This study examines how the trade war and the Zero Covid policy have accelerated the diversification of foreign direct investment (FDI) flows from the U.S. and China into Southeast Asia. We analyze FDI data from key ASEAN economies, exploring correlations between the trade war and the evolving FDI patterns of the U.S. and China in the region. Our research finds that neither the trade war nor the COVID-19 pandemic has had a statistically significant impact on the growth and pattern of U.S. FDI into the region. However, there has been a notable shift in the distribution of Chinese FDI across the region. This suggests that U.S. government policies aimed at reshaping global supply chains have partially succeeded—not by altering American manufacturers\u27 supply chains in the region, but by prompting their Chinese counterparts to restructure theirs.https://scholarship.depauw.edu/srfposters/1150/thumbnail.jp
Reducing Selection Bias in the Training Data of ASL Champ! To Improve the Sign Language Recognition (SLR) System
Get PDFAmerican Sign Language (ASL) is a natural language that is critical for effective communication within the Deaf community and also to bridge the gap between hearing and Deaf or Hard-of-Hearing individuals. Conventional methods of ASL learning apart from in person classroom instruction provide foundational knowledge but often lack the immersive and interactive elements. People often opt to learn ASL through textbooks and videos due to the limited availability of proficient ASL instructors, lack of other educational resources and limited time. This creates challenges of replicating real-life conversational scenarios and lack of real time feedback. To address these limitations, Virtual Reality (VR) technology has emerged as a promising tool for ASL education by offering an immersive learning environment where users can practice ASL, a 3D language in a three dimensional space to enhance their learning as well as retain the language. The motivation behind this study is to explore the efficacy of the VR-based ASL learning platform, ASL Champ! and its potential to revolutionize the way ASL is taught and learned. Additionally, this study will also evaluate its Sign Language Recognition (SLR) system by addressing the research question: How does reducing the selection bias in the training data of ASL Champ! affect the accuracy of its Sign Language Recognition (SLR) system?https://scholarship.depauw.edu/srfposters/1145/thumbnail.jp
A Comparative Analysis of Urea vs. Acetamide in AOT reverse micelles
Get PDFIn our exploration of the interactions between water and amide osmolytes, we focused on the effects of urea and acetamide on the stability of reverse micelles (RMs) formed with Sodium Bis(2-ethylhexyl)sulfosuccinate (AOT) in isooctane. Water, with its unique polarity and its ability to facilitate hydrogen and proton transfer, played a crucial role in our study, as we aimed to uncover how these amides would influence micellar behaviour. Our results revealed a compelling contrast between urea and acetamide. Acetamide, with its lower polarity due to a methyl group substitution, demonstrated superior solubility and significantly reduced precipitate formation compared to urea. This enhanced stability suggests that acetamide\u27s structural properties allow for a more harmonious integration within the micellar system. Employing dynamic light scattering (DLS) and fluorescence spectroscopy, we found that increasing the water-to-surfactant ratio (w0) led to a marked rise in the fluorescence intensity of the coumarin dye (C343). This indicated greater accommodation of dye molecules in the core of the RMs, enhancing our understanding of micellar dynamics. In contrast, varying the concentration at a constant w0 resulted in inconsistent fluorescence trends, underscoring the complexities inherent in micellar behaviour. Ultimately, our study highlights the pivotal role of amide polarity in determining micellar stability, paving the way for future research into the implications of these interactions in biological and chemical contexts. We set the stage for novel applications and further investigations into micellar systems by deepening our insights into osmolyte behaviour.https://scholarship.depauw.edu/srfposters/1154/thumbnail.jp
Communicating Sustainability Effectively Online
No full textHow my Summer 2024 Marketing Internship at Valent BioSciences changed my thinking about what to post online.https://scholarship.depauw.edu/srfposters/1166/thumbnail.jp
IWrite Podcast - Abby McArthur-Self \u2724 interviewing Nina Thompson
No full textIWrite is a series of podcast interviews and (pandemic permitting) live events showcasing conversations with DePauw community members about their writing lives. Interviews in the podcast series were conducted by Writing Center tutors and are generally 5-10 minutes long. Thanks for listening
The Failed Promise of Gun Legislation: The Assault Weapons Ban and Sandy Hook
Get PDFThis paper has three chapters. The first details the Assault Weapons Ban and what led to its passage in 1994. It goes through the different provisions and exemptions in the ban. This chapter analyzes the impact that the ban had on crime, gun violence, government spending, and electoral politics. The chapter then details why the ban failed to pass again in 2004 and the resulting impact. The second chapter analyzes the shooting at Sandy Hook Elementary School and the shooting’s role in the gun control debate. This chapter looks at why the Assault Weapons Ban failed to pass in 2013 and the responses from legislators and organizations. There is a closer look at the National Rifle Association’s role in the failure to pass gun control legislation. The third chapter studies the entrenchment of gun ownership as a political identity. This chapter looks at how political identities are formed and the impact that the identities have. This chapter analyzes how entrenchment of the gun ownership identity leads to more polarization and perpetuates the failure to pass gun control. The aim of this paper is to explain why gun control was able to pass in 1994 but has failed to pass since
Percussion @ Peeler
No full textThe DePauw Percussion Ensemble presents its annual program of contemporary solo and chamber works for percussion, composed and improvised, in a non-traditional concert setting. Directed by Dr. Ming Hui-Kuo, the one-hour performance fuses contemporary art and music in the galleries at Peeler. Refreshments will be served following the event.https://scholarship.depauw.edu/peeler_event/1001/thumbnail.jp
DePauw Men\u27s Basketball vs Wabash 1-24-24
No full textIt\u27s the men vs Wabash at home, broadcast 1-24-24. Joined in progress