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Design and Synthesis of Novel NO-Drug Hybrid Compound and Green Catalytic Activity Evaluation of Synthesized Silver Nanoparticles-Halloysite Nanocomposite
Get PDFAcetaminophen is a well-known analgesic that can manage pain and reduce fever. SCP-1 is a derivative of acetaminophen that showed significantly reduced hepatotoxicity and nephrotoxicity comparative to acetaminophen. Nitric oxides have been well known to play a key role in a wide variety of physiological and pathophysiological important processes. It was therefore of interest to synthesize a nitric oxide donor linked to SCP-1 that could have enhanced analgesic and antipyretic activity. A furoxan CAS 1609 as NO-donor was synthesized and linked to SCP-1 successfully. The furoxan CAS 1609 was initially synthesized from tetronic acid to give 1,2- dioxime in 86 % yield. The furoxan 4-hydroxymethyl carboxymethyl ester was obtained in 55 % yield by using t-butyl hypochlorite as an oxidation agent. The furoxan 4-hydroxymethyl carboxymethyl ester was treated with ammonia solution in methanol and converted the ester group into an amide moiety and furnish the targeted furoxan CAS 1609 in 98% yield. The CAS 1609 was coupled with SCP-1, after bromination of the hydroxyl group by thionyl bromide, using DBU as base at room temperature to produce NO-SCP-1 in 57%.
Halloysite is a naturally available clay with a hollow tubular structure, and it is abundant and durable. Metallic nanoparticles supported by halloysite to form nanocomposite materials have huge potential in heterogeneous catalysis. Silver nanoparticles (~10 nm, AgNP) were synthesized inside the lumen of halloysite under green conditions to form Ag@Hal. The nanocomposite was characterized by Transmission Electron Microscopy and Inductively Coupled Plasma Atomic Emmision Spectroscopy and determined to be 6% Ag@Hal (wt/wt). The Ag@Hal nanocomposite exhibited catalytic activity and selectivity for the synthesis of 1,4-disubstituted over the 1,5- disubstituted triazoles under green condition. The reaction also showed enhanced over all yield when the temperature was increased. The 1-benzyl-4-phenyl-1,2,3-triazole was obtained in 58% yield while the 1,5-disubstituted 1,2,3-triazole was isolated in 19% yield
he Economic Effects of Immigration and Customs Enforcement (ICE) Detention Centers in Louisiana
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Presence / Absence
Get PDFPresence / Absence is a visual and conceptual l exploration of language and issues surrounding experiences of interpersonal relationships. In it I look at various approaches in which artists and writers have approached the subject of intimacy and coexistence as both a context and foundation for my own work addressing relationships. This body of work is specifically looks at experiences of the personally revolutionary presence of an other and the impact of their absence
Flower & Song
Get PDFMy work functions as a spiritual and philosophical inquiry, adapting ideas from a broad variety of sources, from the mythic and literary, to the autobiographical. I seek to harmonize paradoxical elements in service of higher knowledge and consciousness. Genealogical explorations of my unusual familial heritage have provided me with a wealth of photographs, religious and cultural motifs, and conceptual material. I view this personal examination as an idiosyncratic path to the universal, the limbs of my family tree branching through time and space to intertwine with the whole of history. Combining both ancient and modern traditions, I create esoteric liminal spaces in my paintings as a means of arriving closer to a truth that unfolds beyond the reach of material reality. I view my task as a mystical one, a divine, even futile, attempt to make work that serves as a vehicle to the other shore of human consciousness
An American Ambulance Driver in France during the Great War: The Lasting Memory and Relationship between Harry N. Deyo, the Men of Section 591, and French Civilians
Get PDFThis thesis presents the experiences of Harry N. Deyo, a graduate of the University of Michigan, who volunteered to serve in the United States Army Ambulance Service in France during the Great War. The friendship between Deyo and the drivers of Section 591 lasted throughout his lifetime. These friendships were important to his life; they were a way to share common bonds and to remember the war in the context of camaraderie and affection between themselves and the French civilians who cared for them. The role of rural French civilians and the relationships formed with the American ambulance drivers is also explored. Studies of collective memory and remembrance evidence the bond shared among these distinctive groups of people. This thesis argues that the relationships between the men of Section 591 and the French civilians they encountered were unique experiences and had lasting effects long after the end of the war
B&E
Get PDFIn this reflection paper I will cover the production of B&E in its entirety. From the origin of the script to planning the distribution. I will also reflect on my experiences at UNO and remark on how they I learned from mistakes that I made on other films and corrected them during my process for B&E. I will also point out what I believe to be the largest mistakes that I committed during the production of this film and how I plan to correct them in the future
Experimental Investigation into the Boundary Layer of a Robotic Anguilliform Propulsor
Get PDFBoundary layer information local to three longitudinal positions has been characterized for a 130 cm long biomimetic self-propulsor known as NEELBOT-1.1 that swims with undulatory anguilliform-like motions, via analysis of stereo particle image velocimetry (PIV) measurements for key moments in the undulation cycle and for numerous combinations of swimming conditions and motion parameters, ideal and non-ideal. No obvious turbulent flow structures or indications of boundary layer separation were observed at nonzero advance speeds, and skin friction coefficients were subsequently estimated for magnitude relative to the dynamic pressure associated with operation at the design swimming speed of Uo = 0.25 m/s. Estimates were correlated with measurements made for an oscillating and non-oscillating cylindrical test article that were benchmarked by initial mono PIV investigations of steady laminar flow over a flat plate at zero incidence which was tested while stationary and oscillating in its own plane. Behavior of boundary layer profiles pertaining to the robot, apparently significantly influenced by the traveling flexion waves characteristic of the anguilliform motions, is clearly distinguished from local oscillatory flow structures related to the other two test articles. Approximately 10–15% increases in local skin friction are observed for the robot over similar conditions for the cylinder, and downstream vortex shedding is readily observed for the oscillating cylinder.
The results of this thesis will be used in validation of numerical analyses performed in parallel with this research for the purpose of calculating the time-mean frictional drag experienced by the robot and to determine whether it can produce enough thrust to overcome its drag without simultaneously increasing it beyond realizable thrust generation capabilities. Theoretical hydrodynamic descriptions of the wake velocity field agreed well with previous PIV measurements, but the theory does not treat viscous effects. Furthermore, the preliminary semi-empirical, quasi-static attempts to estimate frictional drag were shown to under-predict the actual drag by net force measurements taken while towing the robot at its design speed which was undulating for that expected swimming speed, hence the necessity of this thesis as further investigation