8598 research outputs found
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Dr. J.E. Walmsley
No full textDr. James Elliott Walmsley.https://digitalcommons.longwood.edu/elizabethwagner/1003/thumbnail.jp
Unidentified group of men and women
No full textUnidentified group of men and women, circa early 1900s.https://digitalcommons.longwood.edu/ruthgaver/1008/thumbnail.jp
Swiss Family Ruffner
No full textA History of the descendants of Peter and Mary Steinman Ruffner From their 18th Century Origin in Maienfeld, Switzerland to the Family Presence throughout the United States in the 21st Century.
Interview with Columban Ruffne
Designing Single Molecule Diode
Get PDFThe field of single molecule electronics is based on using single molecule devices to control current in electronic circuits. One area of interest is to reproduce the functionality of traditional components such as wires, switches, and diodes using single molecule junctions. We used computational chemistry to design diodes to investigate what molecular features affect their performance including using different donors, acceptors, and connectors. A comparison of the diode\u27s performance was made by comparing the rectification ratio. About 50 diodes were designed and tested, with rectification ratios ranging from 1.0 to 5.8. The results indicate that multiple factors have a significant impact on the behavior and performance of the diodes. Further research is needed to understand the correlation between donor and acceptor and the rectification ratio. Future work should also investigate the electrode material in order to understand what factors have the greatest influence on diode performance
Understanding overlapping segments for State Park visitors
No full textMarket segmentation remains one of the most important approaches used in tourism to provide crucial information regarding visitors’ profiles. Considering the importance of State and National parks to the tourism industry, there is an increasing interest in examining the motivations of park visitors. Drawing on the push-and-pull theoretical framework, this study employs a canonical correlation analysis and an overlapping segmentation approach to generate market segments of visitors to a State Park system in the United States. A total of 2822 past and current visitors were surveyed and consequently assigned to three overlapping market segments based on the results of canonical correlation analysis. The segments were labeled as “Connecting with Nature”, “Active Recreation”, and “Family Bonding”. Specifically, the “Family Bonding” market segment was found to have the most overlap with the other two groups. On the other hand, the segment of “Active Recreation” had the least overlap, suggesting that the members of this segment are uniquely defined and display a high degree of homogeneity. Additionally, 75 visitors were found to overlap across all three segments. Such findings suggest that this group of respondents score positively on all motivation items and share the same preferences of State Park systems’ attributes. Thus, park managers should refrain from assigning tourists to fit just one segment and target the potential visitors considering the substantial overlapping between groups. The study findings have important practical implications for State Park system managers and provide critical insights to inform future marketing strategies and to improve parks’ offerings
Costimulatory Domains Alter the Efficacy and Safety of Chimeric Antigen Receptor-expression Gamma Delta T cells
Get PDFEngineering T cells with a chimeric antigen receptor (CAR) recognizing proteins specifically expressed on tumor cells is a new cancer therapy. While CAR T cells can successfully treat hematopoietic malignancies, CAR T cells have not shown success in treating solid tumors. In addition, one side effect observed after CAR T cell infusion is Cytokine Release Syndrome (CRS) which causes damaging inflammation. There are many factors that may enhance CAR T cell efficacy and safety for solid tumor treatment, including costimulatory domains to increase T cell functions and switching T cell type from alpha beta to gamma delta T cells. We developed a novel CAR (chimeric PD-1, chPD1) that targets the programmed death 1 receptor (PD-1) ligands expressed on many types of solid tumors. The aim of this study was to compare anti-tumor efficacy and CRS induction between chPD1-expressing gamma delta and alpha beta T cells in murine breast cancer models. Inclusion of different costimulatory domains, CD28, 4-1BB, and Dap-10, in the chPD1 receptor was also compared. There were no differences in T cell viability and proliferation when comparing costimulatory domains or T cell type. Additionally, there were no significant differences in killing of murine 4T-1 and E077 breast cancer cells. ChPD1-CD28 T cells had increased secretion of proinflammatory and CRS-inducing cytokines and chemokines, including IFN-gamma, IL-2, and nitric oxide, compared to chPD1-41BB and chPD1-Dap10 receptors. Overall, alpha beta chPD1 T cells also had increased cytokine secretion compared to chPD1 gamma delta T cells. Therefore, inclusion of 4-1BB or Dap10 domains in gamma delta T cells may be a safer and more efficacious option for CAR T cell therapy of solid tumors
Constance Rumbough Scrapbook, page 1
No full textConstance Rumbough Scrapbook, 1912-1914, page 1.https://digitalcommons.longwood.edu/constancerumbough/1000/thumbnail.jp