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Application of chitosan membranes on the neurovascular bundles after robot-assisted radical prostatectomy: Preliminary results of a phase II study
No full textINTRODUCTION & OBJECTIVES: A physical damage can occur to the neurovascular bundles during the procedure, due to the use of cautery and tractions.Nowadays bio-engineeringis developing novel devices with the aim of co-operate the neural renewal. Among them chitosan seems to be promising with neuro-regenerative properties. In our Institution we tried to use chitosan membranes as scaffold for neural renewal after nervesparingrobot- assisted radical prostatectomy (RARP). In laboratory setting results were promising so we designed a prospectivestudytrying to confirmchitosanproperties in clinicalpractice. Primary end-point: to evaluate the feasibility of the application of chitosan membrane on neuro-vascular bundles after nerve-sparing RARP. Secondary end-point: To evaluate the recovery of erectile function at 1, 2, and 3 months postoperatively by performing a matched-pair analysis comparing the group of patients who underwent chitosan application to a control group who did not. MATERIAL & METHODS: 47patients who underwent nerve sparingRARP (07/2015 - 01/2016) were enrolled. Criteria for inclusion was an IIEF>17. A control group of patients was selected. Potency recovery was defined as erection enough for intercourse or masturbation. Membranes were adequately prepared by immersion in saline solution and cutting. After that reconstructive phase of RARP was performed, chitosan membranes were introduced and applied on the bundles. RESULTS: Baseline data of patients in the Groups were comparable.Concerning intraoperative data, no modifications of operative time was recorded in the Chitosan Group;No intraoperative complications occurred. Postoperative complications rate was not affected by the application of the membrane. Concerning the functional data, a faster erectile function recovery was recorded in the cohort of patients who underwent chitosan application. CONCLUSIONS: In our experience, the application of chitosan membranes on the neurovascular bundles after robot-assisted RP was easy and safe. Preliminary functional outcomes showed a faster recovery of erectile function in the cohort of patients who underwent the application of the membranes.Larger sample size and randomized trials are needed in order to confirm these preliminary outcomes
Architettura e Montagna, Arte e Montagna
No full textPresentazione dei lavori del Politecnico di Torino e dell''Ecole Nationale Supérieure d'Architecture de Grenoble e inaugurazione delle sette mostre su "Montagna e Architettura" e "Arte e Montagna" in un convegno con la partecipazione dell' ENSAG (Jacques Francois Lyon-Caen, Felix Faure, Barbara Martino) e del Politecnico di Torino (Daniele Regis), della "Banca del Fare" , degli artisti Paolo Albertelli e Mariagrazia Abbaldo ( Studio C&C) Corrado Ambrogio e Claudia Ciardi, nell'ambito delle manifestazioni promosse dalla Fondazione Nuto Revelli e La Rete del Ritorno su "Una scuola di memoria Attiva, per le comunità che riabitano la montagna " .Con Fondazione Nuto Revelli, Rete del Ritorno, e la collaborazione Simbidea, Rete dei piccoli paesi, Kosmoki, Forte di Vinadio nell'ambito di Nuovi Mondi Festival, e il patrocinio di Unione Montana Valle Stura e Comune di Rittana .Coordinamento scientifico Mostra Architettura e Montagna: Daniele Regis ( Politecnico di Torino) e Corrado Colombo coordinamento scientifico Mostra Arte e Montagna: Daniele Regis (Politecnico di Torino
Results from CHIPIX-FE0, a Small Scale Prototype of a New Generation Pixel Readout ASIC in 65nm CMOS for HL-LHC
No full textCHIPIX65-FE0 is a readout ASIC in CMOS 65nm designed by the CHIPIX65 project for a pixel detector at the HL-LHC, consisting of a matrix of 64x64 pixels of dimension 50x50 μm2. It is fully functional, can work at low thresholds down to 250e− and satisfies all the specifications. Results confirm low-noise, fast performance of both the synchronous and asynchronous front-end in a complex digital chip. CHIPIX65-FE0 has been irradiated up to 600 Mrad and is only marginally affected on analog performance. Further irradiation to 1 Grad will be performed. Bump bonding to silicon sensors is now on going and detailed measurements will be presented. The HL-LHC accelerator will constitute a new frontier for particle physics after year 2024. One major experimental challenge resides in the inner tracking detectors, measuring particle position: here the dimension of the sensitive area (pixel) has to be scaled down with respect to LHC detectors. This paper describes the results obtained by CHIPIX65-FE0, a readout ASIC in CMOS 65nm designed by the CHIPIX65 project as small-scale demonstrator for a pixel detector at the HL-LHC. It consists of a matrix of 64x64 pixels of dimension 50x50 um2 pixels and contains several pieces that are included in RD53A, a large scale ASIC designed by the RD53 Collaboration: two out of three front-ends (a synchronous and an asynchronous architecture); several building blocks; a (4x4) pixel region digital architecture with central local buffer storage, complying with a 3 GHz/cm2 hit rate and a 1 MHz trigger rate maintaining a very high efficiency (above 99%). The chip is 100% functional, either running in triggered or trigger-less mode. All building-blocks (DAC, ADC, Band Gap, SER, sLVS-TX/RX) and very front ends are working as expected. Analog performance shows a remarkably low ENC of 90e-, a fast-rise time below 25ns and low-power consumption (about 4μA/pixel) in both synchronous and asynchronous front-ends; a very linear behavior of CSA and discriminator. No significant cross talk from digital electronics has been measured, achieving a low threshold of 250e-. Signal digitization is obtained with a 5b-Time over Threshold technique and is shown to be fairly linear, working well either at 80 MHz or with higher frequencies of 300 MHz obtained with a tunable local oscillator. Irradiation results up to 600 Mrad at low temperature (-20°C) show that the chip is still fully functional and analog performance is only marginally degraded. Further irradiation will be performed up to 1 Grad either at low or room temperature, to further understand the level of radiation hardness of CHIPIX65-FE0. We are now in the process of bump bonding CHIPIX65-FE0 to 3D and possibly planar silicon sensors during spring. Detailed results will be presented in the conference paper
A Vortex-In-Cell Method for the Simulation of Viscous Flows
No full textA numerical technique of solving incompressible, vortex-dominated flows is described. The Navier-Stokes equations in velocity-vorticity formulation are integrated by a fractional step algorithm which treats convective motions and diffusive phenomena separately. Convection of vorticity is treated in a Lagrangian fashion, whereas the vorticity diffusion is computed on a grid by finite differences. The two problems are solved and combined at each time-step. The technique is as simple and robust as classical finite difference methods. Although being a bit more dissipative, it still preserves the spectral accuracy of fully Lagrangian vortex methods. The numerical procedure is validated against theoretical, experimental and numerical data from literature
SITI DEL PATRIMONIO COSTRUITO CULTURALE: RILIEVI E TECNICHE DI VALUTAZIONE SPEDITIVA DELLA VULNERABILITÀ SISMICA ALLA SCALA DELL'AGGREGATO EDILIZIO ED URBANO. ANALISI GEOMETRICO DEDUTTIVE. IL CASO DI STUDIO DEGLI EDIFICI PORTICATI DI PIAZZA SANTAROSA A SAVIGLIANO
No full textLocation of parking lots for plug-in electric vehicles considering traffic model and market participation
No full textThis paper addresses the location of parking lots (PLs) to be used for plug-in electric vehicles (PEVs) by using a probabilistic traffic model and taking into account the PL participation in electricity markets. The PLs are used both for grid-to-vehicle and vehicle-to-grid. The system includes private or public charging stations only used for PEV charging. The traffic model considers the partitioning of the territory into areas. The case study is based on traffic and market data referring to Italy
Aggregation of Distributed Energy Resources Under the Concept of Multienergy Players in Local Energy Systems
No full textIn recent years, in addition to the traditional aspects concerning efficiency and profitability, the energy sector is facing new challenges given by environmental issues, security of supply, and the increasing role of the local demand. Therefore, the researchers have developed new decision-making frameworks enabling higher local integration of distributed energy resources (DER). In this context, new energy players appeared in the retail markets, increasing the level of competition on the demand side. In this paper, a multi-energy player (MEP) is defined, which behaves as a DER aggregator between the wholesale energy market and a number of local energy systems (LES). The MEP and the LES have to find a long-term equilibrium in the multienergy retail market, in which they are interrelated through the price signals. To achieve this goal, in this paper the decisionmaking conflict between the market players is represented through a bi-level model, in which the decision variables of the MEP at the upper level are parameters for the decision-making problem at the lower level (for the individual LES). The problem is transformed into a mathematical program with equilibrium constraints by implementing duality theory, which is solved with the CPLEX 12 solver. The numerical results show the different MEP behavior in various conditions that impact on the total flexibility of the energy system
