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Defending the Unreached and Unknown: American Evangelical Advocacy for International Religious Freedom
No full textThroughout the Cold War, US evangelical groups rallied to support fellow Christians suffering persecution behind the Iron Curtain. They also sought ways to circumvent restrictions on evangelizing in the closed societies of the Soviet bloc and other communist countries so as to create opportunities to win new adherents to their faith. By the 1970s and 1980s, these efforts included intercessory prayer, or prayer on behalf of others, as well as more direct political activism and lobbying. This chapter explores how evangelical organizations in the United States made the “unknown” peoples of the world “known” to believers in the United States, and argues that this led to an outpouring of evangelical activism promoting religious freedom abroad. This chapter shows that, during the Carter administration, evangelical lobbying contributed to the increased attention that US policymakers devoted to foreign religious persecution in diplomatic negotiations and prisoner exchanges with the Soviet Union
Stepping Down? Theorizing the Process of Returning to the Faculty After Senior Academic Leadership
Get PDFWhile scholars have devoted considerable attention to identifying and developing future academic leaders, scant empirical research has considered the firsthand experiences of senior leaders who returned to the faculty. This grounded theory study developed a theoretical understanding of the process of returning to the faculty after serving as a senior campus administrator. This research examined a common academic rite of passage using the analysis of interviews with 43 former college presidents, provosts, deans, and “other senior leaders” from a variety of postsecondary institutions. Academic leaders in the study characterized the process of returning to the faculty as mostly positive and liberating, prompting the need to reconsider the use of the phrase “stepping down” in this contex
“Not the Lover’s Choice, but the Poet’s”: Classical Receptions in \u3cem\u3ePortrait of a Lady on Fire\u3c/em\u3e
No full textCéline Sciamma’s film Portrait of a Lady on Fire (Portrait de la jeune fille en feu, 2019) tells its 18th-century story of love and loss in part by retelling an ancient story, the myth of the poet Orpheus and his beloved Eurydice, as related by the Roman poet Ovid in his epic Metamorphoses (c. 8 CE). The myth’s most iconic moment, when Orpheus turns around to look at Eurydice and therefore loses her to Hades, occupies a central position in the film’s plot and underlies its running theme of ‘looking at’ as ‘looking back.’ By changing certain aspects of the myth – replacing poetry or singing with painting, making both main characters women, and having them alternate between the two main mythic roles – Portrait does not so much update the ancient story as debate its meanings. What does it mean to lose someone beloved but gain their image? How is every loss a kind of death, and in its train, the life that remains a kind of afterlife? Most generally, what are the links among lived experience, memory, and art? By raising these questions via the ancient myth, Portrait meditates on the effect of making, as Orpheus did, “not the lover’s choice, but the poet’s.
The Effect of Experienced Buyers\u27 Feedback on Consumer Behavior: Evidence from the Largest Online Marketplace in China
No full textFake online reviews are so prevalent that e-commerce platforms attempt to control it from affecting the trustworthiness between buyers and sellers. The issue has also attracted sporadic scholarly endeavor to understand this new field. To address this issue, we propose a new model to examine three interrelated stakeholders of e-Commerce platforms: experienced buyers, future buyers and the online sellers in terms of purchasing behaviors and sales with three objectives. Experienced buyers influence future consumers\u27 behaviors and increase sales from sellers. Using data collected from the largest online e-commerce platform in China, we test relevant hypotheses. Our findings show that experienced buyers and their positive reviews increase future buyers\u27 purchasing and promote corporate sales. These findings contribute knowledge to the online feedback mechanism and literature on fake review studies. This study also provides a novel method to help buyers avoid fake online review from a market structure perspective
Roles for a Lipid Phosphatase in the Activation of its Opposing Lipid Kinase
Get PDFFig4 is a phosphoinositide phosphatase that converts PI3,5P2 to PI3P. Paradoxically, mutation of Fig4 results in lower PI3,5P2, indicating that Fig4 is also required for PI3,5P2 production. Fig4 promotes elevation of PI3,5P2, in part, through stabilization of a protein complex that includes its opposing lipid kinase, Fab1, and the scaffold protein Vac14. Here we show that multiple regions of Fig4 contribute to its roles in the elevation of PI3,5P2: Its catalytic site, an N-terminal disease-related surface, and a C-terminal region. We show that mutation of the Fig4 catalytic site enhances the formation of the Fab1-Vac14-Fig4 complex, and reduces the ability to elevate PI3,5P2. This suggests that independent of its lipid phosphatase function, the active site plays a role in the Fab1-Vac14-Fig4 complex. We also show that the N-terminal disease-related surface contributes to the elevation of PI3,5P2 and promotes Fig4 association with Vac14 in a manner that requires the Fig4 C-terminus. We find that the Fig4 C-terminus alone interacts with Vac14 in vivo and retains some functions of full-length Fig4. Thus, a subset of Fig4 functions are independent of its phosphatase domain and at least three regions of Fig4 play roles in the function of the Fab1-Vac14-Fig4 complex
Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury
No full textWe describe here the design, synthesis, and biological evaluation of a reactive oxygen species (ROS)-activatable prodrug for the selective delivery of 147, a small molecule ATF6 activator, for ischemia/reperfusion injury. ROS-activatable prodrug 1 and a negative control unable to release free drug were synthesized and examined for peroxide-mediated activation. Prodrug 1 blocks activity of 147 by its inability to undergo metabolic oxidation by ER-resident cytochrome P450 enzymes such as Cyp1A2, probed directly here for the first time. Biological evaluation of ROS-activatable prodrug 1 in primary cardiomyocytes demonstrates protection against peroxide-mediated toxicity and enhances viability following simulated I/R injury. The ability to selectively target ATF6 activation under diseased conditions establishes the potential for localized stress-responsive signaling pathway activation as a therapeutic approach for I/R injury and related protein misfolding maladies
Philosophy of Western Music: A Contemporary Introduction
No full textThis is the first comprehensive book-length introduction to the philosophy of Western music that fully integrates consideration of popular music and hybrid musical forms, especially song. Its author, Andrew Kania, begins by asking whether Bob Dylan should even have been eligible for the Nobel Prize in Literature, given that he is a musician. This motivates a discussion of music as an artistic medium, and what philosophy has to contribute to our thinking about music. Chapters 2-5 investigate the most commonly defended sources of musical value: its emotional power, its form, and specifically musical features (such as pitch, rhythm, and harmony). In chapters 6-9, Kania explores issues arising from different musical practices, particularly work-performance (with a focus on classical music), improvisation (with a focus on jazz), and recording (with a focus on rock and pop). Chapter 10 examines the intersection of music and morality. The book ends with a consideration of what, ultimately, music is.https://digitalcommons.trinity.edu/mono/1147/thumbnail.jp