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A discourse analysis of media representation of women political leaders in Uganda
Get PDFThis study is a qualitative desktop research project. The study employed a Feminist Critical Discourse Analysis to analyse and unpack the discursive ways in which female politicians are discussed and talked about in Ugandan online media. This study was a response to the realisation that online media portrayals of female politicians in Uganda remain largely unexplored. Additionally, the study discovered that the Daily Monitor and The Observer, the two newspapers that this thesis researched, often employ gender stereotypes and sexist coverage of female politicians in Uganda using personalisation, trivialisation and demonisation frames. The study illustrates that these misogynistic frames are intended to diminish women’s importance in the political sphere. Moreover, women who do not conform to the gender stereotypes are portrayed as social deviants. This work concludes that one of the challenges faced by women politicians in Uganda, and in Africa as a whole, is how to exploit online media’s productive capacity while, at the same time, resisting its use as an instrument that undermines them. Given the limited scope of the study using only two media organisations, future studies on media representation of female politicians could expand the range to include print and visual sources to provide generalisable results.Thesis (MA) -- Faculty of Humanities, Political and International Studies, 202
Enforced sojourn: Zimbabwean dispensation, special and exemption permits
Get PDFThis thesis investigates Zimbabwean’s immigration to South Africa. Zimbabwean’s immigration to South Africa dates back to the early 2000s. This thesis uses a combination of theories to interrogate and discuss the Zimbabwe special permits and some of the post-apartheid government’s amendments to the South African Citizenship Act and other immigration policies. Some of the theories that theoretically underpin this research project’s methodology include Marxism, Pan-Africanism, Liberalism and culture-based theories. This thesis interrogates the discursive strategies these permits draw on to frame and understand Zimbabwean immigrants in South Africa. This study has found that these permits use similar operating logic as the White South African governments used the migrant labour system to exploit Blacks from all of Southern Africa in the 20th century. For instance, the migrant labour system used during apartheid made all Blacks in South Africa “guest workers” who could be deported at the government’s whim. The apartheid government used racist pass laws to regulate the movement of Black people in South Africa, whereas the post-apartheid government uses Zimbabwean special permits to regulate the movement of Zimbabweans in South Africa. The pass laws were fundamentally racist, and their ultimate objective was to reinforce the idea of White citizenship, whereas the Zimbabwe special permits are not racist. Their colonial similarity, however, lies in how they make Zimbabwean migrants perpetual migrants in South Africa and the various ways in which they cast Zimbabweans as not deserving of South African citizenship. These special permits force Zimbabwe migrants to become “guest workers” who build the post-apartheid economy and then return home when they are no longer “useful” to the economy. This thesis concludes that the post-apartheid Zimbabwe special permits achieve analogous objectives.Thesis (MA) -- Faculty of Humanities, Political and International Studies, 202
Investigating thermoregulatory responses of rhabdomys pumilio at high wet-bulb temperatures
Get PDFAs the Anthropocene continues to be characterised by ever rising temperature highs, increasingly sporadic and extreme climatic events, and their accompanying mass mortality events, climate scientists now warn that the continued climate destabilisation may for the first time in recorded history prevent terrestrial homeothermic endotherms from being able to thermoregulate. Having evolved to maintain body temperatures (Tbs) well above their ambient (Ta) conditions, these endotherms have evolved a suite of adaptations to a colder environment to allow for homeothermic thermoregulation to occur. However, by the same vein, having evolved in a colder climate to stay warm also has led to a reduced capacity to prevent heat stress when temperature conditions are elevated. In absence of behavioural counter measures, the only physiological means available to thermoregulation to prevent such heat stress is that of evaporative water loss (EWL). If still inefficient, the endotherm will risk becoming hyperthermic. Literature has established that excessive heat exposure or reduced evaporative cooling capacities strain or retard thermoregulatory processes. If an endotherm experiences severe heat exposure, the rate at which passive heating is experienced will increase. Should an endotherm be in a humid environment, evaporative cooling efficiency is reduced. As a result, these two abiotic factors are therefore known to contribute towards heat storage, and therefore thermal stress. However, should both factors occur in the same environment, the heat stress effects are compounded, creating an environment dangerous for thermoregulating endotherms. For this reason, authors have emphasised that future wet-bulb (Tw) conditions may pose a penultimate threat to thermoregulating endotherms. Being a measure of coldest temperature attainable as a result of evaporative cooling, Tw has been proposed to represent a lower temperature thermal limit to endothermic thermoregulation. Once reaching a 2°C differential below an endotherms Tb (Tb – Tw = 2˚C), Tw is believed to impede the evaporative cooling process and, consequentially, commit endotherms to becoming hyperthermic. Considering that most mammals defend constant Tbs within the range of predicted Tw maxima increases that future Tw conditions may pose a significant threat to mammalian thermoregulation. However, to date, despite being well supported in the literature, ii empirical investigations into how extreme Tw conditions will affect endothermic thermoregulation are scant. Therefore, understanding of the proposed inhibitory nature of extreme Tw conditions is lacking. Considering that such conditions are to have a profound effect of endothermic survival, this dearth in understanding could prove fatal. As such, this thesis sought to provide evidence on how extreme Tw conditions may affect thermoregulatory processes in homeothermic endotherms.Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 202
Learning to make a difference: Small-scale women farmers in social learning spaces for climate action
Get PDFHow do women farmers in Africa learn about climate change? What is quality climate change learning for farmers? How do farmers interface new knowledge with their long-held and trusted traditional knowledge? How do we evaluate learning at farm level and beyond? Using Okoli’s theory mining review, I untangled a tripartite knot of social learning literature to find Social Learning Theory (SLT) suitable for a study to explore my practical and scholarly curiosity as reflected in the above questions. Wenger’s theory of Social Learning emerged as the most appropriate for my research. The second phase of my study explored the climate change learning and practice terrain for small-scale women farmers, analysing the connection between learning, practice, and the resultant value in two case study areas, municipalities in the Amathole District of the Eastern Cape Province of South Africa. In addition to a paper on SLT mining review that unravels and chooses between the strands of social learning, the two case studies resulted in three articles that responded to the study’s objectives and the research questions. The thesis is introduced and synthesised through five 'book-end' chapters, as well as through these four articles. What were my findings? In the first case study, in the drought-stricken Raymond Mhlaba Municipality, I gathered the data through individual semi-structured interviews with farmers, extension officers and representatives of the involved organisations. I also conducted a group interview with farmers and analysed documents to supplement interview data. I analysed the data using concepts of Communities of Practice (CoP) and SLT to map out the learning and practice landscape. I discovered a constellation of CoPs interconnected by the shared drive for adaptive water management. The constellation is made up of tertiary institutions, government departments, non-governmental organisations and farmers of varying experiences and competencies, with women emerging as the more proactive gender, and state-led extension services being willing but overstretched and under-resourced. SLT effectively traced the apparent fragmented learning within and outside the CoPs and the sudden and extensive shifts in the CoP boundaries, especially in the context of COVID-19 pandemic lockdowns and the increased adoption of digital learning platforms. Despite the richness and diversity brought by the emergent new learning networks that involve participants in the province and further afield, the adoption of digital learning platforms worsened the existing generational digital divide among farmers. iii In the second case study, in the water scarce Buffalo City Metropolitan Municipality, I adopted the Value Creation Framework (VCF) to conduct an ethnographic evaluation that used semi-structured interviews, participant observation and document analysis of the learning experiences of women farmers in a social movement on agroecology. I found that the farmer-centred learning approach of the movement has created value for the farmers involved, evidenced by the adoption of agroecology by over 2700 members (including new urban farmers who are occupying open spaces typically used as dumpsites). The learning approach has facilitated expansive learning, enhanced resource mobilisation, new collaborations, partnerships, and seed sharing networks. Additionally, it necessitated context-appropriate and transformative changes to intersectional justice issues associated with historical inequalities in access to land and water and gender discrimination, leading to improved practices, new access to markets and improved quality yields. These are examples of immediate, potential, applied, realised, orienting, enabling and transformative as well as strategic value, as defined by the VCF. In reflecting on how women farmers learn in these social learning spaces I elucidate the learning impact pathways and local contextual influences in shifting CoP boundaries, domains, and practices during the climate crisis as it intersects with other compounding factors. I generated insights that could be useful for stakeholders in the agricultural (extension) sector to build better pathways for emancipatory and empowering expansive social learning in contexts characterised by resource constraints, but also by strong women-led agency. Such learning could make a difference and cushion small-scale farming from collapse especially in times of unprecedented changes. The agroecology movement and associated communities of practice explored in this study create transformative social learning spaces that are able to respond to climate change, and hence a model that state-led extension might want to adopt in other resource-constrained contexts.Thesis (PhD) -- Faculty of Education, Education, 202
Factors affecting pinniped skull morphology
Get PDFMorphologies have evolved due to trade-offs between competing selective pressures. This is especially true for the skull. Not only does it contain the brain and the organs that are responsible for sensory function, but it is also contains components that play important roles in feeding, breathing, balance, defence, aggression and communication. The pinnipeds, a group of species that has evolved from terrestrial origins and became adapted to the marine environment, are under numerous selective pressures within the marine environment. These species have had to evolve in order to capture and process food underwater, and to dive. In addition, they are also characterised by substantial sexual size dimorphism in some species. Pinnipeds also make use of numerous marine and haul-out habitats with varying characteristics and complexity. Hybridisation has been recorded among pinnipeds, resulting in the production of hybrid offspring with characteristics that are different to their parent species. The aim of the study was to investigate the effect of these life history characteristics on skull and mandible morphology of pinniped species using three dimensional geometric morphometrics. To achieve this, 43 skull and 15 mandible 3D landmarks were collected using a Microscribe G2X digitizer with 0.2mm accuracy, on the skull and mandibles of 17 species of pinnipeds across three families, and one hybrid species. In total, 96 specimens across these species were examined. Data on the different life history characteristics of each species were collected from the literature. These data were plotted onto the PCA results in order to create and visually compare minimum convex polygons for each life history category. The results found that phylogeny, feeding strategy and sexual dimorphism were the most important factors in explaining differences in pinniped skull and mandible shape and size. may have resulted in these changes. Similarly, the inclusion of more species, covering a broader range of life histories may be beneficial.Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 202
With dreams in our hands: Towards transgressive knowledge-making cultures
Get PDFKnowledge-making in universities is not neutral and takes different forms. This thesis critically examines the politics of knowledge to propose and present a transgressive schema for knowledge-making that is co-created with students. It emerges from teaching and learning encounters in the Humanities Extended Studies (ES) Programme at Rhodes University, where for the past decade we have experimented with different ways of knowledge-making that run counter to conventional pedagogic practices. We set up a project for the thesis that allowed us to work with knowledge in ways that are Afrocentric, and that hold and nurture our dreams. The theory and methodology of the project are explained in the first academic paper for this PhD by publication. The project and its derivatives use an African Feminist framing, and centre the ontoepistemologies of African young people who find themselves alienated and marginalised by a western bias in university curricula. Former ES student volunteers came up with topics, responded to them, reviewed each other’s work, and co-wrote two academic papers that demonstrate a praxis of African Feminist research and pedagogic principles. Two further projects practise the principles that emerge from the primary project, and together they have tested knowledge-making cultures that inspire critical thinking and creative humanity. These are explained in two further academic papers. One is co-written with the copresenter of an online inter-continental short course for PhD students on African Feminist Research Methodology. The other is single authored, and introduces the third project, a Political and International Studies third-year course on African Feminist theory. The schema for knowledge-making uses the hand, which holds our dream, as a descriptive metaphor. Each of the five fingers of the hand represents an aspect of how we have collaborated on the projects and in lecture rooms, and what this has taught us about how to nurture and inspire the dreams of young African people through transgressive knowledgemaking cultures. The five aspects – framing, activating, seeing, creating, imagining – are mutually constitutive elements of knowledge-making that are introduced throughout the thesis, and explained in careful detail in the conclusion as a synthesis of the collaborations.Siphethe amaphupha ezandleni zethu: ukwenza iinckubeko zolwazi ezigxile ekuphazamiseni isiqhelo Isishwankathelo Ukwenziwa kolwazi kwiiunivesithi asiyonto engathathi cala kwaye yenzeka ngeendlelangeendlela. Le thisisi iphonononga ipolitiki yolwazi ngenjongo yokucebisa nokuvelisa iindlela zokwenziwa kolwazi ezigxile ekuphazamiseni kwesiqhelo, ndlela leyo eyenziwa ngentsebenziswano nabafundi. Le Ndlela yokuphazamisa isiqhelo ivela kwindlela zokufunda nokufundisa kwinkqubo yeExtended Studies kwiUnivesithi iRhodes, apho kwiminyaka elishumi edlulileyo besisebenzisa amalinge ohlukileyo okwenza ulwazi ohlukileyo kwindlela zokufunda eziqhelekileyo. Siqulunqe inkqubo yale thisisi evumele ukuba sisebenze nolwazi ngendlela ekhokhelelisa ubuAfrika phambile, nkqubo leyo eyondla nebamba amaphupha ethu. Inkcazo-bungcali neendlela zokwenza uphando lwalo msebenzi zicacisiwe kwiphepha lokuqala lethisisi yePhD ezakupapashwa. Lo msebenzi neminye imisebenzi efana nawo isebenzisa iAfrikan Feminism ngenjongo yokubeka ngokusesikweni ndlela le ingxile kwindlela yokufundisa neengcambu zayo ezizinze eAfrika, kwaye ikhokhelisa imfundo yabantu abatsha abazifumana besenziwe amakheswa nabahlelelekileyo kunyenjwa kwasentshona kwizifundo zaseunivesithi. Abafundi ababefunda kwiES baze nezihloko, yangabo abaziphendulayo, bahlola imisebenzi yoogxa babo, kwaye bancedisa ekubhaleni amaphepha amabini abonakalisa indlela yokuphanda kusetyenziswa iziseko zokufunda zeAfrikan Feminism. Eminye imisebenzi isebenzise iziseko eziphuma kulo msebenzi wokuqala, kwaye yomibini le misebenzi iphonononga iinkcubeko zokwenza ulwazi ezikhuthaza ukuzikisa ukucinga nobuntu obunobuchule. Oku kucaciswa nzulu kumaphepha amabini. Omnye ubhalwe nomfundi kunye nombhali obefundisa kwikhosi emfutshane ebikwi-intanethi ephakathi kwamazwekazi eyenzelwe abafundi be- PhD kwiAfrican Feminist Research Methodology. Omnye umsebenzi ubhalwe ngumntu omnye, nothi wazise umsebenzi wesithathu, ikhosi yonyaka wesithathu yePolitical and International Studies yenkcazo-bungcali iAfrican Feminism. Icebo lokwenza ulwazi lisebenzisa isandla esibambe amaphupha ethu, njengesafobe esinika inkcazelo. Umnwe ngamnye umele indlela esisebenzisene ngayo kule misebenzi nakumagumbi okufundela, kunye nesikufundileyo ngokukhulisa nokukhuthaza amaphupha wabantu abasebatsha baseAfrika ngokusebenzisa imisebenzi egxile kwiinkcubeko zolwazi eziphazamisa ukwenziwa kolwazi ngendlela eqhelekileyo. Imiba emihlanu- ukwenza isakhelo, ukuqalisa, ukubona, ukudala, ukusebenzisa imifanekiso ntelekelelo- iyingqokelela yenxalenye yokwenza ulwazi ngendlela enentsebenziswano kwaye ezi ziseko zaziswa banzi kwithisisi, kwaye zicaciswe gabalala kwisishwankathelo njengengqokelela yentsebenziswano kulo msebenzi.Thesis (PhD) -- Faculty of Education, Education, 202
Use of flow reactors for an improved synthesis of Tenofovir derivatives
Get PDFTenofovir disoproxil fumarate (TDF) is a prescription drug used to treat and prevent human immunodeficiency virus (HIV) infections. It aids in the reduction of HIV in the body, allowing the immune system to function more effectively. This reduces the risk of HIV complications, such as infections, whilst improving the quality of life. TDF belongs to the nucleotide reverse transcriptase inhibitors category of drugs. These drugs limit the ability of the reverse transcriptase, an enzyme essential for each virus to replicate itself. A reduction in the cost of HIV treatment could improve supply security and make it more accessible to patients in need. Thus, this project aims to use flow technology to achieve a guaranteed supply chain and access. In this thesis, a method for the synthesis of TDF was developed using microreactors starting from the readily available adenine. The method was adapted from the traditional batch synthesis as currently there is no literature on the synthesis of TDF in flow chemistry. The batch methods used for the synthesis of the working standards were successfully translated to flow systems. For the best results to be obtained, optimisation of the reaction temperature, reagent molar equivalents and concentration was critical. From the optimisation studies, an improvement in conversion is evident throughout all stages. The flow synthesis of the first intermediate resulted in a conversion of 100 % in N,N-dimethylformamide in 6 min residence time. This study was conducted at 200 °C, which is higher than the boiling point of the solvent with the aid of a back pressure regulator. A key reagent in the synthesis of tenofovir, namely ((tosyloxy)methyl)phosphonic acid, had to be synthesised and it was successfully produced in 96 % yield. The second intermediate was synthesised through a successful coupling reaction between (R)-9-(2-hydroxypropyl)adenine and ((tosyloxy)methyl)- phosphonic acid, which afforded a 100 % conversion of tenofovir in 20 min total residence time. The multistep synthesis of tenofovir was a success as it afforded a 65 % overall conversion. The prodrug TDF was successfully synthesised at 120 °C with a 30 min residence time, yielding a conversion of 100 %. ii | P a g e This thesis consists of four chapters. Chapter one describes the background on HIV and a literature review on HIV drugs. This chapter also demonstrates flow chemistry and microreactors in detail and different routes for the synthesis of TDF in traditional batch methods. Chapter two provides a detailed methodology for batch synthesis and flow synthesis with analytical data. 1H-NMR, 13C-NMR and FTIR spectroscopy was used to evaluate all the compounds synthesised in this chapter. Chapter three thoroughly discusses the results that were obtained graphically, showing that the flow synthesis gives better yields than batch synthesis. In chapter 4, the conclusion of the whole investigation is stated along with the future work for the preparation of TDF.Thesis (PhD) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 202
An evaluation of the legislative framework for public infrastructure investment to reduce unemployment in South Africa
Get PDFThis study evaluated South Africa’s legislative framework for public infrastructure investment to determine its effectiveness in reducing unemployment. The study is primarily driven by South Africa’s persistent challenge of unemployment with Statistics South Africa estimating the unemployment rate at 35.5 per cent or 7.9 million labourers. Persistently high levels of unemployment harm the socio-economy as unemployment increases poverty and contributes to inequality. For the government an increase in expenditure on social relief programmes, while offering some relief, decreases revenue collection. In order to mitigate this imbalance, the South African government identified public infrastructure investment as a stimulus for economic growth and create employment, such as in the Expanded Public Works Programme initiative. The legislative framework is an important aspect of study as policy is legitimised and implemented through the legislative framework. Previous studies have focused on the effect of fiscal policy on economic growth and employment creation. These studies have also used quantitative data analysis to explain the relationship between fiscal policy, economic growth, and unemployment. Other studies have focused on public policy planning and implementation, and some of the policies that have been implemented to address unemployment. This study focused on public infrastructure investments specifically rather than fiscal policy in general. The study also examined the legislative framework to determine whether it is effective in reducing unemployment through public infrastructure investment. The study made used qualitative data analysis as the researcher undertook a document analysis of publicly available documents which were sampled using a purposive sampling technique and analysed using the thematic analysis method. The findings of the study were that the legislative framework supported employment creation through public infrastructure investment through the establishment of a public institution to support the construction industry, the use of local content as inputs and labour-intensive technologies in the infrastructure delivery process. The legislative framework was not effective in supporting the policy, which is demonstrated by the perpetually high unemployment rate despite unemployment alleviating initiatives being implemented in the early and mid-2000sThesis (MSc) -- Faculty of business and economic sciences, 202
Quinolone-Pyrazinamide Derivatives: synthesis, characterisation, in silico ADME analysis and in vitro biological evaluation against Mycobacterium tuberculosis
Get PDFTuberculosis is one of the leading causes of death worldwide caused by an infectious species, Mycobacterium tuberculosis (Mtb). Some of the factors that contribute to the prevalence of this disease include the complexity of diagnosis, prolonged period of therapy, side effects associated with current TB drugs, the prevalence of resistance against the current treatment options and a high incidence of co-infection with HIV/AIDS. Thus, there is a need for new alternative drugs to provide safer and shorter treatment therapy options that are not susceptible to the development of drug resistance. In this project, we focus our attention on the quinolone pharmacophore. Quinolones are currently used as alternative options in the treatment of resistant strains of Mtb. Previous work pertaining to quinolone-isoniazid hybrid compounds showed promising in vitro activity against the H37Rv strain of Mtb and served as the inspiration to pursue this project. The journey commenced with the synthesis of quinolone-pyrazinamide hybrid compounds (Figure 3.1). These compounds were synthesised, through the attachment of the quinolone and the pyrazinamide entity through a hydrazine linker. The synthesised compounds were purified, and their structural identity confirmed using common spectroscopic techniques including 1H and 13C NMR, infra-red (IR) and mass spectrometry. In vitro biological assays were performed by testing for the activity against the H37RvMA strain of Mtb. The bioassays were performed in triplicates to ensure the accuracy of the results. Moxifloxacin and isoniazid were tested as control compounds. Finally, the resultant compounds were profiled in silico for physicochemical and ADMET properties using open access software SwissADME. All the synthesised compounds 3.8a-f showed no activity against H37RvMA. In most cases, the resulting compounds showed minimal to no activity (MICs ≥ 57.3 μM) in all three media. During the in vitro studies, the compounds showed significant precipitation in the media over time suggesting poor aqueous solubility. The SwissADME analysis of these compounds indicated poor solubility in aqueous media, which is likely linked to their molecular size and complexity. Despite poor aqueous solubility, compounds 3.8a-f showed acceptable physicochemical properties and ADME parameters. No PAINs (Pan-assay interference compounds) were observed. Minimal to no interaction with CYP enzymes were predicted. Most of the compounds were compatible with the Lipinski’s rules of five.Thesis (MSc) -- Faculty of Science, Pharmacy, 202
Local peoples’ knowledge and perceptions of Australian wattle (Acacia) species invasion, ecosystem services and disservices in grassland landscapes, South Africa
Get PDFMany alien tree species were introduced into grassland ecosystems in South Africa by the commercial forestry industry for paper and timber for furniture. Over decades some of these introduced species escaped into neighbouring farms and community land. Adult trees from these alien species now provide other ecosystem services, notably fuelwood. Depending on the spatio-temporal context, many of these species can also negatively affect ecosystem services. We collected interview data from commercial and communal farmers in the upper Umzimvubu catchment in South Africa to compare farmers’ knowledge and perceptions of invasive wattle species invasion and their associated ecosystem services and disservices. Fuelwood and fencing poles were the most common uses of wattle by commercial (83%; 67%) and communal (99%; 49%) farmers. On the other hand, the reduction of grass cover and loss of grazing land were the most commonly mentioned negative impacts of wattles by commercial (83%; 75%) and communal (92%; 80%) farmers. Although both groups recognise the importance of wattles in providing ecosystem services, most communal farmers perceived wattles to have more negative effects than benefits. The findings demonstrate that both farmer groups highly depend on ecosystem services and are affected by disservices of wattles. However, while large-scale commercial households favour the presence of wattles in the landscape, communal households prefer complete removal of the wattles from the landscape. This may be due to lack of locally available alternative options or inability to replace or purchase ecosystem services affected by wattles from other sources or markets like commercial farmers