Institute of Chemistry
Changchun Institute of Applied Chemistry, Chinese Academy Of SciencesNot a member yet
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Convenient Recycling of 3D AgX/Graphene Aerogels (X = Br, Cl) for Efficient Photocatalytic Degradation of Water Pollutants
No full text3D AgX/graphene aerogel (GA) composites (X = Br, Cl) are synthesized. Not only is the photocatalytic performance increased in comparison with pristine AgX, but also the photocatalytic cycling process is facilitated just using tweezers Thus, the comprehensive performance of the AgX/GA composites provides robust support for future industrial applications of the photocatalyst
ZnO-Functionalized Upconverting Nanotheranostic Agent: Multi-Modality Imaging-Guided Chemotherapy with On-Demand Drug Release Triggered by pH
No full textLimited therapeutic efficiency and severe side effects in patients are two major issues existing in current chemotherapy of cancers in clinic. To design a proper theranostic platform seems thus quite needed to target cancer cells accurately by bioimaging and simultaneously release drugs on demand without premature leakage. A novel ZnO-functionalized upconverting nanotheranostic platform has been fabricated for clear multi-modality bioimaging (upconversion luminescence (UCL), computed tomography (CT), and magnetic resonance imaging (MRI)) and specific pH-triggered on-demand drug release. In our theranostic platform multi-modality imaging provides much more detailed and exact information for cancer diagnosis than single-modality imaging. In addition, ZnO can play the role of a gatekeeper to efficiently block the drug in the mesopores of the as-prepared agents until it is dissolved in the acidic environment around tumors to realize sustained release of the drug. More importantly, the biodegradable ZnO, which is non-toxic against normal tissues, endows the as-prepared agents with high therapeutic effectiveness but very low side effects. These findings are of great interests and will inspire us much to develop novel effective imaging-guided on-demand chemotherapies in cancer treatment
Multifunctional hollow CaF2:Yb3+/Er3+/Mn2+-poly(2-Aminoethyl methacrylate) microspheres for Pt(IV) pro-drug delivery and tri-modal imaging
No full textCombining the multi-modal medical imaging with cancer therapy in one single system has attracted the great interests for theranostic purpose. In this paper, CaF2:Yb3+/Er3+/Mn2+-poly(2-Aminoethyl methacrylate) (UCHNs-PAMA) hybrid microspheres were successfully fabricated. The synthetic route to the nanocomposite based on a facile hydrothermal method for fabrication of hollow upconversion (DC) nanospheres at first and then post-filling the PAMA interiorly through photo-initiated polymerization. The UCHNs showed orange fluorescence under 980 nm near infrared (NIR) laser excitation, which provided the upconverting luminescence (UCL) imaging modality. Meanwhile, the presence of functional Mn2+ and Yb3+ offered the enhanced Ti-weighted magnetic resonance (MR) and computed tomography (CT) imaging, respectively. Thanks to introducing amine groups-containing PAMA inside the hollow nanospheres, the Pt(IV) pro-drug, c,c,t-Pt(NH3)2C12(00CCH2CH2COOH)2 (DSP), can be conveniently bonded on the polymer network to construct a nanoscale anti-cancer drug carrier. The UCHNs-PAMAPt(IV) nanocomposite shows effective inhibition for Hela cell line via KIT assay. In contrast, Pt(IV) pro-drug and UCHN5-PA1VIA microspheres behave little cytotoxicity to Hela cells. This should be attributed the fact that the anti-cancer ability can be recovered only when Pt(IV) pro-drug was reduced to Pt(II)-drug in cellular environment Furthermore, the in vivo experiments on small mice also confirm that the hybrid microspheres have relatively low toxic side effects and high tumor inhibition rate. These findings show that the multifunctional hybrid microspheres have potential to be used as UCL/MR/CT trimodal imaging contrast agent and anti-cancer drug carriers. 0 2015 Elsevier Ltd. All rights reserved
Multifunctional envelope-type mesoporous silica nanoparticles for pH-responsive drug delivery and magnetic resonance imaging
No full textA novel multifunctional envelope-type mesoporous silica nanoparticle (MEMSN) system combining the merits of pH-responsiveness, non-toxicity and biological specificity, is demonstrated for drug delivery and magnetic resonance imaging (MRI). This system is constructed by immobilizing acetals on the surface of mesoporous silica, and then coupling to ultra small lanthanide doped upconverting nanoparticle, which act as a gate keeper. The anticancer drug DOX is thus locked in the pores, and its burst release can be achieved under acidic environment on account of the hydrolyzation reactions of acetals. The nanogated drug release system is highly efficacious for cancer therapy both in vitro and in vivo. Importantly, the nanocomposite could be harmlessly metabolized and degraded into apparently nontoxic products within a few days. The nanoscale effect of the system allows for passive tumor targeting and increased tumor accumulation of the probes via the enhanced permeation and retention (EPR) effect, which is visualized by MRI in vivo. Therefore, such nanosystem should be of great significance in the future development of highly efficient and tumor targeted drug delivery vehicles for cancer chemotherapy. (C) 2015 Elsevier Ltd. All rights reserved
Programmable Downregulation of Enzyme Activity Using a Fever and NIR-Responsive Molecularly Imprinted Nanocomposite
No full textStructurally Ordered Pt3Cr as Oxygen Reduction Electrocatalyst: Ordering Control and Origin of Enhanced Stability
No full textOrdered intermetallic phases provide predictable control over structure and electronic effects, not afforded by the widely studied alloys. However, because of the lack of a unifying principle or model for controlling the ordering and particle size, it is still a great challenge to synthesize the desired ordered phase (5 nm and smaller). Here, we employ Pt3Cr as a typical ordered intermetallic phase to comprehensively study the factors that control both the ordering and particle size. Ordered Pt3Cr intermetallic nanopartides (similar to 5 nm) are successfully synthesized using a KCl-matrix method in combination with adjusting annealing conditions. Such structurally ordered Pt3Cr/C exhibits superior kinetics toward the oxygen reduction reaction (ORR), relative to disordered PtCr alloy phases and commercial Pt/C. More importantly, the ordered Pt3Cr intermetallic catalyst shows a minimal loss of activity after 5000 potential cycles (14.7%) and a minimal Cr leaching loss after 4 weeks of testing (13.5%). The mechanism for the enhanced stability of ordered phases is discussed and elucidated. The high stability and activity of ordered Pt3Cr/C make it very promising for application as cathode catalysts for fuel cells. This work provides a guide to optimizing the synthesis of ordered intermetallic catalysts and improving their catalytic performance
PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for localized and combined treatment of human osteosarcoma
No full textBorane-conjugated poly(ester-carbonate) amphiphilic block copolymers as potential agents for boron neutron capture therapy
No full textTriblock terpolymer/gold nanoparticle hybrid micelles with tunable morphology and nanoparticle location
No full textN-Doped Carbon-Coated Tungsten Oxynitride Nanowire Arrays for Highly Efficient Electrochemical Hydrogen Evolution
No full textIt is highly desired but still challenging to develop active non-precious metal hydrogen evolution reaction (HER) electrocatalysts operating under all pH conditions. Herein, the development of three-dimensional N-doped carbon-coated tungsten oxynitride nanowire arrays on carbon cloth as a highly efficient and durable HER cathode was explored. The material delivers current densities of 10 and 100 mAcm(-2) at overpotentials of 106 and 172 mV, respectively, in acidic medium, and it also performs well in neutral and basic electrolytes