Bryn Mawr College
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Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase
Get PDFTryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the clinic, fewer inhibitors have been described for tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase-2 (IDO2) which also have been implicated more recently in cancer, inflammation and immune control. Consequently the development of dual or pan inhibitors of these Trp catabolizing enzymes may represent a therapeutically important area of research. This is the first report to describe the development of dual and pan inhibitors of IDO1, TDO and IDO2
Blended Learning, Active Learning, iPads Oh My! Exploring What Blended Learning Looks Like For Small Liberal Colleges
No full textStudent success initiatives such as blended learning and active learning have been buzzwords on campuses for quite some time now. The question is what do all those buzzwords really mean and what do they look like at small liberal arts colleges. Many of the definitions are broad and can be uniquely applied depending on your institution\u27s size and culture. How do you get faculty on board with such new initiatives without creating fear around teaching with technology under a blended learning or active learning framework? In this presentation hear about lessons learned from creating a blended learning exploration series for faculty development at a small liberal arts college
Breaking Down Silos Through a Flipped Learning CoP
Get PDFA small group of impassioned Hobart & William Smith staff and faculty have been meeting for three semesters in a new Community of Practice to understand what flipped learning is, network with faculty at other institutions, interrogate newly released standards, and share explorations within their own classes. Recognizing close alignment between flipped learning and the campus curriculum, formal outcomes have been established to strategically engage the campus further. This presentation will outline the process we took to evolve our own understanding of flipped learning, and offer practical suggestions for starting a flipped learning community of practice at your own campus
Co-Creating a First-Year Seminar: Letting A Student Lead the Way
No full textWhile students as partners (SAP) subject-based research has flourished for decades, we decided to tackle a (SAP) curriculum design partnership. In our project, we worked together to create a new first-year seminar that was then offered for the first time to incoming first-year students in the Fall of 2018 called “Star Wars: The Good, The Bad, and The Sociology.” We partnered together on choosing readings, selecting videos, developing assignments and exams, and creating games for the class. Lastly, we designed a variety of assessment mechanisms for measuring the success of our collaboration
Saying Hi to Hybrid!
No full textWhat is gained and lost from the instructors’ perspective by using online learning? What is the time commitment? What ideological/philosophical/logistical challenges emerge? Four instructors, who had exclusively taught face-to-face formats provide insight into their decisions, dilemmas, and processes to transition three multi-section courses to a hybrid format
You Say, They Say, I Say: The Weaving of Positions, Identities, and Narratives in Partnership Work
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Liturgy, Space, and Community in the Basilica Julii (Santa Maria in Trastevere)
Get PDFThe Basilica Julii (also known as titulus Callisti and later as Santa Maria in Trastevere) provides a case study of the physical and social conditions in which early Christian liturgies \u27rewired\u27 their participants. This paper demonstrates that liturgical transformation was a two-way process, in which liturgy was the object as well as the agent of change. Three essential factors - the liturgy of the Eucharist, the space of the early Christian basilica, and the local Christian community - are described as they existed in Rome from the fourth through the ninth centuries. The essay then takes up the specific case of the Basilica Julii, showing how these three factors interacted in the concrete conditions of a particular titular church. The basilica\u27s early Christian liturgical layout endured until the ninth century, when it was reconfigured by Pope Gregory IV (827-844) to bring the liturgical sub-spaces up-to-date. In Pope Gregory\u27s remodeling the original non-hierarchical layout was replaced by one in which celebrants were elevated above the congregation, women were segregated from men, and higher-ranking lay people were accorded places of honor distinct from those of lesser stature. These alterations brought the Basilica Julii in line with the requirements of the ninth-century papal stational liturgy. The stational liturgy was hierarchically organized from the beginning, but distinctions became sharper in the course of the early Middle Ages in accordance with the expansion of papal authority and changes in lay society. Increasing hierarchization may have enhanced the transformational power of the Eucharist, or impeded it