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Long-term geomagnetic activities and stratospheric winter temperature
No full textIn this research, impact of long term solar forcing on stratospheric winter temperature is checked. The 11- year sunspot activity and geomagnetic indices (AE, Kp, Dst) are used as an indicator for solar forcing, as geomagnetic activity indices show good correlation with solar variability. To understand the impact of solar forcing through high latitude, stratospheric winter (November to March) time North Polar Region (60N–90N) temperature anomalies are considered. The findings showed that temperature changes in the stratosphere are significantly correlated with solar activity, as evidenced by a significant positive correlation between the 11-year moving mean of stratospheric (10 hPa) temperature anomalies and sunspot number. Approximately from 1970 to 2000, the North Polar Region saw positive anomalous stratospheric winter temperatures. During the same time, the geomagnetic activity also showed a substantial increase. The year-to-year correlation between stratospheric pole temperature and geomagnetic activity is significant (about 0.5). The Empirical Mode Decomposition analysis reveals a highly significant correlation (around 0.9) between the long-term component of stratospheric winter temperature (IMF-4) and the long-term component of geomagnetic activity (IMF-3 and IMF-4). One of the reasons for the increase in lower stratospheric temperature is an increase in ozone concentration during the same period when geomagnetic activity is higher. Empirical orthogonal function (EOF) and correlation analysis of stratospheric winter temperature with large-scale circulation patterns are also carried out. The spatial correlation is checked for stratospheric winter temperature at North Pole and lower atmospheric levels (250 hPa and 850 hPa) followed by pre-monsoon and monsoon season. This study includes statistical analysis, however, also highlights the necessity of in-depth dynamical analysis to improve our understanding of how solar activity impacts Earth's atmospheric layers, which may be helpful in predicting the weather and climate
Role of Martian Crustal Fields in Ionospheric Electron Density Distribution and Subsequent South‐North Asymmetry: Insights From Multi‐Year MAVEN Observations During (MYs 33–36)
No full textThis study uses Mars Atmosphere and Volatile EvolutioN observations of electron density and magnetic field for a period of four Martian years (MYs 33–36) (∼8 Earth years) to investigate the effects of Martian crustal magnetic fields on the distribution and variability of Mars' ionosphere. The results show a clear enhancement in electron density in the southern hemisphere in the region where the strong crustal magnetic fields are present with the longitudes between 120° and 240° (i.e., the central longitude), which is in agreement with previous studies. On the contrary, the corresponding northern hemisphere region in the central longitudes shows an exactly opposite behavior that the electron density is lower compared to the surrounding longitude regions. These effects are found to be primarily dayside phenomena. As opposed to dayside, the nightside electron density in the central longitudes are slightly reduced at altitudes below 200 km, compared to longitudes on its western and eastern sides. Above 200 km, the nightside effects are not very clear. Significant hemispheric asymmetry is observed in the longitude regions of enhanced crustal magnetic fields compared to other longitude regions during the daytime. This dayside south-north asymmetry in the central longitude region is observed to be a constant feature across all seasons. However, on the nightside, the south-north asymmetry remains more or less similar across all longitude regions, during all seasons implying a weakened control of the crustal fields over the nightside ionosphere. Even then, the southern hemisphere retains a stronger nightside ionosphere during all seasons except summer
Effect of rotational shear on the dielectric dispersion of a nematic liquid crystal above the Freedericksz threshold field
No full textRheo-dielectric studies of soft materials provide important information on the dynamic structure and electric polarization. We study the dielectric dispersion of a nematic liquid crystal by applying a high AC probe field without a DC bias and a low AC probe field with a high DC bias under steady rotational shear. The dielectric anisotropy of the nematic is positive and the applied electric field is parallel to the velocity gradient with a magnitude larger than the Freedericksz threshold field. We find that the dielectric dispersion and the relaxation frequencies are strongly shear rate dependent. The analysis of the results based on a simple physical model shows that the effective dielectric constant of the nematic with non-uniform director tilt in the shear plane can be modelled as a series combination of parallel and perpendicular components. Our experiments demonstrate changes in dielectric dispersion are due to molecular reorientation under the influence of the competing effects of hydrodynamic and dielectric torques
Strategic insertion of heavy atom to tailor TADF OLED material for the development of type i photosensitizing catalytic red emissive assemblies
No full textThe work presented in the manuscript describes a simple strategy for transforming thermally activated delayed fluorescent organic light-emitting diodes (TADF OLEDs) compound 10-(dibenzo[a,c]phenazin-11-yl)-10H-phenoxazine (DPZ-PXZ) into type I photosensitizer 10-(dibenzo[a,c]phenazin-11-yl)-10H-phenothiazine (DPZ-PHZ) by strategically introducing sulfur atom in the photosensitizing core. The synthesized compound DPZ-PHZ exhibits aggregation-induced enhancement (AIE) and through-space charge transfer (TSCT) characteristics and generates red emissive assemblies in mixed aqueous media. The original compound DPZ-PXZ exhibits well-separated HOMO and LUMO levels and is reported to have highly efficient reverse intersystem crossing (RISC). In comparison, the incorporation of sulfur atom in the phenothiazine donor regulates the electronic communication between donor and acceptor units and promotes the intersystem crossing (ISC) in DPZ-PHZ molecules. Interestingly, compound DPZ-PHZ exhibits rapid activation of aerial oxygen for instant generation of superoxide radical anion. Backed by excellent type I photosensitizing activity, DPZ-PHZ assemblies have high catalytic potential for the synthesis of benzimidazoles, benzothiazoles and quinazolines derivatives under mild reaction conditions. The work presented in the manuscript provides an insight into the combination of heavy atom approach and TSCT for achieving adequate electronic communication between donor and acceptor units, balanced RISC/ISC, and stabilized-charge separated state for the development of efficient type I photosensitizing assemblies
The ring rules the chain — inositol pyrophosphates and the regulation of inorganic polyphosphate
No full textThe maintenance of phosphate homeostasis serves as a foundation for energy metabolism and signal transduction processes in all living organisms. Inositol pyrophosphates (PP-InsPs), composed of an inositol ring decorated with monophosphate and diphosphate moieties, and inorganic polyphosphate (polyP), chains of orthophosphate residues linked by phosphoanhydride bonds, are energy-rich biomolecules that play critical roles in phosphate homeostasis. There is a complex interplay between these two phosphate-rich molecules, and they share an interdependent relationship with cellular adenosine triphosphate (ATP) and inorganic phosphate (Pi). In eukaryotes, the enzymes involved in PP-InsP synthesis show some degree of conservation across species, whereas distinct enzymology exists for polyP synthesis among different organisms. In fact, the mechanism of polyP synthesis in metazoans, including mammals, is still unclear. Early studies on PP-InsP and polyP synthesis were conducted in the slime mould Dictyostelium discoideum, but it is in the budding yeast Saccharomyces cerevisiae that a clear understanding of the interplay between polyP, PP-InsPs, and Pi homeostasis has now been established. Recent research has shed more light on the influence of PP-InsPs on polyP in mammals, and the regulation of both these molecules by cellular ATP and Pi levels. In this review we will discuss the cross-talk between PP-InsPs, polyP, ATP, and Pi in the context of budding yeast, slime mould, and mammals. We will also highlight the similarities and differences in the relationship between these phosphate-rich biomolecules among this group of organisms
Comprehensive germline profiling of patients with breast cancer: Initial experience from a Familial Cancer Clinic
No full textIntroduction:
Breast cancer is the most common cancer among Indian females. There is limited data on germline profiling of breast cancer patients from India.
Objective:
The objective of the current study was to analyse the frequency and spectrum of germline variant profiles and clinicopathological characteristics of breast cancer patients referred to our Familial Cancer Clinic (FCC).
Materials and methods:
It is a single-centre audit of patients with a confirmed diagnosis of breast carcinoma referred to our FCC from January 2017 to 2020. All patients underwent pretest counselling. Genetic testing was done by multigene panel testing by next-generation sequencing along with reflex multiplication ligation-dependent probe amplification for BRCA1 and 2. The variants were classified based on American College of Medical Genetics guidelines. Demographic and clinicopathological details were extracted from the case record files.
Results:
One hundred and fifty-five patients were referred to the FCC and underwent pretest counselling. A total of 99 (63.9%) patients underwent genetic testing. Among them, 62 patients (62/99 = 62.6%) had a germline variant. A pathogenic/likely pathogenic (P/LP) germline variant was identified in 41 (41.4%) of the patients who underwent testing. Additional variants of unknown significance (VUS) were identified in seven patients who also carried a P/LP variant. VUS alone was detected in 21 patients (21/99 = 21.2%). Among the P/LP pathogenic variants (PV), BRCA 1 PV were seen in 27 patients (65.8%), BRCA 2 variants in 7 patients (17.1%), ATM variants in 3 patients (7.3%) and RAD51, TP53, CHEK2 and HMMR in 1 patient each. Variants were significantly more common in patients with a family history (FH) of malignancy than those without FH (58.5% versus 29.5%; p = 0.013). Age and triple-negative histology were not found to be significantly associated with the occurrence of P/LP PVs.
Conclusion:
We report a 41% P/LP variant rate in our selected cohort of breast cancer patients, with variants in BRCA constituting 83% and non-BRCA gene variants constituting 17%
Roadmap on perovskite light-emitting diodes
No full textIn recent years, the field of metal-halide perovskite emitters has rapidly emerged as a new community in solid-state lighting. Their exceptional optoelectronic properties have contributed to the rapid rise in external quantum efficiencies (EQEs) in perovskite light-emitting diodes (PeLEDs) from <1% (in 2014) to over 30% (in 2023) across a wide range of wavelengths. However, several challenges still hinder their commercialization, including the relatively low EQEs of blue/white devices, limited EQEs in large-area devices, poor device stability, as well as the toxicity of the easily accessible lead components and the solvents used in the synthesis and processing of PeLEDs. This roadmap addresses the current and future challenges in PeLEDs across fundamental and applied research areas, by sharing the community’s perspectives. This work will provide the field with practical guidelines to advance PeLED development and facilitate more rapid commercialization
Ultrabroad Near Infrared Emitting Perovskites
No full textPhosphor converted light emitting diodes (pc-LEDs) have revolutionized solid-state white lighting by replacing energy-inefficient filament-based incandescent lamps. However, such a pc-LED emitting ultrabroad near-infrared (NIR) radiations still remains a challenge, primarily because of the lack of ultrabroad NIR emitting phosphors. To address this issue, we have prepared 2.5 % W4+-doped and 2.8 % Mo4+-doped Cs2Na0.95Ag0.05BiCl6 perovskites emitting ultrabroad NIR radiation with unprecedented spectral widths of 434 and 468 nm, respectively. Upon band-edge excitation, the soft lattice of the host exhibits broad self-trapped exciton (STE) emission covering NIR-I (700 nm), which then nonradiatively excites the dopants. The II–donor ligand Cl- reduces the energy of dopant d-d transitions emitting NIR-II with a peak at ~950 nm. Vibronic coupling broadens the dopant emission. The large spin-orbit coupling and local structural distortion might possibly enhance the dopant emission intensity, leading to an overall NIR photoluminescence quantum yield ~40 %. The composite of our ultrabroad NIR phosphors with biodegradable polymer polylactic acid could be processed into free-standing films and 3D printed structures. Large (170X 170 mm2 ), robust, and thermally stable 3D printed pc-LED panels emit ultrabroad NIR radiation, demonstrating NIR imaging applications
Affinity Propagation in Semi-Supervised Segmentation: A Biomedical Application
No full textGiven the scarcity of sufficient annotated data, using small sets of labeled samples under semi-supervision in biomedical imaging becomes necessary. Despite being highly successful, deep learning algorithms demand plenty of data to obtain significant performance. Complex data models make the usage of these methods costly. Selecting the correct model and tuning the hyperparameters of a model are also difficult jobs. Hence, a novel approach namely affinity propagation-based semi-supervised segmentation (APSS) is proposed. Here, affinity propagation clustering is modified and integrated with the advanced learning techniques that can efficiently use limited training data by discarding the completely exploited labeled data points. Moreover, a novel affinity calculation method is proposed considering both the Euclidean and geodesic distances to compute the distance between the two points on the histogram. This twofold contribution is tested using the three standard datasets (the International Skin Imaging Collaboration (ISIC) dermoscopic image dataset, the retinal fundus image dataset, and the liver tumor segmentation (LiTS) dataset). Results are compared with the three standard semi-supervised algorithms and four supervised algorithms. The effectiveness of the APSS approach in finding and exploiting the relationship between the labeled and unlabeled datasets is demonstrated in terms of qualitative (subjective evaluation and visual inspection) and quantitative performance (objective evaluation and numerical measurements)
Tuning the interfacial interactions between alumina support and pseudo single atom platinum-tin catalytic sites for heavy naphtha reforming
No full textHeavy naphtha reforming, a crucial downstream process in oil refineries for improving the octane number of the gasoline feedstock, requires expensive Pt metal catalysts and it accounts for 60% of the catalyst cost. These conventional Pt nanoparticle sizes range between 1 – 2 nm and thus, only ≈ 80% of the Pt atoms of the particle are available for the catalytic reactions. In this work, we hypothesized that it might be possible to achieve 100% atom utilization if the Pt atoms are distributed as single or pseudo-single atom clusters, where all the atoms are exposed to the reactant molecules and by tuning their Interfacial Interactions. We aimed to significantly reduce the Pt contents by dispersing the active Pt sites as pseudo-single atoms on industrially relevant γ-Al2O3 support. Interfacial Interactions and stability of Pt sites were then tuned by using tin (Sn) as a promoter. These catalysts were then evaluated for heavy naphtha reforming in a fixed-bed reactor. The catalyst with Sn/Pt mole ratio of 1.68 showed excellent performance with aromatics of 83 wt% and research octane number (RON) of ≈ 103. These results indicated our catalyst preparation methodologies and interfacial interaction tuning successfully disperse Pt on the spherical alumina support leading to better atom economy. With 30–50% less Pt content when compared to the industrially used catalyst, made the heavy naphtha reforming process economical and sustainable