63477 research outputs found
Sort by
Corrigendum to “Automated skills assessment in open surgery: A scoping review” [Eng. Appl. Artif. Intellig. 153 (2025) 110893]
No full textThe authors regret that an affiliation was omitted for author Dehlela Shabir.
The correct affiliation details are as follows:
Dehlela Shabir a,b,1
a Department of Surgery, Hamad Medical Corporation, Doha, Qatar
b Computer Science and Engineering Department, Qatar University, Doha, Qatar.
The authors would like to apologise for any inconvenience caused
تعيين مساعد عميد لشؤون الطلاب بكلية الهندسة = Appointment of the Assistant Dean for Student Affairs, College of Engineering
No full textمكتب نائب رئيس الجامعة للشؤون الأكاديمية يعلن بأنه قد تم تعيين الدكتورة حميدة يوسف الجناحي، مساعداً لعميد كلية الهندسة لشؤون الطلاب، وذلك اعتبارًا من 11 يناير 2026
Liposomal delivery of DK14 chalcone analogue: A promising therapeutic strategy against triple-negative breast cancer
No full textTriple negative breast cancer (TNBC) is considered the most aggressive type of breast malignancy. TNBC management approaches remain limited, with a high risk of relapse and metastasis. Chalcone compounds are established for their anticancer activity. A recently patented novel chalcone compound (DK14) by our group has demonstrated a considerable activity against TNBC; however, its limited water-solubility is a challenge. In this study, we incorporated DK14 into a nano-liposomal formulation to enhance its solubility, safety and anticancer activity. The formulation was characterized in terms of particle size, zeta potential, drug entrapment, and release profile. Additionally, cytotoxicity, cell migration, colony formation and protein expression analysis were conducted. Furthermore, Angiogenesis study was performed using the chorioallantoic membrane (CAM) of the chicken embryo. DK14-liposomes demonstrated the ability to inhibit growth of TNBC cells and trigger apoptosis, accompanied by induction of BAX/BCL-2/Caspase-3 pathway. DK14-liposomes also exhibited an enhanced safety profile on non-tumorigenic mammary epithelial cells (MCF-10A) compared to free DK14 while suppressing cell migration and colony formation. Moreover, DK14-liposomes dysregulated PI3K/AKT/mTOR pathway, which is defective in TNBC; and significantly inhibited angiogenesis in ovo using a chiken embryo model. In conclusion, our results imply that DK14-liposomes have a substantial anticancer activity against TNBC with distinct anti-angiogenic properties.This work was done through fund obtained by Qatar University (grant number: QUCG-22/23-510) for the period from 2022 to 2023, secured by Prof. Ashraf Khalil (PI), Prof. Abdelbary Elhissi (Co-PI) and Prof. Ala-Eddin Al-Moustafa (Co-PI). Open Access funding was provided by the Qatar National Library
Strategic Perception and Representation of Qatar in the U.S. Policy Establishment During the 2017 Blockade
No full textThis thesis examines how Qatar was perceived and represented by U.S. policy elites during the 2017 Blockade, and how these perceptions influenced American foreign policy. Focusing on elite discourse, the study analyzes speeches, statements, and official documents from President Donald Trump, Secretary of State Rex Tillerson, Secretary of Defense James Mattis, and Secretary of State Mike Pompeo between 2017 and 2021. Using Discourse Analysis (DA), it investigates how strategic perceptions were constructed. The findings of the data analysis reveal that Qatar has been constructed as a counterterrorism partner, economic investor, regional mediator, and cooperative actor in crisis management. The findings also show that U.S. perceptions have evolved over time. These changes reflect both skepticism and recognition of Qatar’s contributions to U.S. objectives; particularly in security, economy, and regional stability. Building on Foreign Policy Analysis, the study emphasizes how elite interpretations of Qatar guided policy, illustrating that strategic perceptions are shaped by political realities, U.S. hegemonic goals, and broader regional dynamics
Targeting 3Cpro of Enterovirus D68 with Medicinal Phytocompounds Using Structure-Based Molecular Screening and Molecular Simulation Approaches to Rescue the Host Immune Response
No full textPurpose: Enterovirus D68 (EV-D68) is a viral pathogen recognized for its role in inducing severe respiratory illnesses and its link to the development of acute flaccid myelitis (AFM) in children. The 3 C protease (3Cpro) of Enterovirus D68 disrupts TRIF, impairing NF-κB and IFN-β signaling, evading host immunity. EV-D68 also inhibits IRF7 and interferes with MDA5-MAVS interaction, hindering RLR pathway-mediated IFN signaling. Methods: Recognizing the key role of 3Cpro in modulating host immune responses, we employed structure-based drug design combined with molecular dynamics simulations to comprehensively screen phytochemical databases and pinpoint promising compounds with the potential to inhibit EV-D68 3Cpro, thereby supporting immune system restoration. Results: Our analysis identified lead compounds with high docking score such as EA-5317333 (-9.268 kcal/mol) and EA-76313109 (-8.618 kcal/mol) from East African Natural Products Database, NA-5320945 (-7.902 kcal/mol) and NA-101630512 (-7.570 kcal/mol) from North African Natural Products Database, SA-25245604 (-8.899 kcal/mol) and SA-9064 (-7.538 kcal/mol) from South African Natural Compounds Database, NE-5280343 (-7.845) and NE-162817590 (-7.264 kcal/mol) from North-East African Natural Products Database, TCM-71665623 (-8.324 kcal/mol) and TCM-163019889 (-8.414 kcal/mol) from Traditional Chinese Medicines Database as lead compounds. Furthermore, the stronger binding affinity of these lead compounds with the 3Cpro was validated by the results of molecular dynamics (MD) simulation, binding free energy calculation and dissociation constant analysis. The selected compounds exhibited favorable ADMET properties, including high solubility in water, strong gastrointestinal absorption, and no signs of liver toxicity, aligning well with Lipinski’s rule of five. Conclusion: Taken together, these findings provide compelling evidence to support the design of novel therapeutics directed at disrupting the immune evasion strategies employed by the EVD68 virus
Consensus (Ijmāʿ) Based on a Disappeared ʿIllah or Changed ʿUrf: A Foundational and Applied Study
No full textيقرر أغلب الأصوليين قاعدتي ثابت الإجماع كالنص، ودوران الأحكام مع العلل، ويدرس هذا البحث ما يجري على حكم الإجماع حين تعارض هاتين القاعدتين؛ إذ يكون مستند الإجماع علة أو عرفا تغير، وذلك عن طريق منهج الاستقراء لمثل هذه الحالات في الفقه وتحليلها، بحسب آراء العلماء، وعرض الأدلة والشواهد، وبالتعرض للإجماع، ومستنده، وتحرير مسألة تغير الأحكام بتغير العلل، ثم دراسة مسألة الإجماع المستند إلى علة زالت أو عرف تغير أصوليا، والعلاقة بين العلة والعرف والإجماع، ثم أثر التغير على حكم الإجماع، ثم تطبيق ذلك على بابي الجهاد والسياسة الشرعية، خلص البحث إلى وجاهة الرأي القائل بأن حكم الإجماع المبني على علة أو عرف متغير تبع لعلته، وأن تغير الحكم بتغير العلة متفق عليه والخلاف فيه لفظي بين القائلين بأزلية الأحكام والقائلين بإمكان تغيرها، وأوصت الدراسة بأهمية بحث مثل هذه المسائل في الفقه الإسلامي وخاصة ما يمس تغير حكم الإجماع منها، واستقصاء الآراء الفقهية التي خالف أصحابها الإجماع، ومدى وجاهة تلك المخالفة على ضوء المعطيات الحالية في هذا الوقت والظرف.Most scholars of uṣūl affirm two foundational principles: that consensus (ijmāʿ) holds the same authority as textual evidence, and that legal rulings revolve around their effective causes (ʿilal). This study explores the implications for the ruling of ijmāʿ when these two principles appear to be in tension—specifically, when the basis for ijmāʿ is a legal cause or a customary practice (ʿurf) that has changed or ceased to exist. The research employs an inductive methodology to identify and analyze such instances within Islamic jurisprudence, drawing on scholarly opinions, examining relevant evidences and indicators, addressing the nature of ijmāʿ and its underlying justification, and clarifying the issue of rulings changing due to the alteration of their causes. The study then examines, from a uṣūlī perspective, the nature of ijmāʿ based on a disappeared ʿillah or altered ʿurf, as well as the relationship between ʿillah, ʿurf, and ijmāʿ, and how such changes may impact the continued authority of a consensus ruling. To illustrate the practical dimension of the issue, the study applies its findings to the fields of jihād and al-siyāsah al-sharʿiyyah (Islamic governance and public policy). The research concludes that the view asserting the conditionality of a consensus-based ruling upon its ʿillah or underlying custom is well-grounded, and that the principle of legal rulings changing with the transformation of their effective causes is universally acknowledged. The dispute over this point is largely semantic, between those who maintain the immutability of rulings and those who accept their variability in accordance with changing ʿilal. The study recommends further investigation into such issues within Islamic jurisprudence, particularly with respect to cases in which the ruling attributed to ijmāʿ may be affected by evolving causes or customs. It also calls for a thorough review of the juristic views that deviate from consensus, evaluating the validity of such dissent in light of contemporary contexts and realities. And Allah is the source of all guidance and success
أيّهما أفضل: الذهب أم البيتكوين؟
No full textفي هذه الحلقة، نناقش الذهب باعتباره أحد أقدم وأهم أدوات حفظ القيمة عبر التاريخ، ونحاول فهم أسباب استمراره كملاذ آمن في أوقات الأزمات والتضخم. كما نسلّط الضوء على آلية تسعير الذهب عالميًا، وأبسط الطرق المتاحة للاستثمار فيه. بالإضافة إلى المقارنة المثيرة بين الذهب والبيتكوين، في ظل التحولات المتسارعة في عالم الاستثمار والأصول الرقمية مع ضيفتنا الكريمة:
د. العنود المعاضيد - رئيس قسم المالية والاقتصاد، كلية الإدارة والاقتصاد، جامعة قط
Firm Value and Regulatory Transparency: Evidence from the Adoption of a Centralized Electronic Disclosure System
No full textThis paper examines the impact of adopting the Centralized Electronic Disclosure System (CEDS) on firm performance. A panel dataset of 19,149 firms across 28 countries from 1990 to 2023 is analyzed. The central argument is that firms adopting CEDS are more likely to experience improved performance with increased transparency, market liquidity, and informed trading, and reduced information asymmetry, cost of equity, and informed trading. The empirical results found by implementing fixed effect model indicate a positive relationship between CEDS implementation and firm value. The results remain consistent across different platform designs like in platforms with both high and low machine readability, high industry search features, high and low government-operated designs as well as with less user-friendly platforms, with the strongest effect observed with high search functionalities and low machine readability. In addition, we found that the impact of the implementation is weaker in countries with stronger institutional quality which might be due to the diminishing marginal effect, while in a weaker regulatory setting, the adoption of the system could result in major improvements in firm value as they might act as a governance system. Moreover, the positive impact can also be observed after running robustness test with restrictions made to the sample period, treatment status, as well as on an entropy balanced sample. Overall, the findings suggest that the regulators should place greater emphasis on the implementation of the system, particularly in countries with weaker regulatory environment, as the group benefits the most with its implementation
ENHANCING RESILIENT OPERATIONS VIA PREDICTIVE MAINTENANCE: A MACHINE LEARNING APPROACH FOR BEARING FAULTS PREDICTION IN INDUCTION MOTORS
No full textThis thesis presents a machine learning based approach for bearing fault prediction in induction motors to enhance the resilience of operations in industrial facilities. Squirrel cage induction motors are commonly used in industrial facilities to supply critical loads. Therefore, the failure in these induction motors leads to unplanned downtime and production losses. The study investigates bearing fault prediction through utilizing a Feed-forward Neural Network (FFNN) to predict current and speed signals that are then fed into a Random Forest classifier to identify bearing faults in the predicted signals. Both models are implemented, integrated, and tested in MATLAB and Simulink using a simulated induction motor. The results demonstrate the system's ability to predict faults accurately, and the addition of a set-reset logic to minimize redundant alarms supports its practical applicability in industrial facilities. Future work can investigate the use of different machine learning techniques to forecast signals and detect faults, and the system can be tested in a laboratory or industrial settings to validate its performance and reliability
Healthcare Accreditation: A Study of the Role of Accreditation in the Quality of Private Healthcare Facilities in Qatar
No full textHealthcare accreditation involves an external evaluation process in which often an internationally acclaimed independent body assesses a healthcare organization in accordance with pre-defined standards, leading to public recognition of its compliance and commitment to quality and patient safety. This evaluation by an independent body helps healthcare facilities identify areas for improvement and continually enhance patient care and outcomes. Qatar is actively promoting healthcare accreditation in both private and public healthcare facilities. While the existing research addresses the role of accreditation in the public healthcare facilities, there is a dearth of research in the private healthcare facilities. This study examines the role of accreditation in shaping the quality of private healthcare facilities in Qatar. Specifically, this research sets three key objectives: (i) assessing healthcare providers’ perceptions of accreditation’s impact on organizational culture, patient care, and service quality; (ii) evaluating accreditation practices, both processes and outcomes, in enhancing healthcare facilities; and (iii) analyzing patient satisfaction with the quality improvements resulting from accreditation. The research also compares global healthcare accreditation standards with those currently applied in Qatar, highlighting both alignment and divergence. This study adopts a mixed-methods design, combining qualitative interviews with a quantitative survey. The findings reveal that accreditation contributes positively to patient safety, institutional accountability, clinical effectiveness, and staff morale, thereby echoing global literature on its value. Additionally, the study provides new insights into the implementation challenges of international accreditation and the necessity of contextual adaptation. The results underscore both the transformative potential of accreditation and the critical importance of tailoring accreditation strategies to national and institutional realities. The study suggests that accreditation emerges not as a one-size-fits-all mechanism, but as a framework that must be continuously reinterpreted in line with local dynamics, leadership approaches, and cultural norms