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Herzsprung auf Malle
No full textSogar Darwin wird eine Vorliebe für Groschenromane nachgesagt, genauso wie dem Biologieprofessor Tom.
Tom träumt von einem Leben auf Mallorca. Um den Traum endlich wahr zu machen, erforscht er in aller Heimlichkeit ein Verjüngungsmedikament und muss es an die Amerikaner verkaufen, bevor sein Konkurrent Pastorius ihm den Deal vor der Nase wegschnappt.
Aber warum geht ihm die schöne Unbekannte von der Halloweenparty nicht aus dem Sinn und warum schläft Toms holländischer Kumpel Willem immer ein, wenn es spannend wird?
Die Antwort darauf gibt diese rasante Geschichte, in der endlich auch der Kickertisch seine romantische Renaissance feiern darf. Garantiert ohne Smalahove
CEUS and sonoporation
No full textIn this chapter, contrast-enhanced ultrasound (CEUS) and ultrasound contrast agent microbubble adjustments for drug delivery including sonoporation are described. Although hundreds of papers have been published on this subject, we will just briefly touch upon the topic using a physics and engineering approach
REFLEXÕES E EXPERIÊNCIAS EM CIÊNCIAS SOCIAIS
No full text<p><span>"Reflexões e Experiências em Ciências Sociais" oferece uma imersão profunda nas vivências e desafios enfrentados por estudantes e professores do Programa de Residência Pedagógica em Sociologia da UNIVASF. Entre novembro de 2022 e abril de 2024, esses educadores exploraram temas cruciais como inclusão, cooperativismo, e democracia, desenvolvendo práticas pedagógicas inovadoras e reflexões teóricas que dialogam com as realidades das escolas-campo de Petrolina (PE) e Juazeiro (BA). Este livro é um testemunho inspirador do poder transformador da educação e um guia para quem busca promover uma sociedade mais justa e igualitária.</span></p>
A autobiografia do doutor Nunes Garcia Junior
No full textA autobiografia foi organizada por Vandelir Camilo e cobre os anos de 1808 até 1860 da trajetoria desse médic
Vibrations
No full textBefore we can continue to the propagation of sound waves, we have to treat the principles of free and forced vibrations
Fundamentals of Medical Ultrasonics
No full textUltrasonic imaging is an economic, reliable diagnostic technique. Owing to recent therapeutic applications, understanding the physical principles of medical ultrasonics is becoming increasingly important. Covering the basics of elasticity, linear acoustics, wave propagation, nonlinear acoustics, transducer components, ultrasonic imaging modes, basics on cavitation and bubble physics, as well as the most common diagnostic and therapeutic applications, Fundamentals of Medical Ultrasonics explores the physical and engineering principles of acoustics and ultrasound as used for medical applications. It offers students and professionals in medical physics and engineering a detailed overview of the technical aspects of medical ultrasonic imaging, whilst serving as a reference for clinical and research staff
Evidence of backcross inviability and mitochondrial DNA paternal leakage in sea turtle hybrids
No full text<p>This dataset contains ddRAD data used in our sea turtles genomics research on hybridization in Brazil. In this paper, we analyzed hybridization patterns, population structure and relatedness between southwest Atlantic population with a focus on Brazilian populations with high frequency of interspecific hybrids. Source code for the R2SCO pipeline is available at https://github.com/mazzoni-izw/mazzoni-begendiv/ and raw sequencing data is available on on NCBI Sequence Read Archive (SRA) database under BioProject PRJNA857276. Data uploaded here contain:</p>
<ul>
<li><strong>Hybrids_SNPs.vcf</strong>: SNP dataset for population analyses.</li>
<li><strong>Hybrids_SNPs_DP15.recode.vcf</strong>: SNP dataset for population analyses filtered for a minimum coverage (DP) of 15</li>
<li><strong>R2SCO-MseI-EcoRI-384-448_CcEiHyb.fasta</strong>: reference fasta sequences (R2SCO loci) used to map raw reads from loggerheads, hawksbills and their hybrids. Generated using the R2SCO pipeline described in Driller et al (2020)</li>
<li><strong>R2SCO-MseI-EcoRI-384-448_CcEiLoCm.fasta</strong>: reference fasta sequences (R2SCO loci) used to map raw reads from loggerheads, hawksbills, olive ridleys, green turtles, and their hybrids. Generated using the R2SCO pipeline described in Driller et al (2020)</li>
<li><strong>checkRestrictionSites.py</strong>: custom script that filters a fastq file to start and end with defined sequences</li>
</ul>
<p>Structure folder</p>
<ul>
<li><strong>Create_Haplotype_Structure.py</strong>: python script used to convert the VCF output from Stacks populations into a Structure file based on haplotypes (instead of SNPs).</li>
<li><strong>Hybrids_Haps_DP15.str</strong>: input structure file for haplotypes dataset</li>
<li><strong>Hybrids_SNPs_DP15.stru</strong> input structure file for SNP dataset</li>
<li><strong>ParallelStructure_HAPS.R</strong>: Command line used in parallel structure for haplotype dataset</li>
<li><strong>ParallelStructure_SNPs.R</strong>: Command line used in parallel structure for SNP dataset</li>
</ul>
<p>relatedness folder</p>
<ul>
<li><strong>populations.snps.vcf.gz</strong>: VCF file of SNP dataset with only loggerheads, hawksbills and their hybrids</li>
<li><strong>run.sh</strong>: vcftools command line used to run relatedness analysis</li>
<li><strong>relatednessmatrix.relatedness</strong>: square matrix with relatedness estimates</li>
<li><strong>inds.txt</strong>: individuals included in the square matrix.</li>
<li><strong>relatedness.R</strong>: plotting script in R for relatedness results (figure 3)</li>
</ul>
<p>NewHybrids folder</p>
<ul>
<li><strong>Hybrids.NewHyb.input</strong>: input file for NewHybrids analysis.</li>
</ul>Hybridization is known to be part of many species' evolutionary history. Sea turtles have a fascinating hybridization system in which species separated by as much as 43 million years are still capable of hybridizing. Indeed, the largest nesting populations in Brazil of loggerheads (Caretta caretta) and hawksbills (Eretmochelys imbricata) have a high incidence of hybrids between these two species. A third species, olive ridleys (Lepidochelys olivacea), is also known to hybridize although at a smaller scale. Here we used restriction site-associated DNA sequencing (RAD-Seq) markers, mitogenomes, and satellite-telemetry to investigate the patterns of hybridization and introgression in the Brazilian sea turtle population and their relationship with the migratory behaviors between feeding and nesting aggregations. We also explicitly test if the mixing of two divergent genomes in sea turtle hybrids causes mitochondrial paternal leakage. We developed a new species-specific PCR-assay capable of detecting mitochondrial DNA (mtDNA) inheritance from both parental species and performed ultra-deep sequencing to estimate the abundance of each mtDNA type. Our results show that all adult hybrids are first generation (F1) and most display a loggerhead migratory behavior. We detected paternal leakage in F1 hybrids and different proportions of mitochondria from maternal and paternal species. Although previous studies showed no significant fitness decrease in hatchlings, our results support genetically-related hybrid breakdown possibly caused by cytonuclear incompatibility. Further research on hybrids from other populations besides Brazil and between different species will show if backcross inviability and mitochondrial paternal leakage is observed across sea turtle species
Olaparib beyond progression compared with platinum chemotherapy after secondary cytoreductive surgery in patients with recurrent ovarian cancer: phase III randomized, open-label MITO 35b study, a project of the MITO-MANGO groups
No full textBackground: Poly (ADP-ribose) polymerase inhibitors have transformed the management landscape for patients with ovarian cancer, demonstrating remarkable improvements in progression-free survival and overall survival. Unfortunately, most relapses are due to an acquired mechanism of resistance to these agents. We hypothesize that secondary cytoreductive surgery, removing resistant clones, might help to overcome the development of resistance to poly (ADP-ribose) polymerase inhibitors, prolonging their therapeutic effect.
Primary objective: To determine the efficacy of olaparib beyond progression compared with standard platinum-based chemotherapy in patients with recurrent ovarian cancer progressed during or after poly (ADP-ribose) polymerase inhibitor maintenance therapy after secondary cytoreductive surgery.
Study hypothesis: Olaparib administered beyond progression is more effective in increasing progression-free survival and progression-free survival 2 compared with second-line platinum-based chemotherapy in patients after secondary cytoreductive surgery.
Trial design: Phase III, randomized, open-label, multicenter trial. Eligible patients will be randomized in a 1:1 ratio to receive olaparib or platinum-based chemotherapy of the investigator's choice.
Major eligibility criteria: Eligible patients must have high-grade serous or endometrioid ovarian cancer progressed during or after first-line poly (ADP-ribose) polymerase inhibitor maintenance therapy and must have undergone secondary cytoreductive surgery.
Primary endpoint: The dual primary endpoints will include progression-free survival and progression-free survival 2. Progression-free survival is defined by the investigator using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 as the time between randomization and progression or death from any cause. Progression-free survival 2 is defined by the investigator using RECIST version 1.1 as the time frame from randomization to the second progression or death from any cause after subsequent treatment.
Sample size: Approximately 200 patients will be enrolled in this study.
Estimated dates for completing accrual and presenting results: Enrollment will be completed in 2024. Results will be presented in 2026.
Trial registration: EudraCT 2021-000245-41 NCT05255471
Review: Onderzoek naar de veilige toepassing van ultrageluid gebruikt om blauwalg te bestrijden
No full textOnderzoek uitgevoerd in opdracht van de dijkgraaf en hoogheemraden van Rijnlan
