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Boletim BiblioCovid: COVID-19 e os profissionais de saúde: impactos na saúde física e mental dos profissionais de saúde no enfrentamento da COVID-19

Author: Veiga Viviane Santos de Oliveira
Mendes Patrícia
Silva Adriano da
Publication venue
Publication date: 01/01/2020
Field of study

Projeto gráfico e diagramação: Luciana Rocha Mariz Clua - Multimeios|Icict|Fiocruz Ilustração BiblioCovid: Luciana Rocha Mariz Clua - Multimeios|Icict|FiocruzBoletim destinado a apresentação de estratégias e artigos científicos sobre temas relacionados à Covid-19.Icict/RB

The value of mitigating epidemic peaks of COVID-19 for more effective public health responses

Author: Villela Daniel Antunes Maciel
Publication venue: Sociedade Brasileira de Medicina Tropical
Publication date: 01/01/2020
Field of study

Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação

Almanaque Dengue Chikungunya e Zika

Author: Marteleto Regina Maria
David Helena Maria Scherlowski Leal
Nóbrega Nanci Gonçalves da
Nogueira Mariana
Cavalcante Lídia Eugênia
Silva Maria Rocineide Ferreira da
Silva Marcus Vinícius Pereira da
Publication venue
Publication date: 01/01/2020
Field of study

Financiamento do projeto: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/MCTIC). Pesquisadores colaboradores: Maurício Monken (EPSJV/Fiocruz), Grácia Gondim (EPSJV/Fiocruz)

Presidente da Fiocruz fala dos desafios da pandemia de Covid-19

Author: Lima Nísia Trindade
Publication venue: ENSP/Fiocruz
Publication date: 01/01/2020
Field of study

Em entrevista à Agência Fiocruz de Notícias, a presidente da Fiocruz, Nísia Trindade Lima, comentou o contexto da pandemia de Covid-19 e os desafios de sua chegada ao Brasil. Ela também elenca algumas ações da instituição na resposta à crise sanitária, que vai desde a produção de testes ao atendimento aos infectados. Todos os setores e unidades da Fundação estão mobilizadas para o enfrentamento da epidemia. “A Fiocruz está completando 120 anos em maio e o aniversário vai ser marcado pela resposta à essa pandemia, assim como o início da instituição foi uma resposta sanitária às epidemias no Rio de Janeiro”, destacou Nísia

Memória e escrevivência como práticas de (R)existir

Author: Reis Jéssica de Jesus
Publication venue: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Publication date: 01/01/2020
Field of study

Definido como ferramenta avaliativa, ao reconstruir a história de aprendizagem a partir da participação na Residência Integrada em Saúde da Família FIOCRUZ/FESF-SUS, o memorial de trajetória do curso permite além de uma autoavaliação do/a residente, um relato da imersão do sujeito no seu campo profissional em todas as dimensões: sociais, afetivas, políticas, culturais e identitárias, por exemplo. Por isso a enunciação da voz subjetiva da autora e seu lugar social, racial e de gênero – mulher negra – permeará toda escrita de um documento que se formata em memória narrada e trajetória individual, mas que reconhece a coletividade, a conjuntura dos espaços e sociedade e o contexto de cada ação profissional/pedagógica. Em um primeiro momento, falarei sobre a importância da Residência na construção de novas identidades profissionais, sobre aspectos da educação popular em saúde no planejamento e desenvolvimento de espaços coletivos, sobre a invisibilidade da Política Nacional de Saúde Integral da População Negra e sobre a possibilidade de uma educação antirracista para crianças. Com esta reflexão inicial, elaboro o relato de experiência em si, o memorial enquanto escrevivência. Nele busco minhas primeiras memórias sobre educação na infância, adolescência e sobre minha família matriarcal negra até chegar aos tempos de conquistas de títulos e maior consciência do lugar que hoje ocupo como cirurgiã dentista. Vou abordar também o principal contexto da escrita dessa narrativa, a Unidade de Saúde da Família (USF) Parque das Mangabas, e das ações coletivas e educativas em que mais dediquei afeto, força, planejamento e estudo: o Grupo de Gestantes e o Mangabinhas (grupo de crianças), sendo este último contextualizado por um estudo epidemiológico sobre a condição de saúde bucal de escolares da área de abrangência da USF. Finalizo essa escrita tecendo reflexão sobre o processo formativo, os entraves institucionais e também ressaltando os aspectos positivos e encontros político-afetivos significativos que a residência proporcionou ao longo desses intensos dois anos.Defined as an evaluative tool, to reconstruct a learning history based on participation in the Integrated Residence in Family Health FIOCRUZ / FESF-SUS, or memorial of the course's trajectory, in addition to a self-assessment / resident, a report of immersion in the individual in his professional field in all dimensions: social, affective, political, cultural and identity, for example. Therefore, the voice of the voice recorded by the author and her social, racial and gender place - black woman - allows the entire writing of a document that shapes the narrated memory and the individual trajectory, but that registers the collectivity, a conjuncture of spaces and society and the context of each professional / pedagogical action. At first, we talked about the importance of residency in the construction of new professional identities, about aspects of popular health education, in the planning and development of collective spaces, about the invisibility of the National Policy for Integral Health of the Black Population and about the possibility of an anti-racist education for children. With this initial reflection, elaboration or report of experience itself, or memorial while writing. In it I search for my first memories about early childhood education, adolescence and my black matriarchal family until I reached the time of winning titles and greater awareness of the place that today occurs as a dental surgeon. You will also address the main context of writing this narrative, the Family Health Unit (FHU), the Parque das Mangabas, and the collective and educational actions on what are the rights, strength, planning and study: the Group of Pregnant Women and Mangabinhas (group of children), the latter being contextualized by an epidemiological study on the oral health condition of students in the area covered by the USF. Finish this writing by reflecting on the formative process, the institutional records and also highlighting the positive aspects and the political-affected relationships that the residence has offered over these intense two year

Aborto legal en Brasil: revisión sistemática de la producción científica, 2008-2018

Author: Fonseca Sandra Costa
Domingues Rosa Maria Soares Madeira
Leal Maria do Carmo
Aquino Estela Maria Motta Lima Leão de
Menezes Greice Maria de Souza
Publication venue
Publication date: 01/01/2020
Field of study

Revisões anteriores sobre o aborto no Brasil estimaram um milhão de procedimentos anuais, porém, não abordaram o aborto legal. O objetivo desta revisão sistemática foi atualizar o conhecimento sobre o aborto legal, quanto ao perfil dos serviços, das mulheres atendidas, conhecimento de estudantes e médicos, situação de anencefalia e malformações graves. A busca de artigos foi via MEDLINE e LILACS, de 2008 a 2018, sem restrição de idiomas. A qualidade dos artigos foi avaliada com instrumentos do Joanna Briggs Institute. Busca, seleção, avaliação de qualidade e extração de dados foram feitas independentemente por duas pesquisadoras. Selecionaram-se 20 artigos, 11 sobre conhecimento e opinião de profissionais médicos (4 artigos) e estudantes de Medicina (7 artigos), revelando conhecimento aquém do ideal sobre o aborto legal e objeção de consciência elevada. Seis estudos sobre as mulheres atendidas identificaram que elas são jovens, solteiras e a principal demanda foi a gravidez decorrente de estupro. A demora em procurar atendimento ocorreu dentre as mais jovens, solteiras e quando o agressor era alguém próximo. Três estudos sobre malformações graves mostraram autorização judicial em torno de 40%. Nos casos sem autorização, a evolução da gravidez foi complicada e o parto foi cesáreo. Apenas um artigo abordou os serviços de aborto legal, apontando 37 dos 68 cadastrados em atividade, inexistência em sete estados e concentração nas capitais. O conhecimento sobre o aborto legal ainda é escasso, a demanda do procedimento é reprimida e a formação médica é deficiente no tema.Previous reviews on the subject of abortion in Brazil have estimated one million procedures per year but did not address legal abortion. This systematic review sought to update knowledge regarding legal abortion in terms of service and women’s profile, student and doctor knowledge, situations of anencephaly and severe malformations. We searched MEDLINE and LILACS for articles published in all languages between 2008 and 2018. Article quality was assessed using the Joanna Briggs Institute instruments. Search, selection, quality assessment and data extraction were carried out independently by two researchers. We selected 20 articles, 11 on the knowledge and opinion of medical professionals (4 articles) and students (7 articles) revealing a less-than-ideal level of knowledge and a high degree of objection of conscience. Six studies on women who use legal abortion services found that they are young, single and that the main demand was for pregnancy resulting from rape. When women were younger and single and when the aggressor was someone close to them, there were delays in seeking care. Three studies on severe malformation found around 40% of court authorizations. In cases for which no authorization was given, the evolution of pregnancies was complicated and deliveries were done through cesarean sections. Only one article addressed legal abortion services, showing that 37 of the 68 that had been registered were active, lack of services in seven states and concentration in capitals. Knowledge regarding legal abortion is still scarce, the demand for the procedure is repressed and medical training is deficient with regard to this subject.Revisiones anteriores sobre el aborto en Brasil estimaron un millón de procedimientos anuales, sin embargo, no abordaron el aborto legal. El objetivo de esta revisión sistemática fue actualizar el conocimiento sobre el aborto legal, en cuanto al perfil de los servicios, de las mujeres atendidas, conocimiento de estudiantes y médicos, situación de anencefalia y malformaciones graves. La búsqueda de artículos fue vía MEDLINE y LILACS, de 2008 a 2018, sin restricción de idiomas. La calidad de los artículos se evaluó con instrumentos del Joanna Briggs Institute. La búsqueda, selección, evaluación de la calidad y extracción de datos fueron realizadas independientemente por parte de dos investigadoras. Se seleccionaron 20 artículos, 11 sobre conocimiento y opinión de profesionales médicos (4 artículos) y estudiantes de Medicina (7 artículos), revelando conocimiento inferior al ideal sobre el aborto legal y la objeción de conciencia. Seis estudios sobre las mujeres atendidas identificaron que se trata de jóvenes, solteras y la principal demanda fue el embarazo ocasionado por una violación. La tardanza en buscar atención se produjo entre las más jóvenes, solteras y cuando el agresor era alguien cercano. Tres estudios sobre malformaciones graves mostraron una autorización judicial en torno a un 40%. En los casos sin autorización, la evolución del embarazo fue complicada y el parto fue por cesárea. Solamente un artículo abordó los servicios de aborto legal, apuntando 37 de los 68 registrados en actividad, inexistencia en siete estados y concentración en las capitales. El conocimiento sobre el aborto legal todavía es escaso, la demanda de la intervención está reprimida y la formación médica es deficiente en el tema

Neutrophil extracellular trap-enriched supernatants carry microRNAs able to modulate TNF-α production by macrophages

Author: Linhares-Lacerda Leandra
Temerozo Jairo Ramos
Ribeiro-Alves Marcelo
Azevedo Estefania P.
Mojoli Andres
Nascimento Michelle T. C.
Silva-Oliveira Gustavo
Savino Wilson
Foguel Debora
Bou-Habib Dumith Chequer
Saraiva Elvira M.
Publication venue: Nature
Publication date: 01/01/2020
Field of study

Neutrophil extracellular traps (NETs) emerge from the cell as a DNA scaffold associated with cytoplasmic and granular proteins, able to immobilize and kill pathogens. This association occurs following nuclear and granular membrane disintegration, allowing contact with the decondensed chromatin. Thus, it is reasonable to speculate that the DNA can also mix with miRNAs and carry them in NETs. Here, we report for the first time the presence of the miRNA carriers associated with NETs and miRNAs present in NET-enriched supernatants (NET-miRs), thus adding a novel class of molecules and new proteins that can be released and transported in the NET platform. We observed that the majority of NET-miRs were common to all four stimuli used (PMA, interleukin-8, amyloid fibrils and Leishmania), and that miRNA-142-3p carried by NETs down-modulates protein kinase Cα and regulates TNF-α production in macrophages upon NET interaction with these cells. Our findings unveil a novel role for NETs in the cell communication processes, allowing the conveyance of miRNA from neutrophils to neighboring cells

Repositioning of the global epicentre of non-optimal cholesterol

Author: Taddei Cristina
Costa Maria Fernanda Furtado Lima
Peixoto Sergio William Viana
NCD Risk Factor Collaboration (NCD-RisC)
Publication venue: Nature
Publication date: 01/01/2020
Field of study

Bin Zhou Imperial College London, London, UK/NCD Risk Factor Collaboration Honor Bixby Imperial College London, London, UK/NCD Risk Factor Collaboration Rodrigo M. Carrillo-Larco Imperial College London, London, UK/NCD Risk Factor Collaboration Marisa K. Sophiea Imperial College London, London, UK/NCD Risk Factor Collaboration Maria Laura Caminia Iurilli Imperial College London, London, UK/NCD Risk Factor Collaboration Andrea Rodriguez Martinez Imperial College London, London, UK/NCD Risk Factor Collaboration James E. Bennett Imperial College London, London, UK/NCD Risk Factor Collaboration Gretchen A. Stevens Imperial College London, London, UK/Independent researcher, Los Angeles, CA, USA/NCD Risk Factor Collaboration Abbas Dehghan Imperial College London, London, UK/NCD Risk Factor Collaboration Ilpo Tapani Huhtaniemi Imperial College London, London, UK/NCD Risk Factor Collaboration Marjo-Riitta Jarvelin Imperial College London, London, UK/University of Oulu, Oulu, Finland Edward W. Gregg Imperial College London, London, UK/NCD Risk Factor Collaboration Majid Ezzati Imperial College London, London, UK/NCD Risk Factor Collaboration Goodarz Danaei Harvard T. H. Chan School of Public Health, Boston, MA, USA Yanping Li Harvard T. H. Chan School of Public Health, Boston, MA, USA/NCD Risk Factor Collaboration Rod T. Jackson University of Auckland, Auckland, New Zealand/NCD Risk Factor Collaboration/NCD Risk Factor Collaboration Robert Beaglehole University of Auckland, Auckland, New Zealand Patricia Metcalf University of Auckland, Auckland, New Zealand/NCD Risk Factor Collaboration/NCD Risk Factor Collaboration Farshad Farzadfar Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Naser Ahmadi Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Mehrdad Azmin, Sareh Eghtesad Tehran University of Medical Sciences, Tehran, Iran Ali Ghanbari, Erfan Ghasemi Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Rosa Haghshenas Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Reza Malekzadeh Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Parinaz Mehdipour Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Shahin Merat Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Sahar Saeedi Moghaddam Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Bahram Mohajer Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Kazem Mohammad Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Zahra Mohammadi Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Farnam Mohebi Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Shohreh Naderimagham Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Afshin Ostovar Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Hossein Poustchi Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Alireza Sadjadi Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Sadaf G. Sepanlou Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Ramin Shakeri Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Maryam Sharafkhah Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Amaneh Shayanrad Tehran University of Medical Sciences, Tehran, Iran Moein Yoosefi Tehran University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Mariachiara Di Cesare Middlesex University, London, UK/NCD Risk Factor Collaboration Golaleh Asghari Shahid Beheshti University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Davood Khalili Shahid Beheshti University of Medical Sciences, Tehran, Iran/NCD Risk Factor Collaboration Amirabbas Momenan Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Reza Zali Shahid Beheshti University of Medical Sciences, Tehran, Iran Klodian Dhana Rush University Medical Center, Chicago, IL, USA/NCD Risk Factor Collaboration Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina Pablo Gulayin Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina/NCD Risk Factor Collaboration Marilina Santero Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina/NCD Risk Factor Collaboration Laura Gutierrez Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina/NCD Risk Factor Collaboration Vilma E. Irazola Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina/NCD Risk Factor Collaboration Adolfo Rubinstein Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina/NCD Risk Factor Collaboration Sujay Kakarmath Harvard Medical School, Boston, MA, USA/NCD Risk Factor Collaboration Trudy Voortman Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands/NCD Risk Factor Collaboration Oscar H. Franco Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands/NCD Risk Factor Collaboration Albert Hofman Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands/NCD Risk Factor Collaboration M. Arfan Ikram Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands/NCD Risk Factor Collaboration Maryam Kavousi Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands Marileen L. P. Portegies Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands/NCD Risk Factor Collaboration Leanne M. Riley World Health Organization, Geneva, Switzerland/NCD Risk Factor Collaboration Melanie J. Cowan World Health Organization, Geneva, Switzerland/NCD Risk Factor Collaboration Stefan Savin World Health Organization, Geneva, Switzerland/NCD Risk Factor Collaboration Mohamed M. Ali World Health Organization, Geneva, Switzerland/NCD Risk Factor Collaboration Gretchen A. Stevens Independent researcher, Los Angeles, CA, USA/NCD Risk Factor Collaboration Christopher J. Paciorek University of California Berkeley, Berkeley, CA, USA/NCD Risk Factor Collaboration Wichai Aekplakorn Mahidol University, Nakhon Pathom, Thailand Paibul Suriyawongpaisal Mahidol University, Nakhon Pathom, Thailand/NCD Risk Factor Collaboration Renata Cifkova Charles University in Prague, Prague, Czech Republic/Thomayer Hospital, Prague, Czech Republic/NCD Risk Factor Collaboration Simona Giampaoli Istituto Superiore di Sanità, Rome, Italy/NCD Risk Factor Collaboration Chiara Donfrancesco Istituto Superiore di Sanità, Rome, Italy Luigi Palmieri Istituto Superiore di Sanità, Rome, Italy/NCD Risk Factor Collaboration Andre Pascal Kengne South African Medical Research Council, Cape Town, South Africa/NCD Risk Factor Collaboration Young-Ho Khang Seoul National University, Seoul, Republic of Korea/NCD Risk Factor Collaboration Kari Kuulasmaa Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Anne Juolevi Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Eero O. Kajantie Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Seppo Koskinen Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Tiina Laatikainen Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Annamari Lundqvist Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Teemu J. Niiranen Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Markku Peltonen Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Veikko Salomaa Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Hanna K. Tolonen Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Jaakko Tuomilehto Finnish Institute for Health and Welfare, Helsinki, Finland/NCD Risk Factor Collaboration Avula Laxmaiah ICMR–National Institute of Nutrition, Hyderabad, India/NCD Risk Factor Collaboration Nimmathota Arlappa ICMR–National Institute of Nutrition, Hyderabad, India/NCD Risk Factor Collaboration Nagalla Balakrishna ICMR–National Institute of Nutrition, Hyderabad, India/NCD Risk Factor Collaboration Rachakulla Hari Kumar ICMR–National Institute of Nutrition, Hyderabad, India/NCD Risk Factor Collaboration Kodavanti Mallikharjuna Rao ICMR–National Institute of Nutrition, Hyderabad, India Indrapal I. Meshram ICMR–National Institute of Nutrition, Hyderabad, India/NCD Risk Factor Collaboration Paula Margozzini Pontificia Universidad Católica de Chile, Santiago, Chile/NCD Risk Factor Collaboration Catterina Ferreccio Pontificia Universidad Católica de Chile, Santiago, Chile/NCD Risk Factor Collaboration Juan Francisco Miquel Pontificia Universidad Católica de Chile, Santiago, Chile/NCD Risk Factor Collaboration Flavio Nervi Pontificia Universidad Católica de Chile, Santiago, Chile Gonzalo Valdivia Pontificia Universidad Católica de Chile, Santiago, Chile/NCD Risk Factor Collaboration Prashant Mathur ICMR–National Centre for Disease Informatics and Research, Bengaluru, India/NCD Risk Factor Collaboration Børge G. Nordestgaard Copenhagen University Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Marianne Benn Copenhagen University Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Gorm B. Jensen Copenhagen University Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Pia R. Kamstrup Copenhagen University Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Anne Tybjaerg-Hansen Copenhagen University Hospital, Copenhagen, Denmark Anette Varbo Copenhagen University Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Dong Zhao Capital Medical University Beijing An Zhen Hospital, Beijing, China Jing Liu Capital Medical University Beijing An Zhen Hospital, Beijing, China Mette Aadahl Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Thomas M. Dantoft Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Marie Eliasen Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Torben Jørgensen Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Allan Linneberg Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Line T. Møllehave, Betina H. Thuesen Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark Ulla Toft Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark/NCD Risk Factor Collaboration Leandra Abarca-Gómez Caja Costarricense de Seguro Social, San José, Costa Rica Roy A. Wong-McClure Caja Costarricense de Seguro Social, San José, Costa Rica/NCD Risk Factor Collaboration Hanan Abdul Rahim Qatar University, Doha, Qatar Zumin Shi Qatar University, Doha, Qatar/NCD Risk Factor Collaboration Niveen M. Abu-Rmeileh Birzeit University, Birzeit, Palestine Abdullatif S. Husseini Birzeit University, Birzeit, Palestine Benjamin Acosta-Cazares Instituto Mexicano del Seguro Social, Mexico City, Mexico Jorge Escobedo-de la Peña Instituto Mexicano del Seguro Social, Mexico City, Mexico Blanca Sandra Ruiz-Betancourt Instituto Mexicano del Seguro Social, Mexico City, Mexico/NCD Risk Factor Collaboration Robert J. Adams Flinders University, Adelaide, South Australia, Australia/NCD Risk Factor Collaboration Imelda A. Agdeppa Food and Nutrition Research Institute, Taguig, The Philippines Mario V. Capanzana Food and Nutrition Research Institute, Taguig, The Philippines Charmaine A. Duante Food and Nutrition Research Institute, Taguig, The Philippines Glen Gironella Food and Nutrition Research Institute, Taguig, The Philippines/NCD Risk Factor Collaboration Javad Aghazadeh-Attari Urmia University of Medical Sciences, Urmia, Iran/NCD Risk Factor Collaboration Iraj Mohebbi Urmia University of Medical Sciences, Urmia, Iran/NCD Risk Factor Collaboration Carlos A. Aguilar-Salinas Instituto Nacional de Ciencias Médicas y Nutricion, Mexico City, Mexico/NCD Risk Factor Collaboration Charles Agyemang University of Amsterdam, Amsterdam, The Netherlands/NCD Risk Factor Collaboration Lizzy M. Brewster University of Amsterdam, Amsterdam, The Netherlands/NCD Risk Factor Collaboration Marieke B. Snijder University of Amsterdam, Amsterdam, The Netherlands/NCD Risk Factor Collaboration Karien Stronks University of Amsterdam, Amsterdam, The Netherlands/NCD Risk Factor Collaboration Irene G. M. van Valkengoed University of Amsterdam, Amsterdam, The Netherlands/NCD Risk Factor Collaboration Tarunveer S. Ahluwalia Steno Diabetes Center Copenhagen, Gentofte, Denmark/NCD Risk Factor Collaboration Noor Ani Ahmad Ministry of Health Malaysia, Kuala Lumpur, Malaysia/NCD Risk Factor Collaboration Tahir Aris Ministry of Health Malaysia, Kuala Lumpur, Malaysia/NCD Risk Factor Collaboration Norazizah Ibrahim Wong Ministry of Health Malaysia, Kuala Lumpur, Malaysia/NCD Risk Factor Collaboration Muhammad Fadhli Mohd Yusoff Ministry of Health Malaysia, Kuala Lumpur, Malaysia/NCD Risk Factor Collaboration Balkish M. Naidu Ministry of Health Malaysia, Kuala Lumpur, Malaysia/NCD Risk Factor Collaboration Mohd Azahadi Omar Ministry of Health Malaysia, Kuala Lumpur, Malaysia/NCD Risk Factor Collaboration Ahmad Faudzi Yusoff Ministry of Health Malaysia, Kuala Lumpur, Malaysia Ahmad A. Zainuddin Ministry of Health Malaysia, Kuala Lumpur, Malaysia/NCD Risk Factor Collaboration Ali Ahmadi Shahrekord University of Medical Sciences, Shahrekord, Iran Majid Shirani Shahrekord University of Medical Sciences, Shahrekord, Iran/NCD Risk Factor Collaboration Soheir H. Ahmed University of Oslo, Oslo, Norway/NCD Risk Factor Collaboration Espen Bjertness University of Oslo, Oslo, Norway/NCD Risk Factor Collaboration Marius B. Bjertness University of Oslo, Oslo, Norway/NCD Risk Factor Collaboration Ahmed A. Madar University of Oslo, Oslo, Norway Haakon E. Meyer University of Oslo, Oslo, Norway Wolfgang Ahrens University of Bremen, Bremen, Germany/NCD Risk Factor Collaboration Kamel Ajlouni & National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan Mohammad Khateeb National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan Monira Alarouj Dasman Diabetes Institute, Kuwait City, Kuwait Abdullah Alkandari Dasman Diabetes Institute, Kuwait City, Kuwait Fadia AlBuhairan Aldara Hospital and Medical Center, Riyadh, Saudi Arabia/NCD Risk Factor Collaboration Shahla AlDhukair King Abdullah International Medical Research Center, Riyadh, Saudi Arabia/NCD Risk Factor Collaboration Ala’a Alkerwi Luxembourg Institute of Health, Strassen, Luxembourg NCD Risk Factor Collaboration Eman Aly World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt NCD Risk Factor Collaboration Heba M. Fouad World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt NCD Risk Factor Collaboration Deepak N. Amarapurkar Bombay Hospital and Medical Research Centre, Mumbai, India NCD Risk Factor Collaboration Philippe Amouyel University of Lille, Lille, France NCD Risk Factor Collaboration Luc Dauchet University of Lille, Lille, France/ Lille University Hospital, Lille, France Jonathan Giovannelli University of Lille, Lille, France/ Lille University Hospital, Lille, France Frederic Gottrand University of Lille, Lille, France NCD Risk Factor Collaboration Philippe Amouyel Lille University Hospital, Lille, France Lars Bo Andersen Western Norway University of Applied Sciences, Sogndal, Norway NCD Risk Factor Collaboration Sigmund A. Anderssen Norwegian School of Sport Sciences, Oslo, Norway NCD Risk Factor Collaboration Ulf Ekelund Norwegian School of Sport Sciences, Oslo, Norway NCD Risk Factor Collaboration Elin Kolle Norwegian School of Sport Sciences, Oslo, Norway Jostein Steene-Johannessen Norwegian School of Sport Sciences, Oslo, Norway NCD Risk Factor Collaboration Ranjit Mohan Anjana Madras Diabetes Research Foundation, Chennai, India Mohan Deepa Madras Diabetes Research Foundation, Chennai, India Viswanathan Mohan Madras Diabetes Research Foundation, Chennai, India Rajendra Pradeepa Madras Diabetes Research Foundation, Chennai, India NCD Risk Factor Collaboration Alireza Ansari-Moghaddam Zahedan University of Medical Sciences, Zahedan, Iran Seyed Mohammad Hashemi-Shahri Zahedan University of Medical Sciences, Zahedan, Iran NCD Risk Factor Collaboration Hajer Aounallah-Skhiri National Institute of Public Health, Tunis, Tunisia Nada Zoghlami National Institute of Public Health, Tunis, Tunisia Joana Araújo Institute of Public Health of the University of Porto, Porto, Portugal Ana Henriques Institute of Public Health of the University of Porto, Porto, Portugal/NCD Risk Factor Collaboration Inger Ariansen Norwegian Institute of Public Health, Oslo, Norway Sidsel Graff-Iversen Norwegian Institute of Public Health, Oslo, Norway Raphael E. Arku University of Massachusetts, Amherst, MA, USA/NCD Risk Factor Collaboration Krishna K. Aryal Abt Associates, Kathmandu, Nepal/NCD Risk Factor Collaboration Thor Aspelund University of Iceland, Reykjavik, Iceland Vilmundur Gudnason University of Iceland, Reykjavik, Iceland/NCD Risk Factor Collaboration Maria Cecília F. Assunção Federal University of Pelotas, Pelotas, Brazil Paula Duarte de Oliveira Federal University of Pelotas, Pelotas, Brazil Helen Gonçalves Federal University of Pelotas, Pelotas, Brazil Bernardo L. Horta Federal University of Pelotas, Pelotas, Brazil Ana Maria B. Menezes Federal University of Pelotas, Pelotas, Brazil Isabel O. Oliveira Federal University of Pelotas, Pelotas, Brazil Cesar G. Victora Federal University of Pelotas, Pelotas, Brazil/NCD Risk Factor Collaboration Juha Auvinen University of Oulu, Oulu, Finland Marjo-Riitta Jarvelin University of Oulu, Oulu, Finland Raija Korpelainen University of Oulu, Oulu, Finland/Oulu Deaconess Institute Foundation, Oulu, Finland Soile E. Puhakka University of Oulu, Oulu, Finland/ Oulu Deaconess Institute Foundation, Oulu, Finland Sylvain Sebert University of Oulu, Oulu, Finland/NCD Risk Factor Collaboration Juha Auvinen Oulu University Hospital, Oulu, Finland/Oulu University Hospital, Oulu, Finland Sauli Herrala Oulu University Hospital, Oulu, Finland/NCD Risk Factor Collaboration Marjo-Riitta Jarvelin Oulu University Hospital, Oulu, Finland/NCD Risk Factor Collaboration Jari J. Jokelainen Oulu University Hospital, Oulu, Finland Sirkka Keinänen-Kiukaanniemi Oulu University Hospital, Oulu, Finland/NCD Risk Factor Collaboration Mária Avdicová Regional Authority of Public Health, Banska Bystrica, Slovakia Jana Námešná Regional Authority of Public Health, Banska Bystrica, Slovakia/NCD Risk Factor Collaboration Ana Azevedo University of Porto Medical School, Porto, Portugal/NCD Risk Factor Collaboration Elisabete Ramos University of Porto Medical School, Porto, Portugal/NCD Risk Factor Collaboration Fereidoun Azizi Research Institute for Endocrine Sciences, Tehran, Iran/NCD Risk Factor Collaboration Mohamed Bamoshmoosh University of Science and Technology, Sana’a, Yemen/NCD Risk Factor Collaboration Medical University of Lodz, Lodz, Poland Maciej Banach Medical University of Lodz, Lodz, Poland/NCD Risk Factor Collaboration Wojciech Drygas Medical University of Lodz, Lodz, Poland/National Institute of Cardiology, Warsaw, Poland/NCD Risk Factor Collaboration Elzbieta Dziankowska-Zaborszczyk Medical University of Lodz, Lodz, Poland/NCD Risk Factor Collaboration Jolanta Slowikowska-Hilczer Medical University of Lodz, Lodz, Poland/NCD Risk Factor Collaboration Piotr Bandosz Medical University of Gdansk, Gdansk, Poland/NCD Risk Factor Collaboration Marcin Rutkowski Medical University of Gdansk, Gdansk, Poland Tomasz Zdrojewski Medical University of Gdansk, Gdansk, Poland José R. Banegas Universidad Autónoma de Madrid/CIBERESP, Madrid, Spain/NCD Risk Factor Collaboration Pilar Guallar-Castillón Universidad Autónoma de Madrid/CIBERESP, Madrid, Spain/NCD Risk Factor Collaboration Esther Lopez-Garcia Universidad Autónoma de Madrid/CIBERESP, Madrid, Spain/NCD Risk Factor Collaboration Fernando Rodríguez-Artalejo Universidad Autónoma de Madrid/CIBERESP, Madrid, Spain/NCD Risk Factor Collaboration Carlo M. Barbagallo University of Palermo, Palermo, Italy/NCD Risk Factor Collaboration Davide Noto University of Palermo, Palermo, Italy/NCD Risk Factor Collaboration Alberto Barceló Pan American Health Organization, Washington, DC, USA Pedro Ordunez Pan American Health Organization, Washington, DC, USA/NCD Risk Factor Collaboration Amina Barkat Mohammed V University de Rabat, Rabat, Morocco Iqbal Bata Dalhousie University, Halifax, Nova Scotia, Canada Ronald D. Gregor Dalhousie University, Halifax, Nova Scotia, Canada/NCD Risk Factor Collaboration Anwar M. Batieha Jordan University of Science and Technology, Irbid, Jordan/NCD Risk Factor Collaboration Hashem Y. J

A multivariate geostatistical framework for combining multiple indices of abundance for disease vectors and reservoirs: a case study of rattiness in a low-income urban Brazilian community

Author: Eyre Max T.
Pereira Ticiana S. A. Carvalho
Souza Fábio N.
Khalilus Hsein
Hacker Kathryn P.
Serrano Soledad
Taylor Joshua P.
Reis Mitermayer Galvão dos
Ko Albert Icksang
Begon Mike
Diggle Peter J
Costa Federico
Giorgi Emanuele
Publication venue: The Royal Society [Society
Publication date: 01/01/2020
Field of study

Ministério da Ciência, Tecnologia e Inovação, the Conselho Nacional de Desenvolvimento Científico e Tecnológico; the Fundação de Amparo à Pesquisa do Estado da Bahia (grant no. 10206/20155); the Fundação Oswaldo Cruz; Research Councils UK, the Medical Research Council (grant nos. 1964635, MR/P024084/1 and MR/T029781/1); the Ministério da Saúde; the U.S. Department of Health and Human Services, the National Institutes of Health, the National Institute of Allergy and Infectious Diseases (grant nos. F31 AI114245, R01 AI052473, R01 TW009504, R25 TW009338 and U01 AI088752); the Secretaria Municipal de Saúde de Salvador-BA; and the Wellcome Trust (grant nos. 102330/Z/13/Z and 218987/Z/19/Z). MTE is in receipt of a studentship from the Medical Research Council, United Kingdom.A key requirement in studies of endemic vector-borne or zoonotic disease is an estimate of the spatial variation in vector or reservoir host abundance. For many vector species, multiple indices of abundance are available, but current approaches to choosing between or combining these indices do not fully exploit the potential inferential benefits that might accrue from modelling their joint spatial distribution. Here, we develop a class of multivariate generalized linear geostatistical models for multiple indices of abundance. We illustrate this novel methodology with a case study on Norway rats in a low-income urban Brazilian community, where rat abundance is a likely risk factor for human leptospirosis. We combine three indices of rat abundance to draw predictive inferences on a spatially continuous latent process, rattiness, that acts as a proxy for abundance.We show how to explore the association between rattiness and spatially varying environmental factors, evaluate the relative importance of each of the three contributing indices and assess the presence of residual, unexplained spatial variation, and identify rattiness hotspots. The proposed methodology is applicable more generally as a tool for understanding the role of vector or reservoir host abundance in predicting spatial variation in the risk of human disease

Trypanocidal activity of flavanone derivatives

Author: Diogo Gabriela Maciel
Andrade Josimara Souza
Sales Junior Policarpo Ademar
Murta Silvane Maria Fonseca
Santos Viviane Martins Rebello dos
Taylor Jason Guy
Publication venue: MDPI
Publication date: 01/01/2020
Field of study

Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase. Furthermore, strong side effects may result in discontinuation of this treatment. Faced with this situation, we report the synthesis and trypanocidal activity of 3-benzoyl-flavanones. Novel 3-benzoyl-flavanone derivatives were prepared in satisfactory yields in the 3-step synthetic procedure. According to recommended guidelines, the whole cell-based screening methodology was utilized that allowed for the simultaneous use of both parasite forms responsible for human infection. The majority of the tested compounds displayed promising anti-Trypanosoma cruzi activity and the most potent flavanone bearing a nitrofuran moiety was more potent than the reference drug, Benznidazole

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