Higher Institute on Territorial Systems for Innovation
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Il mare d'inverno, e poi anche d'estate. Nizza Marittima, città di villeggiatura nell'età della Restaurazione sabauda (1815-60)
No full textPrima di diventare la capitale della Côte d'Azur, vale a dire la città simbolo della villeggiatura sulle rive del Mediterraneo negli anni della belle époque, nella prima metà dell'Ottocento Nizza è una città già in febbrile trasformazione grazie non soltanto ai favori di cui gode da parte turisti stranieri, inglesi in particolare, oltre che dei Re Carlo Felice e Carlo Alberto, ma anche grazie alla posizione di minor rilievo che il proprio porto assume, all'indomani dell'annessione di Genova al Regno di Sardegna. Temendo di perdere importanza, e dunque risorse, le élite locali avviano la costruzione di nuove strutture e infrastrutture per gli hivernants secondo i principi stabiliti dal nuovo Consiglio di Ornato, incaricato di guidare la trasformazione
Preparation of keratin-based microcapsules for encapsulation of hydrophilic molecules
No full textThe interest towards microcapsules based on non-toxic, biodegradable and biocompatible polymers, such as proteins, is increasing considerably. In this work, microcapsules were prepared using water soluble keratin, known as keratoses, with the aim of encapsulating hydrophilic molecules. Keratoses were obtained via oxidizing extraction of pristine wool, previously degreased by Soxhlet. In order to better understand the shell part of microcapsules, pristine wool and obtained keratoses were investigated by FT-IR, gel-electrophoresis and HPLC. Production of the microcapsules was carried out by a sonication method. Thermal properties of microcapsules were investigated by DSC. Microencapsulation and dye encapsulation yields were obtained by UV-spectroscopy. Morphological structure of microcapsules was studied by light microscopy, SEM, and AFM. The molecular weights of proteins analyzed using gel-electrophoresis resulted in the range of 38-62 kDa. The results confirmed that the hydrophilic dye (Telon Blue) was introduced inside the keratoses shells by sonication and the final microcapsules diameter ranged from 0.5 to 4 µm. Light microscope investigation evidenced the presence of the dye inside the keratoses vesicles, confirming their capability of encapsulating hydrophilic molecules. The microcapsule yield and dye encapsulation yield were found to be 28.87 ± 3% and 83.62 ± 5% respectively
Definizione preliminare del monitoraggio energetico per l'implementazione di un edificio cognitivo. Il Padiglione Mandolesi dell'Università di Cagliari Preliminary definition of an energy monitoring for the implementation of a cognitive building. The "Mandolesi Pavillon" at the University of Cagliari
No full textLa nuova pianificazione tra riforme istituzionali e innovazione urbanistica
No full textNel periodo trascorso dal Rapporto dal Territorio 2010 dell'INU ad oggi, non solo perdurano ma si sono rafforzate le inerzie e le contraddizioni (peraltro già rilevate nel triennio 2007-2010) nel necessario passaggio verso una reale ed efficace innovazione ed una natura maggiormente processuale della pianificazione per il governo del territorio che, pur affermata dalle numerose leggi regionali dell'ultimo quindicennio (spesso più solo formalmente che sostanzialmente), prima è stata molto indebolita dalla persistente e grave assenza di una legge nazionale di principi per il governo del territorio, poi dall'attesa dell' entrata in vigore (considerata pressoché certa) della legge di riforma costituzionale del Governo Renzi che, con l'eliminazione di tutte le materie concorrenti e loro "statalizzazione", colloca anche il "governo del territorio" fra le competenze esclusive dello Stato. La sfida è quella di saper introdurre nella legislazione (quella di Principi fondamentali dello Stato e quella di disciplina e contenuto delle Regioni) relativa alla pianificazione territoriale ed urbanistica, elementi utili a far assumere ai Piani da innovare modalità e comportamenti pianificatori e progettuali, più orientati al processo e meno al prodotto, capaci di cure "antifragili" per la città e il territorio che non possono più essere quelle hard basate sulle grandi trasformazioni urbanistiche (radicali ed una volta per tutte) della fine degli anni 90 e dei primi anni 2000, di prima e seconda generazion
Synthetic biomaterial for regenerative medicine applications
No full textTissue engineering (TE) strategies are aimed at the restoration of tissue architecture and functions by the use of cells in combination with supportive scaffolds. The scaffold should act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent tissue ingrowth. Biomaterials play a critical role in the design of scaffolds and, hence, in the realization of a new functional tissue. A variety of synthetic biomaterials have proved to be useful in the reconstruction of tissues, such as bone, cartilage, and nerve, and some of these are currently used in clinical practice. In this chapter, an overview of the different types of synthetic polymers and their properties and TE applications is reported. They can be nonbiodegradable and biodegradable, and able to produce hydrogel matrices. Special attention has been given to addressing polyurethanes that are available as bioresorbable or biostable biomaterials as well as hydrogels
Investigation of surface functionalization and coatings for biomedical applications by Zeta potential and adsorption measurements on solid surfaces
No full textHip fracture risk prediction through FE analysis: influence of HSA parameters
No full textThis book collects the contributions accepted and presented to the VII National Meeting of the Italian Chapter of the European Society of Biomechanics (ESB-ITA 2017), held in Rome (28-29 September 2017
Efficient High-Fidelity Two-Scale Computational Model for Progressive Failure Analysis of Fiber Reinforced Composites via Refined Beam Models
No full textAn efficient high-fidelity two-scale computational model for progressive failure analysis of fiber reinforced composite is presented. The computational model is based on a class of refined beam finite elements called Carrera Unified Formulation (CUF), a generalized hierarchical formulations which yields refined structural theory via variable kinematic description. The two-scale framework consists of a macro-scale model to describe the structural level components (e.g: open-hole specimens, coupons) and a sub-scale micro-structural model encompassed with a representative volume element (RVE). The RVE is modeled with real composite constitutents, e.g., fiber and matrix with details about packing and heterogeneity. Various classes of RVE architecture is taken into account by randomly embedding multiple fibers in the constituent matrix. Component-Wise approach (CW), an extension of CUF beam model based on Lagrange-type polynomials, is used to model the constituents in the RVE. CW model enables one to use a detailed physical desciption of RVE by placing the problem unknowns on it's physical surface. The two scales are interfaced through the exchange of strain, stress and stiffness tensors at every integration point in the macro-scale model. The energy based crack band theory (CBT) is implemented within the sub-scale model to predict the progressive damage growth in the individual constituents. Mesh objective results are obtained by scaling the post-peak softening slope of stress-strain constitutive relationship. The ability of CUF beam models to obtain accurate 3D-like stress fields at a reduced computational cost(approximately one order of magnitude of degrees of freedom less as compared to standard 3D brick elements) leads to a computationally efficient framework. Numerical predictions includes failure parameters such as stress-strain response,damage contours and ultimate strength and are validated against experimental results
Numerical Analysis of a Potential Debris Flow Event on the Irazú Volcano, Costa Rica
No full textThe active Irazú Volcano is the highest of several composite volcanic cones which make up the Cordillera Central in Costa Rica, close to the city of Cartago. The top of the volcano is strategic for the Country, since at the height of over 3400 m sit 84 telecommunication towers used by government agencies and several TV and radio stations, which guarantee the station coverage of more than 60 percent of the national territory. Since December 2014, a series of minor tremors, or microseisms, occurred at the Irazú and some open and deep fissures formed on the upper part of the volcano associated with formation of landslides. More research is needed to determine if these fissures are directly related to recent seismic activity. However, the landslide formation has made it necessary to relocate the towers and there is evidence of the possible destabilization of a volume of about 3.5 million cubic meters of material. In particular, if the landslide triggers in conjunction with heavy rains the movement could evolve into a huge debris flow that could affect Cartago city, similar to the debris flow disaster of December 1963. The dynamics of this potential event have been analyzed using the numerical code RASH3D. The calculated flow intensities and flow paths could be used to support hazard mapping and the design of mitigation measures. The reliability of the obtained results are a function of assumptions regarding source areas, magnitudes of possible debris flows and calibration of rheological characteristics, but also digital terrain model (DTM) quality. As to this last aspect, a systematic comparison of numerical results, DTM and air photos enabled identification of various weak points of the digital terrain model and identified potentially critical zones due to the presence of man-made structures