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Lysins as antibacterials against Uropathogenic Escherichia coli
No full textOs autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz
Exploring health care for transgender people in the Brazilian health system: Qualitative descriptive-interpretative study.
No full textThe guarantee of rights in Brazil is legitimized through its Constitution of the Republic and its national health system needs to follow a list of prerogatives that include, also, transgender people. Currently there are situations in which the expectation of rights is broken and the free exercise of life of this population is prevented. This article analyzes access to health services by trans people in the health system in Brazil. The investigation was carried out in cities in the metropolitan region of a municipality in southeastern Brazil, through qualitative, exploratory and descriptive-interpretive research. The trans population faces many difficulties in accessing the services that make up the Brazilian Health System, such as the lack of qualification of health professionals, barriers to the use of the social name and structural prejudices in society.3100-12-3
Comparison of systemic immunity following intranasal/intramuscular and intramuscular immunization with meningococci antigens
No full textOs autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz
Diversity of mosquitoes (Diptera: Culicidae) in an atlantic forest urban park, Salvador, Brazil
No full textConselho Nacional do Brasil. Fundação Baiana. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Ministério da Educação do Brasil. Departamento de Ciência e Tecnologia. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Ministério da Saúde. Universidade Federal da Bahia. Fundação Oswaldo Cruz.We identified mosquito species (Diptera: Culicidae) in an Atlantic Forest fragment located in a large urban park in Salvador, Brazil, one year after a citywide epizootic of yellow fever virus (YFV). Between May 2 and August 2, 2018, adult mosquitoes were collected using the human attraction method, followed by trapping with hand-nets, and CO2-baited light traps placed at ground level and in the canopy. We collected a total of 11,914 mosquitoes, which belonged to three tribes, five genera, and at least seven species. The most abundant taxa captured by CO2-baited light traps were Culex quinquefasciatus (Say, Diptera: Culicidae) Limatus spp. (Diptera: Culicidae), and Wyeomyia spp. (Diptera: Culicidae), while by human attraction, Cx. quinquefasciatus, Wyeomyia spp., and Aedes albopictus (Skuse, Diptera: Culicidae) were captured most often. The diversity of mosquitoes by species was greater in the park area with restinga vegetation compared to the area with dense rainforest. Although vectors commonly associated with sylvatic YFV transmission were not captured, we collected several species capable of transmission of other arboviruses. Given the high likelihood of encounters between mosquitoes and human visitors in environments, such as the one studied, periodic entomological surveys to determine the risk of arbovirus transmission in these settings are warranted
Association between sanitation conditions and notifications of leptospirosis cases in the city of Salvador-BA
No full textIntrodução: A Leptospirose é uma doença infecciosa com elevada morbimortalidade, especialmente em países em desenvolvimento, caso do Brasil. Apesar de ser uma doença historicamente associada a ambientes rurais, as precárias condições de moradia presente entre as populações mais vulneráveis dos grandes centros urbanos, atrelado ao acesso deficitário a serviços essenciais, como esgotamento sanitário, tem corroborado para o aumento da infestação de roedores portadores da bactéria Leptospira e exposição dos indivíduos à doença. No Brasil, 45% da população está sem coleta de esgoto, e no ano de 2020 foram registrados 1.898 óbitos por doenças de veiculação hídrica. O que demonstra a importância da ampliação da cobertura sanitária para redução da exposição e a incidência de doenças como a leptospirose. Objetivo(s): Associar a cobertura de esgotamento com à incidência acumulada de leptospirose,
ajustados pela renda e escolaridade, no período de 2009 a 2019 em Salvador – BA. Material e Métodos: Realizou-se um estudo descritivo das notificações de casos de leptospirose no Sistema de Informação de Agravos de Notificação do SUS (Sinan) associando a distribuição espacial das condições socioeconômicas e de esgotamento sanitário domiciliar a partir da análise de variáveis do Censo do ano 2010. Para o status de exposição, construiu-se um escore considerando 0 e 1 para condições de cobertura das variáveis analisadas. Foi atribuído 0 aos setores censitários com maior cobertura de esgotamento sanitário, alfabetização e renda superior a um salário mínimo, e foi atribuído
1 aos setores em situação inversa, ou seja, baixa cobertura de saneamento, baixo número de alfabetização domiciliar e renda inferior a um salário mínimo. A soma da pontuação resultou na identificação dos setores em pior situação, e observou-se que eles estavam associados aos bairros de infecção com média de casos ≥4. Resultados e Conclusão: 21 (12,3%) dos 170 bairros de Salvador apresentaram notificação de casos no período estudado. O resultado do escore foi associado com o aumento na incidência acumulada de leptospirose (RR:1,03; 95%IC: 1,01-1,04), no entanto, esta relação sofreu influência da renda e densidade populacional para alguns setores. Os bairros em pior situação a partir das variáveis analisadas apresentaram maior escore e maior taxa de incidência acumulada, reforçando a hipótese de que intervenções estruturais e sanitárias podem contribuir para redução da exposição e ocorrência casos de leptospirose
Indicadores epidemiológicos da doença de chagas na região metropolitana de Salvador, Bahia, Brasil
No full textIntrodução: Chagas disease is caused by Trypanosoma cruzi, which is transmitted by triatomines. Historical records indicate that T. cruzi has been circulating in the Metropolitan Region of Salvador since the 20th century. Salvador’s Health Surveillance System indicates the presence of triatomines in urban areas, but there is not much information about this vector in other municipalities of the Metropolitan Region of Salvador. Objetivo(s): This study was to investigate Chagas disease in Metropolitan Region of Salvador, considering epidemiological indicators to inform health managers about the importance of entomological surveillance. Material e Métodos: Cross-sectional, descriptive study, conducted through secondary data. Data analyzed were from 2008 to 2015: deaths due to Chagas disease; self-reported cases of Chagas disease registered; and blood donors registered as non-negative for T. cruzi infection.
Resultados e Conclusão: São Francisco do Conde remained one of the municipalities with the highest mortality rate due to Chagas disease. Candeias was the municipality with one of the highest prevalences and considering the total number of blood donors. Seroprevalence varied by year and municipality, with the highest values: 2008 Vera Cruz, 2009 Mata de São João, 2010 Dias D'Ávila, 2011 and 2015 São Francisco do Conde, 2012 São Sebastião do Passé, 2013 and 2014 Pojuca. We did not detect spatial self-relationships between municipalities. We conclude that Chagas disease is present in the municipalities of Metropolitan Region of Salvador. Given the importance of the entomological indicator for the surveillance and control of Chagas disease at the state and national levels, it is important to strengthen the vector surveillance program of Chagas disease at the municipal level, including in regions classified as low risk for vector transmission of T. cruzi
Feed Nasa: edição 5
No full textRevisão de conteúdo/Jornalismo: Glauber Tiburtino. Diagramação e Design Gráfico: Marcelo Santos. Realização em parceria com Ascom Cogepe
Implementation of the Occupational Risk Management Program-ORMP in the production processes of the Covid-19 vaccine: Bio-Manguinhos case study
No full textOs autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz
Secondary infections in a cohort of patients with COVID-19 admitted to an intensive care unit: impact of gram-negative bacterial resistance
No full textSome studies have shown that secondary infections during the COVID-19 pandemic may have contributed to the high mortality. Our objective was to identify the frequency, types and etiology of bacterial infections in patients with COVID-19 admitted to an intensive care unit (ICU) and to evaluate the results of ICU stay, duration of mechanical ventilation (MV) and in-hospital mortality. It was a single-center study with a retrospective cohort of patients admitted consecutively to the ICU for more than 48 h between March and May 2020. Comparisons of groups with and without ICU- acquired infection were performed. A total of 191 patients with laboratory-confirmed COVID-19 were included and 57 patients had 97 secondary infectious events. The most frequent agents were Acinetobacter baumannii (28.9%), Pseudomonas aeruginosa (22.7%) and Klebsiella pneumoniae (14.4%); multi-drug resistance was present in 96% of A. baumannii and in 57% of K. pneumoniae. The most prevalent infection was ventilator-associated pneumonia in 57.9% of patients with bacterial infections, or 17.3% of all COVID-19 patients admitted to the ICU, followed by tracheobronchitis (26.3%). Patients with secondary infections had a longer ICU stay (40.0 vs. 17 days; p < 0.001), as well as a longer duration of MV (24.0 vs 9.0 days; p= 0.003). There were 68 (35.6%) deaths overall, of which 27 (39.7%) patients had bacterial infections. Among the 123 survivors, 30 (24.4%) had a secondary infections (OR 2.041; 95% CI 1.080 - 3.859). A high incidence of secondary infections, mainly caused by gram-negative bacteria has been observed. Secondary infections were associated with longer ICU stay, MV use and higher mortality