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HYDROGEN-BONDED COMPLEXES OF PYRITHIONE WITH FORMIC ACID AND WATER: PREDICTED STRUCTURES AND ROTATIONAL SPECTRA
No full textThis study presents predicted structures and rotational spectra for the most stable complexes formed between pyrithione and both formic acid (pyrithione-formic acid) and water (pyrithione-water). These predictions form the basis for ongoing experimental efforts using microwave spectroscopy to detect rotational transitions of the complexes in the gas phase. Of the dimers formed between pyrithione and either formic acid or water, a combination of both hydrogen bonding and dipole-dipole interactions is expected to induce the greatest stability and tightest binding. The most stable pyrithione-formic acid complex reached an energy of -911.705 Hartrees relative to monomers, with a binding energy of -6292.13 cm-1. Similarly, the lowest energy pyrithione-water complex showed an energy of -798.313 Hartrees and a binding energy of -4029.20 cm-1. Pyrithione serves as a possible analog for the pyrimidine groups found in nucleobases, providing insight into hydrogen-bond interactions between DNA and small organic molecules. While this work primarily focuses on computational modeling and calculations, future studies will delve further into experimental testing of these complexes
WHY THEY STAY: THE CONTEXTUAL REASONS WHY DOMESTIC VIOLENCE SURVIVORS IN PIMA COUNTY FIND DIFFICULTY IN LEAVING THEIR ABUSIVE RELATIONSHIP
No full textDomestic violence is an issue with pressing urgency internationally, but specifically in Pima County. Scholars estimate 1 in 3 women were survivors of domestic violence during the COVID-19 pandemic that emerged in 2020 (Kilfe 2024). In 2022, Tucson saw an increase of 21 percent in calls to domestic violence hotline center Emerge, which should be noted as the highest number of calls they had ever received (Rodriguez 2022). Domestic violence survivors often experience a series of highs and lows that makes it incredibly difficult for them to leave their abusive partner. There are other contributing factors that prevent a survivor from leaving, such as family roles, cultural factors, and lack of external support outside of the relationship. One must ask what resources are currently available to survivors in Pima County, and what opportunities for improvement there are to advance such resources. To understand the bigger picture of domestic violence and propose potential solutions, it is vital to first be familiar with the contextual reasons why a domestic violence survivor may struggle to leave their abusive relationship
CELIAC DISEASE: IS GLUTEN FREE REALLY GLUTEN FREE?
No full textCeliac Disease (CeD) is a relatively new autoimmune disease or gluten induced enteropathy for which there is currently no cure. Gluten was identified as the causative agent of celiac symptoms in 1953 by Dicke, Weijers, and van de Kamer. The only current treatment available for management of symptoms is strict adherence to a gluten free diet (GFD). This paper titled "Celiac Disease: Is Gluten Free Really Gluten Free?" will be a comprehensive overview of the literature on CeD including symptoms, genetic and environmental influences, diagnostic testing for the confirmation of CeD, and comorbidities associated with CeD. Furthermore, I will aim to address concerns of following a GFD within the Celiac population, considering issues such as faulty labeling, cross contamination, "hidden sources of gluten", and the implications on the health of the individual. Lastly, this paper will examine new methods of gluten detection available to the public, the efficacy of these devices, and emerging therapies
INGÉNUE-ITY: A CELEBRATION OF YOUNG WOMEN IN CLASSIC AND CONTEMPORARY MUSICAL THEATRE
No full textThe ingénue is a well-loved, stereotyped stock character in literature, film, and theatre, especially musical theatre. The word itself is derived from the French word that translates to "innocent", precisely how these young women are portrayed onstage. Their purpose in the plot is to be naïve, beautiful, simple, and, often, in love. Throughout my four years here in Tucson, I've been discovering how truly complex American Musical Theatre is and have searched for where I fit its almost three-hundred-year-old history. I quickly began to realize that the simplicity of these characters that I related to the most can be harmful for the young girls in the audience and those portraying them. Their reliance on men can impact expectations and self-worth without anyone noticing. So, I sought out to find female-led stories that empower audiences instead. To honor the young women who have graced Broadway's stages and inspire those to come, I developed an hour-long solo cabaret-style show that highlights some of the most iconic ingénues and those who break from the mold to show just how dynamic young women are. My performance was on May 14, 2025, at 6 pm in the Harold Dixon Studio Theatre, and featured ten songs that span almost eighty years of Broadway history. The process of building a show has been invaluable, and I've learned so much about myself and the industry that I am graduating into
THE ROLE OF INTERNATIONAL SCIENTIFIC COLLABORATION ON DATASETS AND CITATION IMPACT: A SCIENTOMETRIC ANALYSIS OF NATURE SCIENTIFIC DATA (2014-2024)
No full textScientific datasets are foundational to building scientific knowledge. In this study, we investigated how dataset origin and current author affiliation location affect a publication's citations, an indicator of success and impact. We examined the effect of local author involvement and Global North-South collaboration on publication citation outcomes. We analyzed 1,440 datasets from Nature Scientific Data (2014"“2024) across seventeen fields. On average, 40% of authors had an affiliation matching the abstract's referenced location, marking them as local authors. A general linear regression analysis showed the local author proportion had no significant impact on citation counts. Using World Bank income classifications to distinguish Global North and Global South countries, further analysis revealed disparities in authorship patterns. Specifically, when the team was from the Global North 90% of citations were from datasets also published in Global North. When the team was from the Global South, 65% of citations were from datasets with data from both the Global North and South. These findings highlight a citational advantage for Global North datasets and authors and highlight the greater recognition Global South authors receive when collaborating across regions. Local author involvement alone does not impact the citation count, raising questions about equity in data publication and recognition
MATERNAL ADVERSE CHILDHOOD EXPERIENCES AND THE INTERGENERATIONAL IMPACT ON INFANT EPIGENETICS: A REVIEW
Get PDFThis paper investigates the impact of maternal adverse childhood experiences (ACEs) on the epigenome of their infants, with a particular focus on DNA methylation. ACEs, which encompass a range of traumatic experiences in childhood, have been shown to have long-term effects on physical and mental health, often persisting into adulthood. One mechanism through which ACEs may influence health outcomes is through epigenetic changes, such as DNA methylation, which regulates gene expression without altering the DNA sequence itself. This review synthesizes findings from studies exploring how maternal ACEs are linked to epigenetic modifications in infants, specifically focusing on methylation patterns. The literature reveals an association between maternal ACEs and differential methylation of genes such as FKBP5, SCG5, and COMT/TXNRD2, which are linked to mental health, stress regulation, and neurodevelopment. The paper also explores interventions that may mitigate these epigenetic effects, including prenatal home visits and psychosocial support for mothers. Overall, the findings emphasize the importance of addressing maternal ACEs through targeted interventions to potentially reduce the transmission of trauma to the next generation and support healthier epigenetic outcomes for infants. Further research is needed to explore the full scope of these mechanisms and refine intervention strategies
BARRIERS AND FACILITATORS TO DIVERSITY IN SPEECH-LANGUAGE PATHOLOGY
No full textThe field of speech-language pathology (SLP) plays a critical role in diagnosing and treating communication disorders; however, it remains predominantly monolingual and monocultural despite serving an increasingly diverse U.S. population. With 90.3% of certified SLPs identifying as White (ASHA, 2024) and demographic projections indicating that less than half of the U.S. population will be White and non-Hispanic by 2060 (Vespa et al., 2021), the profession faces a pressing need to address disparities in representation, training, and service delivery. This study investigates the academic and professional experiences of minoritized students enrolled in undergraduate and graduate SLP training programs. Through qualitative inquiry, we explore how institutional structures, such as faculty diversity, affinity group support, and curriculum related to cultural and linguistic variation shape students' sense of belonging, access to mentorship, and preparedness to serve culturally and linguistically diverse populations. Findings highlight both structural barriers and key facilitators that influence students' trajectories, including limited exposure to language varieties in coursework, the underrepresentation of multicultural and bilingual clinicians, and the value of identity-affirming spaces. The study underscores the importance of embedding equity and cultural-linguistic responsiveness in clinical education to better align the profession with the needs of the communities it serves. Recommendations include targeted recruitment, curricular reform, and the cultivation of inclusive learning environments informed by student voices. Ultimately, this research contributes to ongoing efforts to diversify the SLP workforce and ensure equitable, high-quality care across language and cultural boundaries
UNIVERSITY OF ARIZONA FASHION WEEK: A CASE STUDY IN FASHION SHOW EVENT PRODUCTION
No full textThis capstone project investigates the planning and execution of The University of Arizona Fashion Week (UAFW) as a case study in event management, creative leadership, and community building within a university setting. Addressing a significant gap in existing scholarship on fashion show and event production, particularly within the context of emerging collegiate fashion communities, this project aimed to develop a comprehensive and practical framework for organizing such events. This research has documented the entire process, from initial conceptualization and logistical planning to the final execution of the fashion show. The final form of this project includes the successful execution of University of Arizona Fashion Week and a detailed handbook serving as a sustainable resource and framework for future Creative Directors of TREND Fashion Events Board, therefore contributing to the establishment and elevation of a prominent and impactful fashion community on the University of Arizona Campus. This research and guidebook may be transferable to additional contexts, including other college campuses and volunteer-based fashion events
GETTING TO THE HEART OF THE MATTER: LDL AND HEART DISEASE IN WOMEN (TEACHING CHILDREN ABOUT HEART HEALTH)
No full textThe cardiovascular system consists of the heart, arteries, veins and capillaries. The heart and blood vessels work together to supply blood flow to every part of the body. Obstruction to the cardiovascular system results in the number one leading cause of death, heart disease. Excessive amounts of cholesterol in the circulatory system is considered one of the major causes of CVD. LDL-C (low density lipoproteins) particles are the lipids responsible for delivering excess cholesterol from the liver to the tissues and arteries. Therefore, high levels of LDL-C poses a major risk in terms of developing heart disease in the future. Although women are diagnosed with heart disease at a later age than men, the burden is much more significant. This is likely due to the fact that after menopause, women no longer experience protection from estrogen. However, data also suggests that post-menopausal women suffer from an increase in LDL-C levels. For that reason, it is reasonable to claim that the additional burden women experience from CVD is not only due to lack of estrogen but is also a result of an increase in their LDL-C levels. This literature review begins with a detailed overview of the cardiovascular system, followed by in-depth analysis of women's LDL trends from adolescence to adulthood. To conclude, I will suggest beneficial lifestyle modifications for women and discuss the importance of adhering to healthy habits throughout adolescence
WHEY OR NO WAY? EXPLORING THE EFFECT OF WHEY PROTEIN ON KIDNEY HEALTH
No full textWhey protein, widely recognized for its superior amino acid profile and high bioavailability, has become a popular dietary supplement among athletes, bodybuilders, and individuals seeking to improve muscle mass and recovery. While its physiological benefits are well documented, concerns have been raised about its potential impact on kidney health, particularly in individuals with preexisting renal conditions. This paper examines the relationship between whey protein consumption and kidney function by exploring physiological mechanisms related to protein metabolism, renal workload, and biomarker
changes. A narrative review of the literature, including animal and human studies, was performed to assess the effects of high-protein intake on kidney markers, such as glomerular filtration rate, urinary calcium excretion, and proteinuria. Findings suggest that while high protein diets may transiently increase renal workload in healthy individuals, there is limited evidence linking whey protein intake to long-term kidney damage. In contrast, individuals
with chronic kidney disease may be more vulnerable to adverse effects, even with moderate increases in protein intake. Overall, whey protein appears to be safe for healthy individuals when consumed in moderation and, under certain conditions, may offer indirect renal benefits