Institute of Chemistry
Changchun Institute of Applied Chemistry, Chinese Academy Of SciencesNot a member yet
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一种改性葡聚糖及其制备方法、葡聚糖胶束及其制备方法、载药颗粒及其制备方法和水凝胶
No full text本发明提供了一种改性葡聚糖及其制备方法,具有式I或式II所示的结构。本发明提供了一种葡聚糖胶束及其制备方法,这种葡聚糖胶束可作为药物载体,具有较好的缓释性。本发明提供的葡聚糖胶束制备得到的载药颗粒能够缓慢释放,具有较好的药效；此外,本发明提供的载药颗粒粒径较小、大小均一,在水中的分散性和稳定性较好。本发明提供的水凝胶由载药颗粒和聚-L-赖氨酸均聚物交联而成,这种水凝胶可在病灶部位靶向缓慢释放,在肿瘤治疗领域具有明显优势；此外,这种水凝胶可以担载抗肿瘤药物,载药效果好；另外,这种水凝胶具有较好的生物降解性和生物相容性
一种阿霉素键合药及其制备方法、物理凝胶及其应用
No full text本发明提供了一种阿霉素键合药,具有式I或式II所示的结构。本发明提供了一种阿霉素键合药的制备方法,包括：将具有式III或式V所示结构的阿霉素衍生物和具有式IV所示结构的化合物进行反应,得到阿霉素键合药。本发明提供了一种物理凝胶,包括质量比为(10～30):(90～70)的阿霉素键合药和无机溶剂。本发明提供的物理凝胶在25℃以下呈现溶液状态,随着温度的升高,这种物理凝胶呈现出凝胶的状态；因此本发明提供的这种物理凝胶在体内呈现凝胶状态,能够延长阿霉素在肿瘤部位的作用时间,增强阿霉素的长效治疗效果。而且,本发明提供的这种物理凝胶可用于负载其他相同或不同作用机理的抗肿瘤药物,增强抗肿瘤的协同作用
一种菲并咔唑类染料及其制备方法和染料敏化太阳电池
No full text本发明提供了一种菲并咔唑类染料,具有式I所示的结构；式I中,R1选自碳原子数为1～36的烷基；R2和R3独立地选自氢、氟、碳原子数为1～36的烷基；R4选自羧基取代的芳基；R5选自氢、芳基或碳原子数为1～36的烷基。本发明提供了一种菲并咔唑类染料的制备方法,包括：将具有式1所示结构的化合物和具有式2所示结构的化合物进行偶联反应,得到菲并咔唑类染料。本发明提供了一种染料敏化太阳电池,包括上述方案所述的菲并咔唑类染料。本发明提供的菲并咔唑类染料具有电子给体单元菲并咔唑,菲并咔唑结构单元具有高荧光量子产率和长激发态寿命；使本发明提供的菲并咔唑类染料制备得到的染料敏化太阳电池具有较高的功率转化效率
Sr9Mg1.5(PO4)(7):Eu2+: A Novel Broadband Orange-Yellow-Emitting Phosphor for Blue Light-Excited Warm White LEDs
No full textA new orange-yellow-emitting Sr9Mg1.5(PO4)(7):Eu2+ phosphor was prepared via high-temperature solid-state reaction. The structure and optical properties of it were studied systematically. Sr9Mg1.5(PO4)(7):Eu2+ can be well-excited by 460 nm blue InGaN chips and exhibit a wide emission band covering from 470 to 850 nm with two main peaks centered at 523 and 620 nm, respectively, which originate from 5d-4f dipole-allowed transitions of Eu2+ in different crystallographic sites. The sites attribution, concentration quenching, fluorescence decay analysis, and temperature-dependent luminescence properties were investigated in detail. Furthermore, a warm white LED device was fabricated by combining a 460 nm blue InGaN chip with the optimized orange-yellow-emitting Sr9Mg1.5(PO4)(7):Eu2+. The color coordinate, correlated color temperature and color rendering index of the fabricated LED device were (0.393, 0.352), 3437 K, and 86.07, respectively. Sr9Mg1.5(PO4)(7):Eu2+ has great potential to serve as an attractive candidate in the application of blue light-excited warm white LEDs
Donor/Acceptor Molecular Orientation-Dependent Photovoltaic Performance in All-Polymer Solar Cells
No full textThe correlated donor/acceptor (D/A) molecular orientation plays a crucial role in solution-processed all-polymer solar cells in term of photovoltaic performance. For the conjugated polymers PTB7th and P(NDI2OD-T2), the preferential molecular orientation of neat PTB7-th films kept face-on regardless of the properties of processing solvents. However, an increasing content of face-on molecular orientation in the neat P(NDI2OD-T2) films could be found by changing processing solvents from chloronaphthalene (CN) and o-dichlorobenzene (oDCB) to chlorobenzene (CB). Besides, the neat P(NDI2OD-T2) films also exhibited a transformation of preferential molecular orientation from face-on to edge-on when extending film drying time by casting in the same solution. Consequently, a distribution diagram of molecular orientation for P(NDI2OD-T2) films was depicted and the same trend could be observed for the PTB7-th/P(NDI2OD-T2) blend films. By manufacture of photovoltaic devices with blend films, the relationship between the correlated D/A molecular orientation and device performance was established. The short-circuit current (J(sc)) of devices processed by CN, oDCB, and CB enhanced gradually from 1.24 to 8.86 mA/cm(2) with the correlated D/A molecular orientation changing from face-on/edge-on to face-on/face-on, which could be attributed to facile exciton dissociation at D/A interface with the same molecular orientation. Therefore, the power conversion efficiency (PCE) of devices processed by CN, oDCB, and CB improved from 0.53% to 3.52% ultimately
Yb3+/Er3+-Codoped Bi2O3 Nanospheres: Probe for Upconversion Luminescence Imaging and Binary Contrast Agent for Computed Tomography Imaging
No full textIn this work, water-soluble Yb3+/Er3+ codoped Bi2O3 upconversion (UC) nanospheres with uniform morphology have been successfully synthesized via a solid-state-chemistry thermal decomposition process. With 980 run near-infrared irradiation, the Bi2O3:Yb3+/Er3+ nanospheres have bright UC luminescence (UCL). Moreover, multicolor UC emissions (from green to red) can be tuned by simply changing the Yb3+ ions doping concentration. After citric acid molecules were grafted on the surface of Bi2O3:20% Yb3+/2% Er3+ nanospheres, the MTT assay on HeLa cells and CCK-8 assay on osteoblasts show that the UC nanospheres exhibit excellent stability and biocompatibility. The possibility of using these nanoprobes with red UCL for optical imaging in vivo has been demonstrated. Furthermore, Bi3+ and Yb3+ containing nanospheres as binary contrast agent also exhibited significant enhancement of contrast efficacy than iodine-based contrast agent via X-ray computed tomography (CT) imaging at different voltage setting (80-140 kVp), indicating they have potential as CT imaging contrast agent. Thus, Yb3+/Er3+ codoped Bi2O3 nanospheres could be used as dual modality probe for optical and CT imagings
Rapid, sensitive, and selective fluorescent DNA detection using iron-based metal-organic framework nanorods: Synergies of the metal center and organic linker
No full textConsiderable recent attention has been paid to homogeneous fluorescent DNA detection with the use of nanostructures as a universal "quencher", but it still remains a great challenge to develop such nanosensor with the benefits of low cost, high speed, sensitivity, and selectivity. In this work, we report the use of iron-based metal-organic framework nanorods as a high-efficient sensing platform for fluorescent DNA detection. It only takes about 4 min to complete the whole "mix-and-detect" process with a low detection limit of 10 pM and a strong discrimination of single point mutation. Control experiments reveal the remarkable sensing behavior is a consequence of the synergies of the metal center and organic linker. This work elucidates how composition control of nanostructures can significantly impact their sensing properties, enabling new opportunities for the rational design of functional materials for analytical applications. (C) 2015 Elsevier B.V. All rights reserved
Phenyliodine(III) Diacetate Mediated Oxidative Cyclization of 1-Alkenoyl-1-carbamoyl Cycloalkanes: Access to Spiro-Fused Dihydrofuran-3(2H)-ones
No full textFacile and efficient synthesis of spiro-fused dihydrofuran-3(2H)-ones was developed via phenyliodine(III) diacetate (PIDA) mediated oxidative cyclization of 1-alkenoyl-1-carbamoyl cydoalkanes under very mild conditions
Beyond theoretical capacity in Cu-based integrated anode: Insight into the structural evolution of CuO
No full textAn excellent CuO/Cu integrated anode with CuO nanoparticle-aggregated microsheets on Cu current collector showed higher capacity beyond the theoretical capacity of CuO. The reoxidation of Cu including converted Cu nanoparticles and Cu current collector into CuO guaranteed the highly reversible conversion reaction and high capacity. The combined current ex-situ methods of XRD, SEM and TEM were used to find the origin of the additional capacity by examining the structural evolution and phase transformation of CuO/Cu integrated anode during electrochemical cycling. After 110 cycles, the discharge capacity of CuO/Cu integrated anode retained a large value of 706 mAh g(-1), which is beyond the theoretical capacity of CuO materials (674 mAh g(-1)). The specific electrode configuration and the release of Cu from integrated Cu current collector made these CuO/Cu electrodes maintain high capacity and cycling Stability. The present research demonstrates a protocol for the design of high-performance anode structure: in situ chemical and electrochemical activating integrated electrode system. (C) 2014 Elsevier B.V. All rights reserved
A cerium-lead redox flow battery system employing supporting electrolyte of methanesulfonic acid
No full textA novel cerium-lead redox flow battery (RFB) employing Ce(IV)/Ce(III) and Pb(II)/Pb redox couples in the supporting electrolyte of methanesulfonic acid (MSA) is developed and preliminarily investigated. The RFB requires no additional catalyst and uses kinetically favorable reactions between low-cost reactants, and provides a desirable discharge voltage of approximately 1.7 V, with high average coulombic efficiency (CE) of 92% and energy efficiency (EE) of 86% over 800 cycles at 298 K. Stable cycling with an acceptable performance is achieved for a board operating temperature range of 253 K-313 K. The excellent performance obtained from the preliminary study suggests that the cerium-lead RFB promises to be applicable to large-scale energy storage for electricity grids. (C) 2015 Elsevier B.V. All rights reserved