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Versober het arbeidsrecht of verlies de AI-race en grip op onze toekomst
No full textIs het Nederlandse arbeidsrecht een sta-in-de-weg voor onze toekomst? Zowel in het AI Deltaplan (https://aiplan.nl/deltaplan) als het Rapport Wennink (De route naar toekomstige welvaart, 2025) worden arbeidsrechtelijke verplichtingen aangewezen als rem op de innovatie en de groei van bedrijven. Daarmee dreigt Nederland de AI-race te verliezen met grote gevolgen voor ons verdienvermogen en onze maatschappij. Wat vinden wij arbeidsrechtjuristen van de dringende oproep om voor bepaalde groepen werknemers het ontslagrecht te versoberen
Versober het arbeidsrecht of verlies de AI-race en grip op onze toekomst
No full textIs het Nederlandse arbeidsrecht een sta-in-de-weg voor onze toekomst? Zowel in het AI Deltaplan (https://aiplan.nl/deltaplan) als het Rapport Wennink (De route naar toekomstige welvaart, 2025) worden arbeidsrechtelijke verplichtingen aangewezen als rem op de innovatie en de groei van bedrijven. Daarmee dreigt Nederland de AI-race te verliezen met grote gevolgen voor ons verdienvermogen en onze maatschappij. Wat vinden wij arbeidsrechtjuristen van de dringende oproep om voor bepaalde groepen werknemers het ontslagrecht te versoberen
Teachers learning from their students:The design and evaluation of a professional development program to support the use of students’ perceptions of teaching quality
No full textTeachers are widely recognized as one of the most important factors influencing students’ learning. Yet, many teachers receive limited, actionable feedback to help them reflect on and improve their instructional practices. This PhD thesis investigates how teachers can learn from their own students by using data from students’ perceptions of teaching quality (SPTQ) as part of a structured professional development process.The thesis presents the design, implementation, and evaluation of a teacher professional development (TPD) program that supports teachers in interpreting and using SPTQ data to improve their classroom practices. The research draws on multiple studies conducted in Chilean schools and combines expert consultation, qualitative research, and quantitative analyses. Central to the program is a structured data-use cycle that guides teachers from interpreting student feedback to selecting evidence-informed instructional strategies and reflecting on their implementation within professional learning communities.The findings show that teachers generally value student feedback and feel capable of using it to inform their practice. However, the studies also reveal important challenges. While teachers’ initial beliefs about the usefulness of student feedback are often positive, engaging with the data can be demanding and may challenge teachers’ confidence over time. The professional development program helped teachers maintain positive beliefs and supported meaningful reflection, but implementation was constrained by factors such as time pressure, workload, and organizational conditions within schools.Overall, this thesis demonstrates that students’ perceptions can serve as a valuable source of evidence for teacher learning, provided that teachers are supported through well-designed professional development and realistic implementation conditions. The results contribute to research on data-informed decision-making, teaching quality, and sustainable teacher professional development
Cosmetic gynecology: more than meets the eye:On vaginal tightening and labiareductions as serious medical procedures
No full textCosmetische gynaecologie. De combinatie van deze twee woorden roept bij velen weerstand op. Het vakgebied wordt vaak geassocieerd met jonge onzekere meisjes die in de zoektocht naar perfectie ‘iets aan hun schaamlippen willen laten doen’. Maar dat beeld is achterhaald en doet geen recht aan de realiteit en de diepgang van dit vak
Transport across the yeast peroxisomal membrane
No full textThe eukaryotic cell consists of multiple membrane enclosed compartments, namely organelles. These organelles serve in numerous biological and chemical reactions. One of these organelles is the peroxisome, which is found in most cell types. In mammalian cells, defects in genes related to peroxisomes cause a spectrum of severe genetic disorders, often with a devastating result. To investigate further, yeast is applied as model organism for peroxisome research. Proteins located in the yeast peroxisomal matrix are involved in the beta-oxidation breakdown of fatty acids, amino acids biosynthesis, hydrogen peroxide neutralization, redox balancing, and glyoxylate cycle. All these biochemical reactions and pathways are known to require a substrate and produce a product.However, only few peroxisomal membrane transport proteins have been identified. Such transport proteins are required to facilitate exchange of substrates and products between the cytosol and the peroxisomal matrix. This thesis aims to elucidate the mechanisms of transport across the yeast peroxisomal membrane. This thesis provides an updated yeast peroxisomal metabolic map and the enzymes required to assist in catabolic conversions. From this map, we deduce a number of theoretical transport proteins required to facilitate exchange. Furthermore, the experimental part presents 3 previously known transport proteins to localize to the peroxisomal membrane. Namely, Mir1, a proton/phosphate symporter, and Mpc1/Mpc3 as pyruvate exporters across the peroxisomal membrane. Also, we provide evidence that the unfolded peptide domains of the protein Nsp1 can be imported to the peroxisomal matrix
NOCI-F Electronic Couplings in Assemblies of Indolonaphthyridine Molecules:From Dimers to the Full Stack
No full textKey electronic processes related to molecular excitonic states of finite stacks of indolonaphthyridine molecules are analyzed via the non-orthogonal configuration interaction with fragments (NOCI-F) method. Indolonaphthyridine is an organic chromophore that can undergo several electronic photoexcitation-related intermolecular processes, such as exciton and electron transfer. The structures studied here are noncrystalline arrangements built as either ordered stacks of indolonaphthyridine or stacks extracted from molecular dynamics simulations including thermal disorder. Taking dimers or trimers from either model, we performed CASSCF and NOCI-F calculations to quantify the intermolecular electronic couplings governing singlet fission, excited singlet and triplet diffusion, and hole and electron diffusion processes. Also, comparing the results for the different models, we studied the effect of structural disorder and distortion on these couplings. Finally, we present a newly developed, advanced postanalysis tool. It takes the NOCI-F data as input to carry out a multifragment full Hamiltonian procedure that involves the complete stack, providing physical information not available from the dimer/trimer models, hence giving access to additional insight into the material's properties.</p