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Environmental Concerns of Women in Appalachia
No full textPurpose: Environmental contamination is rampant in the United States and other parts of the world. There are potential health implications related to environmental contamination./= / \u3e/= / \u3e /= / \u3e/= / \u3e
Aims: The purpose of this study was to investigate how concerned women in Appalachia are regarding the environment. The following research question was addressed: What concerns do women have regarding the environment? The objective of this study was to understand how women perceive their environment and to evaluate what concerns they have regarding the environment. We also evaluated demographic factors to see if any demographics contributed to particular concerns related to the environment.
Methods: This study used a qualitative descriptive design. Participants completed one in-depth interview about their environmental concerns followed by a confirmatory interview to ensure main ideas and themes were captured adequately. Interviews were audio recorded with participant permission. Interview transcripts were analyzed for common themes. The IRB approved this research.
Results: Several women expressed concerns about water contamination. Analysis is in progress.
Limitations: Some participants did not have much to say or did not have concerns related to the environment.
Conclusions: Environmental contamination impacts health. Many participants in Appalachia may be unaware of these impacts. The participants in this study expressed a variety of concerns related to the environment and some expressed none. This indicates that education may be needed in current environmental status and the implications of contamination on health
Factors Influence Homeless People’s Psychological Well-being and Suicidal Ideation
No full textIntroduction/Significance: About 582,462 individuals are experiencing homelessness in America. Homelessness is devastating, regardless of age. But for children, it can have serious physical, emotional, and psychological implications.
Purpose: The purpose of this study was to examine the influences of spiritual well-being, coping strategies, family interaction, and personality on psychological well-being, and suicidal ideation among people with homelessness.
Methods: Sixty people with homelessness were recruited in the Eastern Tennessee Downtown Day Center, USA. IRB was approved. This was a cross-sectional descriptive research design. Questionnaires were used to do data collection. SPSS 28.0 was used to do the data analysis. Descriptive data analysis, Pearson Correlations, and Stepwise Multiple Regressions were used to examine the research questions. Questionnaires were used to collect data.
Results: There were 42 males and 18 females. The mean age was 46.08 (SD = 12.54). Most of their diagnoses included Anxiety, Depression, Substance Use, Mood Disorder, and PTSD. Psychological well-being and suicidal ideation had statistically significant relationships with the following variables: spiritual well-being, faith/belief, life satisfaction/ self-actualization, problem-focused engagement, problem-focused disengagement, and personality. The significant predictors for psychological well-being were spiritual well-being and personality. The significant predictors for suicidal ideation were life satisfaction/self-actualization, emotion-focused engagement, and negative family interaction.
Discussion/ Conclusions: Seventeen indicated that they thought seriously about killing themselves. Twenty-six had depression and should talk to a professional, but only sixteen received depression treatments. Therefore, these results could help professionals provide appropriate support for this population
Hepatocellular Carcinoma and CAR-T Cell Therapy in Appalachia and Beyond
Get PDFHepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality without effective treatment. The Appalachian region is identified as a likely high-risk area. Surgical resection is the current leading treatment despite drawbacks such as recurrence and decreased post-op quality of life. While CAR-T cell therapy has shown promising results in hematological malignancy, employing it for solid tumors like HCC is now a growing field of interest. Ballad Health HCC data sets (n=40) were analyzed to compare characteristics of HCC patients in Appalachia against the general U.S. Key variables included age, gender, prevalence of non-alcoholic fatty liver disease (NAFLD), and tumor characteristics. Literature research was performed to understand CAR T-cell therapy and clinical trials status to assess future development of CAR T-cell therapy for treating HCC. The Appalachian HCC population demonstrated a significantly higher mean age (69.6 years vs. 65 years; p = 0.0017) compared to the general U.S. HCC population. There was no significant difference in male predominance (86.1% vs. 75%; p = 0.1757) between the two groups. NAFLD prevalence was substantially higher in the Appalachian cohort (66.7% vs. 30%; p \u3c 0.0001). AFLD prevalence did not differ significantly between the two populations (19.4% vs. 15%; p = 0.4806). Literature review identified c-MET, PD-1, Glypican-3, EpCAM, and alpha-fetoprotein as the major CAR T-cell targets of interest in clinical development for treating HCC. Multiple Phase I-II clinical trials are ongoing, with mixed clinical results identified. Our lab developed c-Met-targeted CAR T-cells derived from Appalachian HCC patients showing efficacy in inhibiting MET-positive HCC cells. Our results suggest statistical significance in Appalachian prevalence of non-alcoholic fatty liver disease (NAFLD), a likely risk factor, with factors such as dietary habits and health literacy possibly at play. While CAR T-Cell therapy in HCC has shown promising results in animal models, clinical efficacy requires further evaluation
Conceptions of Ghosts in Renaissance England
Get PDFLiterature, treatises, and theatrical plays disclose information about the cultural concept of ghosts in Renaissance England. Shakespeare’s Hamlet provides an exemplary examination of the attributes given to ghosts. Hamlet conveys the following characteristics: ghosts can communicate, appear at night, have the form of the deceased, appear to a person known in life, died in violent manners, and were labelled as “ghosts.” Other plays, treatises, and other similar documents from the period share these characteristics, reflecting broader societal belief. By examining these sources, deeper insight can be gained into the beliefs and attitudes of people from Renaissance England regarding ghosts. Furthermore, by analyzing the beliefs of the supernatural in this group of people, insight can be gained into the societal values that the people in Renaissance England held in importance, displaying and accentuating the cultural change over time
How I Learned to Love Peer Review
Get PDFIn this editorial, Editor-in-Chief Wendy Doucette reflects on academic peer review in general, outlines the peer review process used at the Journal of Graduate Librarianship (JGL), and offers tips to future authors for improving the peer review process. She concludes by thanking JGL’s existing roster of peer reviewers for their continued contributions
Adolescent Externalizing Symptoms and Parent Emotion Socialization: An Examination of Longitudinal Effects and Differences by Adolescent Sex
Get PDFAdolescence is an important developmental context with several changes in social and emotional functioning. Though adolescents are gaining independence from their caregivers, they still engage in dynamic interactions with their caregivers who remain key figures in their lives. When adolescents express emotions, caregivers engage in various behaviors in response to these expressions, a process known as emotion socialization. This process has mostly been examined as a parent-driven construct in which parent emotion socialization impacts child-level outcomes, namely internalizing symptoms, with limited research on externalizing symptoms. However, available literature demonstrates that child-level characteristics (e.g., externalizing symptoms) are linked to differences in parent emotion socialization. Extending on Eisenberg and colleagues’ (1998) heuristic model of emotion socialization, the present study aims to examine externalizing behaviors as a child-level characteristic that may have impacts on parent emotion socialization strategies over time in a sample of adolescents. Participants were 87 adolescents (13-15 years old; 50 females) and their caregivers who completed self-report and other report measures across three time points. Change in adolescent externalizing symptoms did not predict change in parent emotion socialization over time. Supplementary analyses indicated that time 1 conduct problems did not predict change in parent emotion socialization. Future directions and clinical implications are discussed
