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Inaccessible Mental Health Care in the Latinx Community: Structures, Legislation, and Neoliberalism / Inaccesibilidad a la salud mental en la comunidad latinx: estructuras, legislaciones y neoliberalismo
No full textMental illness is an issue that impacts many individuals. However, access to mental health treatment and care remains elusive to certain populations in the United States. A disparity in utilization of professional mental health care services exists between Latinx communities and their white counterparts. This lack of utilization of mental health care services by Latinx communities is truly a lack of accessibility, that has developed as a result of a societal divestment from these communities. In consequence, this society-wide divestment forces these individuals with mental illness to seek treatment in unconventional settings such as emergency rooms, homeless shelters, and prisons. This work explores the structural and legislative barriers to accessible mental health care in Latinx communities in the context of neoliberalism and a history of devaluation of these populations in the United States
Examining lateral line development through CXCL14 modulation of CXCL12-CXCR4 mediated gene expression in Danio rerio
Get PDFThe lateral line is a mechanosensory system used by fish to sense the movement of water. It is evolutionarily related to the inner-ear in humans. For both organisms, the binding of the CXCL12 (SDF-1 ligand) to the CXCR4 receptor induces conformational changes needed to activate signal transduction. This signaling results in numerous cellular responses such as cell fate, chemotaxis, and gene transcription. Interestingly, researchers have found that another signaling molecule, CXCL14, can also bind to the CXCR4 receptor with high affinity (Tanegashima et al., 2013). As a result, we hypothesize that CXCL14 modulates CXCL12-mediated chemotaxis, presumably acting as an allosteric regulator.
We are concerned with the allosteric relationship between CXCL14 and CXCL12 and how those relationships affect gene expression in lateral line development. In order to study this interaction, zebrafish were used as our model organism. To examine the effects of CXCL14 on CXCL12-mediated gene transcription, zebrafish embryos were microinjected with CXCL14 antisense morpholino and incubated for a period of three timepoints: 24 dpf, 36 dpf, and 48 dpf, when lateral line development occurs. Our preliminary results suggest that the absence of CXCL14 affects the gene expression of CXCL14, CXCL12, CXCR4, CXCR7, epcam, claudin, and snail1b during lateral line development, thereby suggesting the allosteric capabilities of CXCL14. Further studies will be conducted to determine the degree to which CXCL14 affects the transcription levels of these genes
Dight - Installation View
No full textMaterial: Nettles, spit, flax, caraway seeds, dill seeds, waxed string, wood
Dimensions: 17.25 x 19.5 inches each
Project Advisor: Rob Neilson
Year of Graduation: 2019https://lux.lawrence.edu/artgallery_se2019/1050/thumbnail.jp
