Bryn Mawr College
Scholarship, Research, and Creative Work at Bryn Mawr College | Bryn Mawr College ResearchNot a member yet
4802 research outputs found
Sort by
Solid state proton spin-lattice relaxation in polycrystalline methylphenanthrenes. IV. 1,4-dimethylphenanthrene
Get PDFWe present and model the NMR frequency (8.50, 22.5, and 53.0 MHz) and temperature (97–300 K) dependence of the solid state 1H spin-lattice relaxation process in polycrystalline 1,4-dimethylphenanthrene. The solid state gives rise to a situation where methyl group rotation is the only motion on the NMR time scale and the relaxation rates due to the rotations of the 1- and 4-methyl groups are conveniently well-separated in temperature. At these low NMR frequencies, both the slow- and fast-motion limits are observed for the rotation of both methyl groups which allows for a more stringent test of the models. The relaxation is nonexponential as expected when it is caused by methyl group rotation in which case the initial relaxation rate is modeled. Parameters characterizing stretched-exponential fits of the relaxation process are also used both to quantify the degree of nonexponential relaxation and indicate that the observed relaxation is indeed due to the rotation of the two methyl groups. The results are compared with several other polycrystalline methylphenanthrenes and dimethylphenanthrenes. These systems allow for an investigation into how intramolecular and intermolecular interactions between methyl groups and neighboring atoms on the same and neighboring molecules determine the barriers to methyl group rotation
Science literacy can save democracy
Get PDFCommunicating complex ideas is difficult, yet the ability to clearly articulate and communicate is essential for a democracy to work well. In an age of gaslighting and fake news, the integrity of basic concepts is threatened and lost. This is true in science, where complex ideas such as climate change and evolution have been politicized for years. Here, I present how developing science literacy allows students to appreciate how scientific issues relate to their own lives in the context of community. Developing science literacy in an authentic social context creates agency and is a transferable skill that can promote advocacy
Hacking the Core: Developing & Using an App Book
Get PDFThis interactive session will showcase strategies to enhance student learning through the use of a mobile app book version of a core text required of all students at our university, St. Augustine\u27s Confessions. The pedagogical value of such a multidisciplinary, multi-authored text is enhanced by the further development of our companion resource website, and the session will address both the value of creating either or both in consideration of the needs of other humanities programs
Creating an Anti-Anxiety DH Course
No full textHow can we improve digital humanities accessibility? In other words, how can a small, resource-strapped liberal arts humanities classroom foreground the transformative impact of digital methods of analysis without imposing a high skills or materials threshold on students
Resting state coupling between the amygdala and ventromedial prefrontal cortex is related to household income in childhood and indexes future psychological vulnerability to stress
Get PDFWhile child poverty is a significant risk factor for poor mental health, the developmental pathways involved with these associations are poorly understood. To advance knowledge about these important linkages, the present study examined the developmental sequelae of childhood exposure to poverty in a multiyear longitudinal study. Here, we focused on exposure to poverty, neurobiological circuitry connected to emotion dysregulation, later exposure to stressful life events, and symptoms of psychopathology. We grounded our work in a biopsychosocial perspective, with a specific interest in “stress sensitization” and emotion dysregulation. Motivated by past work, we first tested whether exposure to poverty was related to changes in the resting-state coupling between two brain structures centrally involved with emotion processing and regulation (the amygdala and the ventromedial prefrontal cortex; vmPFC). As predicted, we found lower household income at age 10 was related to lower resting-state coupling between these areas at age 15. We then tested if variations in amygdala–vmPFC connectivity interacted with more contemporaneous stressors to predict challenges with mental health at age 16. In line with past reports showing risk for poor mental health is greatest in those exposed to early and then later, more contemporaneous stress, we predicted and found that lower vmPFC–amygdala coupling in the context of greater contemporaneous stress was related to higher levels of internalizing and externalizing symptoms. We believe these important interactions between neurobiology and life history are an additional vantage point for understanding risk and resiliency, and suggest avenues for prediction of psychopathology related to early life challenge
Mirabile Dictu: Newsletter of the Bryn Mawr College Libraries 22 (2019)
Get PDFhttps://repository.brynmawr.edu/mirabile/1023/thumbnail.jp
A Queer Ethic of Conflict and the Challenge of Friendship. Review of Conflict Is Not Abuse: Overstating Harm, Community Responsibility, and the Duty of Repair
Get PDF
Passive Coping Strategies During Repeated Social Defeat Are Associated With Long-Lasting Changes in Sleep in Rats
Get PDFExposure to severe stress has immediate and prolonged neuropsychiatric consequences and increases the risk of developing Posttraumatic Stress Disorder (PTSD). Importantly, PTSD develops in only a subset of individuals after exposure to a traumatic event, with the understanding of this selective vulnerability being very limited. Individuals who go on to develop PTSD after a traumatic experience typically demonstrate sleep disturbances including persistent insomnia and recurrent trauma-related nightmares. We previously established a repeated social defeat paradigm in which rats segregate into either passively or actively coping subpopulations, and we found that this distinction correlates with measures of vulnerability or resilience to stress. In this study, we examined differences between these two behavioral phenotypes in sleep changes resulting from repeated social defeat stress. Our data indicate that, compared to control and actively coping rats, passively coping rats have less slow-wave sleep (SWS) for at least 2 weeks after the end of a series of exposures to social defeat. Furthermore, resilient rats show less exaggerated motor activation at awakenings from rapid eye movement (REM) sleep and less fragmentation of REM sleep compared to control and passively coping rats. Together, these data associate a passive coping strategy in response to repeated social defeat stress with persisting sleep disturbances. Conversely, an active coping strategy may be associated with resilience to sleep disturbances. These findings may have both prognostic and therapeutic applications to stress-associated neuropsychiatric disorders, including PTSD