Institute of Chemistry
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一种Bi2Te3二维纳米片、其制备方法及应用
No full text本发明提供了一种Bi2Te3二维纳米片的制备方法,包括：将Bi2Te3纳米材料、水与功能化配体分子进行超声剥离,得到Bi2Te3二维纳米片；所述功能化配体分子为聚乙烯吡咯烷酮、细胞色素C或牛血清白蛋白。本申请一功能化配体分子作为剥离剂,对Bi2Te3纳米材料进行超声剥离,从而得到水溶性较高的功能化配体分子-Bi2Te3二维纳米片,其粒径均一、形貌可控,水溶性好,不但有很好的生物相容性,而且具有高的光热转换效率,是一种良好的光热试剂,可用于肿瘤的光热治疗。本发明可以简单的实现具有光热性能的水溶性Bi2Te3的大规模合成,制备过程简单,成本低廉,适合工业化生产
一种载药聚合物囊泡及其制备方法
No full text本发明提供了一种载药聚合物囊泡及其制备方法,该载药聚合物囊泡包括：两亲性嵌段共聚物囊泡与包载在其中的药物；所述两亲性嵌段共聚物囊泡的粒径为6～15μm。与现有技术相比,本发明以两亲性嵌段共聚物囊泡将药物包载在疏水壳层或亲水内核内,具有很好的血液稳定性与生物相容性,同时也具有逐层释放的效果,并且该载药聚合物囊泡具有微米级的粒径,在血液循环中稳定,可在肺的毛细血管着床,滞留于肺的毛细血管,从而可被动靶向于肺部
一种染料敏化电池、含有氮环化苊并苝结构的有机染料及其制备方法
No full text本发明提供了一种染料敏化电池、含有氮环化苊并苝结构的有机染料及其制备方法；该有机染料具有式I结构。本发明提供的具有式I结构的有机染料以氮环化苊并苝单元为核心构建了一种新型电子给体,并通过引入不同的受体单元和修饰基团调节染料分子的相对能级和三维立体结构。本发明将上述有机染料作为染料敏化太阳电池的敏化剂制备染料层,制得的染料敏化太阳电池具有较高的功率转化效率。实验结果表明：采用本发明提供的有机染料制备的染料敏化太阳电池的功率转化效率可达9.8％
一种高分子量聚乳酸制备丙交酯的方法
No full text本发明提供了一种高分子量聚乳酸制备丙交酯的方法,包括以下步骤：在真空条件下,聚乳酸溶液中的高分子量聚乳酸在催化剂作用下进行裂解反应,得到丙交酯；聚乳酸溶液中的溶剂包括C2～C20的多元醇、数均分子量为200～20000g/mol的聚醚、C10～C30的醚类化合物、丙交酯、数均分子量为200～8000g/mol的乳酸低聚物、C8～C30的多元羧酸酯类化合物和离子液体中的一种或多种；催化剂包括含锡化合物和/或含钛化合物；裂解反应的温度为180～240℃。本发明以高分子量聚乳酸为原料,将聚乳酸制备成溶液后直接裂解制备丙交酯,与现有技术相比,此工艺的反应条件温和,减少了高温碳化和丙交酯的消旋化
Near-infrared absorbing mesoporous carbon nanoparticle as an intelligent drug carrier for dual-triggered synergistic cancer therapy
No full textHerein a novel multifunctional nanoplatform based on surface engineered mesoporous carbon nanoparticle (MCN) is developed for effective dual-triggered synergistic cancer therapy. MCNs employed in the study not only function as near-infrared absorbing agents but also as nanocarriers with a high drug loading efficiency. The surface modification of MCN with biomacromolecules (hyaluronic acid) through disulfide unit makes the system be sensitive to both intracellular hyaluronidase-1 and GSH to release the carried drug. The hyaluronic acid on MCN simultaneously confers the system biocompatibility and a cancer cell targeting ability. By combining these capabilities, the multifunctional nanoplatform shows an effective therapeutic efficiency toward the target cells. (C) 2014 Elsevier Ltd. All rights reserved
Influence of Topology on the Free Energy and Metric Properties of an Ideal Ring Polymer Confined in a Slit
No full textUsing off-lattice Monte Carlo simulation, we investigate the effects of topological constraints on the free energy and metric properties of an unknotted ring polymer without exclude volume interactions confined in a slit with width d, as well as the effect of confinement on the probability of forming an unknot in a freely jointed ring. Because of the topological constraints, the polymer size of an unknotted ring is shown to behave differently from that of a freely jointed ring: the in-plane radius of gyration R-g parallel to increases with increasing confinement. However, the free energy of an unknotted ring follows the same scaling law as a freely jointed ring for strong confinement. This abnormal phenomenon is explained on the basis of the fact that the length of subchains inside the confinement blobs is smaller than the topological blob size, i.e., the characteristic length below which topological constraints become unimportant. As in the bulk, the probability of forming an unknot decreases exponentially with the chain length, but the decay length decreases with decreasing confinement length. We propose an efficient method for calculating the probability of forming unknot from a freely jointed ring in confinement
Aligned Electroactive TMV Nanofibers as Enabling Scaffold for Neural Tissue Engineering
No full textElectroactive nanofibers were fabricated by in situ polymerization of aniline on the surface of tobacco mosaic virus (TMV) using sodium poly(styrenesulfonate) (PSS) as dopant. These electroactive TMV/PANi/PSS nanofibers were employed to support growth of neuronal cells, resulting in augmentation of the length of neurites. In addition, the percentage of cells with neurites was increased in comparison to cells cultured on TMV-derived nonconductive nanofibers. The TMV-based electroactive nanofibers could be aligned in capillaries that could guide the outgrowth direction of neurites, increase the percentage of cells with neurites, and lead to a bipolar cellular morphology. Our results demonstrate that the electroactivity and topographical cues provided by TMV/PANi/PSS nanofibers can synergistically stimulate neural cells differentiation and neurites outgrowth, which make it a promising scaffolding material for neural tissue engineering
Biomolecule-Free, Selective Detection of o-Diphenol and Its Derivatives with WS2/TiO2-Based Photoelectrochemical Platform
No full textHerein, a novel photoelectrochemical platform with WS2/TiO2 composites as optoelectronic materials was designed for selective detection of o-diphenol and its derivatives without any biomolecule auxiliary. First, catechol was chosen as a model compound for the discrimination from resorcinol and hydroquinone; then several o-diphenol derivatives such as dopamine, caffeic acid, and catechin were also detected by employing this proposed photoelectrochemical sensor. Finally, the mechanism of such a selective detection has been elaborately explored. The excellent selectivity and high sensitivity should be attributed to two aspects: (i) chelate effect of adjacent double oxygen atoms in the o-diphenol with the Ti(IV) surface site to form a five/six-atom ring structure, which is considered as the key point for distinction and selective detection. (ii) This selected WS2/TiO2 composites with proper band level between WS2 and TiO2, which could make the photogenerated electron and hole easily separated and results in great improvement of sensitivity. By employing such a photoelectrochemical platform, practical samples including commercial clinic drugs and human urine samples have been successfully performed for dopamine detection. This biomolecule-free WS2/TiO2 based photoelectrochemical platform demonstrates excellent stability, reproducibility, remarkably convenient, and cost-effective advantages, as well as low detection limit (e.g., 0.32 mu mol L-1 for dopamine). It holds great promise to be applied for detection of o-diphenol kind species in environment and food field
Application of Mass Spectrometry in the Synthesis and Characterization of Metal Nanoclusters
No full textIn recent years, mass spectrometry has been widely used in the characterization of metal nanoclusters. In this Feature, we first give an introductory tutorial on mass spectrometry and then highlight the versatile applications of mass spectrometry in accurately analyzing core size, atom-level composition, charge states, etc. of metal nanoclusters and size evolution during synthesis. Finally, some perspectives on the future applications of mass spectrometry in nanocluster research are given
Real-time Imaging of Rabies Virus Entry into Living Vero cells
No full textUnderstanding the mechanism of rabies virus (RABV) infection is vital for prevention and therapy of virulent rabies. However, the infection mechanism remains largely uncharacterized due to the limited methods and viral models. Herein, we utilized a powerful single-virus tracking technique to dynamically and globally visualize the infection process of the live attenuated rabies vaccine strain-SRV9 in living Vero cells. Firstly, it was found that the actin-enriched filopodia is in favor of virus reaching to the cell body. Furthermore, by carrying out drug perturbation experiments, we confirmed that RABV internalization into Vero cells proceeds via classical dynamin-dependent clathrin-mediated endocytosis with requirement for intact actin, but caveolae-dependent endocytosis is not involved. Then, our real-time imaging results unambiguously uncover the characteristics of viral internalization and cellular transport dynamics. In addition, our results directly and quantitatively reveal that the intracellular motility of internalized RABV particles is largely microtubule-dependent. Collectively, our work is crucial for understanding the initial steps of RABV infection, and elucidating the mechanisms of post-infection. Significantly, the results provide profound insight into development of novel and effective antiviral targets