Institute of Chemistry
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一种四元无规共聚物及其制备方法和应用
No full text本申请属于有机合成领域,尤其涉及一种四元无规共聚物及其制备方法和应用。本申请提供的四元无规共聚物,由式(I)所示结构的重复单元、式(II)所示结构的重复单元、式(III)所示结构的重复单元和式(IV)所示结构的重复单元组成；其中,R1、R2和R3独立地选自C8～C18的烷基。本申请提供的四元无规共聚物对润滑油具有良好的降凝效果。实验结果表明,在150SN基础油中添加5wt％的本申请提供的四元无规共聚物后,其倾点降幅大于6
一种肿瘤细胞靶向的纳米凝胶及其制备方法以及一种肿瘤细胞靶向的纳米凝胶载药颗粒
No full text本发明提供了一种肿瘤细胞靶向的纳米凝胶的制备方法,包括以下步骤：A)将带有苯硼酸基团的引发剂与L-谷氨酸寡聚乙二醇单甲醚-N-环内酸酐溶解于有机溶剂中进行反应,得到混合溶液；B)将具有式(I)结构的化合物、具有式(II)结构的化合物与步骤A)得到的混合溶液混合,进行反应,得到反应液；C)将步骤B)得到的反应液与有机溶剂混合,过滤,得到肿瘤细胞靶向的纳米凝胶；采用本发明提供的肿瘤细胞靶向的纳米凝胶载药颗粒对人体无毒副作用,并且具有良好的水溶性、稳定性以及生物相容
环氧树脂基中子屏蔽复合材料及其制备方法
No full text本发明公开了一种环氧树脂基中子屏蔽复合材料及其制备方法,属于屏蔽材料技术领域。解决了现有技术中屏蔽材料的屏蔽性能与其它物理力学性能难以兼顾、不能满足应用灵活性和施工多样性的要求,且制备工艺复杂的技术问题。该复合材料由15-50重量份的环氧树脂、7-30重量份的固化剂、5-40重量份的快中子慢化剂、5-55重量份的热中子吸收剂、0-10重量份的惰性稀释剂、0-10重量份的活性稀释剂、0-5重量份的促进剂和0.2-4.0重量份助剂组成。该复合材料具有优异的中子屏蔽性能,且材料低毒、无气味、制备工艺简单、施工方便,可广泛应用于严格要求防辐射的各个领域中
一种开环聚合制备ε-聚赖氨酸的方法
No full text本发明涉及一种开环聚合制备ε-聚赖氨酸的方法,属于聚合物合成方法学领域。解决现有ε-聚赖氨酸主要通过生物发酵法制备,生产成本较高,同时通过生物发酵法得到的聚合物分子量不到4千且分子量无法调节,大大限制了ε-聚赖氨酸的应用领域的技术问题。该方法是通过将赖氨酸单体成环得到带α氨基的七元环状内酰胺,再通过七元环状内酰胺单体的开环聚合制备ε-聚赖氨酸。本发明提供的制备方法使用廉价的可再生资源L-赖氨酸为起始原料,能够高效的得到具有很高附加值的分子量可调的ε-聚赖氨酸,所得ε-聚赖氨酸的分子量为3000-100000,且该方法成本低
有机胺氨基甲酸盐的制备方法
No full text本发明公开了一种有机胺氨基甲酸盐的制备方法,属于有机胺氨基甲酸盐制备技术领域。解决了现有技术中有机胺氨基甲酸盐的制备方法存在溶剂脱出困难、能耗高的问题。该制备方法将质量比为100:(2～500)的有机胺与有机溶剂加入反应装置中,在-10℃～100℃下,持续搅拌,并向反应装置中充入CO2气体,使反应装置中气体压力达0.1MPa～15MPa,反应2min～10h后,除去有机溶剂,即得到有机胺氨基甲酸盐；其中,有机溶剂能够溶解有机胺,且能够溶解CO2气体或者被超临界CO2膨胀。该方法大大的提高了反应速率和成盐率；反应后所生成的有机胺氨基甲酸盐分离简单
一种逐级响应的纳米载体、其制备方法及其应用
No full text本发明提供了一种纳米载体、其制备方法及其应用,该纳米载体包括纳米凝胶内核和包裹在纳米凝胶内核表面的嵌段共聚物；所述纳米凝胶内核包括末端的正己基、L-赖氨酸链节、L-胱氨酸链节和L-苯丙氨酸链节；所述嵌段共聚物具有式I结构。该纳米载体通过增强渗透滞留(EPR)效应在肿瘤组织部位富集,在肿瘤组织部位pH值条件下,嵌段共聚物作为外壳脱去,露出带正电的纳米凝胶内核,正电性的纳米凝胶内核有助于细胞内吞,当纳米凝胶内核进入细胞后,在细胞内高谷胱甘肽的浓度下,纳米凝胶内核中作为交联点的二硫键断裂,纳米凝胶内核解体,从而快速释放出药物,因此,该纳米载体通过调节其在肿瘤的各个部位的释放,具有逐级响应性
一种填充型电磁屏蔽硅橡胶的制备方法
No full text本发明提供了一种填充型电磁屏蔽硅橡胶的制备方法,包括以下步骤：A)将依次经过高浓度盐酸活化和低浓度盐酸酸化的碳纤维置于含镍镀液中进行镀镍,得到镀镍碳纤维；所述高浓度盐酸的摩尔浓度为4.0～6.0mol/L,所述低浓度盐酸的摩尔浓度为0.5～1mol/L；B)将所述镀镍碳纤维、硫化剂、白炭黑和炭黑加入硅橡胶进行炼胶,经硫化制样得到电磁屏蔽硅橡胶。本发明通过分别选用高浓度盐酸与低浓度盐酸对碳纤维进行活化与酸化,避免使用SnCl2和PdCl2进行敏化和活化,降低了镀镍成本,减少环境污染
Gold nanoclusters-Cu2+ ensemble-based fluorescence turn-on and real-time assay for acetylcholinesterase activity and inhibitor screening
No full textBased on the specific binding of Cu2+ ions to the 11-mercaptoundecanoic acid (11-MUA)-protected AuNCs with intense orange-red emission, we have proposed and constructed a novel fluorescent nanomaterials-metal ions ensemble at a nonfluorescence off-state. Subsequently, an AuNCs@11-MUA-Cu2+ ensemble-based fluorescent chemosensor, which is amenable to convenient, sensitive, selective, turn-on and real-time assay of acetylcholinesterase (AChE), could be developed by using acetylthiocholine (ATCh) as the substrate. Herein, the sensing ensemble solution exhibits a marvelous fluorescent enhancement in the presence of AChE and ATCh, where AChE hydrolyzes its active substrate ATCh into thiocholine (TCh), and then TCh captures Cu2+ from the ensemble, accompanied by the conversion from fluorescence off-state to on-state of the AuNCs. The AChE activity could be detected less than 0.05 mU/mL within a good linear range from 0.05 to 2.5 mU/mL. Our proposed fluorescence assay can be utilized to evaluate the AChE activity quantitatively in real biological sample, and furthermore to screen the inhibitor of AChE. As far as we know, the present study has reported the first analytical proposal for sensing AChE activity in real time by using a fluorescent nanomaterials-Cu2+ ensemble or focusing on the Cu2+-triggered fluorescence quenching/recovery. This strategy paves a new avenue for exploring the biosensing applications of fluorescent AuNCs, and presents the prospect of AuNCs@11-MUA-Cu2+ ensemble as versatile enzyme activity assay platforms by means of other appropriate substrates/analytes. (C) 2015 Elsevier B.V. All rights reserved
Synthetic Study toward the Misassigned (+/-)-Tronoharine
No full textThe synthesis of a pentacyclic indole compound corresponding to the core structure of the misassigned indole alkaloid, tronoharine (1), is presented. The key reactions were a formal [3 + 3] cycloaddition of an indol-2-yl carbinol with an azadiene for the construction of the 6/5/6/6 tetracyclic system containing an all-carbon quaternary center and an intramolecular substitution reaction of an amine and a triflate for the creation of the bridged azepine ring. In addition, some other interesting transformations discovered during the synthetic studies are also discussed
Viscoelasticity of Poly(ethylene glycol) Solutions on Supported Lipid Bilayers via Quartz Crystal Microbalance with Dissipation
No full textSupported lipid bilayers of 1,2-dioleoyl-sn-glycero-3-phosphocholine were formed on a silicon oxide substrate, and the viscoelasticity of poly(ethylene glycol) (PEG) solutions above the bilayer was subsequently studied by quartz crystal microbalance with dissipation monitoring. No detectable adsorption of PEG molecules to the bilayer was found over a broad range of PEG molecular weight at various concentrations. The viscoelastic properties of the PEG solutions were obtained from the shifts in the resonance frequency and the energy dissipation factor of the polymer solution in contact with the resonator-supported lipid bilayer. The resulting viscoelastic properties of PEG solutions were found to be in excellent agreement with the Zimm model for linear polymer chains in a good solvent. The excluded volume scaling exponent nu for PEG in water shows an ideal-to-real crossover with increasing molecular weight. The exponent adopts a value of 0.50 for short chains and gradually increases to 0.565 for long chains. The onset of the excluded volume effect of PEG in water, a good solvent, lies in the molecular weight range between 4000 and 8000